Nurofen Cold and Flu Tablets- The two active ingredients in Nurofen cold & flu tablets are pseudoephedrine hydrochloride and ibuprofen, which together reduce the discomfort caused by cold and flu symptoms.
Ibuprofen is present in all Nurofen products and helps relieve many of the symptoms associated with headaches and feverishness, as well as those of colds and flu, including blocked sinuses, a sore throat, fever, aches and pains.
The maximum dose is 6 tablets in any 24 hour period.
There are two active ingredients: ibuprofen (200mg) works as a painkiller and pseudoephedrine hydrochloride (30mg), as a decongestant. Falling into the category of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen can relieve mild to moderate pain, as well as inflammation and fever. By blocking the action of cyclo-oxygenase (COX), an enzyme present in the body, COX helps in the making of prostaglandins, as a response to injury and also certain health conditions and diseases. It is the prostaglandins that cause swelling, pain and inflammation and ibuprofen reduces the production of this substance.
It is an increase in prostaglandins in the brain which brings on a fever, by causing the body temperature to increase. Pseudoephedrine brings about a contraction and narrowing of the blood vessels, which are present in the linings of the nasal passages and also the sinuses. By thus reducing the blood flow, pseudoephedrine reduces the production of mucus and the unpleasant feelings of congestion.
Relieving the symptoms which arise with colds and flu, such as fever, blocked nose, sinus congestion, headache, aches, pains and a sore throat.
Whilst taking nurofen cold and flu tablets, don't take any other product which also contains ibuprofen, many of which can be bought over the counter, so always check the ingredients of such purchases, or seek advice from your doctor or a pharmacist. Taking these other medications as well could lead to exceeding the recommended daily dose and possibly heighten the risk of side-effects. Nurofen cold and flu tablets should not be taken at the same time as any of the following, as this could lead to an increase in your blood pressure:
- Appetite suppressants
- Amphetamine-like stimulants, including methylphenidate, modafinil and dexamfetamine
- The antibiotic, linezolid
- MAOI antidepressants, including phenelzine, moclobemide, tranylcypromine and isocarboxazid
- The anti-Parkinson's medicines, rasagiline or selegiline
- Tricyclic antidepressants e.g. amitriptyline.
Don't take Nurofen cold and flu tablets if you are already taking medicines for high blood pressure, as doing so could affect the purpose of the blood pressure tablets.
Don't use Nurofen cold and flu tablets alongside aspirin or any other oral NSAID e.g. naproxen or diclofenac, as there could be an increased risk of side-effects to the stomach and intestines. The same advice applies to those using any selective inhibitors of COX-2 e.g. celecoxib or etoricoxib, as these could also have the same negative effect.
If ibuprofen is taken with corticosteroids, of which prednisolone is an example, you could increase the risk of bleeding or ulceration in your gut. Ibuproen with other medicines can also increase the chances of bleeding in the gut, so consult your doctor before taking nurofen cold and flu tablets, if you are taking:
- Anticoagulant (anti-blood-clotting) medicines such as warfarin, edoxaban, dabigatran, apixaban, rivaroxaban, heparin and low molecular weight heparins e.g. enoxaparin
- Antiplatelet medicines to thin the blood or reduce the risk of blood clots e.g. dipyridamole, prasugrel, clopidogrel, low-dose aspirin
- Ginko biloba (a herbal remedy)
- SSRI antidepressant, e.g. fluoxetine, citalopram, paroxetine
There could be an increased risk of certain side-effects on the kidneys, if you take ibuprofen when also taking any of the following:
- ACE inhibitors e.g. enalapril
- Diuretics e.g. furosemide (ibuprofen may also have a reducing effect on diuretc medicines)
Ibuprofen can also have the effect of reducing the removal of some medicines from the body, increasing the blood levels and also the risk of side effects. These medicines include:
- If taken with quinolone antibiotics, which include ciprofloxacin or norfloxacin, ibuprofen may increase the risk of seizures (fits), especially in those who already suffer from epilepsy.
Other medicines containing the same active ingredients are:
- Nurofen sinus pressure and headache relief
- RobiCold sinus relief.
- Sudafed sinus pressure and pain tablets
There are many other medicines available for the treatment of colds and flu. Many of these will also contain ibuprofen or pseudoephedrine in their active ingredients. Ibuprofen and pseudoephedrine are also available separately.