Paludrine (proguanil) tablets are an effective, low-cost anti-malarial tablet. Taken daily, they reduce your risk of contracting malaria while travelling to a high-risk area.
The tablets are suitable for use in all areas where resistance to malaria is not yet present. To learn whether Paldurine is appropriate for your trip, check the Fit for Travel website
Like all anti-malarials, Paludrine can significantly reduce your risk of your contracting malaria where it is prevalent. As no anti-malarial is 100% effective, it is important that you take the necessary precautions for avoiding mosquito bites while you travel.
Paludrine tablets contain the active ingredient proguanil hydrochloride, an antimalarial medication.
Paludrine’s dosage is two tablets daily beginning one week before travel, continuing during your trip and for four weeks after your return. Paludrine tablets have been proven effective against malaria in areas where there is currently no resistance. They are popular with patients since they are well-tolerated and cost effective.
You can take Proguanil if you are pregnant or breastfeeding but get your doctor’s approval first. The tablets should be taken with or after food to he reduce side effects.
Malaria is a potentially fatal disease caused by Plasmodium parasites. Plasmodium are carried by infected mosquitoes who inject them into humans during a bite. Once inside the blood, the parasite travels to the liver, then into the bloodstream where it invades the red blood cells and reproduces. An attack of malaria develops when the red blood cells burst, releasing a mass of parasites into the bloodstream.
Proguanil prevents the malaria parasite from reproducing once it enters the red blood cells. It does this by blocking the action of dihydrofolate reductase, a compound that exists in the Plasmodium parasite and is involved in its reproduction.
Dihydrofolate reductase normally converts folic acid into folinic acid in the parasite, an essential step for the parasite to produce new DNA and reproduce. By blocking its production, proguanil prevents the reproduction of any malarial parasites that have entered the red blood cells.
Proguanil hydrochloride is often taken in combination with chloroquine, another antimalarial. Since the malaria parasite is resistant to these medicines in certain areas of the world, consult your pharmacist about which are recommended for the country to which you are travelling. You can also check the travel section of this site.
If your doctor recommends proguanil, begin treatment a week before your trip. If this is not possible, take Paldurine at least two days before you leave. Continue to take the tablets throughout your travels and for an additional four weeks after your return.
• Begin taking Paldurine one week before your trip. If this is not possible, start taking this medicine at least two days prior. Continue to take it during your stay and for 4 weeks after you return home.
Adults and children over 14 years
Take two tablets daily.
• Take the tablet(s) at the same time every day, after food.
• Swallow the tablet(s), or part tablets, whole with water.
• For children, the tablet(s) may be given crushed in milk, honey or jam.
No medication is guaranteed to protect against malaria in every instance. If you develop a fever during your visit to an area at risk for malaria, or up to a year after, you should suspect malaria. Contact a doctor immediately and inform him or her that you visited a country with malaria.
Take TWO tablets WEEKLY starting ONE WEEK before travelling and continuing until FOUR WEEKS after return.
Paludrine tablets should be taken with or after food to help reduce the chance of side effects.
Paludrine tablets are not affected by a moderate alcohol intake.
Whilst taking Paludrine (proguanil) tablets there is a small chance that you will experience side effects. The liklihood of these occuring can be reducing by taking them with or after food. If you do experience side effects they may include:
- Allergic reaction (itch rash, difficulty breathing, swelling of the face, lips, tongue and throat).
- Diarrhoea or constipation (these usually get better as treatment persists).
- Mouth ulcers or inflamed mouth.
- Skin reactions.
- Hair loss.
- Kidney or liver problems.
If you experience any side effects from this medicine it is important to check with your doctor, especially if they are prolonged or serious.
You should not take Paludrine tablets if you:
- Take warfarin - Paludrine may change the effect of warfarin.
- Have kidney problems.
- Are allergic to proguanil or any of the other ingredients.
Paludrine tablets can interact with antacids that contain aluminium, calcium or magnesium. If you take any of these antacids you should leave at least two hours between doses of Paludrine and your antacid to ensure that Paludrine is effective.
It is always best to check with your doctor before taking Paludrine if you are pregnant or breast-feeding.
- Each Paludrine tablet contains 100 mg of proguanil hydrochloride (the active ingredient).
- The other ingredients are calcium carbonate, gelatin, magnesium stearate and maize starch.