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Differin 0.1% Cream

Differin 0.1% Cream

Pack Size: 45g
RRP: £35.00
Saving: £5.05
Our Price: £29.95
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Age: 18 years + Pregnancy: Not suitable Breastfeeding: Not suitable

Differin 0.1% Cream is available to order online from The Independent Pharmacy Online Doctor. Differin cream contains the active ingredient adapalene. Adapalene is a form of vitamin A, which reduces the growth of keratin skin cells that would normally act to block pores in acne. Additionally adapalene increases the turnover of surface skin cells, aiding the natural exfoliation of the skin. These dual actions help to clear acne and leave skin looking clear and oil-free.

Pharmacist Tip
Do not wash your skin more than twice daily. This can irritate your skin, remove essential oils and make your symptoms worse.

Differin 0.1% cream is available to buy from The Independent Pharmacy Online Doctor service, following a free consultation, to help to treat acne. To find out more about acne and see all the available treatments, see our Online Doctor Acne page.

Differin cream contains the active ingredient adapalene and is used in the treatment of acne. Differin is a retinoid-like compound that is manufactured by Galderma UK Limited. The active ingredient in Differin, Adapalene, is a form of vitamin A. It works to reduce the growth of keratin surface skin cells that can block pores.

Sebum is produced by glands just under the surface of the skin called sebaceous glands. Sebum is a natural, oily substance needed to keep the skin smooth and supple. However, sufferers of acne often produce too much sebum, which can mix with the dead keratin skin cells and cause the pores to become blocked. Blocked pores can then lead to the formation of spots, blackheads (comedones) and whiteheads. Applying Differin 0.1% Cream to the affected areas will help reduce the amount of keratin skin cells and unblock the pores and sebaceous glands, allowing the sebum to escape. This will result in a reduction of inflammation, whiteheads, comedones and spots.

Differin 0.1% cream is also beneficial as it increases the natural turnover of the skin cells. This aids the natural exfoliation of the skin’s outer layers. This action will help keep pores unblocked, thus reducing the formation of spots and blackheads.

Differin 0.1% cream is for external use only and is designed to treat mild to moderate acne symptoms. Currently, Differin is the only licensed medicine in the UK to contain the active ingredient Adapalene.

Pharmacist tip: Differin cream should be applied once daily, in the evening. It should be applied to the affected areas after they have been washed and patted dry. You can use cosmetics and moisturisers whilst using Differin cream, however you should let it absorb into your skin fully before applying them.

  • Differin cream should be applied to the affected areas once daily in the evening, after washing with a mild cleanser.
  • Apply a small amount to cover the affected areas using clean fingertips and rub in lightly.
  • At the start of treatment with Differin, if it is used correctly it will produce effects similar to that of mild sunburn including mild itching, redness and warmth. This is normal and should subside.

To get the best effects from Differin cream it is important that it is for up to THREE months continuously depending on response. Improvement should be seen after a few weeks.

You may use cosmetics and moisturisers whilst you are using Differin cream however you should wait for it to be fully absorbed into the skin before applying anything else.

Differin cream has drying effect on the skin so it is important to try to ensure that any toiletries containing alcohol or other skin-drying ingredients are not used.

Differin Cream contains the active ingredient adapalene 0.1%.

It also contains: carbomer 934P, Macrogol-20 methyl glucose sesquistearate, glycerol (E422), natural squalene, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide & purified water. 

Like all creams there is the potential that you may be allergic to Differin cream. We recommend you do a spot test before commencing treatment.

If you do experience side effects from Differin cream, they can include a burning, stinging or tingling feeling, dry skin, itching, redness, or a rash. Differin can also cause your skin to be more sensitive to sunlight meaning you may burn in the sun more easily than normal. You should take action to reduce this risk such as wearing protective clothing or using sunscreen. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects. 

If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 0117 971 1603. In a medical emergency you should contact the emergency services or go straight to your local Accident & Emergency.

Differin cream should not cause a harmful interaction with any of your other current medicines. Differin cream should not be used with other acne treatments containing benzoyl peroxide as they can have additive drying effects. Please read the Patient Information Leaflet enclosed with your medicines for further information.

During treatment with Differin cream if you experience severe itching, redness, blistering, peeling or swelling of the skin you should stop using it temporarily. If the symptoms persist stop using Differin cream and consult your doctor.


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All our orders are sent out using Royal Mail. Tracking is available on all orders. We always aim to dispatch all orders within 24 hours of them being received, if we are unable to meet this high standard for whatever reason we will always contact you to advise you of the delay.

We offer free UK standard delivery on orders over £40.

The following delivery options are available:

  • Standard Delivery - 2/3 day delivery - £2.95
  • Express Delivery - 1/2 day delivery - £4.45
  • Special Delivery (Guaranteed before 1pm) - £8.95
  • Saturday Guaranteed before 1pm - £10.45

The cut-off for same day dispatch of orders is 4pm. Orders processed after this time will be dispatched the following working day. Orders are dispatched Monday - Friday. Orders will not be processed on weekends or bank holidays.

We ensure all deliveries are in plain packaging for discreet delivery of your medicines and pharmacy goods.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 


We are currently unable to ship orders outside of the UK.

Differin Cream FAQ's

What does Differin Cream contain? 

Differin Cream is a acne treatment that contains Adapalene 0.1%, which helps to reduce the growth and increase the turnover of keratin skin cells that can build up and block pores causing acne.

How do I use Differin Cream? 

In adults and children 18 years and over, Differin apllied once daily, usually in the evening. You should not apply Differin more than once in a 24-hour period. For best effects, Differin should be appied after washing your face with warm water and a mild cleanser to clear away and excess oil, skin cells and bacteria.

Can I use other acne treatments with Differin Cream?

You can combine Differin with antibiotic acne treatments such as Tetralysal (lymecycline), Minocin (minocycline) or Erythromycin tablets. Differin should not be used with any other acne creams as it may cause excess drying or irritation to your skin.

I have started using Differin Cream and the treated area is red and irritated, is this normal?

Redness and irritation of the treated area, almost like sunburn, can commonly occur when you use Differin for the first time. This is not usually serious and is a sign that it is working. These effects normally subside within a week. During this time you can reduce the frequency of Differin application to once every other day to allow your skin to recover and then slowly build up to applying it daily.  

Why can I only buy three packs of Differin online at one time?

Differin Cream is an prescription-only acne treatment. For that reason, to ensure the safety of our patients and the legal & ethical operating of our pharmacy, we only supply a maximum of 3 months treatment at one time. Differin treatment is normally judged for effectiveness after 2-3 months. This means that if you do not find Differin as effective as you would like after this time, you are not stuck with an excess of medication. If you are happy with the results you can easily log in and re-order another supply.

Is Differin available for next day delivery?

Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 4pm, Differin cream is available for next day delivery.

Is it safe to buy Differin Cream online?

Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Differin online. The Independent Pharmacy is an NHS Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.

How do I buy Differin online?

It simple! Just select 'Start Consultation' above, you will need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Differin to you. It all takes around 3 minutes and your treatment can be delivered to your door.

What are the advantages of buying Differin Cream online?

There are many advantages to buying Differin online, some include:

  • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
  • Fast delivery - We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
  • Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
  • Tons of information - we provide all the information you could need on Epiduo (adapalene/benzoyl peroxide) and other acne treatments, in easy to digest formats, at a time to suit you.

The Independent Pharmacy is an online pharmacy and online doctor service is owned and operated by ABSM Healthcare Ltd (Company Reg. 08515600) and Red Label Medical Ltd (Company Reg. 08676338). All information that appears on this website is intended for information purposes only and should be used to supplement, not replace, your relationship with your local healthcare professionals. You should consult your doctor if you think you may have a health problem or before you start taking a new medicine. Please ensure you always read the information leaflets supplied with any medicinal products.For more information see our policies and terms and conditions at the bottom of every page. © 2014 ABSM Healthcare Ltd. All rights reserved.
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