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Epiduo 0.1%/2.5% Gel

Epiduo 0.1%/2.5% Gel

Pack Size: 45g
RRP: £35.00
Saving: £2.00
Our Price: £33.00
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Age: 18 Years + Pregnancy: Not suitable Breastfeeding: Not suitable
Pharmacist Tip

Epiduo is a good treatment option for acne that should be chosen when benzoyl peroxide (Panoxyl) or adapalene (Differin) used on their own have failed. Using them in combination, as in Epiduo, may be more effective.

Epiduo 0.1%/2.5% gel is available to buy from The Independent Pharmacy Online Doctor service, following a free consultation, to help to treat acne. To find out more about acne and see all the available treatments, see our Online Doctor Acne page.

Epiduo is a topical gel used to treat acne. It is manufactured by Galderma UK Ltd and comes in a 45g pump dispenser. Epiduo gel contains two active ingredients, Adapalene 0.1% and Benzoyl Peroxide 2.5%. These two ingredients will help significantly reduce acne breakouts, as well as preventing or reducing future acne occurrences.

Epiduo gel contains Adapalene, which is a synthetic retinoid. It works to reduce the growth of keratin surface skin cells that can block pores. When Adapalene is applied to an affected area, it will help unblock the pores and sebaceous glands, allowing the sebum to escape. This will decrease the redness, swelling and inflammation associated with acne. 

Epiduo gel also contains Benzoyl peroxide, an antimicrobial medicine designed to kill the bacteria that can lead to acne symptoms. It also helps promote skin turnover, which will further help clear blocked pores and reduce the bacterial count on the skin’s surface. It is effective at treating blackheads, whiteheads and inflamed red spots.

Combining both these ingredients in a single treatment will help provide an effective means of treating and controlling mild to moderate symptoms of acne. Epiduo has been clinically tested and approved for both short and long-term acne treatment.  

Sebum is produced by glands just under the surface of the skin called sebaceous glands. Sebum is a natural, oily substance needed to keep the skin smooth and supple. However, sufferers of acne often produce too much sebum, which can cause the pores to become blocked and infected. Blocked pores can then lead to the formation of spots, blackheads and whiteheads.

Early signs of improvement in acne symtpoms usually appear after 1 to 4 weeks of treatment. 

Apply a thin layer of Epiduo gel to the affected area once daily in the evening. You should apply gel to the whole affected area, not just the spots themselves. Use continuously for up to THREE months.

You should wash your face using warm water and a mild cleanser or soap before use. Pat it dry, rubbing can irritate the skin and cause redness.

If dry skin or irritation occurs at the start of treatment, try applying Epiduo every other day and slowly work up to daily applications.  

Epiduo 0.1%/2.5% gel contains the active ingredients adapalene 0.1% w/w and benzoyl peroxide 2.5% w/w.

It also contains: docusate sodium, disodium edetate, glycerin, poloxamer, propylene glycerol (E1520), simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethylaurate, isohexadecane, polsorbate 80, sorbitan oleate) & purified water. 

Epiduo gel can cause side effects in a small number of people who use it. Side effects are most common at the start of treatment as your skin gets used to Epiduo.

Common (affect between 1 in 10 and 1 in 100 people)

  • Dry skin: If this occurs you can used a non-comedogenic moisturiser (like Cetaphil) to remoisturise the skin.

  • Irritant contact dermatitis.

  • Skin irritation and burning: You should reduce the frquency of application or disontinue use until your skin is better then slowly reintorduce treatment.

Uncommon (affect between 1 in 100 and 1 in 1000 people)

  • Itching (pruritus).

  • Sunburn.

Epiduo Gel should not be applied to skin that is broken or has eczema.

Epiduo should not come into contact with the eyes, mouth, nostrils or mucous membranes. If product enters the eye, wash immediately with warm water.

This product contains propylene glycol (E1520) that may cause skin irritation.

If a reaction suggesting sensitivity to any component of Epiduo occurs, use should be discontinued.

Excessive exposure to sunlight or UV light (including sun beds) should be avoided.

Epiduo should not come into contact with any coloured material including hair and dyed fabrics as this may result in bleaching and discoloration.

Epiduo should not be used during pregnancy. 

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All our orders are sent out using Royal Mail. Tracking is available on all orders. We always aim to dispatch all orders within 24 hours of them being received, if we are unable to meet this high standard for whatever reason we will always contact you to advise you of the delay.

We offer free UK standard delivery on orders over £40.

The following delivery options are available:

  • Standard Delivery - 2/3 day delivery - £2.95
  • Express Delivery - 1/2 day delivery - £4.45
  • Special Delivery (Guaranteed before 1pm) - £8.95
  • Saturday Guaranteed before 1pm - £10.45

The cut-off for same day dispatch of orders is 4pm. Orders processed after this time will be dispatched the following working day. Orders are dispatched Monday - Friday. Orders will not be processed on weekends or bank holidays.

We ensure all deliveries are in plain packaging for discreet delivery of your medicines and pharmacy goods.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 


We are currently unable to ship orders outside of the UK.

Epiduo Gel FAQ's

What does Epiduo Gel contain? 

Epiduo Gel is a dual-action acne treatment that contains Adapalene 0.1% and Benzoyl Peroxide 2.5%. When combined in Epiduo Gel, these two ingredients help to kill the bacteria that cause acne as well as helping to increase the turnover of keratin skin cells that can build up and block pores.

How do I use Epiduo Gel? 

In adults and children 18 years and over, Epiduo apllied once daily, usually in the evening. You should not apply Epiduo more than once in a 24-hour period. For best effects, Epiduo Gel should be appied after washing your face with warm water and a mild cleanser to clear away and excess oil, skin cells and bacteria.

Can I use other acne treatments with Epiduo Gel?

You can combine Epiduo with antibiotic acne treatments such as Tetralysal (lymecycline), Minocin (minocycline) or Erythromycin tablets. Epiduo should not be used with any other acne creams as it may cause excess drying or irritation to your skin.

I have started using Epiduo Gel and the treated area is red and irritated, is this normal?

Redness and irritation of the treated area can occur when you use Epiduo for the first time. This is not usually serious and normally subsides within a week. During this time reduce the frequency of Epiduo application to once every other day to allow your skin to recover and then slowly build up to applying it daily.  

Why can I only buy three packs of Epiduo online at one time?

Epiduo Gel is an prescription-only acne treatment. For that reason, to ensure the safety of our patients and the legal & ethical operating of our pharmacy, we only supply a maximum of 3 months treatment at one time. Epiduo treatment is normally judged for effectiveness after 2-3 months. This means that if you do not find Epiduo as effective as you would like after this time, you are not stuck with an excess of medication. If you are happy with the results you can easily log in and re-order another supply.

Is Epiduo available for next day delivery?

Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 4pm, Epiduo Gel are available for next day delivery.

Is it safe to buy Epiduo Gel online?

Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Epiduo online. The Independent Pharmacy is an NHS Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.

How do I buy Epiduo online?

It simple! Just select 'Start Consultation' above, you will need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Epiduo to you. It all takes around 3 minutes and your treatment can be delivered to your door.

What are the advantages of buying Epiduo Gel online?

There are many advantages to buying Epiduo online, some include:

  • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
  • Fast delivery - We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
  • Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
  • Tons of information - we provide all the information you could need on Epiduo (adapalene/benzoyl peroxide) and other acne treatments, in easy to digest formats, at a time to suit you.

The Independent Pharmacy is an online pharmacy and online doctor service is owned and operated by ABSM Healthcare Ltd (Company Reg. 08515600) and Red Label Medical Ltd (Company Reg. 08676338). All information that appears on this website is intended for information purposes only and should be used to supplement, not replace, your relationship with your local healthcare professionals. You should consult your doctor if you think you may have a health problem or before you start taking a new medicine. Please ensure you always read the information leaflets supplied with any medicinal products.For more information see our policies and terms and conditions at the bottom of every page. © 2014 ABSM Healthcare Ltd. All rights reserved.
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