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Isotrex Gel 0.05%

Isotrex Gel 0.05%

Pack Size: 30g
RRP: £20.00
Saving: £1.00
Our Price: £19.00
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Age: 18 Years + Pregnancy: Not suitable Breastfeeding: Not suitable

Isotrex gel contains a the topical retinoid, isotretinoin, for the treatment of moderate acne. It helps to reduce the oiliness of the skin as well as incresing the turnover of skin cells to prevent blocked pores. When used regularly over period of 6 - 8 weeks, it can help to improve acne on the face, neck, back and chest.

Pharmacist Tip

Avoid using too much make-up. If you do wear make up ensure it is water-based and non-comedogenic. Always make sure you remove your make up fully before going to bed.

Isotrex gel is available to buy from The Independent Pharmacy Online Doctor service, following a free consultation, to help to treat acne. To find out more about acne and see all the available treatments, see our Online Doctor Acne page.

Isotrex gel contains the active ingredient Isotretinoin and is used in the topical treatment of acne vulgaris. Isotretinoin belongs to a category of medicines known as retinoids, which are derivatives of vitamin A. Isotrex gel is manufactured by Stiefel Laboratories.

The exact mechanism of action of isotretinoin isn’t fully understood. It is thought to:

  • Make your skin less oily (due to a reduction in sebum production).
  • Loosen the surface cells of the skin

These actions result in:

  • A reduction in the number of existing blackheads and whiteheads (due to unblocking of the pores).
  • A reduction in the number of newly forming blackheads and whiteheads.
  • A reduction in the number of red, inflamed spots.

These effects are because the sebaceous glands in the skin are allowed to function normally. The skin cell loosening action will also promote skin cell turnover. This turnover will provide a natural exfoliation of the skin’s outer layers. This exfoliation will also help to unblock pores, reducing redness, inflammation and the formation of blackheads and spots.

Isotrex gel can take six to eight weeks before the beneficial effects become visible. Isotrex is for external use only and is suitable for treating mild to moderate acne symptoms.  


Isotrex gel should be used once or twice daily, depending on response. Most people should start using Isotrex once daily and then slowly try to increase this to twice daily, if necessary, after around one week of treatment if there have been no side effects. Use continuously for up to THREE months.

How to apply Isotrex

  1. Wash your hands to remove any oil, dirt or bacteria before applying the cream.
  2. Completely remove any make-up, cosmetics or other creams.
  3. Wash the treatment area with a mild soap or cleanser and warm (not hot) water.
  4. Pat the area dry.
  5. Apply a thin layer of Isotrex over all of the affected area (not just to the spots) using a clean fingertip and smooth into the skin.
  6. Wash your hands to remove any excess gel.

Isotrex gel contains the active ingredient isotretinoin 0.05% w/w.

The other ingredients contained in this product are: hydroxypropylcellulose, butylated hydroxytoluene (E321) & ethanol. 

Like all medicines, Isotrex gel can cause side effects. however not everybody that uses it will get them. Side effects are most common at the start of treatment as your skin gets used to your new medicine.

  • Local skin reaction, eg stinging, burning, redness, irritation or peeling at site of application.
  • Increased sensitivity of skin to sunlight.
  • Dry skin at where Isotrex has been applied.
If you experience any of the above side effects when using Isotrex gel, you should try cutting down the frequency of application or not using it for a few days to allow your skin to recover. You can then slowly start to increase the use of Isotrex back to the prescribed amount.

Please see the maunfacturers patient information leaflet for a comprehensive list of side effects.

  • This preparation is for external use only.
  • Avoid contact of this medicine with the eyes, mouth, mucous membranes (eg linings of the nose) and broken areas of skin or areas affected by eczema. Take care to avoid the gel building up in skin creases or the angles of the nose.
  • If your skin is sunburnt you should not use this medicine until your skin is fully recovered, as it may potentially cause severe irritation to the skin.
  • You should avoid exposing treated areas of skin to sunlight or sunlamps while using this medicine, as it increases the sensitivity of your skin. If exposure to sunlight cannot be avoided, use protective measures such as sun-creams or protective clothing.

If you experience severe redness, peeling, or severe irritation of the skin you should stop using Isotrex. If the irritation persists you should consult your doctor.

Isotrex should be used with caution in:

  • Eczema (avoid getting the gel on areas of skin affected by eczema).
  • People with a personal or family history of growths on the skin, eg skin cancer.
  • Sensitive areas of skin such as the neck.

Isotrex should not to be used in:

  • Sunburnt skin, broken skin or skin affected by eczema.
  • Pregnancy.
  • Breastfeeding.
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All our orders are sent out using Royal Mail. Tracking is available on all orders. We always aim to dispatch all orders within 24 hours of them being received, if we are unable to meet this high standard for whatever reason we will always contact you to advise you of the delay.

We offer free UK standard delivery on orders over £40.

The following delivery options are available:

  • Standard Delivery - 2/3 day delivery - £2.95
  • Express Delivery - 1/2 day delivery - £4.45
  • Special Delivery (Guaranteed before 1pm) - £8.95
  • Saturday Guaranteed before 1pm - £10.45

The cut-off for same day dispatch of orders is 4pm. Orders processed after this time will be dispatched the following working day. Orders are dispatched Monday - Friday. Orders will not be processed on weekends or bank holidays.

We ensure all deliveries are in plain packaging for discreet delivery of your medicines and pharmacy goods.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 


We are currently unable to ship orders outside of the UK.

The Independent Pharmacy is an online pharmacy and online doctor service is owned and operated by ABSM Healthcare Ltd (Company Reg. 08515600) and Red Label Medical Ltd (Company Reg. 08676338). All information that appears on this website is intended for information purposes only and should be used to supplement, not replace, your relationship with your local healthcare professionals. You should consult your doctor if you think you may have a health problem or before you start taking a new medicine. Please ensure you always read the information leaflets supplied with any medicinal products.For more information see our policies and terms and conditions at the bottom of every page. © 2014 ABSM Healthcare Ltd. All rights reserved.
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