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Kliofem Tablets

Kliofem Tablets

Pack Size: 84
RRP: £27.00
Saving: £1.00
Our Price: £26.00
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Age: 18 Pregnancy: Not suitable Breastfeeding: Not suitable

Kliofem tablets contain two active ingredients, estradiol (previously spelt oestradiol in the UK) and norethisterone acetate. These are forms of the main female sex hormones, oestrogen and progesterone. Estradiol is a naturally occuring form of oestrogen and norethisterone acetate is a synthetic form of progesterone.

Womens’ ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, such as irregular periods, hot flushes, night sweats, mood swings and vaginal dryness or itching.

Oestrogen (in this case in the form of estradiol) can be given as a supplement to replace the falling levels in the body and help reduce these distressing symptoms of the menopause. This is known as hormone replacement therapy (HRT). HRT is usually only required for short-term relief from menopausal symptoms and its use should be reviewed at least once a year with your doctor.

A progestogen (in this case in the form of norethisterone acetate) is needed as part of HRT for women who have not had a hysterectomy. This is because in women with an intact womb, oestrogen stimulates the growth of the womb lining (endometrium), which can lead to endometrial cancer if the growth is unopposed. A progestogen is given to oppose oestrogen's effect on the womb lining and reduce the risk of cancer, though it does not eliminate this risk entirely. This is known as combined HRT.

Kliofem is a continuous form of combined HRT. Each tablet contains both estradiol and norethisterone, so that a dose of both hormones is taken daily. This type of HRT does not produce a monthly withdrawal bleed, and so is more suitable for women whose periods have already stopped, eg for postmenopausal women who are more than 12 months after their menopause.

HRT is also sometimes used to prevent osteoporosis in postmenopausal women. The declining level of oestrogen at menopause can affect the bones, causing them to become thinner and more prone to breaking. Oestrogen supplements help prevent bone loss and fractures that may occur in women in the years after menopause.

However, in December 2003, a review of the available evidence on the risks and benefits of HRT by the Medicines and Healthcare products Regulatory Agency (MHRA) and the Committee on Safety of Medicines (CSM) in the UK, concluded that the risks of using HRT long-term to prevent osteoporosis in women aged over 50 years exceed the benefits. As a result, this medicine should not be used as a first-line option for preventing postmenopausal osteoporosis in women over 50. However, it may be used as a second-line option for women at high risk of fractures who cannot take other medicines that are licensed for preventing osteoporosis.

Women considered to be at risk of developing fractures following the menopause include those who have had an early menopause, those with a family history of osteoporosis, those who have had recent prolonged corticosteroid therapy (eg prednisolone), those with a small thin frame, and smokers.

You can read more about the risks and benefits of HRT and other medicines for preventing osteoporosis in the factsheets about menopause and osteoporosis linked below.


  • Hormone replacement therapy to relieve symptoms of the menopause
  • Second-line option for preventing osteoporosis in postmenopausal women who are at high risk of fractures and cannot take other medicines licensed for preventing osteoporosis

It’s important to read the enclosed leaflet carefully before using Kliofem Tablets.

The dose is one tablet to be taken each day, at around the same time each day. It can be taken before or after food. The tablets are taken continuously without a break between packs.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

  • Breast pain, tenderness or enlargement
  • Breakthrough bleeding and spotting
  • Vaginal thrush
  • Excessive fluid retention in the body tissues, resulting in swelling (oedema)
  • Headache/migraine
  • Gut disturbances, such as nausea, abdominal pain, bloating, flatulence, indigestion
  • Leg cramps
  • Weight gain
  • Nervousness
  • Depression
  • Skin reactions such as rash and itch
  • Hair loss
  • Abnormal hair growth
  • Dizziness
  • Visual disturbances
  • Changes in sex drive
  • Rise in blood pressure
  • Steepening of corneal curvature which may make contact lenses uncomfortable.
  • Disturbance in liver function
  • Irregular brown patches on the skin, usually of the face (chloasma)
  • Blood clots in the blood vessels (eg, DVT, pulmonary embolism, heart attack, stroke - see warnings above)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

  • Women taking any form of HRT should have regular medical and gynaecological check-ups. Your need for continued HRT should be reviewed with your doctor at least once a year.
  • It is important to be aware that all women using HRT have an increased risk of being diagnosed with breast cancer compared with women who don't use HRT. This risk needs to be weighed against the personal benefits to you of taking HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. You should discuss these with your doctor before starting HRT. Women on HRT should have regular breast examinations and mammograms and should examine their own breasts regularly. Report any changes in your breasts to your doctor or nurse.
  • It is important to be aware that women using HRT have a slightly increased risk of stroke and of blood clots forming in the veins (eg deep vein thrombosis/pulmonary embolism) compared with women who don't use HRT. The risk is higher if you have existing risk factors (eg personal or family history, smoking, obesity, certain blood disorders - see cautions below) and needs to be weighed against the personal benefits to you of taking HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. Discuss these with your doctor before starting treatment.
  • The risk of blood clots forming in the veins (thromboembolism) while taking HRT may be temporarily increased if you experience major trauma, have surgery, or are immobile for prolonged periods of time (this includes travelling for over five hours). For this reason, your doctor may recommend that you stop taking HRT for a period of time (usually four to six weeks) prior to any planned surgery, particularly abdominal surgery or orthopaedic surgery on the lower limbs, or if you are to be immobile for long periods. The risk of blood clots during long journeys may be reduced by appropriate exercise during the journey and possibly by wearing elastic hosiery. Discuss this with your doctor.
  • Stop taking this medicine and inform your doctor immediately if you experience any of the following symptoms while taking this medicine: stabbing pains or swelling in one leg; pain on breathing or coughing; coughing up blood; breathlessness; sudden chest pain; sudden numbness affecting one side or part of the body; fainting; worsening of epilepsy; migraine or severe headaches; visual disturbances; severe abdominal complaints; increased blood pressure; itching of the whole body; yellowing of the skin or eyes (jaundice); or severe depression.
  • This medicine will not usually cause a monthly withdrawal bleed. However, you may experience spotting or breakthrough bleeding during the first few months of treatment. Forgetting a dose may increase the likelihood of breakthrough bleeding and spotting. If any breakthrough bleeding continues after a few months of taking the medicine, or after stopping treatment, you should consult your doctor.
  • A woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. HRT does not provide contraception for women who fall within this group. If a potentially fertile women is taking HRT but also requires contraception, a non-hormonal method (eg condoms or contraceptive foam) should be used.

Use with caution in

  • Close family history of breast cancer (eg mother, sister or grandmother has had the disease)
  • History of benign breast lumps (fibrocystic breast disease)
  • History of fibroids in the womb
  • History of endometriosis
  • History of overgrowth of the lining of the womb (endometrial hyperplasia)
  • Personal or family history of blood clots in the veins (venous thromboembolism, eg deep vein thrombosis or pulmonary embolism)
  • Blood disorders that increase the risk of blood clots in the veins, eg antiphospholipid syndrome, factor V Leiden
  • Women taking medicines to prevent blood clots (anticoagulants), eg warfarin
  • Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
  • Personal or family history of recurrent miscarriage
  • Severe obesity
  • Varicose veins
  • Smokers
  • History of high blood pressure (hypertension)
  • Raised levels of fats called triglycerides in the blood (hypertriglyceridaemia)
  • History of liver disease, eg liver cancer
  • Decreased kidney function
  • Heart failure
  • History of diabetes
  • History of gallstones
  • History of migraines or severe headaches
  • History of epilepsy
  • History of asthma
  • History of an ear disorder that may cause hearing loss (otosclerosis)
  • History of irregular brown patches appearing on the skin, usually of the face, during pregnancy or previous use of hormone preparations such as contraceptive pills (chloasma). Women with a tendency to this condition should minimise their exposure to the sun or UV light while taking HRT.

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The Independent Pharmacy is an online pharmacy and online doctor service is owned and operated by ABSM Healthcare Ltd (Company Reg. 08515600) and Red Label Medical Ltd (Company Reg. 08676338). All information that appears on this website is intended for information purposes only and should be used to supplement, not replace, your relationship with your local healthcare professionals. You should consult your doctor if you think you may have a health problem or before you start taking a new medicine. Please ensure you always read the information leaflets supplied with any medicinal products.For more information see our policies and terms and conditions at the bottom of every page. © 2014 ABSM Healthcare Ltd. All rights reserved.
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