Lercanidipine belongs to a group of medicines called calcium channel blockers that block the entry of calcium into the muscle cells of the heart and the blood vessels that carry blood away from the heart (the arteries). It is the entry of calcium into these cells that causes the heart to contract and arteries to narrow. By blocking the entry of calcium, calcium channel blockers decrease contraction of the heart and dilate (widen) the arteries, and the blood pressure is reduced.
Lercanidipine has been prescribed to you to treat your high blood pressure, also known as hypertension.
Always take Lercanidipine exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
The usual dose is one Lercanidipine hydrochloride 10 mg film-coated tablet daily at the same time each day, preferably in the morning at least 15 minutes before breakfast, because a high fat meal significantly increases your blood levels of the medicine.
Your doctor may decide to increase your dose to one Lercanidipine hydrochloride 20mg film-coated tablet daily, if needed.
The tablets should preferably be swallowed whole with 1/2 glass of water. The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.
Lercanidipine is not recommended for use in children and adolescents below 18 years.
If you take more Lercanidipine than you should
Immediately contact a doctor, the nearest hospital casualty department or the centre for poison information for advice.
Exceeding the correct dosage may cause blood pressure to become too low, and the heart to beat irregularly or faster. It may also lead to unconsciousness.
If you forget to take Lercanidipine
If you forget to take your tablet, take it as soon as you remember, unless it is almost time for your next dose. Then go on as before. Do not take a double dose.
If you stop taking Lercanidipine
If you stop taking Lercanidipine your blood pressure may increase again. Please consult your doctor before stopping the treatment.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
- The active substance is lercanidipine hydrochloride.
One 10mg film-coated tablet contains 10mg lercanidipine hydrochloride, equivalent to 9.4mg lercanidipine.
One 20mg film-coated tablet contains 20mg lercanidipine hydrochloride, equivalent to 18.8mg lercanidipine.
The other ingredients are: Tablet core: Magnesium stearate, povidone, sodium starch glycolate (Type A), lactose monohydrate, microcrystalline cellulose.
Film-coating 10mg tablets: Macrogol, polyvinyl alcohol (partly hydrolysed), talc, titanium dioxide (E 171), yellow iron oxide (E 172).
Film-coating 20mg tablets: Macrogol, polyvinyl alcohol (partly hydrolysed), talc, titanium dioxide (E 171), yellow iron oxide (E 172), red iron oxide (E 172).
Like all medicines, Lercanidipine can cause side effects, although not everybody gets them.
The frequencies of side effects have been listed below according to the following definitions:
Very common: affects more than 1 user in 10
Common: affects 1 to 10 users in 100
Uncommon: affects 1 to 10 users in 1,000
Rare: affects 1 to 10 users in 10,000
Very rare, not known: affects less than 1 user in 10,000, frequency cannot be estimated from the available data
Uncommon: Headache, dizziness, faster heartbeats, awareness of the beating of the heart, flushing (transient episodic redness of the face and neck), ankle swelling.
Do not take Lercanidipine if you:
- are allergic (hypersensitive) to lercanidipine or to any of the ingredients in Lercanidipine hydrochloride tablets
- have had an allergic reaction to medicines that are closely related to Lercanidipine hydrochloride tablets (such as amlodipine, nicardipine, felodipine, isradipine, nifedipine or lacidipine)
- are suffering from certain heart diseases:
- uncontrolled cardiac failure
- an obstruction to flow of blood from the heart
- unstable angina (angina at rest or progressively increasing)
- have had a heart attack less than one month ago
- have severe liver or kidney problems
- are taking drugs that are inhibitors of CYP3A4 isoenzyme:
- antifungal medicines (such as ketoconazole or intraconazole)
- macrolide antibiotics (such as erythromycin or troleandomycin)
- antivirals (such as ritonavir)
- at the same time as another drug called ciclosporin or cyclosporin
- with grapefruit or grapefruit juice
- are pregnant, or if you wish to become pregnant or if you are a woman in child-bearing age and do not use any contraceptive method
- if you are breast-feeding
Take special care with Lercanidipine
You should consult your doctor before taking Lercanidipine hydrochloride tablets if you:
- have a heart condition known as sick sinus syndrome, and do not have a pacemaker
- suffer from chest pain (angina pectoris), Lercanidipine may in very rare cases cause increased frequency of attacks that may last longer and become more severe. Heart attacks have been reported in isolated cases.
- have problems with your liver or kidney, or you are ondialysis
Using other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Taking Lercanidipine with certain other medicines (see below), may alter the effect of these medicines or of Lercanidipine.
It is especially important for your doctor to know if you are already being treated with any of the following medicines:
- phenytoin or carbamazepine (medicines for epilepsy)
- rifampicin (a medicine to treat tuberculosis)
- midazolam (a medicine that helps you sleep)
- cimetidine, more than 800mg (a medicine for ulcers, indigestion, or heartburn)
- digoxin (a medicine to treat a heart problem)
- terfenadine or astemizole (medicines for allergies)
- amiodarone or quinidine (medicines to treat a fast heart beat)
- metoprolol (a medicine to treat high blood pressure)
- simvastatin (a medicine for high cholesterol value)
Using Lercanidipine with food and drink
You must not eat grapefruit or drink grapefruit juice as this may increase the effect of Lercanidipine.
If you use alcohol together with Lercanidipine you may experience dizziness/fainting, tiredness or weakness. This is because the medicine may lower your blood pressure considerably together with alcohol.
Pregnancy and breast-feeding
Ask your doctor for advice before taking any medicine.
If you are taking Lercanidipine and think that you may be pregnant, consult your doctor.
Do not use if you are pregnant, or if you wish to become pregnant or if you are a woman in childbearing age and do not use any contraceptive method.
Do not use if you are breast-feeding.
Driving and using machines
Lercanidipine has a negligible influence on the ability to drive or use machines. However, side effect such as dizziness, weakness, tiredness and rarely sleepiness may occur. You should be careful until you know how you react to Lercanidipine.
Important information about some of the ingredients of Lercanidipine
Lercanidipine contains lactose monohydrate. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
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