The name of this medicine is Lisinopril 2.5mg, 5mg, 10mg or 20mg tablets (called lisinopril throughout this leaflet).
This belongs to a group of medicines known as ACE inhibitors (Angiotensin Converting Enzyme inhibitors).
Lisinopril is recommended in children (above 6 years old) only for the treatment of high blood pressure (hypertension).
Lisinopril should not be used in children with severe kidney impairment.
Lisinopril works by making your blood vessels wider. This helps your blood pressure to fall. It also makes it easier for your heart to pump blood around your body.
Lisinopril can be used
- To treat high blood pressure - also called hypertension
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The dose of lisinopril will depend on the condition being treated and any other medicines you are taking. This leaflet gives the usual dose but you should read the amount prescribed for you on the medicine label. You should check with your doctor or pharmacist if you are not sure.
- Swallow the tablets with water. You can take them with or without food.
- Take your tablet at about the same time each day. Take the lisinopril tablet marked for the correct day on the blister pack. This will help you remember whether you have taken it.
The first lisinopril tablets you take might make you feel dizzy or light-headed. This is because the first dose may make your blood pressure fall by more than doses you take after that. It may help to lie down until you feel better. If you are concerned talk to your doctor or pharmacist.
The doctor may check how you are responding to taking lisinopril by taking your blood pressure and doing some blood tests.
Adults with high blood pressure (hypertension)
- The starting dose is usually 10mg each day. This may be increased gradually to a maintenance dose (the dose you will stay on) of 20mg daily. The maximum daily dose is 80mg.
- The actual dose, decided by your doctor, will depend on your blood pressure and other medical conditions.
If you are taking high a dose of water tablets (diuretics), your doctor may ask you to stop taking them for 2 to 3 days before you start taking lisinopril.
If you take more lisinopril than you should
Contact your doctor or go to the nearest hospital casualty department straight away. Remember to take with you any tablets
If you forget to take lisinopril
If you miss a dose do not worry. Simply take your normal dose when it is next due. Do not take a double dose to make up for a forgotten tablet.
If you stop taking lisinopril
Keep taking your tablets until your doctor tells you to stop. If you feel better, do not stop taking the tablets. If you stop them, your conditions may get worse.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Each tablet contains 2.5mg, 5mg, 10mg or 20mg of lisinopril dihydrate as the active substance. Other ingredients are mannitol, calcium hydrogen phosphate dihydrate, maize starch, pregelatinised starch, colloidal silicone dioxide and magnesium stearate.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Stop taking lisinopril and see a doctor or go to a hospital straightaway if:
- You get swelling of the hands, feet, ankle, face, lips or throat which may cause difficulty in swallowing or breathing, itching of the skin and nettle rash.
- You get red, swollen or scalded skin with blisters on the lips, eyes, mouth, nose and/or genitals. You may also have a high temperature swollen glands or joint pain.
This may mean you are having an allergic reaction to lisinopril.
Allergic reactions to medicines such as lisinopril are more common in people of black race or African-Caribbean origin.
Talk to your doctor straight away if you notice any of the following serious side-effects.
These are rare (affect less than 1 in 1000 people):
- Severe stomach or back pain. These could be signs of pancreatitis.
- Blood disorders including the bone marrow problems and anaemia. Symptoms include bruising more easily, bleeding longer after injury, bleeding from the gums or elsewhere, purple spots or blotching on the skin (caused by damage to small blood vessels), a greater chance of infection.
- High temperature, tiredness, loss of appetite, stomach pain, feeling sick, yellowing of the skin or eyes (jaundice) and liver failure. These are symptoms of hepatitis (inflammation of the liver).
- A condition which may include some or all of the following: high temperature, inflamed blood vessels, painful inflamed muscles and joints, blood problems detected by a blood test, rash, being very sensitive to sunlight, other effects of the skin.
Common (affects less than 1 in 10 people):
- Dizziness, headache or cough
- Feeling faint or light-headed when standing up quickly. This could be due to low blood pressure
- Diarrhoea, being sick (vomiting)
- Kidney problems including kidney failure
Do not take lisinopril if:
- You are more than 3 months pregnant. (It is also better to avoid lisinopril in early pregnancy-see pregnancy section.)
- You are breast-feeding (see pregnancy and breast-feeding section).
- You are allergic (hypersensitive) to lisinopril, any other ACE inhibitor medicine, or any of the ingredients in these tablets (see contents of the pack and other information section).
- Any member of your family has had an allergic reaction to these medicines or you have ever had an allergic reaction for no apparent reason. Signs of allergic reaction include: rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
Do not take lisinopril if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist.
Warnings and precautions
Talk to your doctor or pharmacist before taking lisinopril if you:
- Think you are (or might become) pregnant. Lisinopril is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that early stage (See pregnancy section).
- Have been told to limit the amount of salt in your diet, are having kidney dialysis, or have had severe diarrhoea or sickness (vomiting)
- Have recently had a heart attack (myocardial infarction)
- Have a narrowed heart valve (mitral valve stenosis) or aorta (aortic stenosis), or have a heart problem known as "hypertrophic cardiomyopathy". These all cause the blood to flow less freely away from the heart
- Have kidney problems, including narrowed blood vessels in your kidneys (renal artery stenosis) or a recent kidney transplant
- Have rheumatoid arthritis or other diseases affecting your joints
- Have ever had "angioneurotic oedema" or "angioedema". The signs include itching, red marks on the hands, feet and throat, swelling around the eyes and lips, difficulty breathing
- Are having treatment to reduce your reaction to bee and wasp stings
- Are having treatment of your blood by a machine to lower cholesterol (LDL apheresis)
- Take extra potassium in your diet or a salt substitute that contains potassium
Please talk to your doctor before taking lisinopril if any of the above apply to you, even if they applied only in the past
People who are of black race or African-Caribbean origin need to be aware that in this group of patients:
- Allergic reactions to medicines such as lisinopril are more common
- Lisinopril may not work as well
Other medicines and lisinopril
Tell your doctor or pharmacist if you are taking or have recently taken or might have take any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because lisinopril can affect the way some other medicines work. Also some medicines can affect the way lisinopril works.
Talk to your doctor before taking lisinopril if you are taking any of the following medicines:
- Water tablets (diuretics) such as spironolactone, triamterene or amiloride. Lisinopril may increase the levels of potassium in your blood
- Water tablets (diuretics) such as thiazides, frusemide, or other medicines to lower your blood pressure, medicines for chest pain (angina). Taking lisinopril at the same time may cause low blood pressure
- Lithium (for some types of mental illnesses)
- Medicines for depression such as amitriptyline, medicines for serious mental illness such as chlorpromazine, morphine (for severe pain) or anaesthetics. Taking these medicines at the same time as lisinopril may cause low blood pressure
- Non-steroidal anti-inflammatory drugs (NSAIDs), such as indometacin or diclofenac (for pain or inflammation). These medicines may make lisinopril work less well
- Medicines such as ephedrine, noradrenaline or adrenaline (for low blood pressure, shock, heart failure, asthma or allergies). These medicines may make lisinopril work less well
- Medicines for diabetes, such as insulin. Lisinopril may cause your blood sugar levels to drop even further when taken with these medicines. This is more likely to occur during the first weeks of taking lisinopril and in patients with kidney problems. You should check your blood sugar level closely during the first month of taking lisinopril
- Allopurinol (used to treat gout and kidney stones), procainamide (used to treat heart rhythm disturbances), medicines used to suppress your immune system (such as ciclosporin after transplant surgery and to treat rheumatoid arthritis).
- Gold injections (for example, sodium aurothiomalate) which may cause flushing, dizziness, nausea (feeling sick) and your blood pressure to drop too much.
Please tell your doctor or pharmacist if you are taking or have recently taken, any other medicine - even those not prescribed.
If you are going to have an anaesthetic (for an operation), tell your doctor or dentist that you are taking lisinopril.
Lisinopril with food and drink
You can take lisinopril with or without food.
Pregnancy and breast-feeding
- You must tell your doctor if you think you are (or might become) pregnant or you are planning to have a baby. Your doctor will normally advise you to stop taking lisinopril before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of lisinopril. Lisinopril is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
- Do not take lisinopril during weeks 13 to 40 of your pregnancy. This is because your baby may be harmed.
If you have taken lisinopril during this period, it is best to have an ultrasound (scan) check of the baby's kidneys and skull.
- Use contraception to stop you getting pregnant when taking lisinopril.
- Tell your doctor if you are breast-feeding or about to start breast-feeding. Lisinopril is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Driving and using machines
Lisinopril may make you feel tired or dizzy. If this happens do not drive or use any tools or machines.
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