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Naproxen Gastro-Resistant Tablets 500mg

Naproxen Gastro-Resistant Tablets 500mg

Pack Size: 56 tablets
RRP: £25.00
Saving: £4.05
Our Price: £20.95
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Age: 18 Years + Pregnancy: Not suitable Breastfeeding: Not suitable

Naproxen is a powerful anti-inflammatory painkiller. It is used to relieve muscular and joint pain as these normally also involve some sort of inflammation. Naproxen is taken twice daily with or after food whilst pain is present. The Independent Pharmacy can provide Naproxen online for fast, effective treatment of short-term pain and inflammation without the need to see your GP.

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It has a similar method of action of the over-the-counter medicine ibuprofen; it blocks chemicals that cause pain and inflammation at the site of injury. Naproxen is a stronger anti-inflammatory than ibuprofen and is used in moderate pain and inflammation or where ibuprofen has been ineffective.

Naproxen is used to treat pain or inflammation caused by conditions such as:

  • Back pain
  • Sprains
  • Strains
  • Gout
  • Menstrual cramps

Naproxen is thought to have less side effects than other anti-inflammatory drugs, with it being less harsh on the stomach than treatments such as ibuprofen or diclofenac. At The Indpendent Pharmacy we only supply Naproxen in gastro-resistant tablets, which means that they have an extra protective coating to help reduce the chance of side effects even further. Naproxen should always be taken with or after food to help protect the stomach lining.

Naproxen is suitable to purchase online for those with short-term, non-serious injuries that do not require a visit to the doctor. For serious injuries or long-term conditions, it is more appropriate to see your GP for examination and management.

Naproxen 500mg tablets should be taken TWICE daily, with a gap of at least six to eight hours between doses. They are normally taken with breakfast and your evening meal. Naproxen can be taken as required although it is often best to take it regularly for a number of days to help an acute injury such as a sprain or strain.

Always ensure Naproxen is taken with or after food.

If you miss a dose of Naproxen, take the missed dose as soon as you remember. You should never take more than two Naproxen 500mg tablets in 24 hours and ensure you leave a gap of at least six to eight hours between doses.

Whilst taking Naproxen you should ensure you avoid other medicines containing NSAIDs (e.g. aspirin, ibuprofen & diclofenac). 

You should try to avoid drinking alcohol as it may increase your risk of stomach bleeding.

Naproxen can cause you to burn more easily in direct sunlight. Ensure that you wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. You should avoid tanning beds and sun lamps.

Naproxen 500mg gastro-resistant tablets contain 500mg naproxen as the active ingredient.

It also contains the following inactive ingredients: Methacrylic acid-ethylacrylate copolymer (1:1), Lactose, Magnesium stearate, Maize starch, Crospovidone, Propylene glycol, Sodium hydroxide, Triethyl citrate, Titanium dioxide (E171) , Potassium sorbate (E202) , Sodium citrate (E331) , Xanthan gum (E415), Hydroxypropyl cellulose (E463), Purified talc (E553), Beeswax.

Like all anti-inflammatory medicines, Naproxen can cause side effects. 

Common side effects can include:

  • Gastric side effects including upset stomach, heartburn, stomach pain, constipation, or diarrhoea. These can also include bloating and gas.
  • Dizziness & headache.
  • Blurred vision or ringing in the ears.
  • Skin itching and rash.

Some of these side effects may be less likely to occur if Naproxen is taken with or after food.

Naproxen can cause an allergic reaction in a very small number of people. You should not take Naproxen if you know you are allergic or if you have an allergy to any other anti-inflammatory medicines such as ibuprofen, aspirin or diclofenac. If you suffer with an allergic reaction to Naproxen, symptoms may include: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. If any of these symptoms occur you should seek medical attention immediately.

You should stop taking Naproxen and see your doctor as soon as possible if any of the following symtpoms occur:

  • chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

  • black, bloody, or tarry stools;

  • coughing up blood or vomit that looks like coffee grounds;

  • swelling or rapid weight gain, little or no urinating;

  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • bruising, severe tingling, numbness, pain, muscle weakness;

  • fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions) or

  • severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Naproxen 500mg tablets can interact with some medicines and should not be purchased online if you are taking any of the following:

  • Other anti-inflammatory drugs such as aspirin, ibuprofen or diclofenac.
  • Blood-thinners or medicines that reduce blood clotting such as heparin or warfarin.
  • corticosteroids such as prednisolone or dexamthasone.
  • diuretics (‘water tablets’) such as furosemide.
  • Medicines to treat high blood pressure such as captopril, ramipril or propranolol, losartan or candesartan.
  • Ciclosporin or tacrolimus
  • Mifepristone – do not take NSAIDs 8-12 days after mifepristone
  • SSRI antidepressants such as citalopram and fluoxetine.
  • Zidovudine.
  • Quinolone antibiotics such as ciprofloxacin.
  • Probenecid.
  • Methotrexate.
  • Bisphosphonates such as alendronic acid.
  • Colestyramine (take naproxen 1 hour before or 4 to 6 hours after colestyramine to avoid interference with absorption).
  • Lithium.
  • Hydantoins such as phenytoin.
  • Sulphonamides such as sulfamethoxazole.
  • Sulphonylureas such as glibenclamide or gliclazide.
  • Cardiac glycosides such as digoxin.

If you are taking any of the above medicines you should always check with your doctor before taking Naproxen as it can interfere with the action of your current medicines.

Naproxen should not be used during preganacy or breast-feeding.

Naproxen may cause a small increase in the risk of heart attack or stroke, especially when used long-term or if you have an existing heart disease. You should not use Naproxen before or after any kind of heart surgery.

Long-term use of Naproxen can cause internal bleeding of the stomach or intestines. This can be fatal if untreated. Whilst taking Naproxen you should always look out for stomach pain, indigestion, passing blood or black, tarry stools. If any of hese symptoms occur, seek medical treatment immediately.

You should see your doctor before taking Naproxen if you have:

  • a history of heart attack, stroke, or blood clot;

  • heart disease, congestive heart failure, high blood pressure;

  • a history of stomach ulcers or bleeding;

  • liver or kidney disease;

  • asthma;

  • polyps in your nose;

  • a bleeding or blood clotting disorder; or

  • if you smoke.


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All our orders are sent out using Royal Mail. Tracking is available on all orders. We always aim to dispatch all orders within 24 hours of them being received, if we are unable to meet this high standard for whatever reason we will always contact you to advise you of the delay.

We offer free UK standard delivery on orders over £40.

The following delivery options are available:

  • Standard Delivery - 2/3 day delivery - £2.95
  • Express Delivery - 1/2 day delivery - £4.45
  • Special Delivery (Guaranteed before 1pm) - £8.95
  • Saturday Guaranteed before 1pm - £10.45

The cut-off for same day dispatch of orders is 4pm. Orders processed after this time will be dispatched the following working day. Orders are dispatched Monday - Friday. Orders will not be processed on weekends or bank holidays.

We ensure all deliveries are in plain packaging for discreet delivery of your medicines and pharmacy goods.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 


We are currently unable to ship orders outside of the UK.

Naproxen Frequently Asked Questions (FAQs)


What is Naproxen?

How does Naproxen work?

How do I take Naproxen?

What’s the difference between Naproxen and other pain treatments?

Is it safe to use Naproxen continuously?

What are the side effects?

How long will it take to work?

What should I do if I miss a dose?

Will Naproxen affect my driving?

Can I take Naproxen during pregnancy and breastfeeding?




What is Naproxen?

Naproxen is a painkiller belonging to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Other well known NSAIDs include aspirin, ibuprofen and diclofenac. Naproxen is a stonger anti-inflammatory than aspirin and ibuprofen; it is thought to be similar in strength to diclofenac but carries fewer risks and side effects.

It can be used to treat pain where there is also inflammation present such as sprains, strains and mild arthritis.


How does Naproxen work?

Naproxen works by blocking chemical transmitters called prostaglandins that are responsible for pain and inflammation at the site of injury.

Prostaglandins are responsible for many different roles in the body, these include acting as pain messengers at the site of injury. Cyclooxygenase (COX) enzymes are important for prostaglandin production which in turn regulates pain, inflammation, platelet production and protecting the stomach.

Naproxen and other NSAIDS are non-specific and block both cyclooxygenase enzymes (COX-1 and COX-2) to reduce all prostaglandin production and therefore reduce pain and inflammation.

Stomach irritation, due to prostaglandin reduction, is a common side effect of NSAIDSs. To combat this we supply Naproxen with a gastro-resistant coating to ensure that the tablet dissolves further down the gastrointestinal tract and not in the stomach. 


How do I take Naproxen?

Naproxen is normally taken at a dose of one tablet twice a day, morning and night (roughly 12 hours apart).

The Naproxen tablets have a special coating, which ensures they don’t dissolve in the stomach but further down in the intestines. If the tablets are crushed, chewed or broken this coating will be damaged and will not work properly. This means that the contents will be absorbed in the stomach which may lead to unwanted side effects such as stomach irritation or pain.

Take Naproxen with or after food. This doesn’t have to be a main meal, as long as it is not on an empty stomach.

Naproxen will start to work usually within an hour and the effects will last for up to 12 hours.

Naproxen can be taken with paracetamol to boost pain relief. It should never be taken with other anti-inflammatories such as aspirin, ibuprofen or diclofenac. For more details please contact us for free and impartial advice.

It is best to avoid indigestion remedies at the same time as Naproxen as they can change the acid environment of the stomach. The tablet will then dissolve in the stomach where it is not intended which may lead to side effects.


What’s the difference between Naproxen and other pain treatments?

Naproxen 500mg tablets are a prescription-strength anti-inflammatory and painkiller. They are stronger than the over-the-counter treatments such as ibuprofen and aspirin. Naproxen and diclofenac are thought to have similar effects although Naproxen is thought to carry less risk of unwanted effects.

Naproxen and other NSAIDs are better at inflammation and swelling compared to paracetamol. Naproxen 500mg tablets are a stronger painkiller than paracetamol, however they can be taken together when extra pain relief is required.

Naproxen does not have the potential to be habit forming like opiate-based painkillers such as codeine.


Is it safe to use Naproxen continuously?

It is safe to take Naproxen as a painkiller for the length a minor injury (normally for a few weeks) on a when required basis. The effect doesn’t decrease when it is used over long periods and it is not habit forming. Naproxen can be stopped at any time without tapering or reducing the dose.


What are the side effects?

Most patients successfully treat their pain and inflammation using Naproxen without any side effects. The most common side effects are gastro-intestinal including stomach irritation, diarrhoea, wind, constipation, nausea and vomiting. Most of these can be avoided or reduced by taking Naproxen with or after food.

When taking Naproxen its is important to be aware of the following points:

The mode of action of Naproxen means that it not only blocks the production of prostaglandins used in pain and inflammation but also those responsible for protecting the stomach. It is important to recognise the need to a see a doctor if you have stomach pains, vomit blood, or have tarry/bloody stools.

There is recent documented evidence that NSAIDs can increase the risk of heart attack. This side effect is considered to be rare and affect less than 1 person in 10,000. It is important to contact your doctor if you have pains in the chest and or pain running down your arm.


How long will it take to work?

It can take up to two hours for Naproxen to reach a full effect, however in most patients it is quicker than this. The effects usually last 7 - 12 hours.


What should I do if I miss a dose?

If you miss a dose then take another tablet when you remember. If a long time has passed and it’s nearly time for the next dose, do not double up to make up for the missed dose. 


Will Naproxen affect my driving?

Naproxen can cause drowsiness (although it is not a common side effect) and it can affect your vision. Driving or operating machinery should be avoided if either of these side effects occur.


Can I take Naproxen during pregnancy and breastfeeding?

Naproxen shouldn’t be taken in the first six months of pregnancy without speaking to a doctor to weigh up the risks and benefits of treatment. It is not recommended in the last three months of pregnancy or during breastfeeding.

Babies have a hole in the heart during their development in the mother, this is normal. In the last 3 months the hole starts to heal and is completely closed when the baby is born. Naproxen and other NSAIDs can prevent the hole from healing and should not be taken in the last three months of pregnancy.

The Independent Pharmacy is an online pharmacy and online doctor service is owned and operated by ABSM Healthcare Ltd (Company Reg. 08515600) and Red Label Medical Ltd (Company Reg. 08676338). All information that appears on this website is intended for information purposes only and should be used to supplement, not replace, your relationship with your local healthcare professionals. You should consult your doctor if you think you may have a health problem or before you start taking a new medicine. Please ensure you always read the information leaflets supplied with any medicinal products.For more information see our policies and terms and conditions at the bottom of every page. © 2014 ABSM Healthcare Ltd. All rights reserved.
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