Perindopril Tablets are angiotensin converting enzyme (ACE) inhibitor.
These work by widening the blood vessels, which makes it easier for your heart to pump blood through them.
Perindopril Tablets are used:
- to treat high blood pressure (hypertension),
Always take Perindopril Tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
Swallow your tablet with a glass of water, preferably at the same time each day, in the morning, before a meal. Your doctor will decide on the correct dose for you.
The usual dosages are as follows:
High blood pressure: the usual starting and maintenance dose is 4 mg once daily. After one month, this can be increased to 8 mg once a day if required. 8 mg a day is the maximum recommended dose for high blood pressure.
If you are 65 or older, the usual starting dose is 2 mg once a day. After a month this can be increased to 4 mg once a day and then if necessary to 8 mg once daily.
Heart failure: the usual starting dose is 2 mg once daily. After two weeks, this can be increased to 4 mg once a day, which is the maximum recommended dose for heart failure.
Stable coronary artery disease: the usual starting dose is 4 mg once daily. After two weeks, this can be increased to 8 mg once daily, which is the maximum recommended dose in this indication.
If you are 65 or older, the usual starting dose is 2 mg once a day. After a week this can be increased to 4 mg once a day and after a further week to 8 mg once daily.
If you take more Perindopril Tablets than you should
If you take too many tablets, contact your nearest accident and emergency department or tell your doctor immediately. The most likely effect in case of overdose is low blood pressure which can make you feel dizzy or faint. If this happens, lying down with the legs raised can help.
If you forget to take Perindopril Tablets
It is important to take your medicine every day as regular treatment works better. However, if you forget to take a dose of Perindopril Tablets, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.
If you stop taking Perindopril Tablets
As the treatment with Perindopril Tablets 2 mg is usually life-long, you should discuss with your doctor before stopping this medicinal product.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Like all medicines, Perindopril Tablets can cause side effects, although not everybody gets them.
If you experience any of the following, stop taking the medicinal product at once and tell your doctor immediately:
- swelling of the face, lips, mouth, tongue or throat, difficulty in breathing,
- severe dizziness or fainting,
- unusual fast or irregular heart beat.
In decreasing order of frequency, side effects can include:
- Common (occur in fewer than 1 in 10 users but in more than 1 in 100 users): headache, dizziness, vertigo, pins and needles, vision disturbances, tinnitus (sensation of noises in the ears), light-headedness due to low blood pressure, cough, shortness of breath, gastro-intestinal disorders (nausea, vomiting, abdominal pain, taste disturbances, dyspepsia or difficulty of digestion, diarrhoea, constipation), allergic reactions (such as skin rashes, itching), muscle cramps, feeling of weakness,
Do not take Perindopril Tablets
- if you are allergic (hypersensitive) to perindopril, to any other ACE inhibitor or to any of the other ingredients of Perindopril Tablets,
- if you are more than 3 months pregnant. (It is also better to avoid Perindopril Tablets in early pregnancy - see pregnancy section.),
- if you have experienced symptoms such as wheezing, swelling of the face, tongue or throat, intense itching or severe skill rashes with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema).
Take special care with Perindopril Tablets
If any of the following apply to you please talk to your doctor before taking Perindopril Tablets:
- if you have aortic stenosis (narrowing of the main blood vessel leading from the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood),
- if you have any other heart problems,
- if you have liver problems,
- if you have kidney problems or if you are receiving dialysis,
- if you suffer from a collagen vascular disease such as systemic lupus erythematosus or scleroderma,
- if you have diabetes,
- if you are on a salt restricted diet or use salt substitutes which contain potassium,
- If you are going to have a general anaesthetic and/or major surgery,
- if you are to undergo LDL apheresis (which is removal of cholesterol from your blood by a machine),
- if you are going to have desensitisation treatment to reduce the effects of an allergy to bee or wasp stings,
- if you have recently suffered from diarrhoea or vomiting, or are dehydrated,
- if you have been told by your doctor that you have an intolerance to some sugars,
You must tell your doctor if you think that you are (or might become) pregnant. Perindopril Tablets are not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Perindopril Tablets are not recommended for use in children and adolescents.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Treatment with Perindopril Tablets can be affected by other medicines. These include:
- other medicines for high blood pressure, including diuretics (medicines which increase the amount of urine produced by the kidneys),
- potassium-sparing diuretics (spironolactone, triamterene, amiloride), potassium supplements or potassium-containing salt substitutes,
- lithium for mania or depression,
- non-steroidal anti-inflammatory drugs (e.g. ibuprofen) for pain relief or high dose aspirin,
- medicines to treat diabetes (such as insulin or metformine),
- medicines to treat mental disorders such as depression, anxiety, schizophrenia etc (e.g. tricyclic antidepressants, antipsychotics),
- immunosuppressants (medicines which reduce the defence mechanism of the body) used for the treatment of auto-immune disorders or following transplant surgery (e.g. ciclosporin),
- allopurinol (for the treatment of gout),
- procainamide (for the treatment of an irregular heart beat),
- vasodilators including nitrates (products that make the blood vessels become wider),
- heparin (medicines used to thin blood),
- medicines used for the treatment of low blood pressure, shock or asthma (e.g. ephedrine, noradrenaline or adrenaline).
Taking Perindopril Tablets with food and drink
It is preferable to take Perindopril Tablets before a meal.
Pregnancy and breast-feeding
Ask your doctor or pharmacist for advice before taking any medicine.
You must tell your doctor if you think you are (or might become) pregnant.
Your doctor will normally advise you to stop taking Perindopril Tablets before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Perindopril Tablets.
Perindopril Tablets are not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Tell your doctor if you are breast-feeding or about to start breast-feeding.
Perindopril Tablets are not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Driving and using machines
Perindopril Tablets usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in certain patients. If you are affected in this way, your ability to drive or to operate machinery may be impaired.
Important information about some of the ingredients of Perindopril Tablets
Perindopril Tablets contain lactose. If you have been told by your doctor that you have intolerance to some sugars, contact your doctor before taking this medicinal product.
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