Pravastatin Sodium Tablets belongs to a group of medicines called statins (or HMG-CoA reductase inhibitors). It prevents the production of cholesterol by the liver and consequently reduces the levels of cholesterol and other fats (triglycerides) in your body. When there are excessive levels of cholesterol in the blood, the cholesterol accumulates on the walls of blood vessels and block them. This condition is called hardening of the arteries or atherosclerosis, may lead to:
? chest pain (angina pectoris), when a blood vessels in the heart is partially blocked,
? a heart attack (myocardial infraction), when a blood vessels in the heart is completely
? a stroke (cerebrovascular accident), when a blood vessel in the brain is completely
This medicine is used in 3 situations:
In the treatment of high levels of cholesterol and fats in the blood
Pravastatin Sodium Tablets is used to lower high levels of "bad" cholesterol and to raise the levels of "good" cholesterol in the blood when changes to diet and exercise have failed to adequately do this.
In the prevention of heart and blood vessel diseases
? If you have high levels of cholesterol in your blood and risk factors favouring these
diseases (if you smoke, are overweight, if you have high blood sugar levels or high blood pressure, if you take little exercise), Pravastatin Sodium Tablets is used to reduce the risk of you having heart and blood vessel diseases and to lower your risk of dying from these diseases.
? If you have already had a heart attack or have unstable angina (chest pain) and you have normal cholesterol levels, Pravastatin Sodium reduces the risk of you having another heart attack or stroke in the future.
After organ transplants:
If you have had an organ transplant and are taking medication to stop your body rejecting the transplant, Pravastatin Sodium reduces increased lipid levels.
Always take your tablets exactly as your doctor has instructed you. You should check with your doctor or pharmacist if you are not sure.
? Pravastatin Sodium Tablets can be taken with or without food. Swallow the correct number of tablets with glass of water.
? You should continue taking Pravastatin Sodium Tablets as long as your doctor has advised you to do so. This will vary from person to person and your doctor will adjust the number and strength of the tablets to suit you.
Dose instructions for adults and adolescents (14-18 years)
? In the treatment of high level of cholesterol and fats in the blood: The usual dose of Pravastatin Sodium is 10-40 mg once a day preferably in the evening.
? In the prevention of heart and blood vessel diseases: the usual dose is 40 mg once a day, preferably in the evening.
The maximum daily dose of 40 mg of pravastatin should not be exceeded. Your doctor shall tell you which dose suits you.
Dose instructions for children (8-13 years)
The usual dose is 10-20 mg once a day.
3. How to take Pravastatin Sodium Tablets
After organ transplant:
Your doctor may prescribe a starting dose of 20 mg once a day. The dose may be adjusted up to 40 mg by your doctor.
If you are also taking a medicine which lowers the body’s immune system (ciclosporin), your doctor may prescribe a starting dose of 20 mg once a day. The dose may be adjusted up to 40 mg by your doctor.
If you suffer from kidney or severe liver disease, your doctor may prescribe a lower dose of Pravastatin Sodium to you.
If you have the impression that the effect of this treatment is too strong or too weak, talk to your doctor or pharmacist.
Duration of treatment
Your doctor will indicate the duration of your treatment with Pravastatin Sodium. This medicine must be used very regularly and for as long as your doctor advises, even if it is for a very long time. Do not stop your treatment by yourself.
If you take more Pravastatin Sodium Tablets than you should
If you take more tablets than you have been told to take, or if someone else accidentally takes your medicine, contact accident and emergency department of your nearest hospital for appropriate advice. Take any left over tablets or empty box with you for easier identification.
If you forget to take Pravastatin Sodium Tablets
If you miss a dose, simply take your usual dose when it is next due.
Do not take a double dose to make up for the forgotten dose, take your next dose as usual and continue your course.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Like all medicines, Pravastatin Sodium Tablets can cause side effects, although not everybody gets them.
4. Possible side effects
Uncommon side effects (≥ 1/1000 < 1/100)
? Dizziness ?
? Insomnia ?
? Abdominal pain ?
? Diarrhoea ?
? Scalp and hair ? problems (including
? Fatigue (tiredness)
Very rare side effects (< 1/10,000):
Vision disturbance (blurred vision or double vision) Nausea(urge to vomit)/ Vomiting Flatulence
Abnormal urination (pain,frequent urination at night)
? Sleep disturbances
? Dyspepsia (difficulty in digesting food)/
? Skin reactions like itching and rashes
? Disturbed sexual functions
Do not take Pravastatin Sodium Tablets in following conditions:
? if you have a liver disease.(active liver diseases);
? if you are hypersensitive (allergic) to Pravastatin Sodium or any of the other ingredients of
this medicine(see further information);
? if you are pregnant, trying to become pregnant or if you are breast-feeding (see Pregnancy and
? if several blood tests have shown abnormal functioning of your liver (increased levels of liver
enzymes in the blood).
Take special care with Pravastatin Sodium Tablets
Tell your doctor if you have ever had any of the following:
2. Before you take Pravastatin Sodium Tablets
an underactive thyroid (hypothyroidism); Past history of liver disease.
Alcohol problems (If you regularly drink large amounts of alcohol).
A hereditary muscle disorder in yourself or a blood relative.
Side effects affecting your muscles when taking another cholesterol-lowering medicine such as statin or fibrate.
If you have suffered any of these problems, your doctor will need to carry out a blood test before and possibly during Pravastatin Sodium treatment to assess your risk of muscle-related side effects. You may also need this blood test if you are aged older than 70 years. If you feel any unexplained cramps or muscle pains during treatment, tell your doctor immediately.
While you are on this medicine your doctor will monitor you closely if you have diabetes or are at risk of developing diabetes. You are likely to be at risk of developing diabetes if you have high levels of sugars and fats in your blood, are overweight and have high blood pressure.
Check with your doctor or pharmacist before taking Pravastatin sodium Tablets if you: ? Have severe respiratory failure
Using other medicines:
If you are already being treated with any of the following talk to your doctor before you start to take Pravastatin Sodium Tablets as the combination may result in an increased risk of developing muscle problems.
? A group of cholesterol lowering drugs called fibrates (e.g. gemfibrozil, fenofibrate) or
? The immunosuppressant ciclosporin.
? The antibiotics such as erythromycin or clarithyromycin treats the infection caused by
? another medicine which lowers the level of cholesterol in your blood (nicotinic acid).
? A resin type lipid-lowering agent such as colestyramine or colestipol, Pravastatin Sodium
Tablets should be taken atleast one hour before or four hours after you have taken the resin. This is because the resin can affect the absorption of Pravastatin Sodium if the two medicines are taken too closely together.
? Warfarin and other oral anticoagulants (agents that help in thinning the blood).
? Product metabolized by cytochrome P450 (diltiazem, verapamil, itraconazole, ketoconazole, protease inhibitors and CYP2C9 inhibitors like fluconazole).
It is important that you tell your doctor about all the medicines you are taking, including those you have bought without a prescription.
Using Pravastatin Sodium Tablets with food and drink:
Taking food and drink has no influence on your treatment with Pravastatin Sodium Tablets. Take the advise of your doctor before taking grape fruit juice with Pravastatin Sodium
You should always keep your alcohol intake to a minimum. If you are concerned about how
much alcohol you can drink while you are taking this medicine, discuss with your doctor if you drink alcohol and seek his advice.
Pregnancy and breast-feeding:
Do not take Pravastatin if you are pregnant, trying to become pregnant or suspect you may be pregnant, as the safety in pregnant women has not been established, if you become pregnant while using Pravastatin, you must stop taking tablets immediately and contact your doctor.
A small amount of the active substance of Pravastatin passes into breast milk. Therefore, you must not take Pravastatin while breast-feeding.
Ask your pharmacist or doctor for advice before taking any medicine.
Driving and using machines:
? Pravastatin Sodium Tablets usually does not affect your ability to drive but if you experience dizziness make sure you are fit to drive or operate machinery.
Important information about some of the ingredients of Pravastatin Sodium Tablets.
This medicine contains lactose.
If you have been told by your doctor that you have intolerance to some sugars (eg. Lactose), contact your doctor before taking this medicinal product.
All our orders are sent out using Royal Mail. Tracking is available on all orders.
We always aim to dispatch all orders within 24 hours of them being received, if we are unable to meet this
high standard for whatever reason we will always contact you to advise you of the delay.
We offer free UK standard delivery on orders over £40.
The following delivery options are available:
- Standard Delivery - 2/3 day delivery - £2.95
- Express Delivery - 1/2 day delivery - £4.45
- Special Delivery (Guaranteed before 1pm) - £8.95
- Saturday Guaranteed before 1pm - £10.45
The cut-off for same day dispatch of orders is 4pm. Orders processed after this time will be dispatched the following working day. Orders are dispatched Monday - Friday. Orders will not be processed on weekends or bank holidays.
We ensure all deliveries are in plain packaging for discreet delivery of your medicines and pharmacy goods.
Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt.
Delivery is free for all NHS prescriptions.
Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering.
We are currently unable to ship orders outside of the UK.