Vesicare 5mg Tablets

Vesicare Tablets (5mg & 10mg)

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Product Information

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Vesicare relieves the symptoms of overactive bladder: a strong, sudden urge to urinate without warning, frequent urination or wetting yourself because you could not reach the bathroom in time.

Vesicare tablets contain the active ingredient solifenacin succinate, an antimuscarinic (or anticholinergic) muscle relaxant. It works by relaxing the involuntary muscle in the wall of the bladder.

The muscle in the bladder wall is called the detrusor muscle. When it contracts in uncontrollable spasms, this is known as having an overactive bladder. An overactive detrusor muscle can increase the frequency with which you urinate, or cause uncontrollable urges to pass urine or urinary incontinence.

Solifenacin provides relief by relaxing the detrusor muscle. It blocks receptors called muscarinic (or cholinergic) receptors found on the surface of the muscle cells which prevents a natural body chemical called acetylcholine from acting on these receptors.

Usually, when acetylcholine acts on these receptors, the detrusor muscle contracts and the bladder empties. By blocking acetylcholine, solifenacin helps the muscle in the bladder wall to relax. This reduces the bladder’s unstable, involuntary contractions and increases the bladder’s capacity to hold urine. This, in turn, reduces the need to pass urine.

It may take at least four weeks of treatment for this medicine to become fully effective.

  • Take one 5mg Vesicare tablet a day. If your symptoms don’t respond to this dosage, your doctor may increase it to one 10mg tablet a day. Try to take your tablet at the same time each day.
  • Swallow Vesicare tablets whole, with a drink. Take them with or without food.
  • If you miss a dose, take it as soon as you remember. If you dont remember until your next dose is due, however, just leave out the missed tablet. Do not take a double dose to make up for a missed one.


The most common side effects of Vesicare include:

  • Dry mouth
  • Call your doctor if you experience abdominal pain or become constipated for 3 or more days.
  • Urinary tract infection
  • Blurred vision


The recommended dose of Vesicare is one 5mg tablet daily. If the 5mg dose is well tolerated, your doctor may increase the dose to 10mg once daily.

  • Reducing urinary frequency, urgency and incontinence in people with an overactive bladder.

Instructions for proper use

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
You should swallow the whole tablet with some liquid. It can be taken with or without food, according to your preference. Do not crush the tablets.
The usual dose is 5 mg per day, unless your doctor told you to take 10 mg per day.
If you take more Vesicare than you should

If you have taken too much Vesicare or if a child has accidentally taken Vesicare, contact your doctor or pharmacist immediately.
Symptoms of overdose may include: headache, dry mouth, dizziness, drowsiness and blurred vision, perceiving things that ,are not there (hallucinations), over- excitability, seizures (convulsions), difficulty breathing, elevated heart rate (tachycardia), accumulation of urine in the bladder (urinary retention) and dilated pupils (mydriasis).
If you forget to take Vesicare

If you forget to take a dose at the usual time, take it as soon as you remember, unless it is time to take your next dose. Never take more than one dose per day. If you are in doubt, always consult your doctor or pharmacist.
If you stop taking Vesicare

If you stop taking Vesicare, your symptoms of overactive bladder may return or worsen. Always consult your doctor, if you are considering stopping the treatment.
If you have any further questions on the use of this product, ask your doctor or pharmacist.

Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you experience an allergic attack, or a severe skin reaction (e.g. blistering and peeling of the skin), you must inform your doctor or pharmacist immediately.
Angioedema (skin allergy that results in the swelling that occurs in the tissue just below the surface of the skin) with airway obstruction (difficulty in breathing) has been reported in some patients on solifenacin succinate (Vesicare). If angioedema occurs, solifenacin succinate (Vesicare) should be discontinued immediately and appropriate therapy and/or measures should be taken.
Vesicare may cause the following other side effects:
Very common (may affect more than 1 in 10 people)
dry mouth
Common (may affect up to 1 in 10 people)
blurred vision
constipation, nausea, indigestion with symptoms such as abdominal fullness, abdominal pain, burping, nausea, and heartburn (dyspepsia), stomach discomfort
Uncommon (may affect up to 1 in 100 people)
urinary tract infection, bladder infection
sleepiness, impaired sense of taste (dysgeusia)
dry (irritated) eyes
dry nasal passages
reflux disease (gastro-oesophageal reflux), dry throat
dry skin
difficulty in passing urine
tiredness, accumulation of fluid in the lower legs (oedema)

Do not take Vesicare

if you have an inability to pass water or to empty your bladder completely (urinary retention)
if you have a severe stomach or bowel condition (including toxic megacolon, a complication associated with ulcerative colitis)
if you suffer from the muscle disease called myasthenia gravis, which can cause an extreme weakness of certain muscles
if you suffer from increased pressure in the eyes, with gradual loss of eye sight (glaucoma)
if you are allergic to solifenacin or any of the other ingredients of this medicine (listed in section 6)
if you are undergoing kidney dialysis
if you have severe liver disease
if you suffer from severe kidney disease or moderate liver disease AND at the same time are being treated with medicines that may decrease the removal of Vesicare from the body (for example, ketoconazole). Your doctor or pharmacist will have informed you if this is the case.
Inform your doctor if you have or ever had any of the above mentioned conditions before treatment with Vesicare starts.
Warnings and precautions

Talk to your doctor or pharmacist before taking Vesicare
if you have trouble emptying your bladder (= bladder obstruction) or have difficulty in passing urine (e.g. a thin urine flow). Risk of accumulation of urine in the bladder (urinary retention) is much higher.
if you have some obstruction of the digestive system (constipation).
if you are at risk of your digestive system slowing down (stomach and bowel movements). Your doctor will have informed you if this is the case.
if you suffer from severe kidney disease.
if you have moderate liver disease.
if you have a stomach tear (hiatus hernia) or heartburn.
if you have a nervous disorder (autonomic neuropathy).
Children and adolescents

Vesicare is not to be used in children or adolescents under 18 years.
Inform your doctor if you have or ever had any of the above mentioned conditions before treatment with Vesicare starts.
Before starting Vesicare, your doctor will assess whether there are other causes for your need to pass urine frequently (for example heart failure (insufficient pumping power of the heart) or kidney disease). If you have a urinary tract infection, your doctor will prescribe you an antibiotic (a treatment against particular bacterial infections).
Other medicines and Vesicare

Please tell your doctor or pharmacist if you are taking or have recently taken or might take other medicines.
It is especially important to inform your doctor if you are taking:
other anticholinergic medicines, effects and side effects of both medications can be enhanced.
cholinergics as they can reduce the effect of Vesicare.
medicines, like metoclopramide and cisapride, which make the digestive system work faster. Vesicare can reduce their effect.
medicines, like ketoconazole, ritonavir, nelfinavir, intraconazole, verapamil and diltiazem, which decrease the rate at which Vesicare is broken down by the body
medicines like rifampicin, phenytoin and carbamazepine, as they may increase the rate at which Vesicare is broken down by the body.
medicines such as bisphosphonates, that can cause or exacerbate inflammation of the gullet (oesophagitis).
Vesicare with food and drink

Vesicare can be taken with or without food, depending on your preference.
Pregnancy and breast-feeding

You should not use Vesicare if you are pregnant unless clearly necessary.
Do not use Vesicare if you are breast-feeding as solifenacin may get into your breast milk.
Ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines

Vesicare may cause blurred vision and sometimes sleepiness or tiredness. If you suffer from any of these side effects, do not drive or operate machinery.
Vesicare contains lactose. If you have been told by your doctor that you have a rare hereditary problem of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption you should not use this medicine.

  • The active substance is solifenacin succinate 5 mg or 10 mg
  • The other ingredients are maize starch, lactose, hypromellose (E464), magnesium stearate, macrogol, talc, titanium dioxide (E171) and iron oxide (E172)
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Frequently Asked Questions

  • What is Vesicare?

    Vesicare is a tablet which is taken to help with bladder control. It works by binding to protein receptors which make the bladder muscle contract. There is no generic form of Vesicare.

  • How long will it take for Vesicare to work?

    Vesicare will not start working immediately. It will take up to several weeks to reach its full effect. Continue to follow your prescription for Vesicare. Consult your GP if you have any further concerns.

  • How do I take Vesicare?

    Always follow your prescription exactly. You will likely be prescribed one tablet per day. Swallow each tablet whole with a sip of water. This can be done either with or without food.

  • Is Vesicare suitable for me?

    Vesicare is unsuitable for you if you suffer from any of the following conditions:

    • Urinary retention (difficulty urinating)
    • Gastric retention (a delayed emptying of the stomach)
    • Glaucoma
    • An allergy to any of the ingredients of this medicine

    Vesicare is only suitable for adults.

    Please read all packaging and the Product Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.

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