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Lariam 250mg Tablets

Lariam 250mg Tablets

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Warning - we can only provide up to 300 days of medication in advance
Please note the below order is only calculated for 300 days from the first date selected. If you require any assistance with your order please contact our support team.

Order before 3pm for delivery from Sat. 07 Aug.

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Please note, we calculate the required treatment quantity for you, including any dose to cover the full course before and after the time period specified so you will always have a complete course of medication. If you would like to find out more before purchasing please contact our UK support team via Email or Phone

Description for Lariam 250mg Tablets

Lariam 250mg tablets are available to order online from The Independent Pharmacy Online Doctor. Lariam tablets contain the active ingredient mefloquine and are a convenient once-weekly treatment for malaria prevention and are effective in a number of countries around the world.

Lariam Information

  • Age: 18 years +

    Maximum per order: N/A

  • Pregnancy: N/A

    Breastfeeding: N/A

What is Lariam?

Lariam is an effective malaria treatment and preventative. It available as a tablet and is taken once a week. Treatment begins two weeks prior to travel, continues throughout your trip and should be taken for four weeks after your return. It is important that you continue to take the tablets post-travel, to cover the disease’s incubation period.

Lariam is a branded medication manufactured by Roche and is available from our UK-based pharmacy. It contains mefloquine hydrochloride, which targets the parasite and stops it from reproducing. This product is adept at tackling the parasites present in regions where malaria has developed an immunity to other antimalarials, such as chloroquine. It also treats active malarial strains, but this needs to be done under a doctor’s supervision.

Malaria is caused by the plasmodium parasite carried by mosquitoes and is transferred to humans through bites. Symptoms can take three months to develop after infection, or even longer in some cases. These include fever, flu-like signs and headache. Some, aggressive strains may cause organ failure and death, so it is important to take precautions.

According to estimates, nearly 1,500 British travellers have contracted malaria in recent years. The condition adapts to and resists certain medications and vaccines so it is essential to research the area to which you are travelling and learn which strains may exist there. This will influence the type and course of treatment you use. Consult the Fit for Travel NHS website.

You should take Lariam weekly, on the same day each week. Take the first dose ten days and a second dose three days before your trip.

Your dosage of Lariam tablets depends on your body weight. Adults weighing over 45kg, should take one whole tablet once a week.

Preventing Malaria

In addition to taking anti-malaria tablets, you can lower your risk of developing malaria by avoiding mosquito bites.

  • Stay in air-conditioned rooms with screens on the doors and windows. If this is not possible, ensure that doors and windows close properly.
  • If you cannot sleep in an air-conditioned room, sleep under a mosquito net that has been treated with insecticide.
  • Protect your skin with insect repellent, especially in sleeping environments, and reapply it frequently. The most effective repellents contain diethyltoluamide (DEET) and are available in roll-ons, sprays, sticks and creams.
  • Instead of shorts wear light, loose-fitting trousers and shirts with long sleeves. This is particularly important during early evening and at night when mosquitoes prefer to feed.
  • Vitamin B, garlic and ultrasound devices do not protect against mosquito bites.

There are currently no effective non-prescription alternatives for malaria prevention, however you can take more steps in avoiding being bitten while away by;

  • Using mosquito repellent containing DEET.
  • Using a mosquito net treated with insecticide while you are sleeping.
  • Using a sunscreen designed to help prevent mosquito bites
*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Lariam directions

  • You should take one tablet every week on the same day each week.
  • Lariam needs to be taken two weeks before entering an area where malaria is present and continued until four weeks after leaving the malaria area.
  • You should take Lariam with or after food.
  • Lariam remains effective with a moderate alcohol intake.

Lariam side effects

If you do experience side effects from Lariam they may include depression, mood changes, anxiety, confusion, hallucinations, panic attacks, restlessness, paranoia and general agitation. Lariam has a small risk of nausea, vomiting, diarrhoea, and skin rash as with all medicines. There have been rare reports of suicidal thoughts whilst taking Lariam. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects.

Lariam ingredients

Lariam tablets contain the active ingredient mefloquine 250mg per tablet.

The other ingredients are poloxamer, microcrystalline cellulose, lactose, maize starch, crospovidone, ammonium calcium alginate, talc, magnesium stearate.

Lariam warnings

Lariam should not cause a harmful interaction with any of your other current medicines. Lariam should not be taken if you currently take carbamazepine, chloroquine, halofantrine, ketoconazole, phenobarbital, phenytoin, quinidine, quinine, rifampicin, or valproic acid (valproate). Please read the Patient Information Leaflet enclosed with your medicines for further information.

Lariam is not 100% effective at preventing malaria, however it is still very effective if taken properly and combined with bite avoidance methods.

Remember it is also important to get the correct vaccinations for your trip before you travel. These should be administered around 6 weeks before you leave. 

Remember, malaria can take up to a year to develop after you have been bitten. If you experience symptoms including headaches, night sweats and abdominal pain any time during your trip or up to one year afterwards you must see a doctor as soon as possible. 

You should take adequate contraceptive precautions to ensure you do not become pregnant whilst taking Lariam and for three months after you have finished the course.

Please seek medical help immediately if you experience serious mental problems while taking Lariam. Lariam should be stopped immediately and replaced with another medicine to prevent malaria.

Stop taking this medicine and contact your doctor immediately if you experience:

  • attempted suicide.
  • suicidal thoughts.
  • self-endangering behaviour.
  • allergic reaction (anaphylaxis) with symptoms such as difficulty in breathing, swollen tongue, itching and severe rash.
  • severe changes in texture and appearance of the skin, especially if it affects your mouth and eyes (Stevens Johnson syndrome).
  • psychosis (losing touch with reality).
  • severe anxiety.
  • panic attacks.
  • fits (seizures or convulsion).
  • fever, chills, cough, shortness of breath or chest pain. These could be signs of inflammation of the lungs also known as pneumonitis.
  • Severe liver problems which might be demonstrated by a transient increase in your liver enzymes shown by blood tests or other symptoms such as tender, firm or possibly enlarged liver, jaundice (yellowing of skin/eyes), dark urine, light coloured stools and generalised itchiness.
  • Pins and needles, weakness, numbness, new or worsening clumsiness or unsteadiness on your feet, or shaking of the hands and fingers.
  • Painful mouth or throat ulcers, fever, chills, bruises on the skin, nosebleeds, bleeding in the stomach or vaginal bleeding. These could be signs of blood disorders.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Malaria Prevention?

Visit our advice area or contact our support team

Lariam 250mg Tablets Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • Can I drink alcohol while taking Larium?

    Yes. Larium should not interact with alcohol.

  • Will I be able to drive?

    Yes, but only with special care. In some cases, Larium may cause side effects which could make driving dangerous. If you experience these, do not drive and contact your nearest doctor for help.

  • Can I take Larium while pregnant?

    Larium is not recommended for use during pregnancy or breastfeeding. Speak to your doctor in these cases for advice.

  • How should I store Larium?

    Keep in a safe place, below 30°C and away from sources of moisture.

  • Am I allergic to any of Larium’s ingredients?

    Larium contains: mefloquine, poloxamer, lactose, microcrystalline cellulose, maize starch, ammonium calcium alginate, talc, crospovidone and magnesium stearate. Do not take it if you are allergic to any of these ingredients.

  • Is Larium available over-the-counter?

    Larium is a prescription-only product. However, our service allows you to have your case reviewed by a doctor. If approved, a prescription will be prepared for you.

  • Is Larium suitable for everyone?

    Most people can take Larium, although it is not recommended for people susceptible to anxiety, depression, psychiatric symptoms or illness. Because travel is often stressful, Larium may increase stress-related symptoms. Some patients may experience nightmares, agitation, poor sleep and other psychological or psychiatric symptoms. Such symptoms can be-long lasting. If you develop symptoms of this nature, stop taking Larium. Further details can be found in the patient information leaflet supplied with Larium tablets.

    Do not take Larium if you are allergic to mefloquine, or if you have mental health problems, severe liver problems or a history of fits or seizures.

  • Does immunity to malaria reduce over time?

    Long-term immigrants to the UK will lose acquired immunity to malaria when they are no longer living in an area with the disease.

  • What are the symptoms of malaria?

    Malaria symptoms are similar to flu and include shivers, fever, sweating, backache, headache, joint pains, vomiting, diarrhoea and sometimes delirium. These symptoms may develop a week and up to a year after you have been bitten by a mosquito.

    For this reason, malaria is suspected in anyone with a feverish illness who has travelled to a malarial area within the past year, especially in the previous three months.

    If you experience these symptoms after your return, you should seek medical evaluation immediately and tell the doctor that you have recently travelled.

Authored By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Published on: 02-02-2017

Last modified on: 22-02-2021

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

Reviewed By:

A photo of  Andy Boysan

Andy Boysan


Reviewed on: 22-02-2021

Next review date: 22-02-2023

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

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