Malarone Tablets are available to buy from The Independent Pharmacy Online Doctor service, following a free consultation, to help prevent malaria. To find out more about malaria and see all the available treatments, see our Malaria page.
Malarone Tablets contain two active ingredients; Proguanil Hydrochloride and Atovaquone. It is mainly used to prevent malaria. It is manufactured by GlaxoSmithKline and is classified as a prescription-only-medicine (POM). Malarone is one of the newer treatments for malaria. It is taken once daily, 2 – 3 days before travel and continuing until 1 week after returning.
Each Malarone tablet contains 100mg of Proguanil Hydrochloride and 250mg of Atovaquone. Both these ingredients are anti-parasitic drugs that are active against the malaria-causing plasmodium parasite. Once the plasmodium parasite enters the bloodstream it starts to reproduce, causing the malaria disease. Proguanil works by inhibiting the parasite’s ability to reproduce. It does this by blocking the action of an enzyme found inside the parasite. This enzyme, dihydrofolate reductase, is involved in its reproduction. By blocking dihydrofolate reductase, Proguanil prevents the formation of any new genetic material forming within the parasite. This means it is unable to reproduce and multiply.
Atovaquone works in a similar way to Proguanil. It inhibits the production of new genetic material from inside the malaria parasite, resulting in the parasite’s inability to reproduce. Both these ingredients work effectively together in a dual attack upon the malaria-causing parasite.
Malarone is highly effective against the strains of malaria caused by the plasmodium falciparum parasite. This parasite is responsible for producing the most serious form of malaria called malignant malaria. For areas where the plasmodium falciparum is prevalent, Malarone will usually be the recommended choice of treatment. Malarone may also be ideal for other areas where there is a known resistance to other forms of antimalarial medicines, such as Chloroquine.
Malarone is also available as an unbranded generic form that is simple called; Atovaquone/Proguanil 250mg/100mg Tablets. These are the same as Malarone but are less expensive due to their unbranded nature.
Please read the Patient Information Leaflet for side effects and additional information.
Pharmacist Tip: Malarone should not be taken if you are pregnant or breastfeeding. It is generally very well tolerated with only mild intestinal upsets and headaches reported. If side effects are experienced then taking the tablets with or after a meal may help to relieve them.
Use only recommended, evidence-based products. There is no evidence that bath oils, electronic “buzzers”, essential oils, garlic, homeopathic remedies, odour baited mosquito traps, tea tree oil, skin moisturisers, smoking, vitamin B tablets or yeast extract will have any effect in preventing mosquito bites.
Malarone & bite avoidance
It’s important to note that even if you’re taking an antimalarial like Malarone, it’s still important to take steps to prevent Mosquito bites. The use of insect repellents, nets and sleeping in a screened room are all highly recommended. It’s also a good idea to wear light, coloured clothing that covers as much of the body as possible.
Using an insecticide like a plug-in or spray is also an effective means of clearing and deterring those pesky insects. All the above measures are particularly important after sunset. This is the time when Mosquitoes are most active. As with so many things in life, prevention is better than cure. This is certainly true with regards to Malaria!