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Naproxen 500mg Gastro-Resistant Tablets

*The brand supplied may vary. Please contact us if you require a specific brand.

Naproxen Gastro-Resistant Tablets (250mg & 500mg)

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Order before 3pm for delivery from Tue. 22 Jun and Wed. 23 Jun.

Naproxen Gastro-Resistant Tablets (250mg & 500mg)

Naproxen – sometimes called Naproxen Sodium – is a powerful anti-inflammatory painkiller. It is used to relieve muscular and joint pain, such as arthritis, as this normally also involves some sort of inflammation. Naproxen is taken twice daily with or after food whilst pain is present. Based in the UK, The Independent Pharmacy can provide Naproxen 250mg & 500mg online for fast, effective, low-cost treatment of short-term pain and inflammation without the need to see your GP.

Naproxen: Important Information

  • Age: 18 Years +

    Maximum per order: 2

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Naproxen?

Naproxen is a painkiller belonging to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Other well known NSAIDs include aspirin, ibuprofen and diclofenac. Naproxen is a stronger anti-inflammatory than aspirin and ibuprofen; it is thought to be similar in strength to diclofenac but carries fewer risks and side effects.

It can be used to treat pain where there is also inflammation present such as sprains, strains and mild arthritis.


What is Naproxen used for?

A non-steroidal anti-inflammatory drug, Naproxen is used for reducing pain and inflammation in the body. It does this by reducing the hormones that are causing the swelling. Naproxen is frequently used to treat conditions like muscle pain, arthritis, period pain and gout.


What’s the difference between Naproxen and other pain treatments?

Naproxen 500mg tablets are a prescription-strength anti-inflammatory and painkiller. They are stronger than the over-the-counter treatments such as ibuprofen and aspirin. Naproxen and diclofenac are thought to have similar effects although Naproxen is thought to carry less risk of unwanted effects.

Naproxen and other NSAIDs are better at inflammation and swelling compared to paracetamol. Naproxen 500mg tablets are a stronger painkiller than paracetamol, however they can be taken together when extra pain relief is required.

Naproxen does not have the potential to be habit forming like opiate-based painkillers such as codeine.


Taking Naproxen with other painkillers

You can take Naproxen together with paracetamol and opioid-type painkillers such as codeine, co-codamol, tramadol or morphine. This is because Naproxen is primarily an anti-inflammatory, whereas codeine is an opiate used to treat pain.

However, don't take aspirin or other related anti-inflammatory painkillers (NSAIDs) like ibuprofen or diclofenac, as this heightens the risk of side effects on the stomach and intestines. If you take selective inhibitors of COX-2 such as etoricoxib or celecoxib you should not take Naproxen for the same reason.

Unlike aspirin, Naproxen does not thin the blood, but the use of blood thinners (like aspirin) alongside Naproxen is not recommended.

Drinking alcohol is fine while taking Naproxen, but it’s advised to stay within moderate quantities, as too much alcohol can irritate the stomach. Naproxen can sometimes lead to feeling dizzy or sleepy, therefore you shouldn’t do any driving while taking it until you know how it affects you.

It is important to remember that cold and flu remedies and over-the-counter painkillers often contain ibuprofen or aspirin. For this reason, you should avoid these medications while you're taking Naproxen to prevent an accidental interaction. Check the ingredients of other medicines you wish to take before buying or, ask us for advice.

You should also check with us before you buy anti-inflammatory gels (such as ibuprofen, diclofenac, ketoprofen or piroxicam) for use alongside Naproxen tablets because this is not safe for everyone and the dosage may be too high.

For pregnant women, paracetamol is usually recommended to control pain during pregnancy. If this doesn’t work and you need something stronger, it’s important to speak to a doctor before taking any NSAIDs during pregnancy. 


Naproxen vs. ibuprofen & diclofenac

Available in dosages of 250mg and 500mg, Naproxen is a non-steroidal anti-inflammatory drug (NSAID). It has a similar method of action of the over-the-counter medicine ibuprofen; it blocks chemicals that cause pain and inflammation at the site of injury. Naproxen is a stronger anti-inflammatory than ibuprofen and is used in moderate pain and inflammation or where ibuprofen has been ineffective.

Naproxen provides a similar level of pain relief to diclofenac and has similar levels of anti-inflammatory activity. Naproxen has now largely replaced diclofenac in the UK due to concerns surrounding the adverse effects on the heart and gastrointestinal system caused by diclofenac.

Naproxen is used to treat pain or swelling caused by conditions such as:

  • Arthritis and joint pain
  • Back pain
  • Bad headaches
  • Sprains
  • Strains
  • Gout
  • Period pain and menstrual cramps

The standard recommended dose for Naproxen is between 250-500 mg taken orally twice a day – or every 6-8 hours as needed. Overdoses can be dangerous, so do not exceed the dose recommended by your pharmacist or doctor.

Naproxen should always be taken with food to protect the stomach. Patients who are taking Naproxen long-term (regularly for periods exceeding two weeks) should take a treatment to protect the stomach, such as Omeprazole, whilst taking Naproxen to reduce the chance of side effects.


What are the side effects of Naproxen?

Naproxen is thought to have fewer side effects than other anti-inflammatory drugs, with it being less harsh on the stomach than treatments such as high-strength ibuprofen or diclofenac. At The Independent Pharmacy, we only supply Naproxen in gastro-resistant tablets, which means that they have an extra protective coating to help reduce the chance of side effects even further. Naproxen should always be taken with or after food, and at the appropriate dosage, to help protect the stomach lining.

Naproxen is suitable to buy online for those with short-term, non-serious injuries that do not require a visit to the doctor. For serious injuries or long-term conditions, it is more appropriate to see your GP for examination and management. If you’re suffering from arthritis, it may be that you are prescribed Naproxen, unless there is a more appropriate long-term option available. 

For further information, take a look at our Naproxen side effects guide.


Naproxen warnings

Before you buy Naproxen, you should see your GP to check that your kidneys are functioning properly. The kidney blood tests should be conducted once or twice a year by your doctor. Please inform us about any issues with your kidneys when you order to prevent any delays.

You may have an increased risk of side effects on the kidneys if you take Naproxen together with any of the following medications:

  • ACE inhibitors, e.g. enalapril, captopril
  • Ciclosporin
  • Diuretics, e.g. furosemide

Naproxen may reduce the body’s removal of the following medicines from the body and thus may increase the risk of their side effects:

  • Digoxin
  • Methotrexate
  • Lithium

Naproxen may counteract the blood pressure lowering effects of certain high blood pressure treatments, such as:

  • ACE inhibitors such as captopril
  • Calcium-channel blockers such as Amlodipine
  • Beta-blockers such as atenolol

If you take Naproxen together with quinolone antibiotics, such as norfloxacin or ciprofloxacin, you may have an increased risk of seizures, particularly if you have epilepsy.

Probenecid may reduce the body’s removal of Naproxen. If you take this combination together, inform your doctor if you develop Naproxen side effects; your dosage may need to be lowered.

Non-prescription alternatives for the treatment of pain are:

  • Ibuprofen
  • Paracetamol
  • Aspirin
  • Topical treatments (Ibuprofen gel)
  • Rest the area

If your pain does not ease or becomes severe, contact your GP or Pharmacist for further advice.

Naproxen Patient Information Leaflet: https://www.medicines.org.uk/emc/product/543/pil

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

How to take Naproxen tablets

Naproxen 500mg tablets should be taken twice daily, with a gap of at least six to eight hours between doses. They are normally taken with breakfast and your evening meal. Naproxen can be taken as required although it is often best to take it regularly for a number of days to help an acute injury such as a sprain or strain.

Always ensure Naproxen is taken with or after food.

If you miss a dose of Naproxen, take the missed dose as soon as you remember. You should never take more than two Naproxen 500mg tablets in 24 hours and ensure you leave a gap of at least six to eight hours between doses.

Whilst taking Naproxen you should ensure you avoid other medicines containing NSAIDs (e.g. aspirin, ibuprofen & diclofenac). 

You should try to avoid drinking alcohol as it may increase your risk of stomach bleeding.

Naproxen can cause you to burn more easily in direct sunlight. Ensure that you wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. You should avoid tanning beds and sun lamps.

Take a look at our Naproxen dosage guide for more information on the correct dosages.

What are the side effects fo Naproxen?

Like all anti-inflammatory medicines, Naproxen can cause side effects. 

Common side effects can include:

  • Gastric side effects including upset stomach, heartburn, stomach pain, constipation, or diarrhoea. These can also include bloating and gas.
  • Dizziness & headache
  • Blurred vision or ringing in the ears
  • Skin itching and rash

Some of these side effects may be less likely to occur if Naproxen is taken with or after food.

Naproxen can cause an allergic reaction in a very small number of people. You should not take Naproxen if you know you are allergic or if you have an allergy to any other anti-inflammatory medicines such as ibuprofen, aspirin or diclofenac. If you suffer with an allergic reaction to Naproxen, symptoms may include: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. If any of these symptoms occur you should seek medical attention immediately.

You should stop taking Naproxen and see your doctor as soon as possible if any of the following symptoms occur:

  • Chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance
  • Black, bloody, or tarry stools
  • Coughing up blood or vomit that looks like coffee grounds
  • Swelling or rapid weight gain, little or no urinating
  • Nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Bruising, severe tingling, numbness, pain, muscle weakness
  • Fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions)
  • Severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling

Naproxen ingredients

Naproxen 250mg gastro-resistant tablets contain 250mg naproxen as the active ingredient.

Naproxen 500mg gastro-resistant tablets contain 500mg naproxen as the active ingredient.

They also contain the following inactive ingredients: Methacrylic acid-ethylacrylate copolymer (1:1), Lactose, Magnesium stearate, Maize starch, Crospovidone, Propylene glycol, Sodium hydroxide, Triethyl citrate, Titanium dioxide (E171) , Potassium sorbate (E202) , Sodium citrate (E331) , Xanthan gum (E415), Hydroxypropyl cellulose (E463), Purified talc (E553), Beeswax.

Naproxen Warnings

Naproxen 250mg & 500mg tablets can interact with some medicines and should not be purchased online if you are taking any of the following:

  • Other anti-inflammatory drugs such as aspirin, ibuprofen or diclofenac
  • Blood-thinners or medicines that reduce blood clotting such as heparin or warfarin
  • corticosteroids such as prednisolone or dexamthasone
  • diuretics (‘water tablets’) such as furosemide
  • Medicines to treat high blood pressure such as captopril, ramipril or propranolol, losartan or candesartan
  • Ciclosporin or tacrolimus
  • Mifepristone – do not take NSAIDs 8-12 days after mifepristone
  • SSRI antidepressants such as citalopram and fluoxetine
  • Zidovudine
  • Quinolone antibiotics such as ciprofloxacin
  • Probenecid
  • Methotrexate
  • Bisphosphonates such as alendronic acid
  • Colestyramine (take naproxen 1 hour before or 4 to 6 hours after colestyramine to avoid interference with absorption)
  • Lithium
  • Hydantoins such as phenytoin
  • Sulphonamides such as sulfamethoxazole
  • Sulphonylureas such as glibenclamide or gliclazide
  • Cardiac glycosides such as digoxin

If you are taking any of the above medicines you should always check with your doctor before taking Naproxen as it can interfere with the action of your current medicines.

Naproxen should not be used during pregnancy or breast-feeding.

Naproxen may cause a small increase in the risk of heart attack or stroke, especially when used long-term or if you have an existing heart disease. You should not use Naproxen before or after any kind of heart surgery.

Long-term use of Naproxen can cause internal bleeding of the stomach or intestines. This can be fatal if untreated. Whilst taking Naproxen you should always look out for stomach pain, indigestion, passing blood or black, tarry stools. If any of these symptoms occur, seek medical treatment immediately.

You should see your doctor before taking Naproxen if you have:

  • A history of heart attack, stroke, or blood clot
  • Heart disease, congestive heart failure, high blood pressure
  • A history of stomach ulcers or bleeding
  • Liver or kidney disease
  • Asthma
  • Polyps in your nose
  • A bleeding or blood clotting disorder
  • If you smoke

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Pain?

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Naproxen Gastro-Resistant Tablets (250mg & 500mg) Reviews

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Frequently Asked Questions

  • How does Naproxen work?

    Naproxen works by blocking chemical transmitters called prostaglandins that are responsible for pain and inflammation at the site of injury.

    Prostaglandins are responsible for many different roles in the body, these include acting as pain messengers at the site of injury. Cyclooxygenase (COX) enzymes are important for prostaglandin production which in turn regulates pain, inflammation, platelet production and protecting the stomach.

    Naproxen and other NSAIDS are non-specific and block both cyclooxygenase enzymes (COX-1 and COX-2) to reduce all prostaglandin production and therefore reduce pain and inflammation.

    Stomach irritation, due to prostaglandin reduction, is a common side effect of NSAIDSs. To combat this we supply Naproxen with a gastro-resistant coating to ensure that the tablet dissolves further down the gastrointestinal tract and not in the stomach. 

  • How do I take Naproxen?

    Naproxen is normally taken at a dose of one tablet twice a day, morning and night (roughly 12 hours apart).

    The Naproxen tablets have a special coating, which ensures they don’t dissolve in the stomach but further down in the intestines. If the tablets are crushed, chewed or broken this coating will be damaged and will not work properly. This means that the contents will be absorbed in the stomach which may lead to unwanted side effects such as stomach irritation or pain.

    Take Naproxen with or after food. This doesn’t have to be a main meal, as long as it is not on an empty stomach.

    Naproxen will start to work usually within an hour and the effects will last for up to 12 hours.

    Naproxen can be taken with paracetamol to boost pain relief. It should never be taken with other anti-inflammatories such as aspirin, ibuprofen or diclofenac. For more details please contact us for free and impartial advice.

    It is best to avoid indigestion remedies at the same time as Naproxen as they can change the acid environment of the stomach. The tablet will then dissolve in the stomach where it is not intended which may lead to side effects.

  • Is it OK to take Naproxen every day?

    Naproxen is mostly recommended for people who have short-term, non-serious injuries or pain. If you’re taking it regularly (over weeks or years), or in high doses, it’s worth speaking to your doctor or pharmacist about whether there is a more appropriate long-term pain relief solution for you.

    Naproxen and other anti-inflammatories can be harsh on the stomach, especially if:

    • You are over 65
    • You are taking them regularly for periods over two weeks
    • You have existing stomach issues

    High doses of Naproxen taken over a long period of time are associated with the risk of gastrointestinal bleeding. If you need to take Naproxen for periods exceeding two weeks, you should take a treatment, such as Omeprazole, to suppress stomach acid and thus protect your stomach lining from damage.

  • Is it safe to use Naproxen continuously?

    It is safe to take Naproxen as a painkiller for the length a minor injury (normally for a few weeks) on a when required basis. The effect doesn’t decrease when it is used over long periods and it is not habit forming. Naproxen can be stopped at any time without tapering or reducing the dose.

  • What are the side effects?

    Most patients successfully treat their pain and inflammation using Naproxen without any side effects. The most common side effects are gastro-intestinal including stomach irritation, diarrhoea, wind, constipation, nausea and vomiting. Most of these can be avoided or reduced by taking Naproxen with or after food.

    When taking Naproxen its is important to be aware of the following points:

    The mode of action of Naproxen means that it not only blocks the production of prostaglandins used in pain and inflammation but also those responsible for protecting the stomach. It is important to recognise the need to a see a doctor if you have stomach pains, vomit blood, or have tarry/bloody stools.

    There is recent documented evidence that NSAIDs can increase the risk of heart attack. This side effect is considered to be rare and affect less than 1 person in 10,000. It is important to contact your doctor if you have pains in the chest and or pain running down your arm.

  • How long will it take to work?

    It can take up to two hours for Naproxen to reach a full effect, however in most patients it is quicker than this. The effects usually last 7 - 12 hours.

  • What should I do if I miss a dose?

    If you miss a dose then take another tablet when you remember. If a long time has passed and it’s nearly time for the next dose, do not double up to make up for the missed dose. 

  • Will Naproxen affect my driving?

    Naproxen can cause drowsiness (although it is not a common side effect) and it can affect your vision. Driving or operating machinery should be avoided if either of these side effects occur.

  • Can I take Naproxen during pregnancy and breastfeeding?

    Naproxen shouldn’t be taken in the first six months of pregnancy without speaking to a doctor to weigh up the risks and benefits of treatment. It is not recommended in the last three months of pregnancy or during breastfeeding.

    Babies have a hole in the heart during their development in the mother, this is normal. In the last 3 months the hole starts to heal and is completely closed when the baby is born. Naproxen and other NSAIDs can prevent the hole from healing and should not be taken in the last three months of pregnancy.

  • Can you get high from taking Naproxen?

    It should go without saying that this is not what Naproxen is supposed to be used for! Taking Naproxen does not get you high, nor does it foster reliance or addiction, in the same way that codeine sometimes can. 

  • What should not be taken with Naproxen?

    Some painkillers are ok to take alongside Naproxen. These include painkillers like paracetamol and codeine. However, Naproxen should not be taken alongside other anti-inflammatories, such as ibuprofen or aspirin, as this can have a damaging effect on the stomach and intestines if taken long-term without the proper precautions.

Authored By:

A photo of  William Obeng

William Obeng

MPharm IP

Published on: 02-02-2017

Last modified on: 23-10-2019

Reviewed By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Reviewed on: 23-10-2019

Next review date: 23-10-2021

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

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