Atovaquone/Proguanil Tablets (Generic Malarone) are available to buy from The Independent Pharmacy Online Doctor service, following a free consultation, to help prevent malaria. To find out more about malaria and see all the available treatments, see our Malaria page.
Atovaquone and proguanil are now available as a generic alternative to Malarone. They are still manufactured to the same high standards as Malarone but are available at a lower cost because the patent on the Malarone brand has now expired. They are taken once daily, 2 - 3 days before travel and continuing 1 week after returning.
Atovaquone/Proguanil Tablets (generic Malarone) contain the active ingredients; Proguanil Hydrochloride 100mg and Atovaquone 250mg. Its main use is for the prevention of malaria. Atovaquone/Proguanil Tablets are classified as a prescription-only-medicine (POM). Each box contains 12 film-coated tablets.
Atovaquone and Proguanil are both anti-parasitic drugs, which are active against the malaria-causing plasmodium (malaria) parasite. Once the plasmodium parasite enters the bloodstream it begins to reproduce, which can result in malaria. Proguanil works by inhibiting the parasite’s ability to reproduce. It does this by blocking the action of an enzyme (dihydrofolate reductase) found inside the plasmodium parasite. Dihydrofolate reductase is essential for the parasite, enabling it to reproduce. By blocking dihydrofolate reductase, Proguanil prevents the formation of any new genetic material, rendering the parasite unable to reproduce and multiply.
Atovaquone works in a similar way to Proguanil. It inhibits the production of new genetic material from inside the malaria parasite, resulting in an inability to reproduce. Both these ingredients combined work effectively together in a dual attack against malaria, helping to prevent an infection from taking hold.
Atovaquone/Proguanil are highly effective against the strains of malaria caused by the plasmodium falciparum parasite. This parasite is responsible for producing the most serious form of malaria (malignant malaria). For areas where the plasmodium falciparum parasite is predominant, Atovaquone/Proguanil will usually be the recommended choice of prevention. Atovaquone/Proguanil may also be suitable in areas where there is a known resistance to other forms of antimalarial medicines, such as Chloroquine.
Please read the Patient Information Leaflet for side effects and additional information.
Pharmacist Tip: Atovaquone and proguanil should not be taken if you are pregnant or breastfeeding. It is generally very well tolerated with only mild intestinal upsets and headaches reported. If side effects are experienced then taking the tablets with or after a meal may help to relieve them.
- You should take one tablet every day at roughly the same time each day.
- Atovaquone/Proguanil tablets need to be taken 2 – 3 days before entering an area where malaria is present and continued until 7 days after leaving the malaria area.
- You should take Atovaquone/Proguanil tablets with or after food or milk
- Atovaquone/Proguanil remains effective with a moderate alcohol intake.
How and when do I take Generic Malarone?
Generic Malarone is a one-a-day dose that you need to start taking 1-2 days before you travel. It is continued every day during your stay and also for an additional week after you return to a Malaria-free area. For example if you were travelling for 2 weeks you would need 23 tablets. That’s 2 (before you travel) + 14 (during your stay) + 7 (upon your return) =23 tablets.
It is important to complete the course as it can take 7 days to ensure any parasites that remain in your blood are effectively killed.
It is advised to take Atovaquone/Progunail tablets with food and drink where possible. This can increase the absorption in the body, increasing its effectiveness and possibly reducing side-effects.
If you do experience side effects from Atovaquone/Proguanil they may include coughing, diarrhea, dizziness, headache, loss of appetite, mouth sores, nausea, stomach pain, vomiting, or weakness. Atovaquone/Proguanil has a small risk of nausea, vomiting, diarrhoea, and skin rash as with all medicines. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects.
If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 0117 971 1603. In a medical emergency you should contact the emergency services or go straight to your local Accident & Emergency.
Atovaquone/Proguanil should not cause a harmful interaction with any of your other current medicines. Please read the Patient Information Leaflet enclosed with your medicines for further information.
Unfortunately Atovaquone/Proguanil is not 100% effective at preventing malaria, however it is still very effective if taken properly and combined with bite avoidance methods. See the Pharmacist Tips for bite avoidance techniques.
Remember it is also important to get the correct vaccinations for your trip before you travel. These should be administered around 6 weeks before you leave.
Things to be aware of before considering or taking Generic Malarone.
Generic Malarone isn’t suitable for everyone. Do not take or take if:
- You are allergic to any of the ingredients
- You have severe Kidney disease
- You are pregnant or breast feeding
Generic Malarone can also interact with other medicines, it may not be suitable if taking any of the following:
- Metoclopramide (anti-emetic)
- Tetracycline, Rifampicin & Rifabutin (antibiotics)
- Efavirenz (protease inhibitor)
- Warfarin (anticoagulant)
- Etoposide (cancer treatment)
Should you be taking any of the above medication it will be necessary to seek medical advice before deciding upon the most suitable treatment. Please read the Patient Information Leaflet enclosed with your medicines for further information.
Each tablet contains 100mg of Proguanil Hydrochloride and 250mg of Atovaquone as the active ingredients.
The other ingredients are:
Tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30, sodium starch glycollate (Type A), magnesium stearate.
Tablet coating: hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogol 400 and polyethylene glycol 8000.