Migraleve Tablets (Pink): Migraleve Pink tablets contain the active ingredients of paracetamol, codeine phosphate and buclizine hydrochloride, making them powerful pain relievers and very effective for migraine headaches. This combination treats headaches and also relieves nausea. If you take this over the counter medication as soon as the first signs of migraine appear, you can lessen its gravity, allowing you to recover much quicker. The presence of buclizine hydrochloride in this combination reduces the chances of nausea.
When ibuprofen, aspirin or paracetamol alone, do not treat the headache and sickness which come with migraine, Migraleve Pink's combination of active ingredients will take effect quickly.
What these active ingredients are responsible for
Codeine is an opioid, a stronger type of painkiller which can copy the action of endorphins (pain-reducing chemicals) in the spinal cord and the brain. The 8 mg of codeine present is sufficient to stop the pain signals to the brain and thus reduce the level of pain being felt.
The paractemol present in this medication relieves pain by curbing the production of prostaglandins in the spinal cord and the brain. It is believed that paracetamol increases our tolerance of pain, so that the true level of pain feels less painful than it actually is.
Buclizine interferes with the messages sent to the vomiting centre of the brain and, by influencing the sensation of sickness, it prevents the need to vomit.
Migraleve Pink can cause dizziness, drowsiness and blurred vision. Should you experience any of these side-effects, do not drink alcohol and do not drive or operate machinery.
In March 2015, a new 'drug driving' law came into force, which addresses the specified limits of certain medicines or drugs in your body. These medicines include morphine and, when codeine is taken, the liver converts this into morphine, so codeine is also included on the list of medicines not allowed to be taken by drivers. This means that driving when taking Migraleve Pink may be an offence. Police will test for the presence of certain drugs via a saliva test and medicines will have a higher limit than will prohibited drugs. Unless driving dangerously, people on these medications will not therefore be breaking the law. If you are taking medication, carry the medication information leaflet in your car, in case you should be asked to take a saliva test. Do not drive if this medication affects your alertness or ability to drive safely e.g. if you feel unable to concentrate, sleepy, dizzy, or if your eyesight seems to be affected.
The body metabolises codeine in different ways for different people and, for some, this means there may be a higher chance of experiencing side-effects. Such side-effects include slow and shallow breathing, reduced levels of consciousness, sleepiness, ‘pin-point’ pupils, nausea, vomiting, a lack of appetite and also constipation. Should you experience side-effects, do not take any more medicine until you have spoken with your doctor. It is possible that some people may find that this medication doesn’t have enough effect and, even in this case, speak with your doctor or a pharmacist.
It is extremely dangerous to overdose on paracetamol, as to do so can cause serious damage to the kidneys and the liver. If you ever exceed your dose of migraleve pink, you must seek immediate medical help, even if you still feel well, because there can be a delayed effect of serious damage. Many over the counter cold and flu products contain paracetamol, so always check the ingredients of over the counter medicines before taking them, or check with your pharmacist.
Heavy drinkers and people with alcoholic liver damage have a greater chance of problems from an overdose of paracetamol. Migraleve should never be taken for more than three days, without speaking with your doctor as, if taken for longer, one can build up a tolerance which will cause the medication to be less effective. You could also become dependent on the codeine element of this medication, with withdrawal leading to associated symptoms of irritability and restlessness.
If painkillers are taken too often for headaches, the pain can actually become worse.
Migraleve pink must not be prescribed to people who have used a monoamine oxidase inhibitor (MAOI) medicine within the last 14 days. Such MAOIs include the
antidepressants phenelzine isocarboxazid, tranylcypromine and moclobemide, and also selegiline, the anti-Parkinson's medicine.
(In the USA and in some other countries, Paracetamol is known as acetaminophen).
Migraleve pink and ibuprofen can be taken at the same time.
Migraleve pink is more likely to cause drowsiness, if it is taken with:
- Sleeping tablets e.g. zopiclone
- Antipsychotics e.g. haloperidol and chlorpromazine
- Benzodiazepines e.g. diazepam and temazepam
- Tricyclic antidepressants e.g. amitriptyline
- Other sedating antihistamines e.g. promethazine, triprolidine, chlorphenamine, hydroxyzine (some of these antihistamines can be found in over the counter cough, cold and hay fever remedies)
- Other powerful opioid painkillers e.g. tramadol, dihydrocodeine, and morphine.
Codeine can reduce muscular activity which occurs in the gut and this can prevent the effect of some medicines on the gut. These include:
There could also be an increased risk of the side-effects of a dry mouth, blurred vision and constipation, if Migraleve pink and antimuscarinic medicines with the same type of side-effects are taken at the same time. These include:
- Antimuscarinic medicines taken for urinary incontinence e.g. oxybutynin, propiverine, trospiumflavoxate and tolterodine
- Antimuscarinic medicines taken for Parkinson's symptoms e.g. procyclidine, trihexiphenidyl and orphenadrine
- Antispasmodics e.g. hyoscine and atropine.
If codeine is used at the same time as antimotility medicines for diarrhoea e.g. loperamide, severe constipation becomes a risk.
The painkilling action of codeine could be reduced if quinidine, rifampicin and ritonavir are taken at the same time.
The absorption of paracetamol present in the gut may be reduced if taken with colestyramine and so these two medications must not be taken within one hour of each other.
Other medicines which contain the same active ingredients
Migraleve is made up of a combination of both Migraleve pink and Migraleve yellow tablets.
There are two types of Migraleve: yellow and pink, both of which contain paracetamol and codeine. The yellow type addresses headaches and discomfort, whilst the pink type addresses nausea and vomiting. A third Migraleve, known as Migraleve Ultra, contains sumatriptan.
The active ingredients which make up Migraleve Yellow are:
- Paracetamol DC 96% 520 mg, which is equivalent to paracetamol 500 mg
- Codeine phosphate 8 mg.
Other ingredients include magnesium stearate, stearic acid, colloidal anhydrous silica, pregelatinised maize starch, hypromellose, gelatin, macrogol, aluminium oxide, E171 (titanium dioxide) and E172 (iron oxide yellow) and E104 (quinoline yellow),