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Solpadeine Plus Soluble Tablets

Solpadeine Plus Soluble Tablets (32 tablets )

Order before 3pm for delivery from Wed. 30 Sep and Thu. 01 Oct.

Product Information

  • Age: 12 years +

    Maximum per order: 1

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

For short term pain relief, Solpadeine plus can be used to treat mild or moderate pains from a variety of causes, including headaches, migraines, period pains, toothaches, muscular pains, strains or sprains, backache, or sciatica. Solpadeine plus is only for use in patients over 12 years of age, and in cases where the pain has not been alleviated by ibuprofen, aspirin, or paracetamol.

Paracetamol is a common painkiller. It is believed that paracetamol works by decreasing production of prostaglandins in the spinal cord and brain. Prostaglandins cause a react of pain when they affect nerve endings. By reducing the amount of prostaglandins, paracetamol reduces the amount of pain we feel.

Codeine is another common painkiller that is slightly stronger. It is an opioid, which is a type of medicine that works by acting as natural chemicals called endorphins. Codeine, like endorphins, bind to opioid receptors and block nerve signals that transmit feelings of pain to the brain. As a result, even though the cause of the pain remains, the pain signals do not reach the brain.

Solpadeine plus, in capsule or tablet form, contains 8mg of codeine in combination with paracetamol. This makes an effective solution for mild or moderate pain.

Caffeine may improve the painkilling effect of paracetamol, and also reduce any feelings of drowsiness that is caused by codeine.

Do not use more than the recommended dose of Solpadeine plus.

Do not use Solpadeine plus for more than three days without first consulting with a doctor or pharmacist. Regular use of codeine for more than three days can result in addiction.

If feelings of pain do not reduce while using Solpadeine plus, consult with a doctor or pharmacist.

Codeiene can cause the side effect of drowsiness. Solpadeine plus does not contain a large dose of codeine, and also contains caffeine, so drowsiness as a result of taking Solpadeine plus is unlikely. However, you should avoid driving or operating machinery after using Solpadeine plus. You should also avoid consuming alcohol whilst using Solpadeine plus.

As of March 2015, a drug driving law has been in effect that allows roadside drug tests for prohibited substances in a drivers saliva. Codeine is converted into morphine, one such prohibited substance, in the liver. As such, it may be considered an offence to drive while using Solpadeine plus. You should refrain from driving if this medicine affects you in any way that reduces your capability to drive, such as creating feelings of sleepiness, dizziness, lack of concentration, or if you suffer from blurred or double vision.

The effects on the body of metabolising codeine can vary significantly. This means that some people may experience side effects. These can include sleepiness, shallow breathing, reduced levels of consciousness, pin-point pupils, reduction in appetite, constipation, nausea, and vomiting. If you begin to experience any of these side effects from Solpadeine plus, you should stop taking the medicine and consult with a doctor or pharmacist. Other people may find that Solpadeine plus do not sufficiently relieve painful symptoms. In this case, you should consult with a doctor or pharmacist.

You should try to avoid a high intake of caffeine whilst using Solpadeine plus, as consuming a lot of caffeine could result in an increased risk in side effects such as anxiety, restlessness, difficulty sleeping, palpitations, headaches, or irritability. Avoid using other products that contain paracetamol alongside Solpadeine plus. Always check the leaflet of any medicines you acquire through a prescription or over the counter, as many medicines contain paracetamol.

Overdosing on paracetamol is dangerous, and can result in serious kidney or liver damage. Never use more than the recommended dose of Solpadeine plus. In the event that an overdose occurs, seek medical advice immediately. It is possible that you will feel completely fine, but suffer serious liver damage afterwards.

The risk of liver damage as a result of a paracetamol overdose can be increased in heavy drinkers, as alcohol increases the risk of liver damage.

Do not use Solpadeine plus for more than three days without consulting with a doctor or pharmacist. Using Solpadeine plus for prolonged periods of time can result in a tolerance to it, making it a less effective treatment for pain. You may also end up dependent on codeine, resulting in withdrawal symptoms when you stop using Solpadeine plus.

Using painkillers to deal with headaches too often can end up making the headaches worse.

You should not use Solpadeine plus if you are also taking, or have taken in the last 14 days, a monoamine oxidase inhibitor (MAOI). MAOIs include the medicine selegiline for Parkinsons, and the antidepressants trancylpromine, phenelzine, isocarboxazid, and moclobemide.

Do not use other medicines containing paracetamol whilst using Solpadeine plus. Many common medicines for pain, colds or flu contain paracetamol, so ensure you check the information of any other medicines you take whilst using Solpadeine plus. Paracetamol can be known as acetaminophen in the USA.

Whilst the amount of codeine contained within Solpadeine plus is unlikely to cause drowsiness, this likelihood can be increased if any of the following are used at the same time:

  • Antipsychotics, such as haloperidol or chlorpromazine
  • Benzodiazepines, such as temazepam or diazepam
  • Sedating antihistamines, such as chlorphenamine, promethazine, tripolidine, or hydroxyzine
  • Sleeping tablets
  • Opioid painkillers, such as dihydrocodeine, morphine, or tramadol
  • Tricyclic antidepressants, such amitriptyline

Codeine can cause reduced muscle activity in the gut, and so may counteract the effect of the following medicines:

  • Domperidone
  • Metoclopramide

If codeine is taken alongside the following antimuscarinic medicines, there can be an increased risk of side effects such as constipation, dry mouth, or blurred vision:

Certain medicines for Parkinsons, such as procyclidine, orphenadrine, or trihexiphenidyl

Certain medicines for urinary incontinence, such as oxybutynin, flavoxate, tolterodine, propiverine, or tropsium

Antipasmodics, such as atropine or hyosine

Using codeine alongside antimotility medicines to treat diarrhoea can cause sever constipation.

Using Quinidine, rifampicin, or ritonavir can hinder the pain reducing effect of codeine.

Do not take Colestryamine within an hour of using Solpadeine plus as it reduces the absorption of paracetamol.

The following other medicines contain the same active ingredients as Solpadeine plus:

  • Solpadeine max soluble tablets
  • Syndol headache relief
  • Ultramol soluble
  • Veganin

The following non-prescription medicines contain paracetamol and codeine, but dont contain caffeine:

  • Migraleve yellow
  • Panadol ultra
  • Paracodol
  • Solpadeine max tablets

The following prescription medicines contain paracetamol and codeine, but dont contain caffeine:

  • Codipar
  • Kapake
  • Solpadol
  • Tylex
  • Zapain

You can also obtain co-codamol and effervescent tablets marketed as generic unbranded medicine, with non-prescription or prescription strength.

Solpadeine plus should not be used for more than three days in a row without consulting a doctor. Using Solpadeine for prolonged periods of time can result in the body growing a tolerance to it, reducing the effectiveness. It is also possible to become dependent on codeine, resulting in withdrawal symptoms when treatment is ceased.

Is it safe to buy Solpadeine plus soluble tablets online?

Buying medicine online is completely safe as long as you use a website that is operated legally and adhering to regulations. The Independent Pharmacy is and NHS Online Pharmacy that provides genuine medicine through a safe and convenient service.

How do I buy Solpadeine plus online?

Very easily! Simply select Buy above, and you will be directed to a short health questionnaire. This is just to ensure that it is safe to supply Solpadeine plus to you. In less than two minutes, your medicine can be on its way!

What are the advantages to buying Solpadeine plus online?

  • You dont have to travel to a pharmacy – it is quick and convenient.
  • We offer home delivery that is reliable and fast.
  • We offer competitive prices.
  • All the information you need when your medicine is available right here in one place.


About pain

Generally, pain is the bodys mechanism for telling us that something is going wrong. An injured area will release chemicals called prostaglandins, which cause inflammation and cause nerve signals to reach the brain.

There are three classifications of pain:

Acute pain

This pain does not last long and is fast to appear, such as an ankle sprain or headache.

Chronic pain

This is pain that stays around long-term, such as pain associated with arthritis. Often this pain requires management by your GP.

Recurrent pain

This pain appears and disappears over time – like period pain.

According to research, millions of people suffer from regular pains and aches, such as simple headaches. Over 25 million work and school days are lost to these recurrent minor pains every year. Click on the body part corresponding to your pain to see more information and how Solpadeine could help you deal with these problems.

Migraines, while less common than headaches, can be incredibly severe and debilitating. They are often associated with specific triggers such as certain foods or stress. Some people experience an aura before a migraine, such as visual disturbances.

Period pain can be a debilitating annoyance to over half of women. The wombs muscle wall can contract, compressing the blood vessels of the womb. These cramps reduce oxygen supply in the area, and so prosaglandins are released and pain is experienced.

Most people experience back pain at some point in their lives. Generally, back pain is a symptom of stress to the muscles, tendons or ligaments in the back. This can be caused by heavy lifting, poor posture, bending incorrectly or twisting the back.

A muscle strain is when a muscle becomes stretched or torn. A muscle sprain is when a ligament becomes twisted or stretched. Often, these types of injuries happen during physical activities such as sports. Usually, sprains are more serious than strains.

Non-Prescription Alternatives for the treatment of Pain are;

  • Ibuprofen
  • Paracetamol
  • Aspirin
  • Topical Treatments (Ibuprofen gel)
  • Rest the area

If your pain does not ease or becomes severe, contact your GP or Pharmacist for further advice.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Adults, including the elderly and children 12 years and over:

  • Take 2 tablets dissolved in a glass of water up to 3-4 times a day if required.
  • Avoid taking more often than every 4 hours. 
  • Avoid taking more than 8 tablets in 24 hour period. 

Not everyone will experience side effects when they take medication, however if you do they can include:

  • Unwanted effects associated with use of paracetamol are uncommon. If you experience effects such as skin rash, you should consult your doctor or pharmacist. 
  • Codeine might cause constipation.
  • High doses of Paracetamol might affect the use of anticoagulants such as warfarin, domperidone and metoclopramide. 

If you are concerned about these effects, or if the product affects you in any other way, stop using it and talk to your doctor or pharmacist.

The active ingredients contained in this medicine is/are:

Paracetamol 500mg, Codeine Phosphate Hemihydrate 8mg and Caffeine 30mg

The medicine also contains the following inactive ingredients to make up the complete product:

Sodium Bicarbonate, Sorbitol Powder (E420), Saccharin Sodium, Sodium Lauryl Sulfate, Citric Acid, Sodium Carbonate, Polyvinylpyrrolidone and Silicone Fluid.

Reading the following warnings carefully will help to ensure you are selecting an appropriate product.

  • Do not exceed stated dose. 
  • Immediate medical advice should be sought in the event of overdose, even if you feel well because of the risk of delayed serious liver damage. 
  • Do not take with other products containing paracetamol. 
  • Consult your doctor or pharmacist before taking this product if you suffer from alcoholism, kidney or liver problems, if you are taking any other medicines or if you are pregnant. 
  • Codeine is used only in combination with other analgesics and the above warnings and side effects should be adhered to. 

Please read all packaging and the Product Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 3 - 5 day delivery - £2.95
  • Express Tracked Delivery - 1 - 3 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Pain?

Visit our advice area or contact our support team

Solpadeine Plus Soluble Tablets Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

Authored By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Published on: 29-05-2019

Last modified on: 29-05-2019

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

Reviewed By:

A photo of  Andy Boysan

Andy Boysan


Reviewed on: 29-05-2019

Next review date: 29-05-2021

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

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