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Treclin Gel

Treclin Gel (30g)

Order before 3pm for delivery from Wed. 04 Aug and Thu. 05 Aug.

Treclin Information

  • Age: 18 Years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Treclin gel?

Treclin gel is a topical acne treatment that is normally used to treat  moderate levels of acne. It is a prescription only medicine that must be prescribed by a doctor or other healthcare professional. It can be bought online using The Independent Pharmacy after simply completing our quick, online consultation. Treclin gel is manufactured by Meda Pharmaceuticals and marketed by Mylan. It comes in 30g tubes and is a translucent yellow gel. 


How does Treclin gel treat acne?

Treclin contains two active ingredients;

  • Clindamycin - an antibiotic that helps to kill acne-causing bacteria that live on the skin.
  • Tretinoin - reduces the ability of skin cells to stick together which helps to shed dead skin cells instead of them blocking follicles.

These two actions combine to help treat acne symptoms such as blackheads, whiteheads, pustules, papules and redness. The combination of the two active ingredients are more effective when combined than if used separately.


How quickly will Treclin treat acne?

Like most topical acne treatments, Treclin gel normally takes a few weeks of continued use to build up an effect. It is normally best to use the gel for a period of 10-12 weeks and it is important that you do not stop using Treclin as soon as your acne gets better.

You can read more about Treclin results here.


Treclin alternatives

Non-prescription alternatives to Treclin acne gel include benzoyl peroxide gel, such as Acnecide. Benzoyl peroxide is an effective acne treatment that is available over the counter in most pharmacies. It helps to kill the bacteria that cause acne, however, it is not an antibiotic. Treclin gel should not be used in combination with benzoyl peroxide or any other treatment containing antibiotics. 

Prescription alternatives to Treclin gel include:



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

How to apply Treclin

Apply Treclin gel once daily at bedtime. Wash the entire face with mild soap and warm water. Pat dry using a towel. Use a pea-sized amount onto one fingertip, dot onto each area of the face: the chin, cheeks, nose, and forehead, then gently rub the gel over the entire face. 

Do not use Treclin for more than 3 months without careful evaluation or consulting with a doctor. Any improvements may not be observed for up to several weeks after beginning treatment.

If you miss a dose of Treclin, just wait for the next dose at the usual time. Never double dose to make up for a forgotten dose.


Does Treclin go out of date?

The shelf life of Treclin is stated on the outer box and refers to the last day of that month. After you first open the tube, Treclin expires within three months.

Treclin side effects

Side effects may occur on areas of skin on which Treclin gel has been applied. If they cause too much of a problem, used Treclin less frequently or stop for a few days until the irritation goes away.

Side effects are most common during the first couple of weeks of using Treclin and are most likely to include dry skin, irritated skin (including stinging or burning) and peeling skin. These side effects tend to subside after a couple of weeks.

These minor side effects can include:

  • slight stinging or skin pain
  • skin irritation or tenderness
  • skin burning sensation
  • dry skin
  • itching

Rare side effects (1 in 10,000 people):

  • Hypersensitivity
  • Hypothyroidism
  • Headache
  • Eye irritation
  • Gastroenteritis
  • Nausea
  • Dermatitis
  • Herpes simplex
  • Macular rash
  • Skin bleeding
  • Skin burning sensation
  • Skin depigmentation
  • Application site erosion or discolouration

Uncommon side effects (1 in 10,000 to 1 in 1,000 people):

  • Acne
  • Dry skin
  • Erythema
  • Seborrhoea
  • Photosensitivity reaction
  • Pruritis
  • Rash
  • Exfoliative rash
  • Skin exfoliation
  • Sunburn
  • Burning

Ensure you read the Patient Information Leaflet thoroughly before starting Treclin gel.

Treclin gel ingredients

Each gram of Treclin gel contains:

Active ingredients:

  • 10 mg (1%) clindamycin (as clindamycin phosphate)
  • 25 mg (0.025%) tretinoin

Inactive ingredients:

  • purified water
  • glycerol
  • carbomers
  • methyl parahydroxybenzoate (E218)
  • propyl parahydroxybenzoate (E216)
  • polysorbate 80
  • disodium edetate
  • citric acid, anhydrous
  • butylhydroxytoluene (E321)
  • trometamol

Treclin warnings

Treclin gel should only be used on the skin. When applying Treclin gel, avoid getting it into the eyes, eyelids, lips, and nostrils. 

Treclin should not be used in patients who:

  • have a history of hypersensitivity to clindamycin and/or tretinoin or any of the excipients or lincomycin
  • have regional enteritis, ulcerative colitis, or a history of any antibiotic-associated colitis
  • have a personal or familial history of skin cancer
  • have a history of acute eczemas, rosacea and perioral dermatitis
  • have pustular and deep cystic nodular acne varieties (acne conglobata and acne fulminans)

Special warnings and precautions for use:

  • Treclin is not for oral, ophthalmic, intranasal or intravaginal use
  • Treclin is not recommended in treatment of mild acne vulgaris
  • Treclin should not be used during pregnancy, especially during the first trimester and women not using contraception
  • Contact with the mouth, eyes and mucous membranes and injured skin should be avoided
  • In the event of accidental contact with the eyes, bathe with large amounts of water.

Antibiotic-associated colitis has been reported with the use of some other topical clindamycin products. This is unlikely to occur with Treclin as plasma levels have been determined and the percutaneous absorption of clindamycin is clinically negligible.

If you notice prolonged diarrhea or suffer from abdominal cramps, treatment with Treclin should be discontinued immediately as the symptoms may indicate antibiotic-associated colitis. 

If severe irritation occurs you should discontinue temporarily or reduce the frequency of application.

Treclin should not be applied at the same time as other topical treatments, including cosmetics, as there is a chance of possible incompatibility.

Particular caution should be exercised in using keratolytic agents such as sulfur, salicylic acid, benzoyl peroxide or resorcinol and chemical abrasives. 

Do not use any cleansers or scrubbing solutions with a strong drying effect. You should also avoid abrasive soaps, cosmetics, and spices or lime should be used with caution.

Photosensitivity may occur during treatment with Treclin Gel and exposure to sunlight should be limited as much as possible and appropriate sunscreen should be worn. 

Avoid using sun-lamps or sunbeds throughout treatment as this product should not be used on sunburnt skin.

Long-term use of clindamycin may cause resistance and overgrowth of non-susceptible dermal bacteria or fungi, although this is rare.

Cross-resistance may occur with other antibiotics such as lincomycin or erythromycin.

Do not use if you are allergic to any of the ingredients listed in the 'Ingredients' section.

Tretinoin causes enhanced permeability for other topically applied medicinal agents.


Treclin in pregnancy, breastfeeding and fertility

Treclin should be given to women of childbearing potential only if effective contraception is used during treatment and for 4 weeks after stopping treatment.

There is not a substantial amount of data regarding the use of Treclin in pregnant women. 

A limited number of pregnancies exposed in the first trimester to clindamycin indicate no adverse effects of clindamycin on pregnancy or on the health of the fetus/new-born child. 

Clindamycin has been shown to not be teratogenic in reproduction studies in rats and mice when applied via subcutaneous and oral methods.

Treclin should not be used during pregnancy, especially during the first trimester, and in women who may become pregnant.

There is not adequate data on the effects of tretinoin and clindamycin and the secretion of breast milk following the use of Treclin. It is advised that Treclin is not be used by women who are breastfeeding.

Reproduction studies in rats and mice, using subcutaneous and oral doses of clindamycin, revealed no evidence of impaired fertility.

Orally administered tretinoin severely affects fertility. Available data regarding fertility after topical administration in humans are limited.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Acne?

Visit our advice area or contact our support team

Treclin Gel Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • How do I use Treclin Gel?

    Before applying any topical treatment, always wash your hands and remove any makeup. 

    Gently wash the area with warm water and a mild soap, drying softly afterward.

    Spread a thin layer of the gel onto the affected skin with your fingertips and gently smooth it in.

    Apply to the entire area in which acne is present, not just each individual spot. 

    Always wash your hands after applying Treclin.

  • When will I see an improvement in my acne?

    When using Treclin daily, it normally takes 4 - 12 weeks to see a substantial improvement in your acne. It is important to use the gel daily and to continue using Treclin when you start to see an improvement for the best effects.

  • What if I experience side effects from Treclin gel?

    If you experience side effects such as redness or irritation in the area of application, you should stop using Treclin gel until the symptoms resolve. When you restart the treatment, you should use it every other day for a week to ease yourself back into the treatment.

  • Can I buy Treclin gel over the counter?

    Treclin gel is a prescription acne treatment that cannot be bought over the counter from a local pharmacy. It needs to be prescribed by your GP or can be purchased from a registered online pharmacy, such as The Independent Pharmacy.

  • Can Treclin gel be used in pregnancy?

    Treclin gel should not be used by women who are pregnant or are trying to become pregnant as it may harm your unborn baby. Women of child-bearing age you should use contraception while using this medicine and for one month after discontinuation of treatment. 


  • Why do I need to protect my skin from sunlight?

    Treclin gel contains the active ingredient, tretinoin. Tretinoin can make your skin more sensitive to light, leading to sunburn. It is recommended that you use sunscreen with at least SPF 30 if you will be exposed to strong sunlight to protect your skin. If you do experience sunburn whilst using the treatment, you should stop using Treclin until this has fully healed.

    You should not use sunbeds or other UV lights whilst using Treclin. 

  • Can I use other acne treatments with Treclin gel?

    We do not recommended patients to use other acne treatments at the same time as Treclin gel. Treclin is a combination treatment that has two active ingredients that work in different ways to cure acne. There are no other acne treatments that would enhance the effects of Treclin if used at the same time and combining it with other treatments will lead to an increased likeliness of side effects such as dry skin, irritation, redness, or burning.

Authored By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Published on: 17-01-2018

Last modified on: 17-01-2018

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

Reviewed By:

A photo of  William Obeng

William Obeng

MPharm IP

Reviewed on: 09-01-2020

Next review date: 09-01-2022

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