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Epiduo 0.1%/2.5% Gel

Epiduo 0.1%/2.5% Gel (45g)

Order before 3pm for delivery from Fri. 30 Jul and Mon. 02 Aug.

Epiduo - prescription acne treatment 

Buy Epiduo gel to treat adult acne from The Independent Pharmacy. This lightweight gel is a prescription-only acne gel that will help control moderate to severe acne flare ups and breakouts — including ones on your back. It has two main active ingredients that help control the skin inflammation and keep your spots from reoccurring: adapalene 0.1% and benzoyl peroxide 2.5%.

You can buy Epiduo online by completing a simple online consultation for review by our medical team. Complete your consultation and place your order before 3pm and your treatment can be delivered as quickly as the next working day.

Epiduo Information

  • Age: 18 Years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Epiduo?

Epiduo 0.1%/2.5% gel is a prescription acne treatment which is available to order from The Independent Pharmacy Online Doctor service. You can buy Epiduo gel online following a free consultation from one of our specialists. To find out more about acne and see all the available treatments, visit our acne page.

Epiduo is a topical gel used to treat acne. It is manufactured by Galderma UK Ltd and comes in a practical 45g pump dispenser. Epiduo gel contains two active ingredients: adapalene 0.1% and benzoyl peroxide 2.5%. 


What causes acne? 

Sebum is produced by glands just under the surface of the skin called sebaceous glands. Sebum is a natural, oily substance needed to keep the skin smooth and supple. However, sufferers of acne often produce too much sebum, which can cause the pores to become blocked and infected. Blocked pores can then lead to the formation of spots, blackheads and whiteheads.


What is adapalene?

Adapalene is a topical retinoid. It is particularly effective at treating acne which has been caused by comedones (clogged hair follicles in your skin). Adapalene addresses your acne by inhibiting the keratinocyte differentiation that leads to comedone formation.  


What is benzoyl peroxide? 

Benzoyl peroxide is a bactericide used to treat acne. It tackles acne by working as an antiseptic. This reduces the amount of acne-causing bacteria (P. acnes) on the surface of your skin.  

The combination of adapalene 0.1% and benzoyl peroxide 2.5% in Epiduo gel helps significantly reduce acne breakouts, as well as preventing or reducing future acne occurrences.


How does Epiduo gel work?

Epiduo gel contains adapalene, which is a synthetic retinoid. It works to reduce the growth of keratin surface skin cells that can block pores. When adapalene is applied to an affected area, it will help unblock the pores and sebaceous glands, allowing the sebum to escape. This will decrease the redness, swelling and inflammation associated with acne. 

Epiduo gel also contains benzoyl peroxide, an antimicrobial medicine designed to kill the bacteria that can lead to acne symptoms. It also helps promote skin turnover, which will further help clear blocked pores and reduce the bacterial count on the skin’s surface. It is effective at treating blackheads, whiteheads, and inflamed red spots.

Combining both these ingredients in a single treatment will help provide an effective means of treating and controlling mild to moderate symptoms of acne. Epiduo has been clinically tested and approved for both short and long-term acne treatment.  


Main benefits of Epiduo gel 

  • It is the only topical combination acne treatment which is free of antibiotics
  • It kills Propionibacterium acnes – the bacteria which cause acne
  • It helps to clear existing acne
  • It helps to stop future acne breakouts  
  • It helps to dry greasy skin

Epiduo is a good treatment option for acne that should be prescribed when benzoyl peroxide (Panoxyl) or adapalene (Differin) used on their own have failed. Using them in combination, as you find with Epiduo gel, may be more effective and help treat more severe cases of acne.


How to use an Epiduo gel pump

Epiduo gel is dispensed from a 45g pump. Before you apply Epiduo gel, make sure you have washed your hands and cleaned the affected area of skin you are treating. Once you have done this, use the pump to dispense Epiduo gel and apply a thin layer of the medication to your skin. This process should be repeated as directed by your doctor or pharmacist (usually once a day).

Early signs of improvement in acne symptoms usually appear after 1 to 4 weeks of treatment. 


Epiduo gel reviews

Reviews from users of Epiduo gel have noted the high success rate of the treatment but explained that you will need to persist (some reviewers explaining that it took 4 months to see a transformative effect) with the treatment to see positive results. 

These reviews detail that some users experience an initial purge period, during which you may find that your acne symptoms get worse before settling down. You may see some redness and irritation in the first few weeks of treatment.


Epiduo alternatives

Epiduo gel is a topical retinoid and it works by normalising hyperkeratinisation, which removes dead skin cells from the surface of your skin and therefore unblocks your pores. The other topical treatments available for your acne are:  

  • Topical antibiotics – this kills the bacteria on your skin which is responsible for infecting your clogged hair follicles. These include Zineryt and Dalacin T.
  • Other topical treatments - these work in a similar way to Epiduo by reducing the build-up of dead skin cells, helping to keep your pores clear and therefore stopping blackheads and whiteheads. These include Acnecide and Differin. They are suitable for mild to moderate acne and can be combined with antibiotics for a greater effect.
  • Azelaic acid (Skinoren) – this removes your dead skin cells and kills Propionibacterium acnes
  • Antibiotic tablets – normally used in combination with topical non-antibiotic treatments, this also kills P.acnes and reduces the inflammation caused by acne. These are suitable for moderate to severe acne and include Tetralysal and Oxytetracycline. Oral antibiotics work well with Epiduo to reduce severe acne.     


Are there any natural treatments for acne?

Alongside the available prescription treatments for acne, there are a number of natural remedies that you can use to tackle your acne. You should also establish good skincare routines and make sure that you are: 

  • Cleansing your skin
  • Exfoliating your skin
  • Moisturising your skin
  • Avoiding excessive sun exposure 

You can read more about preventing acne on our advice page.

Epiduo Patient Information Leaflet: https://www.medicines.org.uk/emc/product/451/pil

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Apply a thin layer of Epiduo gel to the affected area once daily in the evening. You should apply gel to the whole affected area, not just the spots themselves. Use continuously for up to THREE months.

You should wash your face using warm water and a mild cleanser or soap before use. Pat it dry, rubbing can irritate the skin and cause redness.

If dry skin or irritation occurs at the start of treatment, try applying Epiduo every other day and slowly work up to daily applications.  

Epiduo side effects

Epiduo gel can cause side effects in a small number of people who use it. Side effects are most common at the start of treatment as your skin gets used to Epiduo.

Common (affect between 1 in 10 and 1 in 100 people)

  • Dry skin: If this occurs you can used a non-comedogenic moisturiser (like Cetaphil) to remoisturise the skin.
  • Irritant contact dermatitis.
  • Skin irritation and burning: You should reduce the frequency of application or discontinue use until your skin is better then slowly re-introduce treatment.

Uncommon (affect between 1 in 100 and 1 in 1000 people)

  • Itching (pruritus)
  • Sunburn

Ensure you read the Patient Information Leaflet before using Epiduo so you are aware of all the possible side effects.

Epiduo ingredients

Epiduo 0.1%/2.5% gel contains the active ingredients adapalene 0.1% w/w and benzoyl peroxide 2.5% w/w.

It also contains: docusate sodium, disodium edetate, glycerin, poloxamer, propylene glycerol (E1520), simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethylaurate, isohexadecane, polsorbate 80, sorbitan oleate) & purified water. 

Epiduo warnings

Epiduo Gel should not be applied to skin that is broken or has eczema.

Epiduo should not come into contact with the eyes, mouth, nostrils or mucous membranes. If product enters the eye, wash immediately with warm water.

This product contains propylene glycol (E1520) that may cause skin irritation.

If a reaction suggesting sensitivity to any component of Epiduo occurs, use should be discontinued.

Excessive exposure to sunlight or UV light (including sun beds) should be avoided.

Epiduo should not come into contact with any coloured material including hair and dyed fabrics as this may result in bleaching and discoloration.

Epiduo should not be used during pregnancy. 

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Acne?

Visit our advice area or contact our support team

Epiduo 0.1%/2.5% Gel Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What does Epiduo gel contain?

    Epiduo gel is a dual-action acne treatment that contains adapalene 0.1% and benzoyl peroxide 2.5%. When combined in Epiduo gel, these two ingredients help to kill the bacteria that cause acne as well as helping to increase the turnover of keratin skin cells that can build up and block pores.

  • How do I use Epiduo gel?

    In adults and children 18 years and over, Epiduo is applied once daily, usually in the evening. You should not apply Epiduo more than once in a 24-hour period. For best effects, Epiduo gel should be applied after washing your face with warm water and a mild cleanser to clear away and excess oil, skin cells and bacteria.

  • Can I use other acne treatments with Epiduo gel?

    You can combine Epiduo with antibiotic acne treatments such as Tetralysal (lymecycline), Oxytetracycline, Minocin (minocycline) or Erythromycin tablets. Epiduo should not be used with any other acne creams as it may cause excess drying or irritation to your skin.

  • I have started using Epiduo gel and the treated area is red and irritated, is this normal?

    Redness and irritation of the treated area can occur when you use Epiduo for the first time. This is not usually serious and normally subsides within a week. During this time reduce the frequency of Epiduo application to once every other day to allow your skin to recover and then slowly build up to applying it daily.  

  • Why can I only buy three packs of Epiduo online at one time?

    Epiduo Gel is an prescription-only acne treatment. For that reason, to ensure the safety of our patients and the legal & ethical operating of our pharmacy, we only supply a maximum of 3 months treatment at one time. Epiduo treatment is normally judged for effectiveness after 2-3 months. This means that if you do not find Epiduo as effective as you would like after this time, you are not stuck with an excess of medication. If you are happy with the results you can easily log in and re-order another supply.

  • Is Epiduo available for next day delivery?

    Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 4pm Monday to Friday, Epiduo Gel is available for next day delivery.

  • Is it safe to buy Epiduo gel online?

    Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Epiduo online. The Independent Pharmacy is an NHS-registered Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.

  • How do I buy Epiduo online?

    It's simple!

    Just select 'Start Consultation' above, you will need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Epiduo to you. It all takes around 3 minutes and your treatment can be delivered to your door.

  • What are the advantages of buying Epiduo gel online?

    There are many advantages to buying Epiduo online, some include:

    • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
    • Fast delivery - We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
    • Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
    • Tons of information - we provide all the information you could need on Epiduo (adapalene/benzoyl peroxide) and other acne treatments, in easy to digest formats, at a time to suit you.
  • Does Epiduo gel work for acne scars?

    Epiduo gel is used to prevent, reduce, and treat existing acne. It can also help to rid your skin of acne scars that have come from previous outbreaks.

Authored By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Published on: 02-02-2017

Last modified on: 13-11-2020

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

Reviewed By:

A photo of  Andy Boysan

Andy Boysan


Reviewed on: 13-11-2020

Next review date: 13-11-2022

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

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  • 1 Complete a simple health questionnaire
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