The Independent Pharmacy
Epiduo 0.1%/2.5% Gel

Epiduo 0.1%/2.5% Gel

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Epiduo - prescription acne treatment

Buy Epiduo gel to treat adult acne from The Independent Pharmacy. This lightweight gel is a prescription-only acne gel that will help control moderate to severe acne flare-ups and breakouts — including getting rid of the ones on your back. It has two main active ingredients that help control skin inflammation and keep your spots from reoccurring: adapalene 0.1% and benzoyl peroxide 2.5%.

You can buy Epiduo online by completing a simple online consultation for review by our medical team. Complete your consultation and place your order before 3 pm, and your treatment can be delivered as quickly as the next working day.

  • Suitable for age:18 Years +
  • Maximum per order:3
  • Consultation required?Yes
    This treatment requires an online consultation for review by our medical team. The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective.

Epiduo 0.1%/2.5% Gel Summary

Type of medicineTopical retinoid with antibacterial & anti-inflammatory agent.
Works byRemoving dead skin cells and killing bacteria on the surface of the skin.
Active ingredientBenzoyl peroxide & adapalene
Effective within1 - 4 weeks
Pack size45g
ManufacturerGalderma UK Limited
Use with alcoholNo known issues

Epiduo Information

  • How to use Epiduo

    Apply a thin layer of Epiduo gel to the affected area once daily in the evening. You should apply gel to the whole affected area, not just the spots themselves. Use continuously for up to 3 months.

    • You should wash your face using warm water and a mild cleanser or soap before use.
    • Pat it dry. Rubbing can irritate the skin and cause redness.
    • If dry skin or irritation occurs at the start of treatment, try applying Epiduo every other day and slowly work up to daily applications.

    This process should be repeated as directed by your doctor or pharmacist (usually once a day).

    Early signs of improvement in acne symptoms usually appear after 1 to 4 weeks of treatment.

  • Epiduo ingredients

    Epiduo gel contains the active ingredients: adapalene 0.1% w/w and benzoyl peroxide 2.5% w/w.

    It also contains the inactive ingredients:
    docusate sodium, disodium edetate, glycerin, poloxamer, propylene glycerol (E1520), simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, polysorbate 80, sorbitan oleate) & purified water.

  • Epiduo side effects

    Epiduo gel can cause side effects in a small number of people who use it. Potential side effects most often appear at the start of treatment as your skin gets used to Epiduo.

    Common (affect between 1 in 10 and 1 in 100 people)

    • Dry skin: If this occurs you can used a non-comedogenic moisturiser (like Cetaphil) to remoisturise the skin without clogging your pores.
    • Irritant contact dermatitis.
    • Skin irritation and burning: You should reduce the frequency of application or discontinue use until your skin is better, then slowly re-introduce treatment.

    Uncommon (affect between 1 in 100 and 1 in 1000 people)

    • Itching (pruritus)
    • Sunburn

    Ensure you read the Patient Information Leaflet before using Epiduo so you are aware of all the possible adverse effects.

  • Epiduo warnings

    • Epiduo Gel should not be applied to skin that is broken or has eczema.
    • Epiduo should not come into contact with the eyes, mouth, nostrils or mucous membranes (sensitive areas inside your body). If the product enters the eye, wash immediately with warm water.
    • This product contains propylene glycol (E1520) that may cause skin irritation.
    • Excessive exposure to sunlight or UV light (including sunbeds) should be avoided whilst using Epiduo.
    • Epiduo should not come into contact with any coloured material, including hair and dyed fabrics, as this may result in bleaching and discolouration.

    Pregnancy and breastfeeding

    Epiduo should not be used during pregnancy. Speak to a healthcare provider or pharmacist before using Epiduo if you are breastfeeding.

    Read the Patient Information Leaflet thoroughly for full details of warnings and precautions associated with this medicine.

    Patient Information Leaflet

    Before using Epiduo, it is important to read the patient information leaflet enclosed with your treatment.

    Epiduo PIL


    James Leyden, Linda Stein-Gold & Jonathan Weiss (2017). Why Topical Retinoids Are Mainstay of Therapy for Acne -

    NHS (2022). About benzoyl peroxide -

    Epiduo Patient Information Leaflet:

Patient Information Leaflet

Before using Epiduo it is important to read the patient information leaflet enclosed with your treatment.

Epiduo 0.1%/2.5% Gel reviews

Epiduo FAQs

  • Epiduo gel is a dual-action acne treatment that contains adapalene 0.1% and benzoyl peroxide 2.5%. When combined in Epiduo gel, these two ingredients help to kill the bacteria that cause acne and increase the turnover of keratin skin cells that can build up and block pores.

  • In adults and children 18 years and over, Epiduo is applied once daily, usually in the evening. You should not apply Epiduo more than once in a 24-hour period. For best effects, Epiduo gel should be applied after washing your face with warm water and a mild cleanser to clear away excess oil, skin cells and bacteria.

  • You can combine Epiduo with antibiotic acne treatments such as Tetralysal (lymecycline), Oxytetracycline, Minocin (minocycline) or Erythromycin tablets. Epiduo should not be used with any other acne creams as it may cause excess drying or irritation to your skin.

  • Redness and irritation of the treated area can occur when you use Epiduo for the first time. This is not usually serious and normally subsides within a week. During this time, reduce the frequency of Epiduo application to once every other day to allow your skin to recover and then slowly build up to applying it daily.

  • Epiduo Gel is a prescription-only medicine for acne. For that reason, to ensure the safety of our patients and the legal & ethical operation of our pharmacy, we only supply a maximum of 3 months treatment at one time. Epiduo treatment is normally judged for effectiveness after 2-3 months. This means that if you do not find Epiduo as effective as you would like after this time, you are not stuck with an excess of acne medication. If you are happy with the results, you can easily log in and re-order another supply.

  • Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 3pm Monday to Friday, Epiduo Gel is available for next-day delivery.

  • Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy, it is perfectly safe to buy Epiduo online. The Independent Pharmacy is an NHS-registered Online Pharmacy based in Bristol and has all the necessary regulations to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.

  • It's simple!

    Just select 'Continue To Assessment' above. You will need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Epiduo to you. It all takes around 3 minutes, and your treatment can be delivered to your door.

  • There are many advantages to buying Epiduo online. Some include:

    • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
    • Fast delivery - We offer same-day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
    • Great prices - we are able to offer very competitive prices, and we guarantee to beat any other Online Doctor service.
    • Tons of information - we provide all the information you could need on Epiduo (adapalene/benzoyl peroxide) and other acne treatments, in easy to digest formats, at a time to suit you.
  • Epiduo gel is used to prevent, reduce, and treat existing acne. It can also help to rid your skin of acne scars that have come from previous outbreaks.

Haven’t found the right treatment for you?

No problem. Ask our medical team for free, impartial advice.

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