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Oxytetracycline 250mg Tablets

*The brand supplied may vary. Please contact us if you require a specific brand.

Oxytetracycline 250mg Tablets (112 tablets)

Order before 3pm for delivery from Fri. 30 Jul and Mon. 02 Aug.

Oxytetracycline - Oral Antibiotics for Acne

If you’ve been wondering where to buy acne treatments, then you need look no further. Purchase your Oxytetracycline tablets online, directly from The Independent Pharmacy, following a consultation with our Online Doctor. This antibiotic medication is a great treatment for persistent or cystic acne. Order online now for the best price and receive your treatment quickly and discreetly in the UK.

Oxytetracycline tablets are antibiotics used for the treatment of mild to moderate acne. It kills the bacteria on the skin that causes blocked pores and leads to acne. When taken for 8-12 weeks (2-3 months), Oxytetracycline 250mg can help to clear up persistent acne and is available from The Independent Pharmacy.

Oxytetracycline Information

  • Age: 18 Years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Oxytetracycline dosage for acne

Oxytetracycline 250mg tablets are available to buy from The Independent Pharmacy’s Online Doctor service, following a free consultation, to help treat acne. To find out more about acne and see all the available treatments, see our Acne page.

Oxytetracycline is an oral antibiotic used to treat acne, rosacea and other bacterial infections. Acne symptoms will usually present themselves as a mixture of blackheads, whiteheads, and redness which are often referred to as spots or pimples.

The active ingredient, oxytetracycline, belongs to a group of medicines called tetracycline antibiotics. Oxytetracycline is a broad spectrum antibiotic that is effective against a wide variety of bacteria. It can also be used to treat other bacterial infections, such as chest infections, urine infections, skin infections, genital infections, yeast infections and mouth infections. 


Treating acne with Oxytetracycline

To treat acne, oxytetracycline helps to kill the bacteria associated with causing spots (Propionibacterium or Propionibacterium acnes). This common type of bacteria feeds on the sebum that is naturally produced by the skin in the sebaceous glands. This feeding causes Propionibacterium to produce waste products and fatty acids, which can irritate the sebaceous glands. This irritation will cause the glands to become infected and inflamed, resulting in spots and other acne symptoms.

Oxytetracycline 250mg tablets work by interfering with the Propionibacterium’s ability to produce the proteins that are essential for their reproduction. This action stops the spread of the infection, reducing the inflammation of the sebaceous glands and allowing the skin to heal naturally. The remaining bacteria is killed off by the immune system or will eventually die out.

Oxytetracycline tablets should be used alongside a good skincare regime where you wash the affected areas with a mild soap or cleanser once or twice daily to remove excess bacterial waste and sebum. You should use warm (not hot) water and pat the areas dry with a towel. Avoid over-washing the affected area, as drying out your skin too much could further aggravate the problem.

Oxytetracycline 250mg tablets are suitable for treating moderate to severe acne (or rosacea) where there is an active infection and visible inflammation. If you have 20 to 100 whiteheads or blackheads, 15 to 50 inflamed bumps, or 30 to 125 total lesions, your acne is considered moderate. The duration of treatment will depend on how quickly your condition improves.

If you'd like to find out more, take a look at our Oxytetracycline acne guide for more information.


Moderate to severe acne treatment

Acne is a common condition amongst teenagers and adults and often presents itself as clusters of spots, which vary in size from small whiteheads and blackheads to large cysts and pus-filled spots, the larger of which can sometimes leave scars.

Acne usually comes about as a result of a hormonal imbalance in the body, which is most common during puberty. For females, acne can also present itself when a period is due and also in the earlier stages of pregnancy. You can however, get acne at any stage of your life and many adults have acne that comes and goes depending on environmental and hormonal changes.

Acne can also be caused by bacteria, Propionibacterium, which appear when the skin overproduces sebum, an oily secretion of the sebaceous glands – the true purpose of which is to maintain healthy hair and skin. Feeding on the sebum, this bacteria causes redness and swelling, as it releases harmful substances that cause inflammation of the sebaceous glands, leading to acne.

Oxytetracycline can be bought online at The Independent Pharmacy and doses of 250mg come in packs of 112, 224 and 336.

Pharmacist’s tip: Squeezing your spots or trying to remove blackheads can exacerbate the acne and even lead to permanent scarring.


Oxytetracycline with other acne treatments

Oxytetracycline should not be taken with other acne treatments that contain antibiotics. These include:

National guidelines recommend that you should use a topical acne treatment alongside Oxytetracycline for better results than would be achieved with either product used individually. Topical acne treatments that work well with Oxytetracycline include:


Taking Oxytetracycline when pregnant

While exposure to Oxytetracycline in early pregnancy is not directly associated with any specific birth defects, its use in the second or third trimester can cause problems. We do not recommend taking Oxytetracycline if you are (or may be) pregnant.


Oxytetracycline 250mg Tablets Patient Information Leaflet: https://www.medicines.org.uk/emc/product/4175/pil

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

How to use Oxytetracycline

  • You should take two Oxytetracycline tablets twice daily, preferably in the morning and evening.
  • Oxytetracycline tablets should always be taken with a full glass of water.
  • Oxytetracycline should be taken on an empty stomach, this is usually one hour before food or two hours after food.
  • Oxytetracycline should not be taken at the same time as indigestion remedies. A gap of 2 -3 hours should be left between taking each treatment.
  • For treating acne, you will normally need to take Oxytetracycline for at least 8 weeks. Treatment should be assessed after 3 months to determine whether it has been effective. If your treatment has been effective, you can continue to take Oxytetracycline for another 3 months where you should see more improvement. If there has been no improvement in your acne, you should stop taking Oxytetracycline and consider a different acne treatment. The use of topical treatments may be suggested to treat particularly severe or persistent acne, alongside this medication.

Side effects of Oxytetracycline

Like all medicines, Oxytetracycline 250mg tablets can cause side effects. Not all people who take this medicine will experience side effects although if you do they may include:

  • Nausea or abdominal pain
  • Diarrhoea
  • Headache
  • Sensitivity of the skin to sunlight
  • Overgrowth of the yeast Candida, which can cause infections such as thrush
  • Inflammation of the bowel (colitis)
  • Inflammation of the pancreas (pancreatitis)
  • Raised pressure in the skull, leading to persistent headaches or blurred vision (seek medical advice if this happens)
  • Liver disorders such as jaundice (seek medical advice urgently if this happens)
  • Blood disorders (symptoms including bruising, sore throat or infections)

Occasionally Oxytetracycline can cause allergic reactions in a small minority of patients. It should not be taken if you know you are allergic to it or tetracycline antibiotics. If you experience a skin rash or swelling of the lips, face or tongue, you should see your doctor immediately. 

If you’re interested in finding out more, take a look at our ‘Oxytetracycline side effects' page.

Oxytetracycline ingredients

The active ingredient in Oxytetracycline 250mg tablets is oxytetracycline.

It also contains: maize starch, pregelatinated maize starch, povidone, sodium starch glycollate, sodium lauryl sulphate, magnesium stearate, titanium dioxide (E171), quinoline yellow (E104), hydroxypropyl cellulose (E463), sunset yellow (E110), hypromellose, ethylcellulose and dibutyl phthalate. 

You should not take Oxytetracycline tablets if you:

  • Are allergic or sensitive to or have had a bad reaction to tetracyclines or other medicines similar to Oxytetracycline dihydrate in the past. 
  • Are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine.
  • Are pregnant or breast-feeding.
  • Are elderly.
  • Have diabetes.
  • Have had a hypersensitivity or photosensitivity reaction.
  • Have kidney problems.
  • Have liver problems.
  • Have lupus or a lupus-like problem.
  • Have myasthenia gravis.

If you are unsure about the effects or interactions of your current medication with this drug, please get in contact with us.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Acne?

Visit our advice area or contact our support team

Oxytetracycline 250mg Tablets Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What is Oxytetracycline?

    Classed as a tetracycline antibiotic, Oxytetracycline is not related to penicillin. Tetracycline, doxycycline and minocycline are also popular antibiotics from this family of drugs, which are used to treat infections.

    Doctors prescribe 250mg tablets or capsules to treat acne, rosacea, as well as several other types of infection. Alternative antibiotics include doxycycline, erythromycin and clindamycin. Tetralysal 300 (lymecycline) is another widely used acne medication that works similarly to this drug.


  • How do you take Oxytetracycline?

    Abide by the instructions given by your doctor and take each tablet with water. It is important that you do not take Oxytetracycline immediately before lying down or retiring for the night, as this will increase the chances of stomach-related side-effects. Acne treatment supplied by the The Independent Pharmacy Online Doctor usually consists of a three month course, with the advice that four tablets (amounting to 1000mg) should be taken per day. This is achieved by taking two 250mg Oxytetracycline tablets both morning and evening.

    If you forget to take one of your daily doses, do not double up but simply continue with the next dose due. Bacteria lead to spots and lesions and Oxytetracycline works at reducing the inflammation.

  • How do I know that Oxytetracycline is the right medication for me?

    If you have any concerns about taking this medication, speak with your doctor, who will be able to provide you with the answers you need.

  • Does acne return after the Oxytetracycline treatment has finished?

    Always complete the course of Oxytetracycline provided by your doctor, as not finishing the course could mean that the bacteria may not have been fully eliminated and could return more fiercely. Once acne has been cleared, there is still a chance that not having Oxyteracycline in your system may give way to bacteria once again appearing on the skin.

  • When do I stop taking Oxytetracycline?

    Only stop the treatment on your doctor’s advice, as stopping before your skin has truly repaired could cause the return of a much more severe infection. Even if your skin looks clear, it is important that all antibiotic treatments are taken up to the end of their prescribed course.

  • How long can this medication take to treat acne?

    The usual recommended duration of treatment is 8-12 weeks. This time is required to ensure that you have given it a chance to fight the infection.

    If your acne persists after your course of antibiotics, you can have another consultation with our Online Doctor to see if another medicine would work better for you.

  • Should I use topical treatments on top of this medication to treat my acne?

    For effective treatment, it may be advised that you use topical treatments alongside this antibiotic to cure your cystic acne. Skinoren or Benzoyl Peroxide-based treatments may also be an effective addition.

    These topical treatments are not available over the counter. The best way to get them delivered straight to your door in the UK is to buy direct from the Independent Pharmacy online.

  • What is Oxytetracycline used to treat?

    Oxytetracycline is an oral medication which treats several bacterial infections, one of which is acne, a common skin condition which most people experience at some stage or other. This condition presents itself on the face, chest and back and appears as:
    blackheads -a plug of sebum in a hair follicle, which becomes darkened by oxidation
    whiteheads - a pale or white-topped pustule
    pustules - a small blister or pimple which contains pus
    papules - a small pimple or swelling which often forms part of a rash
    nodules – a small swelling
    cysts - a sac or cavity which contains fluid.

    These form when bacteria grows in a blocked hair follicle which already contains trapped sebum (oil) and can be caused by hormones, a vitamin deficiency or a bad diet, stress and genetics.
    Oxytetracycline is formulated to prevent the growth of bacteria, thus alleviating and removing the condition.

    This medicine is also widely used in the treatment of other conditions such as chlamydia, rosacea and urinary tract infections (UTIs). If you need it for another medical compliant, then we recommend you see your doctor for a check-up.

  • How and why can Oxytetracycline cause photosensitivity?

    Some drugs in the tetracycline family, including Oxytetracycline, reportedly cause photosensitivity. Sun exposure can cause redness, swelling and rashes when on this medication, though only in very rare cases. This can be avoided by using a high factor sun block when exposed to strong UV light. 

  • Is wearing makeup advisable when using Oxytetracycline?

    There is no problem in wearing makeup, but choose products that are not greasy or oil-based, as being so would worsen the acne. This is because acne is fundamentally caused by blocked pores, and oil-based makeup is widely recognised as being comedogenic – in other words, it can block pores.

    You can prevent your makeup-related acne flare ups by ensuring that you remove your products thoroughly from your skin with an alcohol-free makeup remover. Alcohol-based makeup removers are an irritant and can aggravate your skin further.

  • Can I help clear my acne in other ways?

    Myths abound as to the cause of acne and include an unbalanced diet, though no clinical studies have shown a link. Stress has also been attributed to acne but, while it will not cause it, it could exacerbate the condition. The best thing to do is to follow the instructions given to you by your doctor.

  • Is wearing make-up prohibited?

    There is no problem in wearing make-up but choose products which are not greasy, as being so would worsen the acne.

  • Is a prescription needed?

    Yes. This can be obtained from your doctor, or by ordering online from The Independent Pharmacy.

  • What do the tablets look like?

    The tablets are circular and biconvex (curved like a ball on both sides) and yellow in colour.

  • Can Oxytetraycline and the contraceptive pill be taken at the same time?

    Oxytetracycline can lessen the effect of oral contraceptives and so, in these circumstances, you should take extra precautions during the treatment and for at least 7 days after the course of Oxytetracycline has finished. A condom and extra spermicide could be considered.

  • Does Oxytetracycline work quickly?

    It takes up to six months to clear acne but severe cases could take up to two years. If you do not notice an improvement within the first three months, speak with your doctor, as an alternative medication may prove more suitable to your needs.

  • Is drinking alcohol prohibited?

    Alcohol is permitted, as it doesn’t interfere with the effectiveness of this medication.

  • Will Oxytetracycline affect my capacity to drive?

    You should still have the same capacity to drive, though if you experience any side-effects which make you feel unable to drive, avoid this responsibility until you have spoken with your doctor.

  • How do I store it?

    Keep it at a temperature below 25°C and safe from children.

  • Can Oxytetracycline be bought over the counter?

    In the UK, Oxytetracycline can only be purchased by prescription. The Independent Pharmacy can provide Oxytetracycline online for people with acne using our Online Doctor service.

  • Can I take Oxytetracycline when I have just consumed milk?

    It is advisable that you avoid taking this medication when you have recently consumed dairy products, including milk. This medicine should ideally be taken on an empty stomach. Taking Oxytetracycline in combination with dairy products may result in it being absorbed into your system less effectively and it could therefore treat your infection less effectively.

  • Why do I need to take Oxytetracycline on an empty stomach?

    Some medicines, particularly antibiotics, must be taken before food or on an empty stomach. This is because some food and drink can interact in negative ways with the medication, which would make it work less effectively to treat your infection. Though not all food or drink will do this, it is best to avoid eating to be on the safe side. Food and drink can also prevent your stomach from absorbing the medication entirely, so to make sure that you get the correct dose, an empty stomach is advisable.

  • What other forms is this medicine available in?

    Oxytetracycline is available in a great number of forms, making it a very useful treatment for most walks of life. This medicine is available as a:

    • Topical gel or cream
    • Powder
    • Ointment
    • Spray
    • Injection

    Currently, we only supply the tablets for acne, but should you require a different form via NHS or private prescription, we would be happy to dispense this for you.

  • Does Oxytetracycline have penicillin in it?

    No, Oxytetracycline does not have penicillin in it and it is not related to penicillin. Oxytetracycline is safe for people with an allergy to penicillin and is sometimes prescribed for infections in those who are sensitive to penicillin.

  • Is Oxytetracycline better than Lymecycline?

    Both treatments are prescribed for patients suffering from acne, rosacea, or cystic acne. Both are tetracycline antibiotics and are very similar in price. They are both considered first-line treatments for acne by national guidelines and have very similar effects.

    Oxytetracycline may be inconvenient for some people as it needs to be taken twice daily and should not be taken with food. Lymecycline only needs to be taken once a day so may be more convenient for some people.

  • Is Oxytetracycline the same as Doxycycline?

    Oxytetracycline and Doxycycline are both part of a family of medication called ‘tetracyclines’ but they are not exactly the same thing. Doxycycline is more fat soluble than Oxytetracycline, and is often prescribed for malaria prevention, as well as for acne.

Authored By:

A photo of  Leanne Sinclair

Leanne Sinclair


Published on: 02-02-2017

Last modified on: 02-09-2020

Leanne is a clinical pharmacist with years of experience working in pharmacy.

Reviewed By:

A photo of Dr Donald Grant

Dr Donald Grant

MB ChB DRCOG MRCGP Dip.orth.med

Reviewed on: 02-09-2020

Next review date: 02-09-2022

Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy

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