Differin 0.1% Cream

Differin 0.1% Cream/Gel

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Order before 4pm for delivery from Fri. 24 Mar.

Description for Differin 0.1% Cream/Gel

Differin 0.1% Cream & Gel is available to order online from The Independent Pharmacy. Differin cream and gel contains the active ingredient adapalene. Adapalene is a form of vitamin A, which reduces the growth of keratin skin cells that would normally act to block pores in acne. Additionally adapalene increases the turnover of surface skin cells, aiding the natural exfoliation of the skin. These dual actions help to clear acne and leave skin looking clear and oil-free.

Product Information

  • Age: 18 Years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Differin 0.1% cream & gel are available to buy from The Independent Pharmacy, following a free consultation, to help to treat acne.

Differin cream & gel contains the active ingredient adapalene and is used in the treatment of acne. Differin is a retinoid-like compound that is manufactured by Galderma UK Limited. The active ingredient in Differin, Adapalene, is a form of vitamin A. It works to reduce the growth of keratin surface skin cells that can block pores.
Sebum is produced by glands just under the surface of the skin called sebaceous glands. Sebum is a natural, oily substance needed to keep the skin smooth and supple. However, sufferers of acne often produce too much sebum, which can mix with the dead keratin skin cells and cause the pores to become blocked. Blocked pores can then lead to the formation of spots, blackheads (comedones) and whiteheads. Applying Differin 0.1% Cream to the affected areas will help reduce the amount of keratin skin cells and unblock the pores and sebaceous glands, allowing the sebum to escape. This will result in a reduction of inflammation, whiteheads, comedones and spots.
Differin 0.1% cream/gel is also beneficial as it increases the natural turnover of the skin cells. This aids the natural exfoliation of the skin’s outer layers. This action will help keep pores unblocked, thus reducing the formation of spots and blackheads.
Differin 0.1% cream/gel is for external use only and is designed to treat mild to moderate acne symptoms. Currently, Differin is the only licensed medicine in the UK to contain the active ingredient Adapalene.
Pharmacist tip: Differin cream/gel should be applied once daily, in the evening. It should be applied to the affected areas after they have been washed and patted dry. You can use cosmetics and moisturisers whilst using Differin, however you should let it absorb into your skin fully before applying them.

  • Differin cream/gel should be applied to the affected areas once daily in the evening, after washing with a mild cleanser.
  • Apply a small amount to cover the affected areas using clean fingertips and rub in lightly.
  • At the start of treatment with Differin, if it is used correctly it will produce effects similar to that of mild sunburn including mild itching, redness and warmth. This is normal and should subside.

To get the best effects from Differin cream/gel it is important that it is for up to THREE months continuously depending on response. Improvement should be seen after a few weeks.

You may use cosmetics and moisturisers whilst you are using Differin cream however you should wait for it to be fully absorbed into the skin before applying anything else.

Differin has drying effect on the skin so it is important to try to ensure that any toiletries containing alcohol or other skin-drying ingredients are not used.

Like all topical applications there is the potential that you may be allergic to Differin. We recommend you do a spot test before commencing treatment.

If you do experience side effects from Differin cream/gel, they can include a burning, stinging or tingling feeling, dry skin, itching, redness, or a rash. Differin can also cause your skin to be more sensitive to sunlight meaning you may burn in the sun more easily than normal. You should take action to reduce this risk such as wearing protective clothing or using sunscreen. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects. 

If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 0333 2200519. In a medical emergency you should contact the emergency services or go straight to your local Accident & Emergency.

  • Do not use this medicine on areas where you have cuts or scrapes or if you have a skin condition called eczema.

  • Avoid contact with the eyes, mouth or nostrils, and avoid other very sensitive areas of the body. If accidental contact does occur, immediately wash with warm water.

  • Avoid exposure to strong sunlight and artifcial UV light. If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor. You may be asked to use the gel less often, or to stop using it for a short time. Talk to your doctor or pharmacist if you are not sure.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

  • Other acne products (containing benzoyl peroxide, erythromycin or clindamycin) may be used with Differin but they must be applied in the morning and Differin at night.
  • Cosmetics may be used but they must not cause blackheads or dry the skin.

Pregnancy and breast-feeding

  • Differin should not be used during pregnancy. If you fall pregnant while using Differin, the treatment must be discontinued and you should inform your doctor as soon as possible for a further follow-up.

Differin contains the active ingredient adapalene 0.1%.

Differin Cream also contains: carbomer 934P, Macrogol-20 methyl glucose sesquistearate, glycerol (E422), natural squalene, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide & purified water.
Differin Gel also contains: carbomer 940, propylene glycol (E1520), poloxamer 182, disodium edetate, methylparahydroxybenzoate (E218), phenoxyethanol, sodium hydroxide and puri ed water.

Need to know more about Acne?

Visit our advice area or chat online to our support team

Frequently Asked Questions

  • What does Differin cream contain?

    Differin Cream is an acne treatment that contains Adapalene 0.1%, which helps to reduce the growth and increase the turnover of keratin skin cells that can build up and block pores causing acne.

  • How do I use Differin cream?

    In adults and children 180 years and over, Differin is applied once daily, usually in the evening. You should not apply Differin more than once in a 24-hour period. For best effects, Differin should be applied after washing your face with warm water and a mild cleanser to clear away any excess oil, skin cells and bacteria.

  • Can I use other Acne treatments with Differin cream?

    You can combine Differin with antibiotic acne treatments such as Tetralysal (Lymecycline), Minocin (Minocycline) or Erythromycin tablets. Differin should not be used with any other acne creams as it may cause excess drying or irritation to your skin.

  • I have started using Differin cream and the treated area is red and irritated, is this normal?

    Redness and irritation of the treated area, almost like sunburn, can commonly occur when you use Differin for the first time. This is not usually serious and is a sign that it is working. These effects normally subside within a week. During this time you can reduce the frequency of Differin application to once every other day to allow your skin to recover and then slowly build up to applying it daily.

  • Why can I only buy three packs of Differin Cream online at one time?

    Differin cream is a prescription-only acne treatment. For that reason, to ensure the safety of our patients and the legal & ethical operating of our pharmacy, we only supply a maximum of 3 months treatment at one time. Differin treatment is normally judged for effectiveness after 2-3 months. This means that if you do not find Differin as effective as you would like after this time, you are not stuck with an excess of medication. If you are happy with the results you can easily log in and re-order another supply.

  • Is Differin available for next day delivery?

    Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 4pm Monday to Friday, Differin cream is available for next day delivery.

  • Is it safe to buy Differin cream online?

    Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Differin online. The Independent Pharmacy is an NHS Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.

  • How do I buy Differin online?

    It's simple!

    Just select 'Start Consultation' above, you will need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Differin to you. It all takes around 3 minutes and your treatment can be delivered to your door.

  • What are the advantages of buying Differin Cream online?

    There are many advantages to buying Differin online, some include:

    • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
    • Fast delivery - We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
    • Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
    • Tons of information - we provide all the information you could need on Epiduo (adapalene/benzoyl peroxide) and other acne treatments, in easy to digest formats, at a time to suit you.
  • How does Differin Gel work?

    Differin Cream and Gel both contain the active ingredient adapalene, a form of vitamin A that treats acne.

    Acne occurs when the skin’s sebaceous glands become blocked and natural oils, or sebum, accumulate. The blocked sebum provides nutrients for acne-causing bacteria which can grow and cause inflammation in the skin. Adapalene reduces the growth of the keratin skin cells that block pores and allows the sebum to escape. This decreases the occurrence of blackheads and spots.

    In addition, adapalene increases the skin’s ability to exfoliate naturally. This also helps to unblock pores, and decrease blackheads and breakouts.

    Differin Cream or Gel should be applied once a day, before bed.

  • Does Differin cause any skin reactions?

    When you first start using Differin you may feel a temporary stinging or warm sensation on your skin. The skin may redden slightly, like a mild sunburn. Differin may also cause your skin to peel or become very red and irritated.

    If you notice severe redness, swelling, itching, burning sensations, blistering, crusting or peeling of your skin after using Differin, apply the medication less often or stop using it temporarily. If the irritation persists, stop using the medication completely and consult your doctor.

  • Can I wear make-up with Differin?

    You can wear cosmetics or moisturisers while using this medication, but you should not  apply them at the same time. Wash your skin thoroughly before applying Differin, wait for it to be absorbed into your skin, then use any cosmetics and moisturisers.

  • How is Differin affected by the Sun?

    Avoid exposure to sunlight, sunlamps or sunbeds while using this medication, as it increases your skin’s sensitivity to UV light. If exposure to sunlight cannot be avoided, use sunscreens or protective clothing over treated skin.

    If your skin is sunburnt, you should not use this medication until your skin has fully recovered. Severe irritation may result.

  • What is a good treatment plan?

    You should continue treatment with Differin for at least 8 weeks. If, after that time, there is no improvement, treatment should be stopped or new medication should be added.

    Your treatment plan should be reviewed after 3 months and, if acne has cleared, Differin can be stopped. Acne may not return, but if it does treatment can be resumed.

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