The Independent Pharmacy

Differin Purge: How Long Does It Last and How to Cope With It

Donald Grant
Dr Donald Grant
MB ChB DRCOG MRCGP Dip.orth.med GMC 3058367
GP & Clinical Advisor

Differin is one of the most effective and widely-used acne treatments on the market, but it can require an eight week ‘purge period' and cause other side effects.

You need to consider a lot before purchasing, so it's a good idea to do your research before spending your money.

Below we discuss the Differin purge, how to cope with it and the difference between Differin purge and suffering from a reaction.

Key Takeaway 1

The Differin purge typically occurs during the first few weeks of treatment as deeper skin blockages surface, before improvement begins.

Key Takeaway 2

True adverse reactions differ from normal purging if acne appears in new areas or is significantly worse than before treatment.

Key Takeaway 3

Most users see initial results within 1-3 weeks, but full benefits require consistent use for 8-12 weeks.

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The purge period – How long does Differin take to work?

Differin results timeline (this is an approximate timeline, results will vary from user to user):

We mentioned that Differin can give rise to the ‘Differin purge’, and even though it isn't a sign that the skin is actually getting worse, it's still very unpleasant for the acne sufferer - so how long does it take to push through the purge and see positive results?

Well, when you first start applying Differin daily, there's an excellent chance that you'll see some results within a week, and possibly even a significant reduction. This is a great thing, but it's also false dawn of sorts because of what follows, and it's important not to get too excited at this stage.

This is because the second week is likely to see the acne return, either slightly or in full force (it will depend on the severity of your case): with the blockage removed and the top layers of skin cleared, the clogged pores in lower layers will quickly reach the surface and leave the skin vulnerable once again.

How to cope with the Differin purge

This purging phase is threatening because it can lead acne sufferers to think that the Differin isn't actually going to work, causing them to stop applying it and seek alternative treatment. While Differin isn't right for everyone, you should have your symptoms inspected before you even think about discontinuing treatment.

In most cases, all that must be done to escape the purge is to endure it for a week or so. Once all the blockages lurking beneath the surface have been cleared, the skin can begin to truly get better, and Differin shines in this regard - users often continue to see improvement for many months after beginning treatment.

How to tell if you're suffering a reaction

Because of the Differin purge causing the acne to (seemingly) return, it can be difficult for a Differin user to tell when they're suffering an actual reaction to the treatment. There are four situations in which you should have your symptoms inspected by a medical professional:

If we've prescribed you Differin and you've found yourself in such a situation, let us know. We'll take a close look at your symptoms and find a better alternative.

How does Differin work?

Differin is an acne medication containing the active ingredient of adapalene, which is a form of vitamin A (check out our product page to view the full range of Differin ingredients). Applied to the area affected by acne, it works to help your skin heal by unblocking your pores (allowing natural oils to escape) and boosting the exfoliation process.

Proving effective in mild to moderate cases, Differin has great reviews and is a great choice for many acne sufferers because it provides enough potency to make a difference without being strong enough to cause major harm. That said, it does have one notable issue known as the Differin purge - an initial period during which your skin seems to get worse, not better.

However, that may not be the truth of the matter. It's believed that this purging period actually results from existing clogged pores coming to the surface, giving the inaccurate impression that things have got worse. If you keep applying Differin as recommended, you should see improvement once the purging period has concluded (usually after 6-8 weeks at the latest).

Differin 0.1% Cream/Gel

Differin 0.1% Cream/Gel

Differin reduces the growth of keratin skin cells that would normally act to block pores in acne vulgaris. Start a free consultation and have it delivered as soon as the next working day.

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What is Differin gel? How does it compare to Differin cream?

Differin is produced in two formulations: a gel, and a cream. Differin gel is transparent and quite dense - when applied, it will be absorbed relatively quickly. Differin cream, though, is white and much oilier - it will take longer to be absorbed, but it also has moisturizing properties that will help if the affected area is uncomfortably dry.

In most cases, the gel formulation of Differin is easier to use because it applies clear and soaks into the skin rapidly, but it will depend on your particular case. If you're not sure, you may want to try each form to see which you prefer.

How does Differin differ from other acne treatments?

As a mid-range treatment, Differin is an excellent first option for acne sufferers - other available treatments can be weaker (for very mild cases), stronger (for particularly severe acne), or designed with broader actions (often containing antibiotics).

For a more detailed explanation of how Differin (and its active ingredient adapalene) compares to other treatments, you can view our acne treatment comparison page.

How to use Differin

Whether you get Differin as a gel or a cream, it should be applied to the affected area daily as long as you continue to suffer from acne. If your acne completely clears up, you can stop the treatment, but be aware that your acne may return at some point.

To apply Differin, take a pea-sized amount and spread it thinly across the affected area until it has been fully absorbed - if you don't notice a difference a week or so, try applying a little more, but be careful. To avoid disrupting the effect, you should apply it in the evening before sleeping, and ideally after showering (or bathing) to clear your skin.

If you experience significant discomfort trying to spread the gel across the affected area, consider using the cream instead. Alternatively, apply a small amount of moisturiser to the area before applying a slightly larger amount of the gel. Make sure, however, the moisturiser you use is non-comedogenic, so it doesn't make your acne worse and make sure it is fully absorbed into your skin before you apply the Differin gel.

Note that applying Differin will raise the affected skin's sensitivity to UV light, so take steps to avoid exposure to direct sunlight or you'll risk further skin damage. Keep the skin covered during the day (though allow it to breathe) or when around strong artificial UV light sources.

See our product page to find out how to buy Differin.

Off-label applications: other uses for Differin

Vitamin A (a form of which constitutes Differin's active ingredient) confers various benefits to the skin, so Differin - on the advice of a dermatologist - can be used for off-label purposes:

Be mindful not to do anything unusual or extreme without the advice of an expert, because things can go easily go wrong.

For instance, if you use it to reduce the appearance of wrinkles but fail to keep the skin suitably moisturized, the wrinkles will likely end up looking worse. In general, we strongly recommend that you don't deviate from the recommended practices without the advice of a dermatologist.

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Donald Grant

Authored by

Dr Donald Grant
Donald Grant
MB ChB DRCOG MRCGP Dip.orth.med
3058367
GP & Clinical Advisor

Dr Don Grant is The Independent Pharmacy's original online prescriber and has advanced in his role to become the Clinical Advisor, using his wealth of experience to advise on our clinical polices and prescribing guidelines.

Daniel Hurley

Reviewed by

Daniel Hurley
Daniel Hurley
MPharm IP
2078790
Pharmacist Independent Prescriber

Dan is an experienced pharmacist having spent time working in both primary and secondary care. He currently supports our clinical team by providing robust clinical governance review of our internal processes and information.