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E45 Itch Relief Cream

E45 Itch Relief Cream (100g)


Order before 3pm for delivery from Tue. 22 Sep and Thu. 24 Sep.

Description for E45 Itch Relief Cream

For targeted relief from itchy, irritated or inflamed skin, E45 Itch Relief works fast using the active ingredients lauromacrogols and urea to soothe and protect while naturally moisturising the affected areas. Dermatologically tested and fragrance free, this anti-itch cream provides fast and effective relief from conditions such as eczema and dermatitis.

Product Information

  • Age: From Birth

    Maximum per order: N/A

  • Pregnancy: Suitable

    Breastfeeding: Suitable

E45 Itch Relief Cream targets and treats itchy, irritated and inflamed skin caused by skin conditions such as eczema and dermatitis. Its unique formula combines lauromacrogols, an anti-itch ingredient, and urea, one of the skin’s natural moisturisers, to moisturise targeted areas for instant relief.

  • Provides quick relief for itchy, irritated and inflamed skin
  • Contains the anti-itch ingredient, lauromacrogols
  • Includes urea for intense moisture

You should try to avoid scratching itchy skin where possible. It can damage the skin and possibly lead to infection, both of which will prolong healing time.

The dry, scaly rash that accompanies eczema frequently causes severe itching, particularly at night. Sufferers - especially young children - tend to scratch inflamed skin which may lead to infection. Repeated scratching can cause permanent thickening of the skin.

It is therefore important that a programme of eczema treatment includes itch relief to manage symptoms.

E45 Itch Relief Cream treats and soothes itchy, irritated dry skin caused by eczema, dermatitis, pruritus and other dry skin conditions.

Formulated with lauromacrogols and urea, this itch relief remedy moisturises affected areas to bring relief.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Adults, elderly and children: apply to affected areas twice a day.

Side effects of E45 Itch relief cream can include:

Burning, itching, redness or pus. May irritate broken or inflamed skin.

If you are concerned about these effects, or if the product affects you in a different way, stop using it and talk to your doctor or pharmacist.

Active ingredients:

Lauromacrogols 3.0% w/w and urea 5.0% w/w

Inactive ingredients:

Dimeticone, phenyl dimeticone, cetyl palmitate, liquid paraffin, glycerol, octyldodecanol, polysorbate, stearic palmitic acid, carbomer trometamol, benzyl alcohol and purified water.

Read the following warnings carefully to ensure you are selecting an appropriate product.

Use this medicine only on your skin. Formulated for adults, the elderly, children and infants over 1 month of age. Do not use if you are allergic to any active or inactive ingredient.

Do not use on reddened or inflamed skin. Do not use on the breasts immediately prior to breast feeding.

Please read all packaging and the Product Information Leaflet before taking any new medication and inform your doctor of medications you are taking or intend to take.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 3 - 5 day delivery - £2.95
  • Express Tracked Delivery - 1 - 3 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Eczema & Dermatitis?

Visit our advice area or contact our support team

E45 Itch Relief Cream Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What is E45 Itch Relief Cream used for?

    Relief of dry, scaly and itchy skin conditions such as eczema and dermatitis. Moisturisers improve dry skin conditions, particularly eczema, which tend to worsen if the skin becomes too dry. With regular use, they restore the skin's smoothness, softness and flexibility.

  • How does E45 itch relief cream work?

    Dry skin results when the stratum corneum (the outer layer of skin cells) becomes dehydrated. Washing can worsen the condition as hot water removes the skin’s natural oils.   

    The urea in E45 itch relief cream penetrates the stratum corneum, where it readily absorbs and retains water. This improves the skin’s capacity to hold moisture and rehydrates the skin. The moisturising base of the cream also provides a layer of oil, which helps prevent water from evaporating. Both actions soothe and soften the skin, and reduce the scaling and itching of dry skin conditions. E45 Itch Relief’s lauromacrogols share properties with local anaesthetics and help soothe and relieve itchy skin.

  • How do I use E45 itch relief cream?

    Apply the cream to the affected skin twice a day.

    Avoid applying the cream to weeping, oozing, broken or inflamed skin because this can cause irritation.

    If symptoms continue, consult your doctor or pharmacist.

  • Who shouldn't use E45 Itch Relief Cream?

    • People allergic to any of the cream’s ingredients. If you believe you have experienced an allergic reaction, stop using E45 Itch Relief Cream and inform your doctor or pharmacist.
    • Babies under one month of age.
    • People with infected, oozing or very inflamed skin.
    • People with severe reddening of the skin (erythroderma).
  • Can I use E45 itch relief cream if I am pregnant or breastfeeding?

    This cream may be used during pregnancy and breastfeeding. However don't apply it to the breasts just before feeding.

Authored By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Published on: 20-09-2016

Last modified on: 20-09-2018

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

Reviewed By:

A photo of  Leanne Sinclair

Leanne Sinclair


Reviewed on: 20-09-2018

Next review date: 20-09-2020

Leanne is a clinical pharmacist with years of experience working in pharmacy.

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