The Independent Pharmacy
Estradot Patches (25, 50, 75 & 100)

Estradot Patches (25, 50, 75 & 100)

from £24.99
  • Free standard delivery on orders over £40
    Spend £40.00 more for free delivery
  • Fast, discreet delivery

    Delivered in secure, plain packaging on fully tracked delivery from just £2.95

  • 100% UK-based pharmacy

    Our team of doctors and pharmacists, and our support staff, are all UK-based.

  • Free advice and support

    Have a question? Telephone support is always free; Monday - Friday, 9am - 5pm.

  • We're rated 4.9 out of 5

    Based on over 24,000 reviews collected on Google and

About Estradot Patches (25, 50, 75 & 100)

Estradot patches are a form of hormone replacement therapy (HRT) for postmenopausal women. They contain the active ingredient estradiol, a naturally occuring form of oestrogen – the main female sex hormone. Estradot can be used to provide relief from menopausal symptoms like hot flushes, as well as for preventing osteoporosis. Buy Estradot HRT patches today from The Independent Pharmacy and receive same day dispatch before 4pm on all UK orders.

  • Suitable for age:18 Years +
  • Maximums per order:
    Estradot 25 Patches3
    Estradot 50 Patches12
    Estradot 100 Patches3
    Estradot 75 Patches3
  • Consultation required?Yes
    This treatment requires an online consultation for review by our medical team. The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective.
Type of medicineOestrgoen steroid hormone
Works byReplacing the missing hormone
Active ingredientEstradiol
Effective within3 months
Pack size8 patches
Strength25, 50, 75 and 100 micrograms/24 hours
Common side effectsHeadache, Breast Pain, Skin Irritation, Menstrual Pain, Menstrual Disorders
ManufacturerNovartis Pharmaceuticals
Use with alcoholNo known issues

We stock 4 different variants of Estradot Patches (25, 50, 75 & 100)

Estradot Patches (25, 50, 75 & 100) information

  • What is Estradot?

    Estradot provides hormone replacement therapy (HRT) in the form of an oestrogen patch applied to the skin, and is used by postmenopausal women with at least 12 months since their last natural period. Throughout the menopause, women start to produce less oestrogen, which can lead to symptoms such as hot flushes, mood swings, and insomnia. Estradot patches help to relieve these symptoms.

    Estradot is an oestrogen-only HRT that should only be used by women who have had a hysterectomy or are taking a separate progesterone (or have a Mirena coil fitted).

    After the menopause, women also become more likely to develop osteoporosis – fragile bones. If your doctor believes you’re at an increased risk of fractures, you may be prescribed Estradot patches to help prevent osteoporosis from developing.

    Estradot patches can only be provided online to women who have had them initiated by their doctor, have had a recent review, and are up to date with their required screening.

    Menopause symptoms

    As women age, their ovaries gradually produce less oestrogen. This hormonal imbalance can lead to some uncomfortable physical and psychological symptoms, including:

    • Insomnia
    • Hot flushes
    • Mood swings
    • Osteoporosis
    • Excessive sweating
    • Dry vagina, mouth or eyes

    Estradot medication works by restoring the hormonal balance in the body, reducing or preventing menopausal symptoms from occurring. The patches are oestrogen-only (not combined with progestogen), which makes them more suitable for women who have had a hysterectomy.

    Recommended dosage

    Estradot patches come in various strengths: 25, 50, 75 and 100 micrograms. The strength you should use will be determined by your GP or consultant when they are first prescribed to you. Unless advised otherwise, the standard dose is to apply one fresh patch twice a week. Never use more or less than your doctor recommends.

    The pros and cons of HRT

    As with many forms of medication, there are pros and cons surrounding the use of HRT. If in doubt, discuss your circumstances with your doctor or pharmacist.


    • Relieves symptoms of the menopause
    • No significant impact on general health or quality of life
    • Can be used to prevent osteoporosis


    • Not suitable if you’ve had blood clots, heart disease, stroke or breast cancer
    • May make existing heart conditions worse
    • May induce side effects such as headaches, nausea and breast tenderness

    Benefits of HRT patches

    What makes HRT patches different to tablets and gels? The benefits of using the patch are not vastly different to taking HRT in tablet form, so to some extent, it depends on your preference. The patch contains hormones that are absorbed through the skin, allowing you to receive hormone replacement without taking tablets by mouth – and likewise for the gel. Some doctors believe it’s preferable for hormones to absorbed through the skin, thereby avoiding the liver.

    Estradot patches contain only oestrogen, rather than a combination of oestrogen and progesterone, and so are only recommended if taken in tandem with progesterone, or for women who’ve had a hysterectomy. This is because oestrogen-only HRT is linked to an increased risk of endometrial cancer.

    HRT patch reviews claim that Estradot patches are “very strong and stick well”, as well as being smaller than most other HRT patches.

    HRT patches and weight gain

    While some say that HRT is a cause of weight gain in women, research suggests that this is not the case. After menopause, women are likely to gain more weight on their belly than on their hips and thighs – HRT can potentially help women to lose this unwanted fat.

  • How to use Estradot patches

    Estradot patches should be used as directed by your doctor or pharmacist – check if you’re not sure. You will be prescribed the lowest possible effective dose to treat your symptoms, for the minimum amount of time required.

    If you’ve never used oestrogen patches or tablets before, you can start using the patches right away. If you’re changing over from a combined HRT treatment, you should start wearing the patches the day after you finish your previous cycle.

    Your Estradot patch should be replaced twice weekly. On the back, you’ll find calendar checklist to help you stay on schedule. Each patch should be worn continuously until it is replaced. Bathing, swimming, showering or exercising should not affect the patch if it has been correctly applied.

    Apply the patch to the lower abdomen, just below the waistline. They should never be applied to, or near, the breasts. Each time you change your patch, apply it to a new area. Before application, ensure that your skin is clean, unbroken, and free of powders, oils and moisturisers.

  • Estradot ingredients

    Depending on what strength you’re prescribed, Estradot patches contain varying levels of estradiol (hemihydrate). Additional ingredients include:

    • Acrylic adhesive
    • Silicone adhesive
    • Oleyl alcohol
    • Dipropylene glycol
    • Povidone (E1201)

    Allergen information: The manufacturer advises that Estradot may contain soy protein.

  • Estradot side effects

    Not everybody will experience side effects while using Estradot patches. Those who do, around 1 in 10, will most likely encounter one of the following:

    • Headache
    • Breast pain
    • Skin irritation
    • Menstrual pain
    • Menstrual disorders

    Note that the following diseases are reported more often in women using HRT:

    • Stroke
    • Breast cancer
    • Heart disease
    • Ovarian cancer
    • Endometrial hyperplasia or cancer
    • Memory loss (if over the age of 65)

    If you experience any of the following symptoms while using HRT patches, stop using Estradot and seek immediate medical attention:

    • Jaundice
    • Painful periods
    • Breast changes
    • Difficulty breathing
    • Sudden chest pain
    • Migraine headaches
    • Painful swelling and redness of the legs
    • Unexpected vaginal bleeding or spotting
    • Chest pain that spreads to your arm or neck
  • Estradot warnings

    The use of HRT – whether you choose tablets or patches – carries risks that should be considered when deciding whether to start using it. In your online consultation, you will be asked about your personal and family medical history. After starting treatment, you should see your doctor for regular check-ups and breast screening.

    Do not use Estradot if you have ever had:

    • Porphyria
    • A blood clot
    • Liver disease
    • Breast cancer
    • Endometrial hyperplasia
    • Oestrogen-sensitive cancer
    • Unexplained vaginal bleeding

    Should the above conditions occur for the first time while using Estradot medication, stop using it.

    Furthermore, stop using Estradot and see a doctor immediately if you notice any of the following:

    • Jaundice
    • Migraine-like headaches
    • Increased blood pressure (symptoms include headaches, tiredness, dizziness)
    • Signs of a blood clot (painful swelling and redness of the legs, sudden chest pain, difficulty breathing)

    You should not use Estradot during pregnancy or while breastfeeding. Note that Estradot is for use in postmenopausal women only. If you do become pregnant, stop using Estradot and contact your doctor.

Estradot Patches (25, 50, 75 & 100) reviews

Estradot Patches (25, 50, 75 & 100) FAQs

  • When you start using Estradot patches, you should notice a gradual reduction in sweats as each day passes. There is no exact amount of time that it takes to work – it varies by person. For some, the changes are noticeable almost right away. If you still haven’t seen an improvement after 3-4 weeks, speak to your doctor.

  • The Vivelle-Dot is an HRT patch available in Canada. It’s very similar to Estradot, in that it’s an oestrogen-only patch. The two are, in effect, sister patches that are sold in different countries.

  • Indometacin is a prescription non-steroidal anti-inflammatory drug used to reduce fever, pain, stiffness, and swelling (see also Naproxen). There is research to suggest that the cardioprotective effect of HRT may be inhibited if women take this type of painkiller in tandem with their medication.

  • The drug Cimetidine is a histamine H2 receptor antagonist that inhibits stomach acid production, and is mainly used to treat heartburn and peptic ulcers. There is nothing to suggest that Cimetidine cannot be taken at the same time as undergoing hormone replacement therapy.

  • Evorel and Estradot are both brands of HRT patches available in the UK. Both contain estradiol, however, Evorel are larger in size. If you are sensitive to soy, you may be better off with Evorel than Estradot.

  • Your oestrogen patch should be applied to a clean, dry and hair-free area of your lower stomach or upper buttocks. When you come to change patches, apply your new patch in a different position to the last – do not put it in exactly the same place.

  • Estradot patches cannot be prescribed for gender reassignment online as it is a complicated area that requires face-to-face consultations with a specialist. You can find out more about gender reassignment here:

  • HRT can transform a woman's life who is living with severe menopause symptoms. It does, however, come with some risks that need to be weighed up in a conversation with your doctor before you start treatment. As with all things, there are ways to minimise risks and having regular check-ups will ensure that any risks from using HRT are monitored and minimised.

    You can find out about the risks associated with HRT here:

Haven’t found the right treatment for you?

No problem. Ask our medical team for free, impartial advice.

A man sat at home ordering his medication online
Related Treatments for Menopause (HRT)

We stock 27 other treatments for Menopause (HRT)

Visit our Menopause (HRT) page for treatments, advice and FAQs.

Ordering as easy as 1, 2, 3...

  • Find the ideal treatment

    We can provide over 1058 leading medicines to treat over 90 conditions.

  • Get a free consultation

    Our qualified healthcare professionals will assess your condition and needs.

  • Enjoy our speedy delivery

    And when the time comes to re-order, it'll only take a couple of clicks.

Need something else?

We stock 1058 treatments for 90 conditions

Or browse all treatments or conditions

A customer at the pharmacist looking for medication