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Estradot 50 Patches

Estradot Patches

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Sorry, this treatment is currently out of stock.

There is currently a nationwide shortage with all Estradot products due to a delay in manufacturing. 

You may want to consider Evorel patches if you need some treatment for the interim.


Sorry, this treatment is currently out of stock.

There is currently a nationwide shortage with all Estradot products due to a delay in manufacturing. 

You may want to consider Evorel  patches if you need some treatment for the interim.


View Evorel 100

Order before 3pm for delivery from Fri. 30 Jul and Mon. 02 Aug.

Description for Estradot Patches

Estradot patches are a form of hormone replacement therapy (HRT) for postmenopausal women. They contain the active ingredient estradiol, a naturally occuring form of oestrogen – the main female sex hormone. Estradot can be used to provide relief from menopausal symptoms like hot flushes, as well as for preventing osteoporosis. Buy Estradot HRT patches today from The Independent Pharmacy and receive same day dispatch before 4pm on all UK orders. 

Product Information

  • Age: 18 Years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Estradot? 

Estradot provides hormone replacement therapy (HRT) in the form of an oestrogen patch applied to the skin, and is used by postmenopausal women with at least 12 months since their last natural period. Throughout the menopause, women start to produce less oestrogen, which can lead to symptoms such as hot flushes, mood swings, and insomnia. Estradot patches help to relieve these symptoms.

Estradot is an oestrogen-only HRT that should only be used by women who have had a hysterectomy or are taking a separate progesterone (or have a Mirena coil fitted).

After the menopause, women also become more likely to develop osteoporosis – fragile bones. If your doctor believes you’re at an increased risk of fractures, you may be prescribed Estradot patches to help prevent osteoporosis from developing.

Estradot patches can only be provided online to women who have had them initiated by their doctor, have had a recent review, and are up to date with their required screening. 


Menopause symptoms 

As women age, their ovaries gradually produce less oestrogen. This hormonal imbalance can lead to some uncomfortable physical and psychological symptoms, including:

  • Insomnia
  • Hot flushes
  • Mood swings
  • Osteoporosis
  • Excessive sweating
  • Dry vagina, mouth or eyes

Estradot medication works by restoring the hormonal balance in the body, reducing or preventing menopausal symptoms from occurring. The patches are oestrogen-only (not combined with progestogen), which makes them more suitable for women who have had a hysterectomy.


Recommended dosage 

Estradot patches come in various strengths: 25, 50, 75 and 100 micrograms. The strength you should use will be determined by your GP or consultant when they are first prescribed to you. Unless advised otherwise, the standard dose is to apply one fresh patch twice a week. Never use more or less than your doctor recommends.


The pros and cons of HRT 

As with many forms of medication, there are pros and cons surrounding the use of HRT. If in doubt, discuss your circumstances with your doctor or pharmacist. 


  • Relieves symptoms of the menopause
  • No significant impact on general health or quality of life
  • Can be used to prevent osteoporosis


  • Not suitable if you’ve had blood clots, heart disease, stroke or breast cancer
  • May make existing heart conditions worse
  • May induce side effects such as headaches, nausea and breast tenderness


Benefits of HRT patches

What makes HRT patches different to tablets and gels? The benefits of using the patch are not vastly different to taking HRT in tablet form, so to some extent, it depends on your preference. The patch contains hormones that are absorbed through the skin, allowing you to receive hormone replacement without taking tablets by mouth – and likewise for the gel. Some doctors believe it’s preferable for hormones to absorbed through the skin, thereby avoiding the liver.

Estradot patches contain only oestrogen, rather than a combination of oestrogen and progesterone, and so are only recommended if taken in tandem with progesterone, or for women who’ve had a hysterectomy. This is because oestrogen-only HRT is linked to an increased risk of endometrial cancer.

HRT patch reviews claim that Estradot patches are “very strong and stick well”, as well as being smaller than most other HRT patches. 


HRT patches and weight gain 

While some say that HRT is a cause of weight gain in women, research suggests that this is not the case. After menopause, women are likely to gain more weight on their belly than on their hips and thighs – HRT can potentially help women to lose this unwanted fat.


Estradot Patient Information Leaflet: https://www.medicines.org.uk/emc/files/pil.7227.pdf

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

How to use Estradot patches 

Estradot patches should be used as directed by your doctor or pharmacist – check if you’re not sure. You will be prescribed the lowest possible effective dose to treat your symptoms, for the minimum amount of time required.

If you’ve never used oestrogen patches or tablets before, you can start using the patches right away. If you’re changing over from a combined HRT treatment, you should start wearing the patches the day after you finish your previous cycle.

Your Estradot patch should be replaced twice weekly. On the back, you’ll find calendar checklist to help you stay on schedule. Each patch should be worn continuously until it is replaced. Bathing, swimming, showering or exercising should not affect the patch if it has been correctly applied.

Apply the patch to the lower abdomen, just below the waistline. They should never be applied to, or near, the breasts. Each time you change your patch, apply it to a new area. Before application, ensure that your skin is clean, unbroken, and free of powders, oils and moisturisers.

Estradot side effects 

Not everybody will experience side effects while using Estradot patches. Those who do, around 1 in 10, will most likely encounter one of the following:

  • Headache
  • Breast pain
  • Skin irritation
  • Menstrual pain
  • Menstrual disorders

Note that the following diseases are reported more often in women using HRT:

  • Stroke
  • Blood clots
  • Breast cancer
  • Heart disease
  • Ovarian cancer
  • Endometrial hyperplasia or cancer
  • Memory loss (if over the age of 65)

If you experience any of the following symptoms while using HRT patches, stop using Estradot and seek immediate medical attention:

  • Jaundice
  • Painful periods
  • Breast changes
  • Difficulty breathing
  • Sudden chest pain
  • Migraine headaches
  • Painful swelling and redness of the legs
  • Unexpected vaginal bleeding or spotting
  • Chest pain that spreads to your arm or neck

Estradot ingredients

Depending on what strength you’re prescribed, Estradot patches contain varying levels of estradiol (hemihydrate). Additional ingredients include: 

  • Acrylic adhesive
  • Silicone adhesive
  • Oleyl alcohol
  • Dipropylene glycol
  • Povidone (E1201)

Allergen information: The manufacturer advises that Estradot may contain soy protein.

Estradot warnings

The use of HRT – whether you choose tablets or patches – carries risks that should be considered when deciding whether to start using it. In your online consultation, you will be asked about your personal and family medical history. After starting treatment, you should see your doctor for regular check-ups and breast screening.

Do not use Estradot if you have ever had:

  • Porphyria
  • A blood clot
  • Liver disease
  • Breast cancer
  • Endometrial hyperplasia
  • Oestrogen-sensitive cancer
  • Unexplained vaginal bleeding

Should the above conditions occur for the first time while using Estradot medication, stop using it.

Furthermore, stop using Estradot and see a doctor immediately if you notice any of the following:

  • Jaundice
  • Migraine-like headaches
  • Increased blood pressure (symptoms include headaches, tiredness, dizziness)
  • Signs of a blood clot (painful swelling and redness of the legs, sudden chest pain, difficulty breathing)

You should not use Estradot during pregnancy or while breastfeeding. Note that Estradot is for use in postmenopausal women only. If you do become pregnant, stop using Estradot and contact your doctor. 

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Menopause (HRT)?

Visit our advice area or contact our support team

Estradot Patches Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • How long does Estradot take to work?

    When you start using Estradot patches, you should notice a gradual reduction in sweats as each day passes. There is no exact amount of time that it takes to work – it varies by person. For some, the changes are noticeable almost right away. If you still haven’t seen an improvement after 3-4 weeks, speak to your doctor.

  • Is Estradot the same as Vivelle-Dot?

    The Vivelle-Dot is an HRT patch available in Canada. It’s very similar to Estradot, in that it’s an oestrogen-only patch. The two are, in effect, sister patches that are sold in different countries.

  • HRT and indomethacin

    Indometacin is a prescription non-steroidal anti-inflammatory drug used to reduce fever, pain, stiffness, and swelling (see also Naproxen). There is research to suggest that the cardioprotective effect of HRT may be inhibited if women take this type of painkiller in tandem with their medication.

  • Can Cimetidine be taken during HRT?

    The drug Cimetidine is a histamine H2 receptor antagonist that inhibits stomach acid production, and is mainly used to treat heartburn and peptic ulcers. There is nothing to suggest that Cimetidine cannot be taken at the same time as undergoing hormone replacement therapy.

  • What is the difference between Estradot and Evorel?

    Evorel and Estradot are both brands of HRT patches available in the UK. Both contain estradiol, however, Evorel are larger in size. If you are sensitive to soy, you may be better off with Evorel than Estradot.

  • Where do you apply an oestrogen patch?

    Your oestrogen patch should be applied to a clean, dry and hair-free area of your lower stomach or upper buttocks. When you come to change patches, apply your new patch in a different position to the last – do not put it in exactly the same place.

  • Can I use Estradot patches for gender reassignment?

    Estradot patches cannot be prescribed for gender reassignment online as it is a complicated area that requires face-to-face consultations with a specialist. You can find out more about gender reassignment here: https://www.nhs.uk/conditions/gender-dysphoria/treatment/

  • What are the risks involved in using Estradot patches?

    HRT can transform a woman's life who is living with severe menopause symptoms. It does, however, come with some risks that need to be weighed up in a conversation with your doctor before you start treatment. As with all things, there are ways to minimise risks and having regular check-ups will ensure that any risks from using HRT are monitored and minimised. 

    You can find out about the risks associated with HRT here:


Authored By:

A photo of  Leanne Sinclair

Leanne Sinclair


Published on: 20-06-2018

Last modified on: 20-06-2018

Leanne is a clinical pharmacist with years of experience working in pharmacy.

Reviewed By:

A photo of Dr Donald Grant

Dr Donald Grant

MB ChB DRCOG MRCGP Dip.orth.med

Reviewed on: 20-06-2020

Next review date: 20-06-2022

Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy

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