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Lenzetto Spray

Lenzetto Spray (56 doses)

Order before 3pm for delivery from Sat. 07 Aug.

Lenzetto Transdermal HRT Spray

Lenzetto transdermal spray is an oestrogen only hormone replacement therapy (HRT) effective at relieving unpleasant and uncomfortable symptoms of the menopause. 

Buy today from The Independent Pharmacy when you complete a free online health consultation and have a previous prescription from your GP. Your prescription will be reviewed and approved by our medical team prior to your treatment being delivered to your home.

Lenzetto Information

  • Age: 18 years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Lenzetto Spray?

Lenzetto Spray contains the active ingredient estradiol, a type of oestrogen naturally produced by the body. Lenzetto is sprayed directly onto the skin where it is absorbed into the blood to increase oestrogen levels and reduce symptoms of the menopause such as vaginal dryness and hot flashes. 

Each 6.5 ml bottle of Lenzetto spray is manufactured by Gedeon Richter and contains 56 sprays. It is suitable for use by women who had their last menstrual bleed 6 months ago, those who have undergone a hysterectomy or it can be used by women who still have an intact uterus alongside a progesterone-only form of HRT.


What is Lenzetto Spray used for?

Lenzetto Spray is a prescription HRT for women whose menopausal symptoms have a significant negative effect on their experience of daily life. 

Lenzetto Spray can help relieve:

  • Hot flushes
  • Night sweats
  • Difficulty sleeping
  • Vaginal dryness and irritation
  • Reduced sex drive
  • Headaches
  • Low mood


How does Lenzetto Spray work?

Menopause is caused by the natural drop in oestrogen levels in a woman’s blood when she ceases to produce eggs as she stops ovulating. It is this decline in oestrogen levels that produces the symptoms that are associated with menopause. 

Lenzetto Spray contains a type of oestrogen called estradiol. When Lenzetto is sprayed on to the skin the hormone is absorbed into the bloodstream where it boosts the levels of oestrogen circulating through the body and effectively reduces symptoms. 


How quickly does Lenzetto Spray work?

It is recommended that you review your dose of Lenzetto Spray every 3 - 6 months to ensure you are on the right dose to suit your needs. If you are starting Lenzetto Spray without having previously used any form of HRT it is likely that it will take around 3 months before you experience a noticeable reduction in your symptoms. 


Alternatives to Lenzetto Spray

At The Independent Pharmacy, we sell a wide range of HRT including tablets, patches, vaginal tablets, creams and gels

If you would like to discuss changing to a different form of HRT you should arrange to speak to your doctor who will be able to advise you of your options.



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Lenzetto Spray dose

  • Lenzetto Spray is only suitable for women who are experiencing menopausal symptoms and who have been prescribed it by their GP following an initial health assessment. 
  • Lenzetto Spray should not be applied to the breasts and face or any areas of irritated or broken skin. Recommended application areas are the inner arms or inner thighs. 
  • Use Lenzetto Spray exactly as you have been prescribed by your doctor. One spray delivers the lowest dose of Lenzetto Spray. Read the Patient Information Leaflet before use. 
  • If you have not had a hysterectomy you should speak to your doctor before using Lenzetto Spray as they will prescribe another HRT containing a form of the hormone progesterone.


How to use Lenzetto Spray

  1. Ensure your application site is clean and dry.
  2. Take off the plastic cover and hold the bottle upright while resting the plastic cone flat against the skin.
  3. Push the pump down fully to release 1 dose. If you need more than 1 spray move the bottle further down the arm, or thigh, for each additional spray. 
  4. Let the spray air dry for 2 minute before dressing and wait 1 hour before showering, bathing or swimming. 
  5. Wash your hands thoroughly after use.

You should speak to a doctor if you want to stop using Lenzetto Spray, they will be able to advise on potential side effects and how to minimise these.

Lenzetto Spray side effects

Lenzetto Spray, like other HRT, may cause some people to experience some unwanted side effects. Most of these side effects will improve within the first 3 months of use. If they do not improve within this time you should speak to a doctor or pharmacist. 

If you develop any severe side effects or an allergic reaction while using Lenzetto Spray you should seek medical advice from your nearest emergency department as soon as possible. 

The most commonly experienced side effects when using Lenzetto Spray are:

  • Headaches
  • Abdominal pain
  • Nausea
  • Rashes and itching
  • Irregular vaginal bleeding
  • Breast tenderness and pain
  • Weight increase or decrease

Before using Lenzetto Spray you must read the Patient Information Leaflet thoroughly. 

Lenzetto Spray ingredients

Lenzetto Spray active ingredients: estradiol hemihydrate.

Other ingredients: octisalate and ethanol 96%.

Lenzetto Spray warnings

Please read the Patient Information Leaflet carefully before using Lenzetto Spray.

Applying any form of HRT treatment, including Lenzetto Spray, increases your chance of developing specific health conditions. If you have any questions or concerns you should discuss these with your GP or specialist. 

Your eligibility to purchase Lenzetto Spray on repeat prescription from The Independent Pharmacy relies upon you attending an annual check-up with your GP, which should include a breast screen, blood pressure, blood tests and a cervical smear test.

  • If you still have an intact womb your doctor should prescribe you a form of HRT that contains a version of the hormone progesterone to use alongside Lenzetto Spray to reduce your risk of developing certain cancers. 
  • Lenzetto Spray may not be an appropriate treatment option for everyone. You should not use this product if you have ever had or are at risk of oestrogen-sensitive cancer, a blood clot, have a blood clotting disorder or have liver disease.
  • Discuss with your GP before using Lenzetto Spray if you have fibroids, endometriosis, have high blood pressure, diabetes, gallstones, SLE, epilepsy, asthma, kidney problems, suffer from migraines as HRT can make these conditions worse.
  • Speak to a doctor or pharmacist before using Lenzetto Spray if you are currently taking or have recently stopped taking any other prescribed or non-prescribed medicine including herbal remedies such as St John’s-Wort.
  • Lenzetto Spray contains alcohol making it flammable. Avoid smoking or naked flames when using this product to avoid burns.


Lenzetto Spray and cancer

Lenzetto Spray, like other oestrogen-only HRT, raises your risk of contracting cancers of the womb. Lenzetto Spray, can consequently, only be used by women who do not have an intact womb or who are prescribed a progesterone HRT alongside it to decrease these risks. 

Using all HRT slightly increases your chances of developing breast cancer or ovarian cancer and therefore you must continue to attend an annual health review and regularly check your breasts for any changes including lumps and dimples. If you notice any irregularities you should get these checked by a doctor as soon as possible.


Lenzetto Spray and blood clots

Using any form of HRT makes you 1 - 3 times more likely to develop either a venous or an arterial blood clot. These can be dangerous and can result in heart attacks and strokes, which can be life-threatening. If you think you are experiencing symptoms of a blood clot you must see a doctor straight away. 


Lenzetto Spray in pregnancy & breastfeeding

Lenzetto Spray is only suitable for women experiencing menopause and should not be taken as a contraceptive or when pregnant. If you have had a menstrual period within the last 12 months you should use additional contraception. If you think you have become pregnant while taking Lenzetto Spray you should speak to a doctor for advice. 

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Menopause (HRT)?

Visit our advice area or contact our support team

Lenzetto Spray Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Authored By:

A photo of  Scott McDougall

Scott McDougall


Published on: 08-04-2021

Last modified on: 08-04-2021

Scott is one of the two founders of The Independent Pharmacy. He is a registered pharmacist and the registered manager of our service with the CQC.

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We are regulated by a number of organisations in the UK including the MHRA, GPhC & CQC to ensure we offer the highest level of service to every one of our customers.

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It's easy! Follow our simple process to get the treatment or advice you need in no time.

  • 1 Complete a simple health questionnaire
  • 2 A healthcare professional reviews your answers
  • 3 You receive the right treatment or advice
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