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Premique Low-Dose for HRT
What is Premique and what is it used for?
Premique is a combined form of hormone replacement therapy (HRT), used to treat the symptoms of the menopause. Its two active ingredients are conjugated oestrogens and medroxyprogesterone acetate. These emulate the female sex hormones oestrogen and progesterone, respectively. Premique is available in two variations, Premique Tablets & Premique & Low-Dose Tablets; your doctor will advise you which form of Premique you should take.
Please note: Premique tablets are no longer made by the manufacturer. Premique Low-Dose tablets are still available.
This form of HRT does not involve a regular period. For this reason, Premique is suited for women who have already reached the menopause but still suffer from distressing symptoms.
All women go through the menopause. This usually occurs between the ages of 45 and 55. As you approach this age, your ovaries will produce less and less oestrogen. This has the effect of stopping the menstrual cycle, but the change in hormone levels can lead to several symptoms which may have a substantial impact on day-to-day life. Physical symptoms include hot flushes (a spontaneous heat that spreads throughout the body, leading to blushing, sweating and an unusually strong heartbeat), night sweats, osteoporosis and dryness of the eyes or vagina. The hormonal change can also cause distressing psychological effects such as irritability, insomnia and depression. Experiences with menopausal symptoms vary significantly depending on the individual. They can begin multiple years prior to the menopause itself, and remain for many years. Women will, on average, experience symptoms for about four years.
Hormone Replacement Therapy eases the symptoms of menopause by supplementing the levels of hormones which the body can produce naturally. Some medicines are oestrogen-only. However, in women who still have a uterus, an uncontrolled increase in oestrogen levels will cause the lining of the uterus (the endometrium) to grow excessively. This will substantially increase your risk of complications such as endometrial cancer. So, each Premique tablet also contains medroxyprogesterone acetate. Because the doses are constant, this medicine will not produce a monthly bleed; however, the medroxyprogesterone will balance the effect of the extra oestrogen on the endometrium.
As your body adjusts to Premique, you may notice breakthrough bleeding or spotting. Talk to your GP if this continues after more than a few months of treatment. HRT should only be necessary as a relatively short-term treatment as your body adjusts to the menopause. You should review your HRT with your GP at least once each year and have regular gynaecological checkups.
HRT will not prevent pregnancy in women who are otherwise fertile. Women under 50 are considered fertile until two years after their final menstrual cycle (for women over 50, this is reduced to one year). Do not use a hormonal contraceptive while undergoing HRT.
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Some non-medicinal alternatives for the symptoms of menopause are;
For Night Sweats and Hot Flushes
- Using A fan
- Cool Showers
- Wearing light clothing
- Healthy diet and regular exercise
- Stopping Smoking
Reading the following warnings carefully will help to ensure you are selecting an appropriate product.
Premique is unsuitable for you if you:
- Have ever had breast cancer
- May have a cancer which is sensitive to oestrogen (including uterine cancer)
- Have untreated endometrial hyperplasia (an excessively thick womb lining)
- Suffer from a blood clotting disorder, or have ever had a blood clot
- Have recently had a heart attack or stroke
- Have unexplained vaginal bleeding
- Have impaired liver function
- Suffer from porphyria (a rare hereditary blood disease)
- Are allergic to any of the ingredients in Premique
- Are pregnant or breastfeeding.
Inform your GP if you plan on taking Premique and have ever had any of the following health complications:
- Impaired liver function
- Uterine problems including endometriosis or endometrial hyperplasia
- Circulation problems (e.g. angina, heart attack)
- Heart disease
- High risk of blood clots
- Systemic lupus erythematosus
- Fluid retention
- High blood pressure
- High fat levels in the blood
- Low calcium levels in the blood
- Otosclerosis (a hereditary ear disorder)
- A family history of breast cancer or another oestrogen-sensitive cancer.
Tell your GP or pharmacist if you have taken or plan to take any of the following medicines:
- Epilepsy medicines (e.g. phenytoin, carbamazepine)
- Tuberculosis medicines (e.g. rifampicin)
- HIV medicines (e.g. nevirapine, ritonavir, nelfinavir)
- St Johns Wort.
As your body adjusts to Premique, you may notice breakthrough bleeding or spotting. Talk to your GP if this continues after more than a few months of treatment.
HRT may increase your risk of breast cancer. The extent of this risk will vary depending on the length of your HRT treatment and whether you are taking combined or oestrogen-only HRT. Check your breasts regularly for changes to the skin or nipple, or for any noticeable lump. For women who use HRT for more than five years, there may also be a slight increase in the risk of ovarian cancer.
Stop taking Premique and seek medical attention immediately if you notice early signs of any of the following:
- Blood clots – pain and swelling of the legs, difficulty breathing
- Stroke – sudden migraines, blurred vision
- Heart disease – chest pain which extends to the neck or arm
- Liver disease – yellow colouration of the skin or eyes.
Discuss with your doctor whether your personal benefits of HRT outweigh the risks mentioned above.
Please read all packaging and the Product Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.
Premique should be taken at a similar time each day, according to the directions on the pack. Swallow the tablet whole with a sip of water. This can be done with or without food. Once you finish a pack (28 days), start a new pack the following day without an interval. You should review your HRT with your GP at least once each year.
If, for any reason, you forget to take a tablet, take it as soon as possible. However, if it is nearly time for your next dose, skip the dose that you missed. Never double your dose to compensate for a dose that you have missed.
The active ingredients contained in Premique are conjugated oestrogens & medroxyprogesterone acetate.
Premique also contains the following inactive ingredients to make up the complete product:
Lactose monohydrate, sucrose, calcium phosphate tribasic, calcium sulfate anhydrous, microcrystalline cellulose, carnauba wax, glyceryl mono-oleates, magnesium stearate, methylcellulose, macrogol, pharmaceutical glaze, povidone, titanium dioxide (E171), stearic acid and colour (E132, indigo carmine), iron oxide black (E172) shellac, n-Buutyl alcohol, propylene glycol, ethyl acetate.
Premique side effects
Not everyone will experience side effects when they take Premique, however if you do they may include:
Breakthrough bleeding, breast pain or tenderness, mood swings, aching muscles or joints, weight change, leg cramps, vaginal inflammation, change in fat levels in the blood.
If you are concerned about these effects, or if the product affects you in any other way, stop using it and talk to your doctor or pharmacist.
Premique Low-Dose Tablets reviews
Premique Low-Dose Tablets FAQs
Conjugated oestrogens are a synthetic version of the naturally occurring hormone oestrogen. Medroxyprogesterone is a synthetic version of the progesterone hormone. When menopause strikes, the body doesn’t produce the female sex hormones in the same abundant quantity. The active ingredients in Premique Low Dose are designed to top up the reduced sex hormone levels, which relieves the symptoms of menopause.
Premique Low Dose contains two active ingredients:
• Conjugated oestrogens 0.3mg
• Medroxyprogesterone acetate 1.5mg
Just select ‘Start Consultation’ next to the product above, or on the links below.
You will need to fill in a simple health questionnaire so that our GPs and Pharmacists can ensure it is safe for us to supply your Premique tablets to you. It only takes a few minutes, and your treatment can be delivered to your door as soon as the next working day.
The price includes the medication you have selected, the private consultation with our doctor or pharmacist and, if the purchase is over £40, it also includes free standard delivery. Under £40, standard delivery is £2.95 and all items are sent using a Royal Mail Tracked Service.
There are many advantages to buying HRT treatments online, some include:
- It's quick and easy- there is no need to spend time at the doctor or pharmacy.
- Fast delivery- We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
- Great prices- we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
- Wealth of information - we provide all the information you could need on Premique tablets and other HRT treatments, in easy to digest formats, at a time that suits you.
Menopause can cause a number of uncomfortable symptoms. Most of these bothersome symptoms can be attributed to a drop in the levels of oestrogen. The most common associated symptoms are:
• Night sweats
• Hot flushes
• Vaginal dryness
• Loss in bone density (which can lead to osteoporosis)
You should take a tablet as soon as you remember and your hormone replacement therapy should carry on as normal. If you have forgotten more than one tablet, only the most recent dose should be taken. Never double-up a dose to make up for a missed tablet. Also, be aware that missed tablets may cause breakthrough bleeding.