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Lyclear 5% Dermal Cream

Lyclear 5% Dermal Cream (30g )

Order before 3pm for delivery from Sat. 07 Aug.

Lyclear Cream for Scabies

Lyclear 5% cream is a highly effective topical treatment used to clear scabies and crab mites and their eggs from the skin.  You can get relief from itching within just a few hours and most cases can be treated with a single, thorough application. 

You can buy Lyclear cream online from The Independent Pharmacy to get fast, discreet delivery directly to your door. Get treatment today by completing our quick online health questionnaire. 

Lyclear Cream Information

  • Age: 2 years +

    Maximum per order: 6

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Lyclear (permethrin)?

Lyclear cream is an effective treatment for infestations of scabies and crab lice on the body. It contains the active ingredient permethrin which paralyses and kills mites and their eggs, offering lasting relief from the itch and irritation of scabies.

Lyclear can be used to treat children and adults from the age of 2 years and so is suitable for the whole family, so you can buy up to six 30g tubes online from The Independent Pharmacy at one time. 

For most people, one to two applications 14 days apart is usually sufficient to completely clear them of scabies or crab mites. 

Lyclear cream is the branded version of the generic treatment, Permethrin 5% cream.

What is Lyclear used for?

Lyclear cream is used to treat infestations of scabies and crab lice on the body. Killing the eggs and mites themselves. 

Scabies and crabs cause intense itching which can lead to irritation and break down of the skin. Although Lyclear kills the mites you may still experience some itching for up to 4 weeks after use - this is normal. You can treat the itch with Eurax cream or E45 Itch Relief. If you do not notice improvement after 14 days you may need to do a second application. 


How does Lyclear work? Does it kill eggs?

Lyclear contains the active ingredient permethrin which is an insecticide that paralyses mites, killing them and their eggs. 


How long does Lyclear take to work?

Once the cream has been applied to the skin and left for 8 hours, preferably overnight, you should notice some reduction to the intensity of the itching. In some cases where the infestation is persistent or there is a renewed infestation, a second application may be needed after 14 days.

If you do not notice significant improvement after the second application you should speak to a pharmacist or doctor for further advice. 



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Lyclear instructions

Lyclear can be purchased for use in children and adults from the age of 2 years for the application to the skin only to treat scabies or for over 18 years for crab lice. Please use only as directed in the Patient Information Leaflet or by your doctor. 

Lyclear cream should only be applied to clean, dry, cool skin. You should avoid taking a hot bath or shower immediately before treatment.

When applying Lyclear cream to treat scabies make sure to cover all areas of the skin including palms of hands, soles of feet, armpits, external genitalia, buttocks and under the fingernails. If your face and scalp are not affected this should be the only area the cream is not applied, unless you are a child or an elderly person. 

Leave Lyclear Dermal Cream on for at least 8 to 12 hours (usually overnight), and then wash off with water and soap. Re-apply Lyclear Dermal Cream to your hands, if within 8 hours of treatment, they have been washed with water and soap.

Approximately 90% of individuals are cured with a single application of cream. If necessary, a second application may be given at least 7 days after the initial application, if there are no signs of the original lesions healing or if new lesions are present.

To treat scabies in adults and adolescents over 12 years of age:

Apply the contents of one 30 g tube to the skin on the whole body. 

To treat scabies in children 6-12 years old:

Apply half a 30 g tube of Lyclear cream to the skin on the whole body.

Children aged from 2 years - 5 years:

Apply a quarter of a 30 g tube of Lyclear cream to the skin on the whole body including the scalp. 

To treat crab lice, Adults, over 18 years of age

Apply up to 30 g of cream to the whole body, paying particular attention to facial hair. Do not apply to the eyelashes, these lice should be removed using tweezers. 

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Lyclear Cream side effects

Lyclear may cause some people to experience side effects that are usually mild and improve after 8 hours once the application is washed off. If you are worried about side effects or do not think Lyclear has improved your condition speak to a doctor for advice.

Side effects may include:

  • Slight stinging or burning of the skin might occur occasionally, but it disappears quickly.
  • Irritation may increase or continue for a short period during treatment with signs such as itching, skin redness, or a rash, manifesting.
  • Itching of the skin might continue for up to four weeks after treatment with Lyclear Dermal Cream. This is usually a normal process caused by sensitivity to the dead scabies mites. 

If you experience any severe side effects or an allergic reaction while using Lyclear you should get immediate medical advice either by calling 999 or attending your nearest emergency department. 

Please read the Patient Information Leaflet for full details on side effects and how to report new symptoms. 

Lyclear ingredients

The active substance in Lyclear cream: Permethrin 5% w/w.

The inactive ingredients in Lyclear cream: Coconut oil, glyceryl monostearate, macrogol cetyl ether, cetomacrogol 1000, isopropyl myristate, lanolin alcohols/liquid paraffin mixture, butylated hydroxytoluene (E321), glycerol, formaldehyde solution, carbomer, sodium hydroxide and purified water.

Please make sure you are aware of all the ingredients in Lyclear cream detailed in the Patient Information Leaflet. 

Lyclear Cream warnings

Reading the following warnings carefully will help to ensure you are selecting an appropriate product.

  • Lyclear contains paraffin, which can be flammable and cause burns Avoid smoking or going near naked flames during use. 
  • Lyclear in some people may worsen symptoms of asthma or eczema. 
  • Speak to a doctor or pharmacist before using Lyclear if you are using, have recently used or might use any other medicines including corticosteroids used to treat skin conditions like eczema.
  • Do not contact the eyes with Lyclear Dermal Cream. 
  • If the eyes get contaminated, immediately rinse with water. 
  • Avoid taking a hot bath just before treatment. 
  • Before application, ensure the skin is clean, dry and cool. 
  • Permethrin Cream should be applied externally only. 
  • Nursing staff who apply this cream to patients may wear gloves to avoid irritation of the hands. 
  • Special care should be taken when applying Lyclear Dermal Cream Permethrin to the elderly. 
  • Keep out of sight and out of reach of children. 

For cutaneous use only. Do not swallow this medicine. Avoid contact with eyes or mucous membranes (inside the nose or throat, genital region) or open wounds.

Please read all the packaging and the Product Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.


Lyclear & Pregnancy

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby and think you may have scabies or crab lice you should ask your doctor or pharmacist for advice before taking this medicine.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Scabies?

Visit our advice area or contact our support team

Lyclear 5% Dermal Cream Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What is Lyclear dermal cream used for?

    •  Crab lice in adults.
    • Scabies in adults and children aged two months and over.
  • How does Lyclear dermal cream work?

    Lyclear dermal cream contains the active ingredient permethrin, an insecticide that treats scabies and crab lice.

    Apply the cream over the whole body; the permethrin kills the parasites by poisoning them.

    Repeat the treatment after seven days to kill any parasites that have survived or that have emerged from eggs.

  • How do I use Lyclear dermal cream?

    Apply Lyclear to clean, dry, cool skin. If you have had a hot bath or shower, allow the skin to cool before application. Rub the cream gently into the skin until it vanishes.


    • All members of an affected household should be treated at the same time.
    • Apply Lyclear Dermal Cream over the whole body, including the external genitals, buttocks, wrists, armpits, elbows, soles of the feet, palms of the hands, between toes and fingers and underneath the toenails and fingernails. You should also treat the neck, face, ears and scalp, but avoid the areas around the eyes.
    • Adults and elderly people should use up to one 30g tube for one treatment. Depending on your size, you may require up to two tubes.
    • Treat children aged 6 to 12 years with up to half a 30g tube. Treat children aged two months to six years with up to one quarter of a 30g tube. With children, avoid applying the cream to areas around their mouth to avoid it being licked off. Children who are likely to put their hands in their mouths should wear gloves.
    • Leave the cream on the skin for 8 to 12 hours (it won’t be visible) and then thoroughly wash the whole body. You could apply the cream at bedtime, for example, and wash it off in the morning.
    • If you must wash a treated area within the 8 to 12 hour period, your hands for example, you should reapply the cream to that area each time you wash.
    • Repeat the treatment after seven days.

    Crab lice

    • Adults should apply enough cream to cover the entire body, including the pubic region, inner thighs down to the knees, area around the anus and any hair that grows up from the pubic area to the chest/stomach. Apply it also to the scalp, face, and neck, facial hair and eyebrows. Take care to avoid the eyes. If you find live lice or eggs on the eyelashes, remove them carefully with tweezers. Dont apply the cream to the eyelashes because it can cause eye irritation.
    • Leave the cream on the skin and hair for 12 hours (it won’t be visible) and then thoroughly wash it off. For example, you could apply the cream at bedtime and wash it off in the morning.
    • Repeat the treatment in seven days.

    Powerful action

    The active ingredient, Permethrin (a pyrethroid—anti-parasitic agent) binds to sodium channels on the parasite’s nerve endings. This leads to paralysis of the nervous system and ultimately the insect’s death.

    Please note that this product is Lyclear Dermal Cream, which is a cream for scabies and pubic lice. 

  • How effective is Lyclear?

    Lyclear Scabies Cream kills mites in their burrows. It contains no colourings or perfume; it is odourless and absorbed completely into the skin without residue. Lyclear is effective in 91% of infestations after one application.

Authored By:

A photo of  Andy Boysan

Andy Boysan


Published on: 29-05-2019

Last modified on: 07-12-2020

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

Reviewed By:

A photo of  Scott McDougall

Scott McDougall


Reviewed on: 07-12-2020

Next review date: 07-12-2022

Scott is one of the two founders of The Independent Pharmacy. He is a registered pharmacist and the registered manager of our service with the CQC.

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