Avloclor (Chloroquine) 250mg Tablets are available to buy from The Independent Pharmacy Online Doctor service, following a free consultation, to help prevent malaria. To find out more about malaria and see all the available treatments, see our Online Doctor Malaria page.
Avloclor Tablets are mainly used for the prevention and the treatment of Malaria. Each tablet contains 250mg of the active ingredient Chloroquine Phosphate. Avloclor is classified as a prescription-only-medicine (POM) and is manufactured in the UK by Alliance Pharmaceuticals. Avloclor tablets are white and round. One side is scored down the middle with the letter ‘A’ marked on either side of the score-line. The other side of the tablet is plain with no markings. Avloclor are taken as a single dose of 2 tablets once weekly, started one week before travelling and continued for 4 weeks after returning.
Malaria is a serious disease that can potentially be fatal. It is caused by various types of parasites known as plasmodium. Mosquitos infected with plasmodium can pass them on to humans through bites. If bitten by an infected mosquito the plasmodium will be transferred into the human bloodstream. Once there, it will begin to reproduce and multiply, resulting in the disease malaria.
Chloroquine Phosphate belongs to a group of medicines called antimalarials. Basically, Chloroquine works by killing the plasmodium once it has entered the red blood cells. It does this by inhibiting the action of a chemical the plasmodium produces to protect themselves. Once inside the red blood cells the plasmodium starts to digest the oxygen carrying pigment haemoglobin, separating it into two parts; haem and globin. However, haem is toxic to the plasmodium. To protect themselves, the plasmodium produces a chemical that renders the haem non-toxic to them. Chloroquine blocks the action of this haem detoxifying chemical, causing a rise in toxicity that will kill the malaria parasites.
Avloclor can be taken on its own or in combination with another antimalarial medicine called Proguanil. Knowing which antimalarial treatment is right for you will depend on your destination. Different regions, countries and continents can be affected by different forms of the malaria causing parasite. Different parasites can react differently to different treatments. In some cases the plasmodium has developed a resistance to one form of treatment. For example, plasmodium falciparum is known to be resistant to Chloroquine. For areas where this plasmodium is prevalent, Chloroquine will not be an effective means of prevention. An alternate, such as Malarone, will be more suitable.
Please read the Patient Information Leaflet for side effects and additional information.
Pharmacist Tip: Chloroquine is suitable during pregnancy and breastfeeding, however it should not be taken if you suffer with epilepsy or psoriasis. The tablets should be taken with or after food to help reduce side effects.
- You should take two tablets every week on the same day each week.
- Avloclor needs to be taken one week before entering an area where malaria is present and continued until four weeks after leaving the malaria area.
- You should take Avloclor with or after food.
- Avloclor remains effective with a moderate alcohol intake.
If you do experience side effects from Avloclor they may include nausea, diarrhoea, headache, rashes, skin itch, blurred vision, hair loss, dizziness, mood change, sun sensitivity or seizures. As such you should not take Avloclor if you or a close relative suffers with epilepsy. Avloclor can also worsen psoriasis; people who suffer with psoriasis should avoid taking Avloclor if possible. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects.
If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 0117 971 1603. In a medical emergency you should contact the emergency services or go straight to your local Accident & Emergency.
Avloclor is not suitable to be prescribed online if:
- You are allergic (hypersensitive) to chloroquine phosphate or any of the other ingredients of Avloclor (see Section 6: Further information).
- You are taking a medicine called amiodarone (used to control the heart rate). Avloclor may increase the risk of uneven heart beats (cardiac arrhythmias) when it is taken at the same time as amiodarone. Check with your doctor or pharmacist if you are not sure.
- You have ever had epilepsy, convulsions or fits.
- You have ever had problems with your liver or kidneys.
- You have ever been told that you have a rare disease of the blood pigment called ‘porphyria’ or anyone in your family has it. This is because Avloclor may cause severe symptoms of porphyria, particularly if you drink alcohol.
- You have a scaly condition of the skin called psoriasis.
- You have a muscle problem called ‘myasthenia gravis’. Avloclor can increase the symptoms of this condition. It can also reduce the effect of medicines used to treat this condition (neostigmine and pyridostigmine).
- You have a blood problem called ‘glucose-6-phosphate dehydrogenase deficiency’. Avloclor may damage blood cells in people with this blood condition.
Avloclor may not be suitable to be prescribed online if you are taking any of the following medicines. This is because Avloclor may affect the amount of these medicines in your blood. Please ensure you let us know in your online consultation if you are taking any of the following medicines:
- Praziquantel (used to treat infections of the bowel and bladder caused by parasites).
- Ciclosporin (mainly used by transplant patients but also used to treat rheumatoid arthritis and psoriasis).
- Anti-convulsant medicines (used to prevent convulsions or fits).
- Digoxin (used to treat heart problems).
- Other medicines used to prevent malaria, such as mefloquine. There is a risk of convulsions or fits when these medicines are taken at the same time as Avloclor.
- Cimetidine (used to treat stomach problems). This medicine affects how Avloclor is broken down by your body and may affect the amount of Avloclor in your blood.
- Medicines like kaolin (used for diarrhoea) which are called ‘adsorbents’.
- Antacid medicines (aluminium, calcium and magnesium salts that are used to treat heartburn or indigestion).
You should try to avoid taking Avloclor around the same time as indigestion or heartburn remedies containing high levels of calcium, iron or magnesium as this can reduce its effectiveness.
Avloclor is not 100% effective at preventing malaria, however it is still very effective if taken properly and combined with bite avoidance methods.
It is also important to get the correct vaccinations for your trip before you travel. These should be administered around 6 weeks before you leave.
The active substance in Avloclor Tablets is chloroquine phosphate. Each tablet contains 250 mg of chloroquine phosphate (equivalent to 155 mg of chloroquine base).
The other ingredients are magnesium stearate and maize starch.