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Femseven 50 patches

FemSeven Patches (50, 75, & 100)

Sorry, this treatment is currently out of stock.

There is a nationwide shortage of Femseven and the manufacturers, Theramex, expected it to be back in stock by mid 2021

If you are looking for an alternative to FemSeven I would suggest ordering Estradot in the same strength instead

These contain the same active ingredient as Femseven, however are in a twice weekly patch rather than once weekly.


View Estradot Here

Description for FemSeven Patches (50, 75, & 100)

FemSeven is a prescription-only hormone replacement therapy (HRT) to relieve symptoms of the menopause. It has a secondary use to prevent osteoporosis in postmenopausal women who experience a high-risk of fracture but are unable to take other osteoporosis medicines. FemSeven patches are most suited to women who have had a hysterectomy. FemSeven is one of our complete range of HRT treatments. All are available from our Online Doctor following a brief consultation. Buy online from a trusted UK pharmacy and you’ll enjoy fast and discreet delivery.

Product Information

  • Age: 18 Years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

FemSeven is an HRT treatment patch that delivers a regulated dose of oestrogen to the body. They are available in strengths of 50, 75 & 100. The patches are placed on the skin below the waist where they are worn continuously. They need to replaced every week. The active ingredient in FemSeven (estradiol hemihydrate) supplements the body’s naturally occurring oestrogen, reducing the negative symptoms many women experience during the menopause.

Unlike some other HRT treatments, FemSeven only contains oestrogen. As such, it is most suitable for women who have had a hysterectomy. Women who have an intact uterus may be on a combination treatment, such as Femseven Conti Patches.

Women who have not had a hysterectomy will also need to take a progestogen medicine alongside FemSeven. Oestrogen can cause the womb lining to grow, which in time can cause endometrial cancer. Progestogen medicine inhibits the growth of the womb-lining, reducing - but not eliminating - this risk. If you have had a hysterectomy (womb removal) then endometrial cancer is no longer a risk and you can safely take FemSeven.


Dealing with the menopause: HRT Therapy

Hormone replacement therapy (HRT) is a tried and trusted treatment for women experiencing menopause. During the approach to menopause, women’s bodies produce less and less oestrogen, reducing the levels of oestrogen in the blood. This can cause symptoms that some can find distressing, including hot flushes, night sweats and mood swings. Other typical symptoms include irregular periods and vaginal itchiness and dryness.

By supplementing the body with oestrogen (in FemSeven a form of oestrogen called estradiol hemihydrate), patients are less likely to experience these symptoms. While effective, HRT shouldn’t be considered a long-term treatment. If you’re using HRT to cope with menopausal symptoms, it’s essential that your use is reviewed by a qualified medical professional yearly.

All HRT treatments carry with them risks that you should be aware of. All women using HRT have an increased risk of developing breast cancer. Women using HRT are also at a slightly elevated risk of stroke and of deep-vein thrombosis and pulmonary embolism (blood clots that form in the veins).

Other potential side-effects include menstrual bleeding or spotting, breast pain, depression and changes in mood, an increase in blood pressure and skin problems. (You can find a full list of potential side effects listed here).

Whether to take HRT or not is a personal choice and you should weigh up the risks and benefits. Our Online Doctors can discuss with you the benefits of HRT medicines available.


How estradiol hemihydrate treats menopausal symptoms

Estradiol (also known as E2 or 17β-estradiol) is a naturally occurring hormone that is produced by the human body. Estradiol plays a crucial role in regulating the menstrual cycle and plays a prominent role in hormonally-mediated diseases. In pre-menopausal women, the ovarian follicle secretes between 70 to 500 mcg of estradiol daily into the body. After the menopause, oestrogen in the body is estrone, created by the conversion of androstenedione to estrone by peripheral tissues.

Estradiol is a much more potent form of oestrogen than estrone. The shift from a strong hormone to a weak one (estradiol to estrone) is the cause of menopausal symptoms, including hot flashes, vaginal dryness, mood changes, irregular menses, chills, and sleeping problems.

Supplementing the body’s natural production of oestrogen with estradiol hemihydrate present in FemSeven reduces and in some cases removes the adverse side effects associated with this natural transition.


Is FemSeven right for me?

FemSeven is only available with a prescription. The easiest way to tell if FemSeven is right for you is to get an online assessment; our online assessment normally takes a few minutes to complete. As FemSeven patches are a long-term medication, they need to be currently prescribed by your GP for us to be able to prescribe them to you online.

As an oestrogen-only HRT patch, FemSeven are a suitable alternative to Evorel or Estradot patches.

It’s simple to order FemSeven from our online service by following these steps:

  • You’ll need to undertake an online consultation with a qualified professional.
  • You’ll also be asked questions about your general health and medications that you may be taking to assess whether FemSeven is safe for you.
  • A doctor will review your case and decide whether FemSeven is right for you.
  • Your prescription of FemSeven will be dispensed and delivered by post.


Is it safe to buy FemSeven online?

It’s crucial that you only purchase prescription medicines from a UK-registered online pharmacy. Only by buying from a trusted supplier like The Independent Pharmacy can you be confident that the medication you receive is safe and genuine.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

FemSeven directions

FemSeven is an oestrogen-only patch that should be applied to the skin once weekly on a continuous basis, i.e. each patch is replaced with a new one after 7 days. Always use FemSeven exactly as your doctor has told you.

Choose a place where there is least wrinkling of the skin and where it will not be rubbed off by clothing, for example on your buttocks, hips or abdomen (avoid the waist).

To remove the FemSeven patch simply lift off one edge and pull. Fold the patch in half (adhesive against adhesive) and throw it away. If the patch starts to come off before 7 days are up, you should take it off completely and apply a new patch.

Replace it when you would normally have done. If you forget to change your patch at the right time, change it as soon as possible, then resume your original schedule. If you still have your womb, breakthrough bleeding is more likely if you forget to change your patch on time.

FemSeven side effects

Like all medicines, FemSeven can cause side effects; although not every body gets them.

The following side effects are reported more often in women using HRT compared to women not using it:

  • Breast cancer;
  • Abnormal growth or cancer of the lining of the womb (endometrial hyperplasia or cancer);
  • Ovarian cancer;
  • Blood clots in the veins of the legs or lungs (venous thromboembolism);
  • Heart disease;
  • Stroke;
  • Probable memory loss if HRT is started over the age of 65;

The following side effects may occur very commonly (in more than 1 in 10 people):

Application site reactions:

  • Itching (purities);
  • Redness (erythema);
  • Eczema;
  • Urticaria;
  • Swelling (Oedema);
  • Changes in skin pigmentation

They were mostly mild skin reactions and usually disappeared 2 or 3 days after patch removal.

The following side effects may occur commonly (up to 1 in 10 people):

  • Headache;
  • Breast discomfort (e.g. mastalgia/ mastopathies, breast enlargement).

The following side effects may occur uncommonly (up to 1 in 100 people):

  • Hair changes, sweating increased;
  • Joint pain (arthralgia), leg cramps;
  • Dizziness, tingling in fingers or toes (paresthesia), migraine;
  • Anxiety, appetite increase, depression, difficulty sleeping (insomnia), nervousness;
  • Nausea, indigestion (dyspepsia), abdominal pain, vomiting;
  • Blood pressure changes;
  • Chest pain;
  • Vein disorders;
  • Vaginal discharge, breakthrough bleeding;
  • Swelling (oedema), fatigue, weight changes.

The following potential side effects may occur rarely (up to 1 people in 1 000):

  • Worsening of uterine fibroids (benign growths of the womb).
  • The following side effects have been reported with other HRTs:
  • gall bladder disease
  • various skin disorders:
  • discolouration of the skin especially of the face or neck known as "pregnancy patches" (cholasma);
  • painful reddish nodules (erythema nodosum);
  • rash with target-shaped reddening or sores (erythema multiforme);

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

FemSeven ingedients

The active substance is: estradiol hemihydrate.

The other ingredients are: transparent polyethylene terephthalate foil, styrene-isoprene block copolymer and glycerine esters of completely hydrogenated resins.

Femseven warnings

Do not use FemSeven

  • If you have or have ever had breast cancer, or if you are suspected of having it.
  • If you have cancer which is sensitive to oestrogens, such as cancer of the womb lining (endometrium), or if you are suspected of having it.
  • If you have any vaginal bleeding for which the cause is not known.
  • If you have excessive thickening of the womb lining (endometrial hyperplasia) that is not being treated.
  • If you have or have ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or in the lungs (pulmonary embolism).
  • If you have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency).
  • If you have or recently have had a disease caused by blood clots in the arteries (such as a heart attack, stroke or angina).
  • If you have or have ever had a liver disease and your liver function tests have not returned to normal.
  • If you have an inherited disease (porphyria) characterised by an accumulation of toxic compounds (porphyrins) in the body.
  • If you are allergic (hypersensitive) to estradiol hemihydrate or any of the other ingredients of FemSeven.

If you are not sure of any of the above, consult your doctor before using FemSeven.

If any of the above conditions appear for the first time while using FemSeven, stop using it at once and consult your doctor immediately.

Tell your doctor if you have ever had any of the following problems, before you start the treatment, as these may return or become worse during treatment with FemSeven. If so, you should see your doctor more often for check-ups:

  • Benign tumours of the womb (fibroids inside your womb);
  • A growth of womb lining outside your womb (endometriosis);
  • A history of abnormal growth of the womb lining (endometrial hyperplasia);
  • An increased risk of developing blood clots;
  • An increased risk of getting a cancer which needs oestrogens for its development (such as having a mother, sister or grandmother who has had breast cancer);
  • High blood pressure;
  • A liver disorder, such as a benign liver tumour;
  • Diabetes;
  • Gallstones;
  • Migraine or severe headaches;
  • A disease of the immune system that affects many organs of the body (systemic lupus erythematosus);
  • Epilepsy;
  • Asthma;
  • A disease affecting the eardrum and hearing (otosclerosis);
  • A very high level of fat in your blood (triglycerides);
  • An increase in the amount of water in your body (fluid retention) due to cardiac or kidney problems.

If you need to have surgery

If you are going to have surgery, tell the surgeon that you are using FemSeven. You may need to stop using FemSeven about 4 to 6 weeks before the operation to reduce the risk of a blood clot. Ask your doctor when you can start using FemSeven again.

When to stop using FemSeven

Stop using FemSeven and see a doctor immediately if you notice any of the following when using HRT:

  • If you develop any of the conditions mentioned above
  • A yellowing of your skin or the whites of your eyes (jaundice). These may be signs of a liver disease;
  • A large rise in your blood pressure (symptoms may be headache, tiredness, dizziness);
  • Migraine-like headaches which happen for the first time;
  • If you become pregnant;
  • If you notice a signs of a blood clot, such as:
    • Painful swelling and redness of the legs;
    • Sudden chest pain;
    • Difficulty in breathing.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Menopause (HRT)?

Visit our advice area or contact our support team

FemSeven Patches (50, 75, & 100) Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Authored By:

A photo of  Leanne Sinclair

Leanne Sinclair


Published on: 05-09-2019

Last modified on: 05-09-2019

Leanne is a clinical pharmacist with years of experience working in pharmacy.

Reviewed By:

A photo of  Andy Boysan

Andy Boysan


Reviewed on: 05-09-2019

Next review date: 05-09-2021

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

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