Mebeverine Side Effects: What To Expect From The IBS Treatment

Scott McDougall
Scott McDougallMPharmDirector & Registered Manager
1602842955 mebeverine side effects

If you are looking for an effective IBS treatment to treat uncomfortable or disruptive symptoms like stomach spasms and intestinal cramps, then Mebeverine is a great option. This prescription-only medicine is effective, fast and safe and Mebeverine side effects are very mild and very unusual.

While Mebeverine side effects are rare and mild, it is still worth doing your research and finding out what you may experience should you decide to take this popular IBS treatment.

That’s why we’ve created this helpful guide — so that you can find out more about the possible side effects of Mebeverine as well as anything else you need to know about, including Mebeverine weight loss, Mebeverine in pregnancy and whether it’s possible to have a Mebeverine overdose.

To read more about Mebeverine in detail, visit our dedicated guide on this product and discover Mebeverine uses and more.

What is Mebeverine used for?

Mebeverine is a popular and effective treatment used to alleviate symptoms of irritable bowel syndrome (IBS). Mebeverine can also be used to treat other stomach and intestinal conditions such as chronic irritable colon, spastic constipation, mucous colitis, or spastic colitis.

Mebeverine is a generic version of the popular IBS treatment Colofac. Colofac is the branded version of this medication. However, both contain the same active ingredient, mebeverine hydrochloride. This is a type of medicine known as an antispasmodic or smooth muscle relaxant, which works by relaxing the muscles in the wall of the intestines and gut, to help control spasms and relieve cramping.

Mebeverine is a prescription-only IBS treatment, which means you can’t get it over the counter, and you will need to visit a doctor or pharmacist first.

You can buy Mebeverine 135mg tablets at The Independent Pharmacy — you just need to answer a few questions on our online consultation form first.

You can find out more about this popular IBS treatment on our Mebeverine guide page, where we answer questions such as ‘can you take Mebeverine long term?’.

Summary list of Mebeverine side effects

As with all medicines, Mebeverine can cause unwanted side effects while treating IBS.

That doesn’t mean that everyone who uses this treatment will experience Mebeverine side effects; the majority of users won’t experience side effects at all. Most people who take this medicine have an overwhelmingly positive experience, and generally, any side effects are likely to be very mild and pass quickly.

However, it is always worth finding out more about the possible side effects of any medicine so that you know what to expect and so that you can speak to your doctor or pharmacist if you encounter any problems.

Below we have listed the known Mebeverine side effects:

  • Dry mouth
  • Bloating
  • Heartburn
  • Indigestion
  • Diarrhoea
  • Dizziness
  • Lightheadedness
  • Headache
  • Depression
  • Insomnia
  • Decreased heart rate
  • Tiredness
  • General malaise
  • Loss of appetite
  • Skin irritations — an itchy rash, swelling, inflamed skin or other signs of an allergic reaction (sometimes known as hypersensitivity)

As you can see, the side effects of Mebeverine are generally mild and are nothing to be worried about. They should pass quickly once your body gets used to this medicine.

Some people may get a mild, itchy rash, swelling or inflamed skin when they use Mebeverine. This is a mild allergic reaction and generally isn’t serious — you can take an antihistamine to help ease these allergic symptoms. If you experience an allergic reaction that is more extreme, then you should seek medical attention immediately.

The above is not exhaustive; there may be other Mebeverine side effects you experience that are not listed above.

If you get any side effects that you are worried about — whether they are listed above or not — speak to your doctor or pharmacist. They will be able to advise you further.

More common side effects and symptoms

Everyone’s bodies are different, which means that it is possible to react to the same medicine in many different ways. However, there are some Mebeverine side effects which are more common than others (although these are still rare).

These side effects are skin irritations, bloating, dry mouth, heartburn, dizziness or lightheadedness when taking this treatment.

As we’ve mentioned above, some users have reported a mild allergic reaction or skin irritation. If this is the case, you may experience some redness, a rash, or itching. However, this is not normally serious and can be treated simply by taking an antihistamine.

If you are concerned about any Mebeverine side effects at all, or your symptoms persist or get worse, seek medical advice.

Serious side effects and symptoms

Serious side effects of Mebeverine are very unusual. However, they may still happen.

If you are worried about any of the side effects we have listed — for example, if they are painful, long-lasting or affect your day-to-day life — then you should stop taking Mebeverine and consult your doctor or pharmacist immediately. They will be able to advise you on whether you should continue taking Mebeverine and suggest an alternative IBS treatment.

The most serious Mebeverine side effect to worry about is a severe allergic reaction (anaphylaxis). We will cover this in the section below.

Allergic reactions

In rare cases, Mebeverine can cause a serious allergic reaction (known as anaphylaxis).

You should not take Mebeverine tablets (or Mebeverine in any other form) if you know you are allergic to mebeverine hydrochloride or any of the other ingredients in Mebeverine. You can find a list of ingredients on our Mebeverine dosage page or in the patient information leaflet.

These are the symptoms and signs that indicate a serious allergic reaction:

  • Changes to skin such as rashes, itchy, red, swollen, blistered or peeling skin
  • Trouble breathing such as breathlessness or wheezing
  • Tightness in the chest or throat
  • Trouble talking
  • Swelling, particularly of the face, mouth, lips, tongue or throat
  • Severe dizziness or fainting

These signs indicate a serious allergic reaction, and this must be treated as an emergency.

Seek medical help immediately if you notice any of the above symptoms after taking Mebeverine. Either call 999 or go to A&E.

Does Mebeverine cause liver-related side effects?

Mebeverine should not cause problems with your liver or liver-related side effects.

However, if you have liver or kidney problems, you should speak to your doctor or pharmacist about using Mebeverine. For example, if you have liver disease, liver failure or cirrhosis then Mebeverine may not be appropriate for you to take.

Nothing has been reported regarding Mebeverine side effects or interactions of the liver, but there is thought to be potential for some sort of adverse reaction.

Your doctor will be able to advise you on whether or not this IBS treatment is still suitable for you, and if not, suggest an alternative.

Does Mebeverine cause weight loss?

Mebeverine weight loss is not a side effect of using this treatment, and there is not thought to be a connection between Mebeverine and weight loss.

Mebeverine does not make you gain weight either.

If you have lost weight or lost your appetite and you have IBS symptoms and other digestive problems, then it’s a good idea to speak to your doctor. There may be some underlying cause that needs to be looked into.

Does Mebeverine cause bloating?

Mebeverine is an antispasmodic IBS medicine, which means that it works to relax the muscles in the walls of the intestines and the gut, stopping them from spasming.

By working on these muscles, Mebeverine helps to relieve the symptoms associated with IBS, including uncomfortable bloating and flatulence.

Mebeverine tablets help your gut and intestines settle and return to a more natural rhythm, which will improve bloating too.

For a small number of people, their bloating may not improve when using Mebeverine, or they may find that they experience Mebeverine bloating. This is unusual, however — most people have a very positive experience with this IBS treatment.

Using Mebeverine in pregnancy

The use of Mebeverine in pregnancy is not usually recommended.

This is because there is currently not enough information for medical experts to definitively say whether this IBS treatment is safe or not for pregnant women to take. Doing so could harm the health of the mother or baby, but because there is no clinical research around this, we cannot be sure exactly how much of a risk using Mebeverine in pregnancy poses.

If you're trying to get pregnant or you're already pregnant, it is best to speak to your doctor or pharmacist about using Mebeverine in pregnancy. They will be able to advise you on the benefits and potential risks of taking this treatment while pregnant, so that you can make an informed decision.

Does Mebeverine cause constipation?

Constipation is not listed as a side effect of Mebeverine and the medicine isn’t thought to cause constipation.

In fact, Mebeverine reduces IBS symptoms — particularly stomach cramps and spasms, but it can also help with other digestive issues, including constipation and trapped wind.

If you are looking for a treatment that specifically helps with constipation as well as IBS, try Fybogel Mebeverine Sachets.

These powder sachets contain 135mg mebeverine and 3.5g Ispaghula husk — a type of fibre known as a bulk-forming laxative. Ispaghula husk helps to maintain your bowel’s normal function and alleviate constipation.

Does Mebeverine make you tired?

Mebeverine won’t really make you tired.

Tiredness or drowsiness have been reported as adverse effects by users, as has insomnia. However, this is very unusual and not a common Mebeverine side effect.

Mebeverine does not affect your ability to drive, ride a bike, or operate heavy machinery.

Feeling very tired is a common symptom of IBS. Many sufferers feel extreme fatigue and a lack of energy. IBS and chronic fatigue syndrome often go together, although medical experts are currently unclear why this is.

If you are worried about bouts of extreme fatigue or tiredness — whether you think it may be a result of using Mebeverine or not — then it is best to speak to your doctor so that they can investigate further.

Can you overdose on Mebeverine?

As with any medicine, you can overdose on Mebeverine. This may result in unwanted and harmful adverse effects.

That is why it is important to take this medicine (or any other) exactly as your doctor or pharmacist has told you.

If you miss a Mebeverine dose or forget to take a tablet for any reason, you should skip the missed dosage and take the next one as you normally would. Never double up to make up for missing a dose.

If you take too many Mebeverine tablets by accident, contact your GP for further advice. However, if you take too much Mebeverine by accident or as a one-off, then it is unlikely to harm you.

You can find out more about how to take Mebeverine and the correct dose over on our Mebeverine dosage page.


Mebeverine is a popular prescription-only treatment which is used to treat IBS (irritable bowel syndrome) symptoms, such as cramps, bloating and constipation.

It is a generic version of the branded IBS treatment Colofac, containing the same active ingredient, mebeverine hydrochloride.

Mebeverine side effects are unusual and, if experienced, tend to be mild and pass quickly.

Some more common side effects of Mebeverine are mild skin irritations, bloating, dry mouth, heartburn, dizziness or lightheadedness.

If you experience a mild allergic reaction or skin irritation when using Mebeverine, you can treat this by taking an antihistamine (although it will subside on its own).

If you are concerned about Mebeverine side effects in any way, then you should always seek medical advice.

You can buy Mebeverine tablets to treat IBS with minimal side effects from The Independent Pharmacy. All you need to do is fill out our free online consultation form. It’s quick and easy to do, and once you do, our team will be able to process and dispatch your treatment ready for delivery as soon as the next day.


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