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Mebeverine 135mg Tablets

*The brand supplied may vary. Please contact us if you require a specific brand.

Mebeverine 135mg Tablets (100 tablets)

Order before 3pm for delivery from Tue. 22 Jun and Wed. 23 Jun.

Mebeverine tablets for IBS

Mebeverine tablets are used to treat the symptoms associated with irritable bowel syndrome (IBS) and other intestinal complaints. It’s a generic version of the popular antispasmodic IBS treatment sold as Colofac; it has the same active ingredient: mebeverine hydrochloride. It’s a fast, safe, and effective IBS treatment that relieves stomach spasms and intestinal cramps safely.

Mebeverine Information

  • Age: 18 Years +

    Maximum per order: 2

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

How Mebeverine is used to treat chronic IBS

IBS is a relatively common digestive system complaint that usually affects young adults — it is significantly more common amongst women than men. IBS can be made worse by diet and stress, and many people have recurring IBS flare-ups throughout their lives. 

When someone has IBS, their gut and bowels painfully spasm whenever food passes through. This can lead to intense pain and feelings of discomfort, and can be very distressing for anyone suffering from IBS — making everyday life, socialising around food, and going to the toilet difficult. Mebeverine tablets help control these stomach spasms and relieve cramping thanks to their active ingredient: mebeverine hydrochloride.

Mebeverine is a medication that can be used to effectively treat the symptoms associated with irritable bowel syndrome (IBS), as well as other stomach and intestinal conditions which cause your abdominal muscles to spasm such as:

  • Chronic irritable colon
  • Spastic constipation
  • Mucous colitis
  • Spastic colitis

Mebeverine should only be used by adults if they have been diagnosed with IBS by a doctor. 

It is a prescription-only IBS treatment and is generally prescribed to be taken as a tablet up to three times a day.

For more information, take a look at our general ‘about’ guide that answers questions such as ‘can you take mebeverine long term?’


Colofac vs. Mebeverine: what’s the difference?

You may have heard of Mebeverine tablets as Colofac — which is the branded version of the same IBS treatment. Both Colofac and Mebeverine have the same active ingredient: mebeverine hydrochloride. Mebeverine is cheaper than Colofac, but just as effective, so it’s become a popular choice for many IBS sufferers.


Antispasmodics: effective treatment for adult IBS 

Mebeverine hydrochloride is a type of medicine known as an antispasmodic or smooth muscle relaxant. It works to relax the muscles in the wall of the intestines and gut.


Why does this matter for IBS?

For anyone suffering from IBS these muscular contractions (known as peristalsis) are often abnormal, leading to abdominal difficulties and pain.

By relieving these muscle spasms, related symptoms will also be reduced:

  • Abdominal pain
  • Cramps
  • Bloating
  • Wind/Flatulence
  • Diarrhoea and suddenly needing to use the toilet
  • Constipation

Mebeverine will help your gut and intestines return to a more natural rhythm and allow you to take pleasure in eating again. IBS disrupts your body’s natural rhythm, so it’s important to try to get back into balance to relieve symptoms and stress. 

Some foods and drinks can make your IBS worse, like fizzy drinks and sugar, so it’s important that you also look into lifestyle changes as well as taking pharmaceutical IBS treatments like these tablets.

Mebeverine will not impact your ability to drive and is not affected by the consumption of alcohol. Mebeverine tablets do however contain lactose, so check with your doctor before taking them if you’re lactose-intolerant. 

It’s very easy to order your IBS treatment online after a brief consultation with our UK-based online pharmacy.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Taking Mebeverine tablets

One tablet of Mebeverine should be taken up to three times a day, ideally around 20 minutes before your usual main meals. Swallow each tablet with plenty of water – do not chew them.

Never exceed the recommended daily dose.

Unless you have been specifically advised by your doctor, only take Mebeverine when needed. This means that you should only take it once your symptoms begin to flare up, and stop taking it when they subside. This can take a couple of weeks.

If your symptoms have not improved after two weeks, or if they get worse, you should stop using Mebeverine and contact your doctor.

There are no known medications that might interfere with Mebeverine; however you should always inform your doctor or pharmacist if you are taking anything else, including store bought and herbal remedies.

For more information about taking Mebeverine, take a look at our ‘Mebeverine Dosage’ guide.

Side effects of Mebeverine tablets

Not everyone will experience side effects when they take Mebeverine, however if you do they may include:

  • Skin irritations 
  • Bloating
  • Dry mouth
  • Heartburn

Allergic reactions, mainly but not exclusively limited to the skin, have been reported.

Immune system disorders:

  • Hypersensitivity (anaphylactic reactions)

Skin and subcutaneous tissue disorders:

  • Urticaria
  • Angioedema
  • Face oedema
  • Exanthema

If you are concerned about these effects, or if the product affects you in any other way, stop using it immediately and talk to your doctor or pharmacist.

For more information, why not take a look at our dedicated Mebeverine side effects guide.

Mebeverine ingredients

The active ingredient contained in Mebeverine is:

  • Mebeverine hydrochloride 135mg

Mebeverine tablets also contains the following inactive ingredients to make up the complete product:

Core tablet:

  • Lactose monohydrate
  • Cellulose, microcrystalline
  • Povidone
  • Sodium Starch Glycolate
  • Talc
  • Magnesium Stearate
  • Water purified


  • Opadry white Y-1-7000 containing the following;
  • Hydroxypropyl Methylcellulose (E464)
  • Titanium Dioxide (E171)
  • Polyethylene Glycol

Please note that Mebeverine 135mg tablets are a generic medicine and as such are made by many manufacturers. The above ingredients are a representation of one manufacturer, however, tablets made by other manufacturers may contain different inactive ingredients, including allergens. Please check the patient information leaflet before you take any treatment for a full list of ingredients.

Mebeverine warnings

Reading the following warnings carefully will help to ensure you are selecting an appropriate product.

Mebeverine is unsuitable for you if you may be allergic to any of its ingredients.

Talk to your doctor or pharmacist before taking Mebeverine if you have developed new symptoms or your symptoms have become worse.

Inform your GP if you plan on taking Mebeverine and have kidney or liver problems.

Mebeverine is not known to interact with any other medicines.

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. There is only limited information about the safety of Mebeverine for pregnant women.

Please read all packaging and the patient information leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about IBS?

Visit our advice area or contact our support team

Mebeverine 135mg Tablets Reviews

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Frequently Asked Questions

  • What are the side effects of Mebeverine?

    Like all medicines, taking Mebeverine can cause some side effects. Some patients have reported dizziness or lightheadedness when taking this treatment. An allergic reaction is unlikely, but you may experience some redness, a rash, or itching. Seek medical help if the symptoms persist or get worse. Seek immediate medical help if you experience difficulties breathing or other severe allergic symptoms like the swelling of your face or tongue and hives.

  • How does Mebeverine compare to other IBS treatments like Colofac, Duspatalin, and Buscopan?

    Mebeverine is exactly the same as Colofac as it has the same active ingredient — Colofac is just the same drug manufactured under a different name (brand).  Same goes for Duspatalin (US brand) — it’s just another name for the same drug. Buscopan is slightly different and is made up hyoscine butylbromide (or scopolamine butylbromide) and is used to treat abdominal pain and bladder spasms. As it’s also an antispasmodic, it is not recommended that you take it at the same time as Mebeverine.

  • What does Mebeverine/Colofac do?

    Mebeverine is an antispasmodic which means that it helps to relax the smooth muscle in the gut and control the cramps and painful stomach spasms associated with IBS.

  • Can I use Mebeverine while pregnant or breastfeeding?

    There is little information regarding the use of Mebeverine during pregnancy. Speak to your GP before taking it. It is important to make your GP aware of any gastrointestinal symptoms during your pregnancy.

  • What is the standard Mebeverine dosage?

    The standard tablet dosage is 135mg, to be taken three times a day.

  • What do Mebeverine reviews say about this IBS medicine?

    It tends to be positively reviewed, but it can take a while for IBS patients to find the ideal treatment for them — it can come down to your individual biology and symptoms. It’s important to also consider how lifestyle changes may improve your condition, as tablets can help relieve symptoms, but not ‘cure’ the condition.

  • Can I get Mebeverine and Colofac on the NHS?

    Mebeverine is available on the NHS.

  • What is the best antispasmodic for IBS?

    It depends — everyone has an individual response. There are a few options: Colofac, Alverine (Spansmonal), Peppermint Oil, and Mebeverine, but no ‘right or wrong’ answers. Speak to your doctor and pharmacist to find out which one is best for you.

  • Can Mebeverine help constipation?

    Yes, it can help relieve constipation and blocked stools, though it is more effective at treating this as a symptom of of IBS rather than treating constipation on its own. For constipation that is not a symptom of IBS, see our Constipation section for appropriate treatments.

Authored By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Published on: 15-09-2016

Last modified on: 15-09-2018

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

Reviewed By:

A photo of  Scott McDougall

Scott McDougall


Reviewed on: 15-09-2020

Next review date: 15-09-2022

Scott is one of the two founders of The Independent Pharmacy. He is a registered pharmacist and the registered manager of our service with the CQC.

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