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Nytol One-A-Night 50mg Caplets

Nytol Tablets (Original & One-A-Night)

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Order before 3pm for delivery from Sat. 07 Aug.

Buy Nytol Online

Nytol Original and Nytol One-A-Night are clinically proven to offer short term relief for sleeplessness or insomnia in children and adults over the age of 16. Nytol sleeping tablets support you to drift off more quickly and help you to stay asleep, leaving you feeling revitalised the next morning. 

You can buy Nytol Original and Nytol One-A-Night online at The Independent Pharmacy without the hassle of visiting a pharmacy. Just fill in our short online consultation so we can make sure Nytol is the right product for you. 

Nytol Information

  • Age: N/A

    Maximum per order: N/A

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Nytol and what is it used for?

Nytol Original and One-A-Night are sleeping tablets that are effective in giving temporary relief from sleeplessness, otherwise known as insomnia

Both Nytol Original and One-A-Night contain the active ingredient diphenhydramine, a drowsy antihistamine. When Nytol is taken 20 minutes before bed it helps you to fall asleep more quickly and promotes a less disturbed sleep.

 

What is insomnia?

Insomnia is another term for the inability to get to sleep or to stay asleep. Many people will experience insomnia at some point in their life and it can have many different causes. 

Some causes of insomnia may be:

  • Stress, anxiety, depression or other mental health conditions.
  • Caffeine or other stimulating substances or activities before going to bed.
  • Sleeping environment
  • Physical health conditions
  • Some medication

The NHS website offers useful sleep advice. Some people find that making small lifestyle changes can help them get more rested nights sleep. 

If you want more information about insomnia, take a look at our Insomnia Advice & Treatment page. 

 

Nytol for anxiety

Nytol is used as a sleeping aid for those that struggle to sleep. Sleep disturbances or insomnia can have many different causes. 

Anxiety, stress and depression are known to cause sleeplessness and therefore Nytol can be used in the short term to help you get a good night's sleep. Nytol should not be used for more than 2 weeks.

Nytol does not, however, help to treat anxiety. If you are suffering from stress or anxiety that is causing you to lose sleep, you must discuss treatment and support options with your doctor or pharmacist. 

 

How does Nytol work?

Nytol Original and Nytol One-A-Night contain the antihistamine diphenhydramine hydrochloride. 

Nytol helps to promote restful sleep. The diphenhydramine works by blocking the histamine receptors inside your brain which has a sedative effect. This process makes you feel less alert and produces drowsiness, helping you get a good night's sleep. 

You may have heard of, or taken, antihistamines such as cetirizine or loratadine for hay fever or other allergies before. These should not be taken as a sleeping aid. They are known as non-drowsy antihistamines which work by blocking antihistamine uptake but outside the brain where it has no little effect on drowsiness. 

 

Does Nytol work and how long does it last?

Nytol takes around 30 minutes to start to make you feel drowsy. It is therefore recommended that for optimal effect Nytol tablets should be taken 20 minutes before you go to bed. 

The effects of Nytol usually last around 4-6 hours, meaning they help you sleep soundly through the night but wake up feeling refreshed. 

 

Nytol side effects and is Nytol safe?

Like other medications, Nytol may cause some people to experience unwanted side effects but these side effects are usually mild when taken as directed. For more information please see our side effects section on this page. 

 

Nytol and alcohol

You should not take Nytol at the same time as alcohol as this can increase your chances of experiencing unwanted side effects. 

 

Nytol in pregnancy

If you are experiencing sleeplessness in pregnancy or while breastfeeding you should discuss this with a doctor or pharmacist before taking Nytol. 

 

Nytol overdose-is it possible?

Nytol Original and One-A-Night should only be taken as directed in the Patient Information Leaflet. 

If you take over the stated dose of Nytol this is called an overdose. Taking too much Nytol is likely to increase unwanted side effects and can in some cases be life-threatening. If you have accidentally taken too much Nytol you should seek medical advice straight away.

 

Sominex or Nytol

Both Sominex and Nytol are brands of sleeping tablets that contain antihistamines that make you drowsy to promote sleep. Both tablets you can buy without a prescription here at the Independent Pharmacy.

The difference between the two brands of sleeping tablets is that Sominex contains the antihistamine promethazine hydrochloride whereas Nytol contains diphenhydramine. 

Sominex and Nytol work in the same way and have similar side effects associated with taking them. It is recommended that with both medications you do not take them for more than 2 weeks. If you are unsure about which medication to take, speak to a doctor or pharmacist for advice. 

 

Kalms or Nytol

Some people may prefer to try using herbal medication to help them sleep. Kalms is a brand of herbal sleeping tablets that contain the ingredient valerian root. 

Unlike Nytol, which contains an antihistamine that makes you drowsy, Kalms use valerian root, this has a mild sedative effect that decreases anxiety making you feel more relaxed, aiding a better night's sleep.

 

Sources

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Nytol dosage

Before taking Nytol Original and Nytol One-A-Night, please ensure that you have read the Patient Information Leaflet thoroughly for full details of the directions for use. 

  • Nytol is suitable for children and adults over the age of 16 years who have difficulties sleeping. 
  • This product is to only be taken orally with a drink of water

Nytol Original 25mg tablets: Take 2 tablets 20 minutes before you go to bed.

Nytol One-A-Night 50mg tablets: Take 1 tablet 20 minutes before bed. 

Nytol should only be used for the short term treatment of sleeplessness and should not be taken for more than 2 weeks. If you are continuing to suffer from sleep difficulties after 2 weeks you must discuss this with your doctor. 

 

Nytol for kids

Nytol should only be taken by children and adults over the age of 16 years. Children often struggle to settle and often wake during the night. The NHS website offers helpful guidance with techniques to help your child sleep better. Alternatively, speak to your doctor or a nurse for support and advice. 

 

How many Nytol can I take?

You must take Nytol tablets as directed in the patient information leaflet.

 

How long does Nytol take to work?

Nytol Original and Nytol One-A-Night should be taken at least 20 mins before bed as it takes around 30 mins for the active ingredient diphenhydramine to take effect. After this time you should start to feel drowsy, helping you to get to sleep more quickly and stay asleep throughout the night.

Nytol side effects

For a full list of side effects please read the Patient Information Leaflet.

In the same way as other medication, Nytol may cause some people to experience some unwanted side effects. If you are concerned about side effects or your side effects do not go away after you stop using Nytol please speak to your doctor or pharmacist. 

If you experience a severe allergic reaction as a result of taking Nytol you should seek immediate medical assistance from your nearest emergency department.

Nytol Original and One-A-Night most commonly are associated with following side effects:

  • Tiredness and drowsiness
  • Difficulty concentrating
  • Dizziness
  • Dry mouth

 

Nytol hallucinations - are they real?

In very rare cases, people have reported experiencing hallucinations as a side effect of taking Nytol. 

The reports from people who have experienced hallucinations as a result of taking Nytol, most commonly occur in those that have taken over the stated dose of this product. 

It is important, with all medications, that they are taken as instructed in the Patient Information Leaflet. 

Nytol ingredients

Please read the Patient Information Leaflet thoroughly before taking Nytol, to ensure you are familiar with the full list of ingredients. 

Nytol contains the active ingredient: Diphenhydramine Hydrochloride (Original: 25mg / One-A-Night: 50mg).

Other ingredients include: Anhydrous lactose.

Nytol warnings

For a full list of warnings and precautions please read the Patient Information Leaflet thoroughly. 

  • Nytol may become less effective in helping you sleep if used regularly.
  • You should speak to a doctor or pharmacist before taking Nytol if you have a diagnosed respiratory condition, liver or kidney disease.
  • Do not drink alcohol when taking Nytol.
  • Speak to a doctor or pharmacist before taking Nytol if you take any other medications, including other over the counter antihistamines. 

 

Is Nytol addictive?

Nytol can cause addiction and it also can become less effective as a sleep aid if used every day for more than 2 weeks. For this reason, it is not advised that you take Nytol for more than 2 weeks. 

If you are continuing to struggle with sleeplessness after 2 weeks you should speak to a doctor or pharmacist about support and treatment options. 

 

Nytol & Pregnancy

It is not recommended that you take Nytol during pregnancy or if you are breastfeeding. If you are finding it difficult to sleep at this time you should speak to a doctor, pharmacist, nurse or midwife for advice.

 

Nytol & driving

Nytol is used to increase drowsiness to help you sleep, it is therefore not recommended that you drive or operate heavy machinery after you have taken it. 

Nytol starts to work after 30 minutes and lasts for around 4-6 hours. However, if you continue to feel drowsy the next morning you should not drive until this effect has worn off.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.

 

UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.

 

Royal Mail

Features:

  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.

 

DPD

Features:

  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.

 

Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

 

BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.

 

Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50
ZE1

 

We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
GY10
HS2
PA60 - 75, 78
ZE2, 3

 

We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
KW17
PH30, 41 - 44

 

Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.

 

International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Insomnia?

Visit our advice area or contact our support team

Nytol Tablets (Original & One-A-Night) Reviews

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Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What are Nytol One-A-Night and Original caplets used for?

    Nytol One-A-Night and Original caplets provide temporary sleeping aid when experiencing sleeping difficulties.

  • How do Nytol caplets work?

    The active ingredient of Nytol One-A-Night caplets is the sedating antihistamine diphenhydramine. Once this chemical reaches the brain, it allows you to fall asleep faster and encourages a deeper sleep. This means Nytol One-A-Night caplets are an effective method for dealing with temporary sleeping difficulties. For best results, take a Nytol One-A-Night caplet twenty minutes before going to bed.

  • How can this medicine affect other medicines?

    If taken alongside any of the following medicines which cause drowsiness, there may be increased effects of drowsiness:

    • Alcohol
    • Antipsychotics (such as haloperidol)
    • Barbiturates (such as phenobarbital and amobarbital)
    • Benzodiazepines (such as diazepam and temazepam)
    • Sedating histamines (such as chlorphenamine and hydroxyzine)
    • Sleeping tablets (such as zopiclone)
    • Opioid painkillers (such as codeine, dihydrocodeine and morphine)
    • Tricyclic antidepressants (such as amitriptyline)

     

    If this medicine is taken alongside monoamine oxidase inhibitors (MAOIs), such as trancylcypromine, isocarboxazid, or phenelzine, there may be an increase in the side effects of blurred vision, drowsiness and a dry mouth.

  • Why are there different herbal formualtions?

    Because the herbal formulations tackle factors such as stress and anxiety, herbal formulations may treat insomnia in some patients better than others.

    Everyone has different sleep needs; some people require eight hours while others need only four. However, if you wake up frequently or find it difficult to wind down, Nytol can give you a fuller night’s sleep and will help you feel refreshed and ready to go the next day.
    On the occasions when you can’t sleep, Nytol is the ideal way to get back into a healthy sleeping routine and enjoy some rest.

  • WHY do the herbal formulations exist, if the conventional formula works fine?

    The best treatment for you will depend on your body and the causes of your insomnia. Whereas the conventional formula simply induces drowsiness, the herbal formulae tackle underlying stress and anxiety. The conventional Nytol formula should only be used in the short term, whereas the Nytol Herbal formula is more suitable for use in the long term.

  • How do herbal sleeping tablets work?

    Some plants such as valerian, hops, wild lettuce and passiflora are well-known for their sedative properties.

Authored By:

A photo of Dr Donald Grant

Dr Donald Grant

MB ChB DRCOG MRCGP Dip.orth.med

Published on: 10-01-2017

Last modified on: 12-10-2020


Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy

Reviewed By:

A photo of  Leanne Sinclair

Leanne Sinclair

BPharm

Reviewed on: 12-10-2020

Next review date: 12-10-2022


Leanne is a clinical pharmacist with years of experience working in pharmacy.


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