Nytol One-A-Night 50mg Caplets

Nytol Tablets (Original & One-A-Night)

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Nytol Original 25mg and its sister brand, Nytol One-A-Night, are clinically proven night-time sleep aids. The two brands differ only number of tablets you take; two for Nytol Original and one for Nytol One-A-Night.

Both medications use a common antihistamine to provide temporary relief for sleeplessness, helping you drift off into your regular sleep rhythm.

If you are have trouble sleeping at night, just two Nytol Easy-Swallow Caplets may be what you need to all into a deep, restful sleep. This easy to swallow, over-the-counter sleep aid from Nytol won't leave you feeling groggy the next morning.

The caplets contain Diphenhydramine Hydrochloride, a sedative that helps patients drift off to sleep naturally and feel refreshed in the morning. 

Unlike traditional sleeping pills, Nytol’s sleep aid ensures that you don’t feel light-headed when you wake up in the morning. 
This medication contains a host of natural ingredients and will enable you to enter into a natural sleep rhythm. 

An older generation antihistamine which causes significant drowsiness, Nytol caplets should be taken 20 minutes before bed. It blocks the normal actions of histamine, the chemical that stimulates arousal-promoting areas of the brain. This reduces alertness and promotes the first drowsy stage of sleep. After entering this stage, most people naturally fall into a deeper sleep.

Whether you regularly struggle for some shut-eye or experience only occasional insomnia, you don't need to suffer endless sleepless nights before you consider a sleep aid.

Nytol Original is designed to help relieve sleep disruption and ease you into sleep without drowsy aftereffects. Nytol has been clinically tested and can be purchased over-the-counter.

Sleep can be disrupted by caffeine, a hectic work schedule, and family and money troubles, overuse of technology, jet lag and snoring.

Adequate rest, however, is essential to physical and mental well-being and helps boost the immune system, increase our metabolism, rejuvenate our skin, and support brain function.

While it's not always easy to switch off, knowing how much sleep you need can make a big difference.


It's not all about 8 hours

Everyone has different sleep needs so you needn’t stress about getting a perfect 8 hours every night. However, you shouldn't expect to run on 4 hours a night long-term. If you regularly wake up tired or need to catch up at the weekend, then you need to improve your sleep-quality throughout the week.

Recognising that you don't need to suffer endless sleepless nights before doing something about it is key.


You might have already tried relaxation techniques to improve your sleep. From keeping your room cool to taking a hot bath before bed, there are many ways to unwind. If you can't sleep, it's worth finding some approaches that work for you and incorporating them into your night time routine.

Have a look at our top sleep tips and see if there are any you haven't tried yet.

Pharmacist tip

Establishing a bedtime routine and removing phones and televisions from the bedroom can help promote sleep.



Adults, including the elderly and children 16 years and over: 

Nytol One-A-Night Tablets: Take 1 caplet, 20 minutes before you go to bed.

Nytol Original Tablets: Swallow 1 to 2 caplets 20 minutes before you go to bed.

Do not exceed the stated dose.

The following side effects of Nytol One-A-Night caplets are common (may affect up to 1 in 10 people):

Drowsiness, tiredness, dizziness, dry mouth, unsteadiness, reduced attention.

If Nytol One-A-Night caplets affect you in any different ways or you are concerned by these effects, cease use of the product and consult with a doctor or pharmacist. Not everyone will experience side effects.

Ensure you read the following warnings carefully:

If you have ever had an allergic reaction with any of the aforementioned ingredients in this product, do not use Nytol One-A-Night caplets. Additionally, do not use Nytol One-A-Night caplets if you suffer from a stomach obstruction (such as from an ulcer).

If you suffer from any of the following conditions, consult with a doctor or pharmacist before using Nytol One-A-Night caplets:

Asthma or bronchitis

Chronic obstructive pulmonary disease (COPD)

Narrow-angle glaucoma

Urinary retention or an enlarged prostate

Moderate to severe kidney or liver disease

Myasthenia gravis, epilepsy or seizure disorders


If sleeping difficulties continue whilst using Nytol One-A-Night caplets, consult with a doctor or pharmacist.

Continued use of Nytol One-A-Night caplets may reduce the effectiveness of the caplets.

If using any of the following medicines, consult with a doctor or pharmacist before taking Nytol One-A-Night caplets:

Tricyclic antidepressants

Monoamine oxidase inhibitors (MAOIs)

Atropine (a medicine used to dilate the pupils of the eyes) or other medicines that induce drowsiness, if used within the last two weeks.

Whilst taking Nytol One-A-Night caplets, avoid using other antihistamines. This includes those used on skin or in cold or cough medicines.

Do not consume alcohol whilst using Nytol One-A-Night caplets.

Nytol One-A-Night caplets are intended to induce drowsiness. As such, do not operate machinery or drive whilst taking the caplets.

Make sure to read the product information leaflet and packaging of any new medicine before taking it. Inform your doctor of medicines you plan on taking.

The active ingredient of a Nytol One-A-Night caplet is diphenhydramine hydrochloride. This is either 50mg for the One-A-Night or the 25mg for the Original variety

Nytol One-A-Night caplets also contain these inactive ingredients:

Anhydrous lactose, microcrystalline cellulose, maize starch, stearic acid and silicon dioxide

Need to know more about Insomnia?

Visit our advice area or chat online to our support team

Frequently Asked Questions

  • What are Nytol One-A-Night and Original caplets used for?

    Nytol One-A-Night and Original caplets provide temporary sleeping aid when experiencing sleeping difficulties.

  • How do Nytol caplets work?

    The active ingredient of Nytol One-A-Night caplets is the sedating antihistamine diphenhydramine. Once this chemical reaches the brain, it allows you to fall asleep faster and encourages a deeper sleep. This means Nytol One-A-Night caplets are an effective method for dealing with temporary sleeping difficulties. For best results, take a Nytol One-A-Night caplet twenty minutes before going to bed.

  • How can this medicine affect other medicines?

    If taken alongside any of the following medicines which cause drowsiness, there may be increased effects of drowsiness:

    • Alcohol
    • Antipsychotics (such as haloperidol)
    • Barbiturates (such as phenobarbital and amobarbital)
    • Benzodiazepines (such as diazepam and temazepam)
    • Sedating histamines (such as chlorphenamine and hydroxyzine)
    • Sleeping tablets (such as zopiclone)
    • Opioid painkillers (such as codeine, dihydrocodeine and morphine)
    • Tricyclic antidepressants (such as amitriptyline)


    If this medicine is taken alongside monoamine oxidase inhibitors (MAOIs), such as trancylcypromine, isocarboxazid, or phenelzine, there may be an increase in the side effects of blurred vision, drowsiness and a dry mouth.

  • Why are there different herbal formualtions?

    Because the herbal formulations tackle factors such as stress and anxiety, herbal formulations may treat insomnia in some patients better than others.

    Everyone has different sleep needs; some people require eight hours while others need only four. However, if you wake up frequently or find it difficult to wind down, Nytol can give you a fuller night’s sleep and will help you feel refreshed and ready to go the next day.
    On the occasions when you can’t sleep, Nytol is the ideal way to get back into a healthy sleeping routine and enjoy some rest.

  • WHY do the herbal formulations exist, if the conventional formula works fine?

    The best treatment for you will depend on your body and the causes of your insomnia. Whereas the conventional formula simply induces drowsiness, the herbal formulae tackle underlying stress and anxiety. The conventional Nytol formula should only be used in the short term, whereas the Nytol Herbal formula is more suitable for use in the long term.

  • How do herbal sleeping tablets work?

    Some plants such as valerian, hops, wild lettuce and passiflora are well-known for their sedative properties.

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