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Nytol One-A-Night 50mg Caplets

Nytol Tablets (Original & One-A-Night)

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Order before 3pm for delivery from Fri. 02 Oct and Mon. 05 Oct.

Product Information

  • Age: N/A

    Maximum per order: N/A

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Nytol Original 25mg and its sister brand, Nytol One-A-Night, are clinically proven night-time sleep aids. The two brands differ only number of tablets you take; two for Nytol Original and one for Nytol One-A-Night.

Both medications use a common antihistamine to provide temporary relief for sleeplessness, helping you drift off into your regular sleep rhythm.

If you are have trouble sleeping at night, just two Nytol Easy-Swallow Caplets may be what you need to all into a deep, restful sleep. This easy to swallow, over-the-counter sleep aid from Nytol won't leave you feeling groggy the next morning.

The caplets contain Diphenhydramine Hydrochloride, a sedative that helps patients drift off to sleep naturally and feel refreshed in the morning. 

Unlike traditional sleeping pills, Nytol’s sleep aid ensures that you don’t feel light-headed when you wake up in the morning. 
This medication contains a host of natural ingredients and will enable you to enter into a natural sleep rhythm. 

An older generation antihistamine which causes significant drowsiness, Nytol caplets should be taken 20 minutes before bed. It blocks the normal actions of histamine, the chemical that stimulates arousal-promoting areas of the brain. This reduces alertness and promotes the first drowsy stage of sleep. After entering this stage, most people naturally fall into a deeper sleep.

Whether you regularly struggle for some shut-eye or experience only occasional insomnia, you don't need to suffer endless sleepless nights before you consider a sleep aid.

Nytol Original is designed to help relieve sleep disruption and ease you into sleep without drowsy aftereffects. Nytol has been clinically tested and can be purchased over-the-counter.

Sleep can be disrupted by caffeine, a hectic work schedule, and family and money troubles, overuse of technology, jet lag and snoring.

Adequate rest, however, is essential to physical and mental well-being and helps boost the immune system, increase our metabolism, rejuvenate our skin, and support brain function.

While it's not always easy to switch off, knowing how much sleep you need can make a big difference.


It's not all about 8 hours

Everyone has different sleep needs so you needn’t stress about getting a perfect 8 hours every night. However, you shouldn't expect to run on 4 hours a night long-term. If you regularly wake up tired or need to catch up at the weekend, then you need to improve your sleep-quality throughout the week.

Recognising that you don't need to suffer endless sleepless nights before doing something about it is key.


You might have already tried relaxation techniques to improve your sleep. From keeping your room cool to taking a hot bath before bed, there are many ways to unwind. If you can't sleep, it's worth finding some approaches that work for you and incorporating them into your night time routine.

Have a look at our top sleep tips and see if there are any you haven't tried yet.

Pharmacist tip

Establishing a bedtime routine and removing phones and televisions from the bedroom can help promote sleep.



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Adults, including the elderly and children 16 years and over: 

Nytol One-A-Night Tablets: Take 1 caplet, 20 minutes before you go to bed.

Nytol Original Tablets: Swallow 1 to 2 caplets 20 minutes before you go to bed.

Do not exceed the stated dose.

The following side effects of Nytol One-A-Night caplets are common (may affect up to 1 in 10 people):

Drowsiness, tiredness, dizziness, dry mouth, unsteadiness, reduced attention.

If Nytol One-A-Night caplets affect you in any different ways or you are concerned by these effects, cease use of the product and consult with a doctor or pharmacist. Not everyone will experience side effects.

The active ingredient of a Nytol One-A-Night caplet is diphenhydramine hydrochloride. This is either 50mg for the One-A-Night or the 25mg for the Original variety

Nytol One-A-Night caplets also contain these inactive ingredients:

Anhydrous lactose, microcrystalline cellulose, maize starch, stearic acid and silicon dioxide

Ensure you read the following warnings carefully:

If you have ever had an allergic reaction with any of the aforementioned ingredients in this product, do not use Nytol One-A-Night caplets. Additionally, do not use Nytol One-A-Night caplets if you suffer from a stomach obstruction (such as from an ulcer).

If you suffer from any of the following conditions, consult with a doctor or pharmacist before using Nytol One-A-Night caplets:

Asthma or bronchitis

Chronic obstructive pulmonary disease (COPD)

Narrow-angle glaucoma

Urinary retention or an enlarged prostate

Moderate to severe kidney or liver disease

Myasthenia gravis, epilepsy or seizure disorders


If sleeping difficulties continue whilst using Nytol One-A-Night caplets, consult with a doctor or pharmacist.

Continued use of Nytol One-A-Night caplets may reduce the effectiveness of the caplets.

If using any of the following medicines, consult with a doctor or pharmacist before taking Nytol One-A-Night caplets:

Tricyclic antidepressants

Monoamine oxidase inhibitors (MAOIs)

Atropine (a medicine used to dilate the pupils of the eyes) or other medicines that induce drowsiness, if used within the last two weeks.

Whilst taking Nytol One-A-Night caplets, avoid using other antihistamines. This includes those used on skin or in cold or cough medicines.

Do not consume alcohol whilst using Nytol One-A-Night caplets.

Nytol One-A-Night caplets are intended to induce drowsiness. As such, do not operate machinery or drive whilst taking the caplets.

Make sure to read the product information leaflet and packaging of any new medicine before taking it. Inform your doctor of medicines you plan on taking.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 3 - 5 day delivery - £2.95
  • Express Tracked Delivery - 1 - 3 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Insomnia?

Visit our advice area or contact our support team

Nytol Tablets (Original & One-A-Night) Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What are Nytol One-A-Night and Original caplets used for?

    Nytol One-A-Night and Original caplets provide temporary sleeping aid when experiencing sleeping difficulties.

  • How do Nytol caplets work?

    The active ingredient of Nytol One-A-Night caplets is the sedating antihistamine diphenhydramine. Once this chemical reaches the brain, it allows you to fall asleep faster and encourages a deeper sleep. This means Nytol One-A-Night caplets are an effective method for dealing with temporary sleeping difficulties. For best results, take a Nytol One-A-Night caplet twenty minutes before going to bed.

  • How can this medicine affect other medicines?

    If taken alongside any of the following medicines which cause drowsiness, there may be increased effects of drowsiness:

    • Alcohol
    • Antipsychotics (such as haloperidol)
    • Barbiturates (such as phenobarbital and amobarbital)
    • Benzodiazepines (such as diazepam and temazepam)
    • Sedating histamines (such as chlorphenamine and hydroxyzine)
    • Sleeping tablets (such as zopiclone)
    • Opioid painkillers (such as codeine, dihydrocodeine and morphine)
    • Tricyclic antidepressants (such as amitriptyline)


    If this medicine is taken alongside monoamine oxidase inhibitors (MAOIs), such as trancylcypromine, isocarboxazid, or phenelzine, there may be an increase in the side effects of blurred vision, drowsiness and a dry mouth.

  • Why are there different herbal formualtions?

    Because the herbal formulations tackle factors such as stress and anxiety, herbal formulations may treat insomnia in some patients better than others.

    Everyone has different sleep needs; some people require eight hours while others need only four. However, if you wake up frequently or find it difficult to wind down, Nytol can give you a fuller night’s sleep and will help you feel refreshed and ready to go the next day.
    On the occasions when you can’t sleep, Nytol is the ideal way to get back into a healthy sleeping routine and enjoy some rest.

  • WHY do the herbal formulations exist, if the conventional formula works fine?

    The best treatment for you will depend on your body and the causes of your insomnia. Whereas the conventional formula simply induces drowsiness, the herbal formulae tackle underlying stress and anxiety. The conventional Nytol formula should only be used in the short term, whereas the Nytol Herbal formula is more suitable for use in the long term.

  • How do herbal sleeping tablets work?

    Some plants such as valerian, hops, wild lettuce and passiflora are well-known for their sedative properties.

Authored By:

A photo of Dr Donald Grant

Dr Donald Grant

MB ChB DRCOG MRCGP Dip.orth.med

Published on: 10-01-2017

Last modified on: 10-01-2019

Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy

Reviewed By:

A photo of  Leanne Sinclair

Leanne Sinclair


Reviewed on: 10-01-2019

Next review date: 10-01-2021

Leanne is a clinical pharmacist with years of experience working in pharmacy.

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