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Xifaxanta (Rifamixin) 200mg Tablets

Xifaxanta (Rifamixin) 200mg Tablets (9 tablets)

Order before 3pm for delivery from Fri. 18 Jun and Mon. 21 Jun.

Product Information

  • Age: 18 Years +

    Maximum per order: 1

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Xifaxanta is an antibiotic tablet used to treat travellers' diarrhoea. The active ingredient is an antibiotic called rifaximin. Xifaxanta tablets require a prescription and are taken over the course of three days. Travellers' diarrhoea comes as a result of bacterial infection. The way Xifaxanta works is by interfering with the bacteria’s cell structure and preventing it from reproducing. Xifaxanta is manufactured by Norgine and is only available via a prescription in the UK. 

Xifaxanta uses an active ingredient called rifaximin, which is a kind of antibiotic. The treatment is localised to work directly in the gut and is largely not taken up into the bloodstream. Rifaximin inhibits the production of an enzyme in the bacteria known as RNA-polymerase which stops its growth process and lets your immune system kill it off.

Travellers' diarrhoea occurs after consuming contaminated food or drinking contaminated water, usually in a foreign country. It is most often caused by a bacterial infection, though in some cases, it is caused by a virus or parasite. Apart from diarrhoea, symptoms include; nausea, stomach pain, loss of appetite and headache. These symptoms may not appear until after you have returned home. Traveller’s diarrhoea affects between 30% and 50% of all people who visit tropical destinations.

If you get travellers' diarrhoea, make sure you rest and keep yourself hydrated. If your symptoms are severe or persist for more than a few days, you may consider a treatment such as Xifaxanta. Xifaxanta contains the antibiotic rifaximin. This targets bacteria within the gastrointestinal system and stops the bacteria from dividing. This allows the immune system to deal with the existing bacteria.

There are a number of precautions you can take while travelling to minimise your risk of contracting travellers' diarrhoea. Avoid drinking tap water, and only eat food that has been properly cooked. Take care of your own hygiene as well.

Why choose The Independent Pharmacy?

  • Fast - order before 4pm and receive your treatment as quickly as the next day
  • Free online consultation service with one of our registered GMC doctors
  • Discreet packaging & confidential service - we don't include any branding or pharmacy logo on our packaging meaning you can get your treatment delivered anywhere
  • UK based and GMC UK registered Doctors
  • Only proven prescription medication available
  • Approved by the General Pharmaceutical Council and Care Quality Commission
*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

The standard recommended dose of Xifaxanta is one tablet, three times daily: one every eight hours. Try to spread these doses out evenly. Never take two tablets at once. Even if you begin to feel well, you should continue the treatment until you have had the nine prescribed tablets.

Swallow the tablet whole with a sip of water. Xifaxanta can be taken either with or without food.

If your symptoms do not improve after 48 hours, you should see a doctor.

Not everyone will experience side effects when they take Xifaxanta, however, if you do they can include:

Common (1 in 10 people or less):

  • Headache
  • Dizziness
  • Flatulence
  • Abdominal bloating
  • Abdominal pain
  • Constipation
  • Diarrhoea
  • Increased bowel urgency
  • Feeling or being sick
  • Involuntary and painful or ineffective straining
  • Fever

Uncommon (1 in 100 people or less):

  • Thrush,
  • Cold sore
  • Throat or nasal inflammation or infection
  • Abnormal liver function test results
  • Loss of appetite
  • Dehydration
  • Abnormal dreams
  • Depressed mood
  • Insomnia
  • Nervousness
  • Numbness
  • Migraine
  • Pins and needles
  • Sinus headache
  • Drowsiness
  • Sight problems
  • Earache
  • Vertigo
  • Increased heart rate
  • Rise in blood pressure
  • Hot flushes
  • Cough
  • Dry throat
  • Shortness of breath
  • Runny nose
  • Upper abdominal pain
  • Indigestion
  • Dry lips
  • Hard or bloody stools
  • Mucus in stools
  • Taste disorders
  • Rashes
  • Blotchy skin
  • Sunburn
  • Back or muscle pain
  • Blood or sugar in urine
  • Frequent urination
  • Increased perspiration

If you are concerned about these effects, or if the product affects you in any other way, stop using it and talk to your doctor or pharmacist.

The active ingredient contained in Xifaxanta tablets is:


Xifaxanta tablets also contain the following inactive ingredients to make up the complete product:

Sodium starch glyconate type A, glycerol distearate, colloidal anhydrous silica, talc, microcrystalline cellulose, hypromellose, titanium dioxide, disodium edetate, propylene glycol, red iron oxide E172.

Reading the following warnings carefully will help to ensure you are selecting an appropriate product.

Xifaxanta is unsuitable for you if:

  • You are allergic to rifamycin antibiotics (e.g. rifampicin, rifabutin)
  • There is blood in your stool
  • You have a fever
  • You have had more than seven liquid stools in the preceding 24 hours

 Xifaxanta should be prescribed for no more than three days. If your symptoms persist or return, see a doctor.

Seek medical help if your symptoms worsen either during or shortly after this treatment. This can be a sign of colitis or an inflamed bowel.

Clinical evidence has shown that Xifaxanta is not effective at treating Traveller’s diarrhoea when it is caused by invasive enteric pathogens such as Campylobacter jejuni, Salmonella spp., or Shigella, which typically produces a kind of dysentery-like diarrhoea characterised by blood in the stools and a high frequency.

If you have taken activated charcoal tablets for your diarrhoea symptoms, wait at least two hours before taking Xifaxanta.

Although Xifaxanta has a negligible absorption rate (less than 1%), it can cause the urine to have a reddish discolouration.

Exercise caution when using Xifaxanta  with any P-glycoprotein inhibitors such as ciclosporin.

Xifaxanta should not be taken by women who are pregnant or breastfeeding.

Please read all packaging and the Product Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Travellers' Diarrhoea?

Visit our advice area or contact our support team

Xifaxanta (Rifamixin) 200mg Tablets Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • Can I use this treatment for other types of infection?

    No – the effect of rifaximin is limited to the gastrointestinal system. It will not treat other kinds of infection, because it is not fully absorbed into the body like some other antibiotics.

  • Is Xifanta suitable for everyone?

    Children should not use Xifanta.

    This medicine is also unsuitable for patients with a fever alongside diarrhoea. It should not be used if you have passed more than seven unformed bowel movements in the previous 24 hours, or if there is blood in your stool. Seek medical attention immediately if you experience these symptoms.

  • How do I use this medicine?

    You will be advised to take one tablet every eight hours. Swallow each tablet whole with a sip of water. This can be done either with or without food. Spread your doses out evenly as best you can. The course of treatment is three days long. See this treatment through, even if it seems that your symptoms have improved.

    Remember that Xifanta cannot be taken as a preventative medicine.

  • What other measures can I take to feel better?

    While you are taking Xifanta, remember to replenish your fluids and stay hydrated with purified water. When you feel as though you can eat, stick to neutral foods such as rice or bread rather than fatty or spicy foods.

  • At what point should I see a doctor?

    Seek medical assistance if your symptoms have not cleared after three days of taking Xifanta, or if your symptoms recur soon afterwards.

    See a doctor if you develop a fever or if you notice your symptoms getting worse over the course of the treatment.

  • Can I drink alcohol while using Xifaxanta tablets?

    It is not recommended to drink alcohol while experiencing symptoms of traveller’s diarrhoea as it can worsen your condition.

  • Can I drive while using Xifaxanta tablets?

    As long as you experience no side effects which may increase your difficulty driving, you can do so. If you do notice any adverse effects then do not drive and contact your doctor.

  • Can I use Xifaxanta tablets if I am pregnant?

    It is not recommended to use Xifaxanta tablets whilst you are pregnant or breastfeeding. You should see your doctor as soon as possible if you have travellers' diarrhoea whilst pregnant or breastfeeding - it is very important to avoid dehydration.

  • How should Xifaxanta tablets be stored?

    Keep Xifaxanta tablets out of the reach of children and below 30°C.

  • Are Xifaxanta tablets available over-the-counter?

    Xifaxanta tablets are a prescription only medication and can only be prescribed by a doctor. When you buy from The Independent Pharmacy, a private prescription from our doctors is included in the price of your treatment so you know that you are getting genuine treatment from a UK pharmacy.

Authored By:

A photo of  Scott McDougall

Scott McDougall


Published on: 15-09-2016

Last modified on: 15-09-2018

Scott is one of the two founders of The Independent Pharmacy. He is a registered pharmacist and the registered manager of our service with the CQC.

Reviewed By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Reviewed on: 15-09-2020

Next review date: 15-09-2022

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

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