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Differin 0.1% Cream

Differin 0.1% Cream (45g)

Order before 4pm for delivery from Sat. 23 Mar.

Description for Differin 0.1% Cream

Differin 0.1% Cream is available to order online from The Independent Pharmacy Online Doctor. Differin cream contains the active ingredient adapalene. Adapalene is a form of vitamin A, which reduces the growth of keratin skin cells that would normally act to block pores in acne. Additionally adapalene increases the turnover of surface skin cells, aiding the natural exfoliation of the skin. These dual actions help to clear acne and leave skin looking clear and oil-free.

Product Information

  • Age: 18 years +

    Maximum per order: 3

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Differin 0.1% cream is available to buy from The Independent Pharmacy Online Doctor service, following a free consultation, to help to treat acne. To find out more about acne and see all the available treatments, see our Online Doctor Acne page.

Differin cream contains the active ingredient adapalene and is used in the treatment of acne. Differin is a retinoid-like compound that is manufactured by Galderma UK Limited. The active ingredient in Differin, Adapalene, is a form of vitamin A. It works to reduce the growth of keratin surface skin cells that can block pores.

Sebum is produced by glands just under the surface of the skin called sebaceous glands. Sebum is a natural, oily substance needed to keep the skin smooth and supple. However, sufferers of acne often produce too much sebum, which can mix with the dead keratin skin cells and cause the pores to become blocked. Blocked pores can then lead to the formation of spots, blackheads (comedones) and whiteheads. Applying Differin 0.1% Cream to the affected areas will help reduce the amount of keratin skin cells and unblock the pores and sebaceous glands, allowing the sebum to escape. This will result in a reduction of inflammation, whiteheads, comedones and spots.

Differin 0.1% cream is also beneficial as it increases the natural turnover of the skin cells. This aids the natural exfoliation of the skin’s outer layers. This action will help keep pores unblocked, thus reducing the formation of spots and blackheads.

Differin 0.1% cream is for external use only and is designed to treat mild to moderate acne symptoms. Currently, Differin is the only licensed medicine in the UK to contain the active ingredient Adapalene.

Do not wash your skin more than twice daily. This can irritate your skin, remove essential oils and make your symptoms worse.

Pharmacist tip: Differin cream should be applied once daily, in the evening. It should be applied to the affected areas after they have been washed and patted dry. You can use cosmetics and moisturisers whilst using Differin cream, however you should let it absorb into your skin fully before applying them.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.
  • Differin cream should be applied to the affected areas once daily in the evening, after washing with a mild cleanser.
  • Apply a small amount to cover the affected areas using clean fingertips and rub in lightly.
  • At the start of treatment with Differin, if it is used correctly it will produce effects similar to that of mild sunburn including mild itching, redness and warmth. This is normal and should subside.

To get the best effects from Differin cream it is important that it is for up to THREE months continuously depending on response. Improvement should be seen after a few weeks.

You may use cosmetics and moisturisers whilst you are using Differin cream however you should wait for it to be fully absorbed into the skin before applying anything else.

Differin cream has drying effect on the skin so it is important to try to ensure that any toiletries containing alcohol or other skin-drying ingredients are not used.

Like all creams there is the potential that you may be allergic to Differin cream. We recommend you do a spot test before commencing treatment.

If you do experience side effects from Differin cream, they can include a burning, stinging or tingling feeling, dry skin, itching, redness, or a rash. Differin can also cause your skin to be more sensitive to sunlight meaning you may burn in the sun more easily than normal. You should take action to reduce this risk such as wearing protective clothing or using sunscreen. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects. 

If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 0117 971 1603. In a medical emergency you should contact the emergency services or go straight to your local Accident & Emergency.

Differin Cream contains the active ingredient adapalene 0.1%.

It also contains: carbomer 934P, Macrogol-20 methyl glucose sesquistearate, glycerol (E422), natural squalene, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide & purified water. 

Differin cream should not cause a harmful interaction with any of your other current medicines. Differin cream should not be used with other acne treatments containing benzoyl peroxide as they can have additive drying effects. Please read the Patient Information Leaflet enclosed with your medicines for further information.

During treatment with Differin cream if you experience severe itching, redness, blistering, peeling or swelling of the skin you should stop using it temporarily. If the symptoms persist stop using Differin cream and consult your doctor.


Delivery & Shipping Information


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2/3 day delivery - £2.95
  • Express Tracked Delivery - 1/2 day delivery - £4.45
  • DPD Next Day - 1 working day - £6.95
  • Special Delivery (Guaranteed before 1pm) - £8.95
  • Saturday Guaranteed before 1pm - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 4pm the same working day. Any orders received after 4pm or over the weekend will be dispatched the next working day. We aim to dispatch all DPD orders placed before 3pm on the same working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 5.30pm the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 5.30pm to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 5.30pm to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Acne?

Visit our advice area or contact our support team

Differin 0.1% Cream Reviews

Unsure about a treatment?
Take a free online assessment with our medical team for impartial help and advice on your condition.

Frequently Asked Questions

  • What does Differin cream contain?

    Differin Cream is an acne treatment that contains Adapalene 0.1%, which helps to reduce the growth and increase the turnover of keratin skin cells that can build up and block pores causing acne.

  • How do I use Differin cream?

    In adults and children 180 years and over, Differin is applied once daily, usually in the evening. You should not apply Differin more than once in a 24-hour period. For best effects, Differin should be applied after washing your face with warm water and a mild cleanser to clear away any excess oil, skin cells and bacteria.

  • Can I use other acne treatments with Differin cream?

    You can combine Differin with antibiotic acne treatments such as Tetralysal (Lymecycline), Minocin (Minocycline) or Oxytetracycline tablets. Differin should not be used with any other acne creams as it may cause excess drying or irritation to your skin. You can combine Differin with antibiotics such as Tetralysal (Lymecycline), Minocin (Minocycline) or Oxytetracycline tablets to cure acne particularly persistent cases of acne. 

    Topical treatments like Differin are frequently used in addition to oral treatments like Accutane (Isotretinoin), but this would need to be started by a dermatologist.

  • I have started using Differin cream and the treated area is red and irritated, is this normal?

    Redness and irritation of the treated area, almost like sunburn, can commonly occur when you use Differin for the first time. This is not usually serious and is a sign that it is working. These effects normally subside within a week. During this time you can reduce the frequency of Differin application to once every other day to allow your skin to recover and then slowly build up to applying it daily.

  • Why can I only buy three packs of Differin cream online at one time?

    Differin cream is a prescription-only acne treatment. For that reason, to ensure the safety of our patients and the legal & ethical operating of our pharmacy, we only supply a maximum of 3 months treatment at one time. Differin treatment is normally judged for effectiveness after 2-3 months. This means that if you do not find Differin as effective as you would like after this time, you are not stuck with an excess of medication. If you are happy with the results you can easily log in and re-order another supply.

  • Is Differin available for next day delivery?

    Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 4pm Monday to Friday, our doctors will review your consultation for Differin the same day. If it is approved your order is can be delivered as quickly as the next day.

  • Is it safe to buy Differin cream online?

    Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Differin online. The Independent Pharmacy is an NHS-licensed Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.

  • How do I buy Differin online?

    It's simple!

    Just select 'Start Consultation' above, you will need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Differin to you. It all takes around 3 minutes and your treatment can be delivered to your door.

  • What are the advantages of buying Differin cream online?

    There are many advantages to buying Differin online, some include:

    • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
    • Fast delivery - We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
    • Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
    • Tons of information - we provide all the information you could need on Differin (adapalene/benzoyl peroxide) and other acne treatments, in easy to digest formats, at a time to suit you.
  • How does Differin gel work?

    Differin cream and gel both contain the active ingredient adapalene, a form of vitamin A that treats acne.

    Acne occurs when the skin’s sebaceous glands become blocked and natural oils, or sebum, accumulate. The blocked sebum provides nutrients for acne-causing bacteria which can grow and cause inflammation in the skin. Adapalene reduces the growth of the keratin skin cells that block pores and allows the sebum to escape. This decreases the occurrence of blackheads and spots.

    In addition, adapalene increases the skin’s ability to exfoliate naturally. This also helps to unblock pores, and decrease blackheads and breakouts.

    Differin Cream or Gel should be applied once a day, before bed.

  • Does Differin cause any skin reactions?

    When you first start using Differin you may feel a temporary stinging or warm sensation on your skin. The skin may redden slightly, like a mild sunburn. Differin may also cause your skin to peel or become very red and irritated.

    If you notice severe redness, swelling, itching, burning sensations, blistering, crusting or peeling of your skin after using Differin, apply the medication less often or stop using it temporarily. If the irritation persists, stop using the medication completely and consult your doctor.

  • Can I wear makeup with Differin?

    You can wear cosmetics or moisturisers while using this medication, but you should not  apply them at the same time. Wash your skin thoroughly before applying Differin, wait for it to be absorbed into your skin, then use any cosmetics and moisturisers.

  • How is Differin affected by the sun?

    Avoid exposure to sunlight, sunlamps or sunbeds while using this medication, as it increases your skin’s sensitivity to UV light. If exposure to sunlight cannot be avoided, use sunscreens or protective clothing over treated skin.

    If your skin is sunburnt, you should not use this medication until your skin has fully recovered. Severe irritation may result.

  • What is a good treatment plan?

    You should continue treatment with Differin for at least 8 weeks. If, after that time, there is no improvement, treatment should be stopped or new medication should be added.

    Your treatment plan should be reviewed after 3 months and, if acne has cleared, Differin can be stopped. Acne may not return, but if it does treatment can be resumed.

  • Does this medication help with acne scars?

    This treatment speeds up the regeneration process of the skin, which may help reduce the appearance of scars. This cream/gel can also prevent future breakouts, which in turn leads to reduced numbers of scars.

    Avoid popping your spots, as this can worsen the problem and create scars. Laser and dermarolling treatments are recent developments, available from cosmetic dermatologist clinics, which are designed to fade scars.

  • Can I use Differin for my rosacea? Or melasma?

    Spots and pustules are one of the main symptoms of rosacea. Differin is therefore often prescribed to treat this condition by dermatologists, however it is not something that we are able to prescribe online.

    Melasma (brown spots/hyperpigmentation on the skin) is also treated by Differin if prescribed by a dermatologist.

  • Is Differin the same as Retin-A?

    Retin-A and Differin work in much the same way, but they are slightly different treatments. One should not be used in replacement of the other.

  • Can Differin be used as an anti-aging wrinkle treatment?

    Differin contains a topical retinoid which can aid the skin in loosening the bond between cells and thereby encourages the old ones to fall off and new cells to form. Because of this, many believe that it can improve the appearance of wrinkles.

    However, it is not recommended that you use Differin for this purpose, as it could dry out your skin and have the opposite effect on wrinkles and fine lines, making them more visible.

  • Can this treatment damage or bleach my clothes and bedsheets?

    Unlike many topical acne treatments, Differin does not bleach fabrics.

  • What parts of my body can I use Differin on?

    This treatment can be used to treat the causes of acne on all parts of the body, including (but not limited to) the face, chin, back and chest.

  • What other treatments are available for my pimples, besides topical and oral medications?

    There are a number of cosmetic treatments that can be provided by a cosmetic dermatologist to treat acne. These can be used in addition to or instead of topical or oral medications. These treatments include microdermabrasion and laser treatment. However, you should always let the treatment provider know what medication you are on before engaging in treatment.

We are a trusted online pharmacy

We are regulated by a number of organisations in the UK including the MHRA, GPhC & CQC to ensure we offer the highest level of service to every one of our customers.

Why choose The Independent Pharmacy?

How does it work?

It's easy! Follow our simple process to get the treatment or advice you need in no time.

  • 1 Complete a simple health questionnaire
  • 2 A healthcare professional reviews your answers
  • 3 You receive the right treatment or advice
  • 4 Easily re-order in a few clicks

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