Tetralysal is one of the most popular and effective acne treatments available on the market. Even so, it’s not suitable for everyone. In some cases, Tetralysal can cause side effects that will make you feel unwell or uncomfortable. In rare cases, side effects caused by this medication can be more serious.

In this in-depth guide, we cover everything you need to know about Tetralysal side effects. From common and serious side effects to how Tetralysal combines with other prescription medicines, you can use this information to help decide whether Tetralysal is the right acne medication for you.

Common Tetralysal side effects

Not everyone will react to taking Tetralysal in the same way. The majority of people taking the medication will not experience any negative side effects. A small minority, though, may experience an adverse reaction to taking the medication.

For an overview of how our customers have found using this acne medication, head over to our Tetralysal reviews page. Affecting just over one in 100 people, in general, the common side effects associated with Tetralysal include:

  • Feeling sick (nausea)
  • Stomach pain
  • Diarrhoea
  • Headaches

Although the common side effects listed above shouldn’t last long. If you are concerned, or the side effects last longer than you are comfortable with, it’s advisable to consult your doctor for further advice.

Serious Tetralysal side effects

When using Tetralysal, serious side effects are extremely rare (affecting less than one in 100 people). These can include:

  • Visual impairment
  • Dizziness
  • Yeast infection (thrush)
  • Skin reactions (increased sensitivity to UV or sunlight)
  • Colitis (inflammation of the bowel)
  • Pancreatitis (inflammation of the pancreas)
  • Raised blood pressure (resulting in persistent headaches)
  • Liver problems

If you experience any of the above side effects, you should stop taking Tetralysal and speak to your doctor.

Allergic reactions to Tetralysal (Lymecycline)

A very small number of people may have an allergic reaction to Lymecycline, the active ingredient in Tetralysal. Signs or symptoms of an allergic reaction to Tetralysal include:

  • A rash
  • Itchy skin
  • Swelling of the face, eyelids or lips
  • Difficulty breathing
  • Tightness in the chest and/or throat
  • Wheezing

The symptoms listed above are all tell-tale signs of an allergic reaction to Tetralysal. If you experience any of these after taking the medication, you should call 999 immediately.

How to cope with Tetralysal (Lymecycline) side effects

As we outlined above, the common side effects of Tetralysal include nausea, headaches, stomach pain, and diarrhoea. After taking the medication, if you experience any of these side effects, there are simple steps you can take to help make yourself feel more comfortable.

Take with or without food

You can take Tetralysal on a full or empty stomach. If you are feeling sick after taking Tetralysal, you can try eating some food while taking the medication.

Alternatively, if you are taking Tetralysal with a meal (for example, breakfast), you can try taking the medication without food. Tetralysal affects people differently, so you may need to experiment to find what works best for you.

Stay hydrated

Drinking plenty of water will ensure that you stay hydrated. Common signs of dehydration include urinating less (or your urine has a dark yellow colour), feeling dizzy, and a lack of energy.

Staying hydrated will also help you cope with lost fluids if you have diarrhoea as a result of taking Tetralysal.

Rest and relaxation

If you have stomach pain after taking Tetralysal, rest and relaxation can help. For example, placing a hot water bottle on your stomach may help; just remember to cover the hot water bottle with a towel when placing it next to your skin to avoid burning yourself.

Take painkillers or ibuprofen

Over-the-counter medications such as paracetamol and ibuprofen are safe to take at the same time as Tetralysal. If you have a headache, it’s fine to take a safe amount of paracetamol or ibuprofen (always follow the instructions as described on the packet).

As a rule, you should not combine Tetralysal and alcohol if you find that the medication is causing you headaches.

The above side effects are most common in the first few weeks of treatment. If you find that they persist longer than this, or they are particularly bad, you should speak to your doctor who may recommend an alternative antibiotic for acne.

Can Tetralysal (Lymecycline) cause depression?

A study by the British Journal of Dermatology found a link between depression and people being treated for acne in the UK.

This is because the skin condition has a physical effect on people’s appearance, which, in turn, can have an adverse effect on their emotional well-being.

However, there is no evidence to suggest that Tetralysal can cause depression.

Can Tetralysal (Lymecycline) cause weight gain?

Again, in recent years, there have been studies that have suggested a link between taking antibiotics and weight gain.

However, there is no proven link between taking Tetralysal acne treatment and weight gain. In comparison, the contraceptive pill, which is prescribed to help with acne, is often associated with weight gain among other symptoms.

Can Tetralysal (Lymecycline) cause hair loss?

Hair loss is another side effect that is often falsely associated with taking Tetralysal. At the time of writing, there are no studies that show a conclusive link between people taking Tetralysal and hair loss.

Can you overdose on Tetralysal (Lymecycline)?

Don’t worry if you forget to take you Tetralysal, it’s fine to take as soon as you remember. If it’s nearly time for your next dose, just take that as usual.

Taking an extra dose of Tetralysal by accident is unlikely to cause any harm. That said, it is not advisable to take two doses at the same time to make up for a missed dose of Tetralysal.

If you keep finding that you forget to take your medicine, try setting regular alarms to remind yourself. Or, if you have taken an extra dose of Tetralysal and are worried or start to feel unwell, contact your GP immediately for more advice.

Can acne become resistant to Tetralysal?

Tetralysal is anantibiotic that kills propionibacterium, a type of bacteria know to cause acne. As with all antibiotics, there is a chance of resistance developing if they are not used appropriately.

To reduce the chance of bacterial resistance developing wen taking Tetralysal, you should use it daily in courses of three to six months - shorter courses are more likely to lead to resistance. It should also be combined with a topical, non-antibiotic acne treatment, such as Skinoren, Acnecide, or Differin.

Taking Tetralysal (Lymecycline) with other medicines

Tetralysal is not suitable to take at the same time as some other prescription medicines. For example, you should talk to your doctor if you are also taking:

  • Indigestion tablets
  • Iron supplements
  • Diuretic tablets
  • Epilepsy medicines
  • Some herbal remedies and supplements

You should also consult with your doctor if you are taking supplements that contain any of the following ingredients:

  • Aluminium
  • Bismuth
  • Calcium
  • Magnesium
  • Zinc

If you take any of the medications listed above, or are taking supplements with any of the ingredients listed above, tell your doctor before taking Tetralysal. They will be able to advise on whether the acne medication is safe to use, or if you need to consider using a different treatment.


Tetralysal is a safe and effective acne medication, but using it can produce some side effects.

As with all medications, Tetralysal affects different people in different ways. If you are using other medications, Tetralysal may be unsuitable. For most other people, though, the medication will be safe, but there may be an adjustment period as your body gets used to taking it.

Tetralysal is available to buy from The Independent Pharmacy. All you need to do is fill in a online questionnaire, which is short, simple and quick to do. Then, if the medication is suitable for you to use, we will deliver Tetralysal straight to your door — in secure and discreet packaging — so you can start your treatment right away.


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