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Lamisil Once

Lamisil Once (4g)

Order before 3pm for delivery from Sat. 07 Aug.

Buy Lamisil Once Online

Lamisil Once is a powerful anti-fungal solution used for the treatment of athlete's foot (tinea pedis interdigitalis). Lamisil Once is a unique product that only requires a single application to combat the fungus that is responsible for the irritation caused by athlete's foot. 

Each 4g tube contains enough Lamisil Once to treat both feet with one application. Lamisil Once works quickly to inhibit further growth and kill the fungi. Lamisil Once is gentle on the skin and is proven to be suitable for people even with sensitive skin. 

Lamisil Once can be purchased online at The Independent Pharmacy for fast and discreet home delivery. 

Lamisil Once Information

  • Age: 18 years +

    Maximum per order: N/A

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Lamisil Once?

Lamisil Once is a brand of anti-fungal treatment which contains 1% of the active ingredient terbinafine hydrochloride and has been proven to be effective in the treatment of athlete's foot

Lamisil Once comes is a liquid solution and can be applied directly to the infected skin on one or both of the feet, taking particular care to cover the skin between the toes. Lamisil Once, as it is inferred in the name, takes effect after just one application unlike other treatments for athlete's foot. 

After applying Lamisil Once to the infected areas of skin the treatment gets to work straight away and you should see noticeable skin healing on the worst affected areas within 4-7 days. 

For best results try to avoid washing or getting your feet wet for 24 hours after applying Lamisil Once. If your feet do get wet in this period you may need to apply Lamisil Once a second time.


What is Lamisil Once used for?

Lamisil Once is used to treat athlete's foot. The active ingredient terbinafine hydrochloride effectively targets and destroys the fungi or yeast (called tinea pedalis interdigitalis) that is responsible for the cracking, dry, inflamed skin that is associated with athletes foot. 


What is athlete's foot?

Athlete's foot is a fungal infection affecting the feet which are caused by an overgrowth of the fungi, tinea pedalis interdigitalis. The symptoms of athlete's foot include dry, flaking, cracked skin that can become sore and itchy.

Athletes foot is common and can be very contagious. You are more likely to catch and become infected with Athletes Foot if you often have wet or sweaty feet, which is why it is named athletes foot. 

If you would like to find out more about athletes' feet you can go to our Advice for Athlete's Foot section for more information. 


Lamisil Once & ringworm

The active ingredient terbinafine hydrochloride that is found in Lamisil Once is also used to destroy the fungi that cause ringworm. Lamisil Once comes in a liquid solution and is not designed to treat other fungal skin infections, such as ringworm.

Lamisil AT 1% gel & Daktarin cream are also available to buy online at The Independent Pharmacy for the treatment of fungal skin complaints and is suitable for the treatment of ringworm.


How does Lamisil Once work and how can you tell it is working?

When Lamisil Once is applied to feet that are infected by athlete's foot, as the solution dries it creates a clear, odourless film over the areas of the feet that are sore and irritated by the fungal infection. 

The terbinafine hydrochloride (1%), which is the anti-fungal agent contained within Lamisil Once, then gets to work immediately by interacting with the fungal cell membranes which prevent them from being able to carry out their normal functions and eventually they are destroyed. 

Lamisil Once has a high moisture content which also provides you with relief from the irritation and itching caused by athlete's foot while it works to kill the fungus.

When following the directions of how to use Lamisil Once correctly you should see the infected skin noticeably healing up to 4 days after application. Your skin should start to become less red, flakey, cracked and itchy. 

If after 7 days you have not noticed an improvement to the infected skin or you feel that your condition has worsened you should speak to a doctor or pharmacist.


How can you tell if Lamisil Once is working?

Lamisil Once if applied following the direction outlined in the Patient Information Leaflet, you should begin to see the infected skin on your feet healing. You should notice the infected skin becomes less red, flakey, cracked and itchy within 4-7 days following the application of Lamisil Once.


How to use Lamisil Once

Lamisil Once should be applied to clean dry feet and spread evenly using clean hands. Lamisil Once solution should be applied directly on to the infected skin on one or both feet straight from the tube using the applicator nozzle, spread over the feet using your hands and allowed to dry. You should avoid getting your feet wet for 24 hours after the application. 

For more details on how to use and apply Lamisil Once please see the Directions section. 

You must also ensure that you have read the Patient Information Leaflet thoroughly before starting any new medication.


Lamisil Once side effects

Lamisil Once may cause side effects in some people. Please see the Lamisil Once side effects section.

Before starting any new treatment it is essential that you have read the Patient Information Leaflet to ensure you are aware of all potential side effects.



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Lamisil Once dosage

Lamisil Once contains enough solution to cover the infected areas of both feet. If you have any leftover solution after you have finished applying Lamisil Once you should make sure to throw the tube away and not be tempted to reuse this. 

If your symptoms are not resolved within 7 days you should speak to a doctor or pharmacist for advice.


Lamisil Once instructions

  • Wash both feet and dry them carefully then wash and dry your hands.
  • Apply Lamisil Once to both your feet using the pointed nozzle, use about half the tube for each foot, finish one foot before treating the other.
  • Spread evenly onto your skin between, under, and over your toes. Then apply over the sole and sides of your foot. Do not rub or massage it in
  • Leave the Lamisil Once to dry into a film for 1 - 2 minutes, before wearing your normal footwear.

Lamisil Once should only be used as directed in the Patient Information Leaflet or as directed by a doctor. Lamisil Once is only suitable for the use in adults over the age of 18 years and is to only be used directly on the skin. 

Lamisil once is not for oral use. If consumed, seek advice from a doctor immediately. 

Lamisil Once should only be used as a single application if you have wet your feet within 24 hours of application or after 7 days do not see an improvement to your athlete's foot symptoms, speak to a doctor or pharmacist for advice. 

Lamisil Once side effects

The most common side effect associated with Lamisil Once affecting 1 in 100 people is peeling or itching skin on the feet. 

In very rare (1 in 10,000) cases people may experience severe allergic reactions or blistered skin following an application of Lamisil Once. 


Lamisil Once not working

If after 7 days you do not see any improvement to the condition of your skin that is infected with athletes foot you should speak to a doctor or pharmacist about other possible treatment options. 

Lamisil Once, like other medication, may cause some unwanted side effects. For a full list of side effects please make sure that you have read the Patient Information Leaflet thoroughly. 

If you experience unwanted side effects and you are concerned or you experience severe side effects you should get advice from a doctor or pharmacist or get help from your nearest emergency department. 

Lamisil Once ingredients

The active ingredients contained in this medicine is/are:

Terbinafine Hydrochloride.

The medicine also contains the following inactive ingredients to make up the complete product:

Acrylates / octylacrylamide copolymer, hydroxypropyl cellulose, triglycerides and ethanol.

Lamisil Once warnings

  • Lamisil is not suitable for the treatment of fungal skin infections anywhere other than on the feet. 
  • Lamisil Once contains alcohol which may irritate any broken or open areas of skin.
  • If you are currently or have recently been taking any other regular medication you should consult with a doctor or pharmacist before commencing treatment with Lamisil Once. 


Lamisil Once & pregnancy

Lamisil Once is not suitable for use during pregnancy or breastfeeding as Lamisil Once can be excreted into your breastmilk. If you are suffering from athlete's foot and are pregnant or breastfeeding you should speak to a doctor or pharmacist for advice. 

For advice on preventative measures around athlete's foot, visit our athlete's foot prevention section.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Athlete's Foot?

Visit our advice area or contact our support team

Lamisil Once Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What is Lamisil Once used for?

    It is an active anti-fungal cream which fights a condition known as athlete's foot (also called tinea pedis).

  • Why should I apply cream to both feet, if only one foot appears to be infected?

    While it may appear that only one foot is infected, the majority of people find that not treating both feet causes re-infection so, as directed, use Lamisil Once on both feet.

  • Only my toes are infected, so why do I need to apply the cream all over my feet?

    Though you don’t yet seem to be experiencing the symptoms all over both feet, athlete’s foot could have already started to infect what appears to be clear skin.  Treating only the visibly affected areas could mean that the fungal infection may not be fully eliminated, allowing the easy spread or return of the condition.  To prevent re-infection, always apply Lamisil Once® as professionally directed.

  • Why choose Lamisil Once?

    No other treatment is as fast for athlete's foot.  Lamisil Once can be applied quickly and easily onto the affected areas and its gentle formula quickly eases the irritation caused by the tinea pedis fungal infection.

  • Where else can I use Lamisil Once?

    Lamisil Once is for external use only and should therefore only be applied to the outside of the body. Washing your hands thoroughly after application is an important procedure, as not doing so could bring about infecting other parts of your body. Never apply Lamisil Once near your eyes or even touch your eyes, whilst the cream is still on your hands. Should the cream somehow enter your eyes, rinse them thoroughly with clean running water and, if irritation occurs, see your doctor immediately.

  • Is there anything else I can do to support the treatment of the athlete’s foot?

    Wash your feet and body regularly during the day and be sure to dry yourself well afterwards. Infection can also spread to towels, wash clothes and sponges, bed linen and personal clothing, during the treatment period, so change these regularly.  Also, avoid scratching the affected area, as this could transfer the infection to your hands.

  • Once opened, how long does Lamisil Once last?

    The quantity in each tube is measured for a single application and so contains just enough cream for both feet.

  • How often should Lamisil Once be applied?

    As its name states, Lamisil Once® need be applied just once as, if applied correctly and to both feet, terbinafine, the active ingredient in Lamisil Once®stays in the skin, and continues fighting the infection, for up to thirteen days.

  • After applying Lamisil Once, when can I take my next shower?

    For maximum effectiveness, your feet need to remain dry for twenty four hours, which is why you shouldn’t shower before this set time, or indeed involve yourself in any activities which could cause dampness to your feet e.g. any water sports.

  • There are other Lamisil products, so how is Lamisil Once different?

    Other Lamisil® products require seven days of application for treating athlete's foot. Also, other Lamisilproducts treat other fungal conditions e.g. jock itch and ringworm. As a one day only treatment, Lamisil Once® is recommended for athlete's foot (tinea between the toes) only.

  • Why does Lamisil Once need only one application? 

    Once applied, Lamisil Once® produces a glove-like film which attaches itself to the toes, a film so adhesive, that it doesn’t wash off, even if you use soap and water. This gives terbinafine, the active ingredient, around thirteen days to be absorbed into the foot, before the film finally wears off.

  • When will Lamisil Once make me free from infection?

    The infection should clear within thirteen days, though damaged skin can take up to a month to heal.

  • Should I take precautions when using Lamisil Once?

    Lamisil Once® is to be used only by people over the age of eighteen and so kept out of the reach of children.    Breast-feeding mothers should not use it and users must make sure the cream does not come into contact with their eyes. Should you suffer any reaction when using Lamisil Once®, contact your doctor, so as to ascertain whether you may be allergic to any ingredients.  Also, when Lamisil Once has been applied, do not put on socks or shoes, until it has been left to dry for at least a couple of minutes, having allowed it time to make that glove-like film which works at removing the infection.

  • Is athlete’s foot likely to re-occur?

    Lamisil Once gives protection for up to three months after application. In order to prevent another infection, you need to air your feet properly and keep them fresh and clean at all times.  Be diligent about any sweating or moisture on your feet and between your toes, to keep any new infection from re-occurring. 

  • Should I go straight for Lamisil Once, or first try a different Lamisil product?

    Lamisil Once® is specific to athlete's foot and is the Lamisil product that an Express Chemist would recommend for this particular fungal condition. That’s because it’s very easy to use and requires just one single application. However, you could also use Lamisil AT, as it contains the same active ingredient, though you would need to apply it every day.

  • What do I do if Lamisil Once fails to work?

    If, when applied correctly, Lamisil Once® doesn’t seem to clear the infection of athlete’s foot, speak with your doctor, as you may have a different fungal infection, or there could be a deeper underlying condition.

  • What is the right amount of Lamisil Once cream to apply?

    Apply the whole tube as, once it is open, it is not designed for keeping.  Remember to apply Lamisil Once® to both feet, or you run the risk of maybe not truly clearing the infection.  In around eighty percent of cases, both feet fall to this infection and so it is important that you apply Lamisil Once® to the whole of both feet.  This should use up all of the cream in the tube.

Authored By:

A photo of  Andy Boysan

Andy Boysan


Published on: 20-09-2016

Last modified on: 14-10-2020

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

Reviewed By:

A photo of Dr Donald Grant

Dr Donald Grant

MB ChB DRCOG MRCGP Dip.orth.med

Reviewed on: 14-10-2020

Next review date: 14-10-2022

Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy

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