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Lamisil Once

Lamisil Once (4g)

Order before 3pm for delivery from Sat. 26 Sep.

Description for Lamisil Once

Lamisil Once is a powerful treatment for athlete's foot which requires just one single application. The unique formula penetrates the skin and targets the fungus, continuing to work for days on end until it is eliminated, after just one application. It is a rich soothing cream with a moisturising content which helps very inflamed, dry or cracked skin.

Product Information

  • Age: 18 years +

    Maximum per order: N/A

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Lamisil Once - Requiring just one application, and continuing to work until its target is eliminated, Lamisil Once® has proved to be a powerful cream for the treatment of athlete’s foot.   This uniquely rich and soothing cream not only moisturises but also penetrates the skin, working on the dry or cracked areas which have become inflamed.

Containing the active ingredient known as terbinafine hydrochloride, this cutaneous solution eliminates fungal infections and yeasts by stopping the production of ergosterol, a substance which is an important component of cell membranes. Lack of ergosterol causes holes to develop in the cell membranes, leading to essential contents of the cells leaking out and unwanted, as well as toxic, compounds entering. It is via these perforations to the cell membrane that allows terbinafine to clear up the infection. As a treatment for athlete’s foot (also known as tinea pedis), Lamisil Once® is readily available in pharmacies.

Before applying the solution, you should wash and dry both hands and feet. Even if only one foot appears to be affected, or some skin appears to be unaffected by fungus, take the safeguard of applying Lamisil Once cream to both feet, to be sure that all chances of the existence of fungus have been eliminated. Applying the Lamisil Once both on and between the toes is a good starting point, then move on to covering the sides, top of the foot and also the sole. When finished, the cream should still be visible on the skin, rather than massaged until it has disappeared.   Once you have reached this point, feel free to wash your hands but leave Lamisil Once in place on your feet for at least twenty four hours. Showering or bathing could be the ideal time to apply Lamisil Once, allowing the cream to do its work until next day at the same time. In the meantime, keep your feet as dry as possible and consider using Daktarin Activ fungal powder to dry off any moisture caused through sweating, or any other situation which may lead to moist feet.

Terbinafine itself is known to stop the spread of athlete’s foot better and, indeed, more quickly, than other anti-fungal treatments and provides long lasting protection. 

Pharmacist Tip

Lamisil Once offers a convenient alternative to treating with some other creams, as others may need to be applied twice daily for a week or more.

Lamisil Once is a powerful treatment for athlete’s foot which requires just one single application. 

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Adults, including the elderly and children 18 years and over:

  • Lamisil Once should be spread quickly and evenly over the whole of both feet and not massaged into the skin.
  • No second application is needed and so the whole content of the tube should be used in this first and only application.
  • Lamisil Once® should dry into a colourless film within two minutes.
  • When you are satisfied that you have successfully applied the cream, wash your hands thoroughly.
  • Only wear socks and shoes when the film has dried.
  • Discard what should now be an empty tube as, once opened, the tube will no longer be effective at a later date
  • Do not share a tube of Lamisil Once with other people, as the quantity is designed for one use only and sharing could cause cross-infection.
  • The film on your feet will continue working for up to thirteen days from that one application.
  • Improvement should be noticeable within four days, though it could take Lamisil Once up to four weeks to completely rid your feet of the infection. 

Not everyone will experience side effects when they take medication, however if you do they can include:

Skin exfoliation, itching at site of application, dry skin.

If you are concerned about these effects, or if the product affects you in any other way, stop using it and talk to your doctor or pharmacist.

The active ingredients contained in this medicine is/are:

Terbinafine Hydrochloride.

The medicine also contains the following inactive ingredients to make up the complete product:

Acrylates / octylacrylamide copolymer, hydroxypropyl cellulose, triglycerides and ethanol.

To be sure you are choosing an appropriate product, take into practice the following warnings:

If allergic to any ingredient stated in the product information leaflet or on the packaging, do not use Lamisil Once.

Take care with Lamisil Once:

  • Do not use this cream on children or adolescents under 18, since there is insufficient experience of its use on minors.
  • If you have long-term or recurring fungal infections on the soles and / or heels of your feet, which lead to flaky or thickened skin, do not use Lamisil Once. Instead, report this condition to your doctor, who may prescribe a different medicine or treatment.

Never use this cream on any skin other than on your feet. If the cream enters your eyes, or is absorbed into an abrasion, it may cause irritation. In the case of open lesions (cuts), the alcohol content of Lamisil Once could cause irritation. In the case of your eyes, rinse thoroughly with clean running water. Should the irritation persist, consult your doctor.

Lamisil Once is for external use only and should never be swallowed.

Keep safely away from naked flames, as Lamisil Once contains an element of alcohol.

When using Lamisil Once on your feet, do not use any other medicine (prescription or non-prescription) or treatment. Before purchase of Lamisil Once, discuss any medication recently taken, including both prescription and non-prescription items, with your doctor or pharmacist.

Breast-feeding mothers must not use Lamisil Once, as the active ingredient of terbinafine will be present in breast milk.

Please read the product information leaflet, as well as any packaging details, before using any new medication and always inform your doctor of other medications you take or may soon take.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 3 - 5 day delivery - £2.95
  • Express Tracked Delivery - 1 - 3 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Athlete's Foot?

Visit our advice area or contact our support team

Lamisil Once Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What is Lamisil Once used for?

    It is an active anti-fungal cream which fights a condition known as athlete's foot (also called tinea pedis).

  • Why should I apply cream to both feet, if only one foot appears to be infected?

    While it may appear that only one foot is infected, the majority of people find that not treating both feet causes re-infection so, as directed, use Lamisil Once on both feet.

  • Only my toes are infected, so why do I need to apply the cream all over my feet?

    Though you don’t yet seem to be experiencing the symptoms all over both feet, athlete’s foot could have already started to infect what appears to be clear skin.  Treating only the visibly affected areas could mean that the fungal infection may not be fully eliminated, allowing the easy spread or return of the condition.  To prevent re-infection, always apply Lamisil Once® as professionally directed.

  • Why choose Lamisil Once?

    No other treatment is as fast for athlete's foot.  Lamisil Once can be applied quickly and easily onto the affected areas and its gentle formula quickly eases the irritation caused by the tinea pedis fungal infection.

  • Where else can I use Lamisil Once?

    Lamisil Once is for external use only and should therefore only be applied to the outside of the body. Washing your hands thoroughly after application is an important procedure, as not doing so could bring about infecting other parts of your body. Never apply Lamisil Once near your eyes or even touch your eyes, whilst the cream is still on your hands. Should the cream somehow enter your eyes, rinse them thoroughly with clean running water and, if irritation occurs, see your doctor immediately.

  • Is there anything else I can do to support the treatment of the athlete’s foot?

    Wash your feet and body regularly during the day and be sure to dry yourself well afterwards. Infection can also spread to towels, wash clothes and sponges, bed linen and personal clothing, during the treatment period, so change these regularly.  Also, avoid scratching the affected area, as this could transfer the infection to your hands.

  • Once opened, how long does Lamisil Once last?

    The quantity in each tube is measured for a single application and so contains just enough cream for both feet.

  • How often should Lamisil Once be applied?

    As its name states, Lamisil Once® need be applied just once as, if applied correctly and to both feet, terbinafine, the active ingredient in Lamisil Once®stays in the skin, and continues fighting the infection, for up to thirteen days.

  • After applying Lamisil Once, when can I take my next shower?

    For maximum effectiveness, your feet need to remain dry for twenty four hours, which is why you shouldn’t shower before this set time, or indeed involve yourself in any activities which could cause dampness to your feet e.g. any water sports.

  • There are other Lamisil products, so how is Lamisil Once different?

    Other Lamisil® products require seven days of application for treating athlete's foot. Also, other Lamisilproducts treat other fungal conditions e.g. jock itch and ringworm. As a one day only treatment, Lamisil Once® is recommended for athlete's foot (tinea between the toes) only.

  • Why does Lamisil Once need only one application? 

    Once applied, Lamisil Once® produces a glove-like film which attaches itself to the toes, a film so adhesive, that it doesn’t wash off, even if you use soap and water. This gives terbinafine, the active ingredient, around thirteen days to be absorbed into the foot, before the film finally wears off.

  • When will Lamisil Once make me free from infection?

    The infection should clear within thirteen days, though damaged skin can take up to a month to heal.

  • Should I take precautions when using Lamisil Once?

    Lamisil Once® is to be used only by people over the age of eighteen and so kept out of the reach of children.    Breast-feeding mothers should not use it and users must make sure the cream does not come into contact with their eyes. Should you suffer any reaction when using Lamisil Once®, contact your doctor, so as to ascertain whether you may be allergic to any ingredients.  Also, when Lamisil Once has been applied, do not put on socks or shoes, until it has been left to dry for at least a couple of minutes, having allowed it time to make that glove-like film which works at removing the infection.

  • Is athlete’s foot likely to re-occur?

    Lamisil Once gives protection for up to three months after application. In order to prevent another infection, you need to air your feet properly and keep them fresh and clean at all times.  Be diligent about any sweating or moisture on your feet and between your toes, to keep any new infection from re-occurring. 

  • Should I go straight for Lamisil Once, or first try a different Lamisil product?

    Lamisil Once® is specific to athlete's foot and is the Lamisil product that an Express Chemist would recommend for this particular fungal condition. That’s because it’s very easy to use and requires just one single application. However, you could also use Lamisil AT, as it contains the same active ingredient, though you would need to apply it every day.

  • What do I do if Lamisil Once fails to work?

    If, when applied correctly, Lamisil Once® doesn’t seem to clear the infection of athlete’s foot, speak with your doctor, as you may have a different fungal infection, or there could be a deeper underlying condition.

  • What is the right amount of Lamisil Once cream to apply?

    Apply the whole tube as, once it is open, it is not designed for keeping.  Remember to apply Lamisil Once® to both feet, or you run the risk of maybe not truly clearing the infection.  In around eighty percent of cases, both feet fall to this infection and so it is important that you apply Lamisil Once® to the whole of both feet.  This should use up all of the cream in the tube.

Authored By:

A photo of  Andy Boysan

Andy Boysan


Published on: 20-09-2016

Last modified on: 20-09-2018

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

Reviewed By:

A photo of Dr Donald Grant

Dr Donald Grant

MB ChB DRCOG MRCGP Dip.orth.med

Reviewed on: 20-09-2020

Next review date: 20-09-2022

Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy

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