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Trimethoprim 200mg Tablets

Trimethoprim 200mg Tablets (6 tablets)

Order before 3pm for delivery from Tue. 22 Jun and Wed. 23 Jun.

Trimethoprim for Cystitis

Trimethoprim 200mg tablets are available to order from The Independent Pharmacy, following a free consultation, for the treatment of simple cystitis in women. Your consultation will be reviewed by one of our medical team and you treatment can be dispatched for delivery as soon as the next working day. To find out more about cystitis and see all the UTI treatments that are available to order, see our Cystitis page.

Taking a three day course of Trimethoprim will clear most bladder and urinary tract infections. However, if your symptoms have not improved once you have completed your medication, you should seek advice from your GP.

Trimethoprim Information

  • Age: 18 years +

    Maximum per order: 1

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Trimethoprim?

Trimethoprim is an antibiotic used to treat bladder (cystitis) and urinary tract infections (UTIs). It is included on the World Health Organisation's List of Essential Medicines.

Trimethoprim 200mg tablets are antibiotics that are mainly prescribed to treat urinary tract infections (also known as UTIs, cystitis, bladder infections or water infections). Trimethoprim is an effective antibiotic at treating cystitis. In some regions of the UK there is increasing resistance to this antibiotic and as a result you may have been treated before with another medication called nitrofurantoin. You may have found that nitrofurantoin is unsuitable to you and caused side effects, in which case trimethoprim is a suitable choice to treat your UTI.


How do I get a bladder or urinary tract infection?

UTIs can be painful and upsetting, but they are easy to treat. Some women are more prone to them than others, and there are some lifestyle changes that you may want to look into if it’s a recurring problem. It’s important to take care of your vaginal and sexual health as there may be repercussions when it comes to intimacy, relationships, and fertility. You can read more about the prevention of cystitis on our advice page.

Most cases of cystitis or UTIs are caused by E.coli, which originates in your gut. Trimethoprim does not kill E.coli. Instead, it stops bacterial DNA synthesis, meaning that the bacteria cannot replicate. This allows your immune system to destroy the infecting bacteria until they are eradicated and your infection is resolved.


How do I take Trimethoprim 200mg tablets?

The NHS advises that, for most uncomplicated cases of cystitis, Trimethoprim 200mg tablets should be taken twice daily, one dosage every 12 hours until the prescribed course is complete. This is normally a three day course for uncomplicated cystitis, however it can also be prescribed as a seven day course. NHS guidance states that your doctor may recommend your first dosage is doubled to 400mg - this is normally only if your symptoms are severe. You should start taking Trimethoprim as soon as you feel the onset of cystitis symptoms.

There are other antibiotics your doctor may feel are more suited to you — these include nitrofurantoin, quinolones, or amoxicillin. Speak to your prescriber to find out more about treating UTIs with antibiotics


Interaction with food, alcohol, and other UTI medications 

Trimethoprim is not affected by food or alcohol, with neither causing a resistance or reaction if you consume them while taking your prescription. This means there is no need to alter your diet whilst taking Trimethoprim. 

Trimethoprim can be safely taken with other over-the-counter cystitis treatments available, such as Cymalon & Cystopurin, which help to reduce the acidity of the urine. You can also take simple painkillers such as Paracetamol and Ibuprofen, alongside Trimethoprim with no problems. Taking Trimethoprim will also not stop your birth control medication (contraceptive pill) from working. 


Trimethoprim dosage and resistance 

Your symptoms will normally improve within 24 - 48 hours of taking Trimethoprim 200mg medication. You should always complete the course, even if you feel better. If your prescribed Trimethoprim 200mg capsules have not improved your symptoms, and you are still feeling the effects of your urinary tract infection, after the three-day course, you should see your doctor. This may suggest that your UTI is resistant to Trimethoprim and requires a different UTI antibiotic, such as the first-line UTI antibiotic called Macrobid, or that your symptoms are caused by something other than a bacterial infection, which requires investigation.

Trimethoprim can also be used to prevent cystitis at a dose of 100mg at night. You would need to see your doctor to discuss recurrent bouts of cystitis to see if Trimethoprim 100mg tablets are suitable for you.


Non-prescription alternatives to Trimethoprim

Effective relief from the symptoms of cystitis, Cymalon sachets are some of the most popular cystitis remedies in the UK. Cymalon sachets contain sodium citrate, which helps to neutralise urine acidity during an attack of cystitis, providing welcome relief from the burning pain and irritation. Keep them in the bathroom for easy access when first symptoms show.

It is important to drink plenty of fluids when you are suffering from cystitis to help flush the bacteria through your system. It is also important to keep hydrated to prevent cystitis recurring.



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Trimethoprim dose for UTI

  • Take one Trimethoprim 200mg tablet twice daily, roughly 12 hours apart.
  • You should always continue the course until it is complete unless otherwise directed by a doctor.
  • You should start taking Trimethoprim 200mg tablets as soon as you recognize the symptoms from cystitis that has previously been diagnosed by your GP.
  • You should see your GP if no improvement in your symptoms once the course is complete.

If you notice blood in your urine, or suffer with fever, chills, back pain, or vomiting your infection may be more serious and you should see your GP as soon as possible.

If you find that you have suffered with cystitis more than 3 times in one year you should see your GP for an investigation into the cause of your recurrent infections.

Trimethoprim side effects

It is possible that you may be allergic to Trimethoprim. If you know you are allergic to Trimethoprim or have suffered a reaction previously do not take Trimethoprim and discuss alternatives with your GP.

Trimethoprim has a small risk of nausea, vomiting, diarrhoea, and skin rash as with all medicines. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects.

If you experience any adverse effects from taking Trimethoprim 200mg tablets it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 03322 00519. In a medical emergency you should contact the emergency services or go straight to your local Accident & Emergency.

You should read the patient information leaflet in full before taking Trimethoprim.

Trimethoprim ingredients

Your treatment contains 200mg of Trimethoprim per tablet.


Trimethoprim warnings

Please ensure that you read the Patient Information Leaflet enclosed with your treatment.

You should not use trimethoprim in the following circumstances:

  • You are allergic to trimethoprim
  • You have liver or kidney problems
  • You have folate deficiency
  • You have hyperkalaemia
  • You have galactose intolerance, total lactase deficiency or glucose-galactose malabsorption


Trimethoprim and other medicines

Trimethoprim 200mg tablets should not cause a harmful interaction with any of your other current medicines. However, it should not be taken if you currently take any of the following:

ACE inhibitors (such as ramipril), azathioprine, cyclosporin, dapsone, digoxin, eplerenone, heparin, mercaptopurine, methotrexate, phenytoin, procainamide, pyrimethamine, repaglinide, rifampicin, or warfarin.


Trimethoprim in pregnancy and breastfeeding

Trimethoprim should not be used during pregnancy and should only be used under the specific advice of your doctor during breastfeeding.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Cystitis (UTI)?

Visit our advice area or contact our support team

Trimethoprim 200mg Tablets Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What is Trimethoprim and what does it contain?

    Trimethoprim tablets contain trimethoprim 200mg per tablet.

    It is an antibiotic that helps to kill the bacteria that cause a number of infections including cystitis (also known as a water infection) or urinary tract infections. It is only available on prescription after a consultation with a Doctor. This can be done online.

    It is the antibiotic of choice for Doctors and is effective in 90% of urine infections.

  • How does it work?

    Bacteria cells need to produce their own DNA when they multiply. Trimethoprim blocks this process and stops them reproducing. The remaining bacterial cells are killed of by the body’s immune system.

    As 80% of trimethoprim is excreted in the urine, this makes it very useful for treating bladder and urine infections, as its in high concentration where it is needed.

  • What’s the difference between Trimethoprim, Cymalon, Cystopurin, and other products you can buy over the counter?

    Trimethoprim is an antibiotic that kills the bacteria that is causing the infection.

    Other over the counter remedies like Cymalon, Cystopurin and Canesten Oasis, neutralise the acidity of the urine. It helps to reduce the burning, pain on urination and changes the acidic environment of the bladder making it harder for the bacteria to survive.

    Trimethoprim and over-the-counter remedies can be taken together. Cymalon and other over the counter remedies will help to make the urine less acidic and ease discomfort whilst the antibiotics have a chance to take effect.

  • How should my Trimethoprim prescription be taken?

    In adults, the dose of Trimethoprim is one tablet twice daily, in the morning and evening for three days.

    You should not take more than two Trimethoprim tablets in a 24-hour period.

    Finish the course of antibiotics - take all the tablets even if you start to feel better.

  • How long will it take to work?

    Symptoms should start to ease within 24 hours and should have gone after 3 days of treatment. If you still have symptoms after this time or they become worse then you need to see a doctor face to face.

  • What’s the difference between Trimethoprim and other antibiotics?

    Not all antibiotics can be used to treat the same infection. They work in different ways and some work on certain bacteria whilst others don’t.

    Trimethoprim is excreted mostly in the urine which means its in high concentration where it is needed and is very effective against bacteria that cause urine infections.

  • Is it safe to use Trimethoprim continuously?

    If you are getting recurrent urine infections it is worth visiting your doctor so they can send a urine sample away for analysis and ensure there is no underlying cause for concern. For this reason we do not recommend you use trimethoprim regularly without speaking to your doctor.

  • How effective is it?

    Trimethoprim is the number one choice for Doctors for treating of Urinary Tract Infections and is effective 90% of the time.

  • What are the side effects of Trimethoprim?

    As most courses of treatment are short (ranging from 3-5 days), most women do not suffer form any side effects at all. The most common unwanted effects are gastro intestinal, like diarrhoea, nausea, vomiting and a rash.

    If a rash occurs then stop taking the tablets and see your doctor.

  • Forgotten to take a tablet - here’s what to do

    If you have forgotten to take a tablet, take one when you remember or if more than 24 hours has past, take the next tablet/capsule at the right time. Do not double up and take twice the dose.

    Its important to take the tablets regularly and as the course is only for 3 days, it missing tablets could prolong the infection.

    Taking first thing in the morning and last thing at night can help to remember or setting an alarm on your phone can also act as a prompt.

  • Trimethoprim should be used with caution in these patients.

    You should not take trimethoprim if you have:

    The following indicate that the infection is no longer located in just in the bladder and may have progressed. If you have nay of the following you should see a doctor straight away

    • Back pain – this may show the infection has now spread to the kidney(s)
    • Fever, high temperature, shivering, hot and cold sensations
    • Nausea, sickness and loss of appetite
    • Flu like symptoms 
  • Trimethoprim and other medication?

    If you are taking or have recently taken any of the following then you need to tell us in your consultation before you take trimethoprim tablets.

    • Any other antibiotics
    • Blood thinners like warfarin
    • Medicines to prevent organ transplantation rejection like ciclosporin
    • Heart medication like digoxin
    • Epilepsy medication like phenytoin
    • Malaria treatments like pyrimethamine
  • Alcohol and Trimethoprim?

    Unlike some antibiotics which can cause you to be sick and feel nausesous

    Trimethoprim is not affected by alcohol.

    It is important to remember that trimethoprim is a diuretic and it will flush the antibiotic out of your system quicker than usual making the treatment less likely to be effective.. It best to drink in moderation.

  • Why can I only buy one course of Trimethoprim online at one time?

    Trimethoprim is an prescription-only antibiotic. For that reason, to ensure the safety of our patients and the legal operating of our pharmacy, we only supply a maximum of one course of treatment at one time. In addition, due to the need for a physical check-up if you are suffering with regular attacks of cystitis and the risk of bacterial resistance to antibiotics over time, our online prescribers will judge each case for the consultation notes and offer treatment and/or advice as appropriate.

  • Should I take Trimethoprim with food?

    There are no specific instructions on whether you need to take Trimethoprim with food or not, however it should be taken with plenty of water.

  • Is Trimethoprim available for next day delivery?

    Yes, we understand that sometimes you want to get your treatment as soon as possible. If ordered before 4pm Monday to Friday, Trimethoprim tablets are available for next day delivery.

  • Is it safe to buy Trimethoprim tablets online?

    Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Trimethoprim online. The Independent Pharmacy is an NHS Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine prescription treatments through our Online Pharmacy & Online Doctor. Our online prescribers always review your consultations thoroughly to ensure that your treatment is as safe and effective as possible.

  • How do I buy Trimethoprim online?

    It's simple!

    Just select 'Order Now' above, you will need to fill in a simple health questionnaire so our GP's & Pharmacists can ensure it is safe for us to supply your Trimethoprim to you. It all takes around 3 minutes and your treatment can be delivered to your door.

  • What are the advantages of buying Trimethoprim online?

    There are many advantages to buying Trimethoprim capsules online, some include:

    It's quick & easy- there is no need to spend time at the doctor or pharmacy.

    Fast delivery- We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.

    Great prices- we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.

    Tons of information - we provide all the information you could need on Trimethoprim and other cystitis treatments, in easy to digest formats, at a time to suit you.

  • Will it stop my contraceptive pill from working?

    Trimethoprim will not stop your contraceptive pill (combined or progesterone only) from working. Only two antibiotics called rifamapacin and rifabutin will reduce the effectiveness the contraceptive pill.

  • What happens if it doesn’t work?

    Trimethoprim is effective in 90% of cases and you should start to see a reduction in symptoms within 24 hours. If the symptoms have not reduced or got any better with 48 hours then you would need to see a doctor face to face.

    They will take a urine sample and send it off for analysis, (it usually takes 2 days for the results to come back). They would then prescribe a specific antibiotic to your infection depending on the results.

    Whilst you are waiting for the results the Doctor may prescribe another antibiotic like ciprofloxacin, norfloxacin, ofloxacin, co-amoxiclav or nitrofurantoin.

  • Can you take painkillers whilst being treated with Trimethoprim?

    You can take trimethoprim safely with any over the counter painkillers like aspirin, ibuprofen or paracetamol.

  • Can you treat cystitis in men online?

    Cystitis is the inflammation of the urinary tract including the bladder. The bacteria move slowly up the urethra and multiply and this causes the burning, urgency and other cystitis symptoms.

    The urethra is the tube that links the bladder to the outside world.

    This tube is a lot longer in men than it is in women and makes it unlikely for men to suffer from cystitis. Therefore if you are a man suffering from cystitis symptoms you need to see a Doctor for a check up as the infection can be more serious. The doctor will need to rule out enlarged or infected prostate possibility of a blockage or tumours. This applies not only to Trimethoprim but also to over the counter medicines as well.

  • Can I have a course of antibiotics as a backup?

    Some women are prone to recurrent urinary tract infections and after visiting their Doctor they know the symptoms. Under these circumstances it is acceptable to have a small course of Trimethoprim at hand so you can treat an infection quickly. You would need to see your GP to get antibiotics to keep in case you get a UTI - we are only able to treat current cystitis online.

  • Will Trimethoprim give you thrush?

    All antibiotics including Trimethoprim reduce the bacteria in the body. After a course of antibiotics the bacteria in the vagina can be greatly reduced and this can cause the naturally occurring fungus to overgrow leading to thrush symptoms. Treatment is simple and varies from a capsule you swallow to a short course of creams or pessaries you apply.

  • Does cranberry juice help treat cystitis?

    It is thought that cranberry juice, extract or containing products stop the bacteria binding to the wall of the bladder. The jury is still out on this even though there are some studies to show it is effective. However, current UK guidelines says that cranberry juice doesn’t treat the symptoms or cure cystitis.

  • Can you take Trimethoprim if you are pregnant?

    While it is safe to take Trimethoprim alongside birth control medication, it has been linked with causing problems to unborn babies if taken during the first 12 weeks of pregnancy. This is because Trimethoprim lowers the levels of folic acid in your bloodstream. If you need cystitis treatment during pregnancy, always see your GP to ensure that your treatment is safe and effective.

  • Can I take Trimethoprim for chest infections?

    Trimethoprim is occasionally used to treat chest infections and other bacterial infections. As these can be caused by many different bacteria that are treated with different antibiotics, if you have a chest infection you should always see your GP for the most effective treatment.

  • Can I take Trimethoprim for kidney infections?

    Trimethoprim is one of the antibiotics that can be used to treat kidney infections. However, this will depend on the state of your kidneys and the severity of your infection, as the use of Trimethoprim is cautioned among those with impaired kidneys. If you have a kidney infection, it is important to see your GP as soon as possible.

    You can find the symptoms of a kidney infection on NHS Choices.

  • How long should I take Trimethoprim?

    For straightforward infections, women will normally take Trimethoprim for three days, while men and pregnant women will take it for 14 days (if their GP thinks it is suitable).

    However, depending on the severity and frequency of your infection(s), you may be required to take a course of treatment for much longer.

  • How long does Trimethoprim stay in my system?

    Trimethoprim will typically remain in your system for 24-48 hours after your last tablet or capsule.

Authored By:

A photo of  Scott McDougall

Scott McDougall


Published on: 02-02-2017

Last modified on: 26-01-2021

Scott is one of the two founders of The Independent Pharmacy. He is a registered pharmacist and the registered manager of our service with the CQC.

Reviewed By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Reviewed on: 26-01-2021

Next review date: 26-01-2023

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

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