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Novofem (84 tablets)

Order before 3pm for delivery from Tue. 22 Jun and Wed. 23 Jun.

Novofem HRT

Novofem is a Hormone Replacement Therapy (HRT) suitable for postmenopausal women. Taking Novofem can help women find some relief from symptoms of the menopause and prevent osteoporosis. 

Novofem can be purchased as a repeat prescription online at The Independent Pharmacy for women who have previously been prescribed it by their GP or specialist and continue to keep their regular reviews up to date. 

Novofem Information

  • Age: 18 years +

    Maximum per order: 1

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Novofem?

Novofem tablets are a combined sequential form of HRT, used to treat symptoms of menopause and prevent osteoporosis in women who have an intact uterus but have not had a natural period in the last 6 months.

Combined, sequential HRT treatments are taken everyday without a break. They contain two active ingredients which relieve menopausal symptoms by imitating the two female sex hormones estrogen and progesterone.


What is Novofem used for?

During the menopause, the estrogen levels in a woman's body drop, which can cause women to experience some unwanted symptoms. Taking Novofem can help to alleviate these symptoms to help you to continue to enjoy your daily life.

Menopause symptoms include:

  • Hot flushes & night sweats
  • Disturbed sleep
  • Reduced sex drive
  • Difficulty remembering or concentrating
  • Vaginal dryness
  • Headaches
  • Low mood or anxiety
  • Fragile bones (osteoporosis)


How does Novofem work?

Novofem contains both red and white tablets which contain two ingredients that act in the same way as your naturally occurring sex hormones, estrogen and progesterone. 

The first ingredient contained in both the red and white tablets is estradiol which is an identical form of estrogen that is produced naturally by the ovaries of women. The white Novofem tablets also contain the substance Norethisterone acetate, which is a synthetic form of progesterone.

Novofem works in the same way as other combined, sequential HRT and uses these two ingredients to mimic the natural menstrual cycle of premenopausal women to alleviate symptoms.

For the first 16 days of each pack of Novofem you will need to take a red tablet that just contains estradiol. In the next 12 days you will take a white tablet that contains both estradiol and norethisterone acetate. Most women will experience a monthly bleed at the beginning of each new pack.


Novofem and weight gain

Although Novofem, like other HRT, has been reported to cause weight gain in some people, the evidence suggests that this is more likely to be fluid retention and bloating rather than true weight gain.

During the menopause generally it is not uncommon for women to gain weight, especially around their abdomen. It is thought that this is partly due to the imbalance in hormones but is also a natural part of ageing for both males and females as you start to lose muscle mass and your metabolism slows.

Most importantly for both men and women, it is therefore essential that you always try to get enough sleep, eat healthily and exercise regularly as you get older to reduce unwanted weight gain. 


Novofem and depression

A more commonly reported symptom of menopausal women is experiencing low mood. Although some women have reported to feel depressed while taking Novofem more often, taking HRT can help to alleviate feelings of both depression and anxiety.

If you are taking Novofem tablets and are suffering with low mood, anxiety or depression it is important that you speak to a doctor or nurse about how you are feeling so they can advise you appropriately about possible support.


Novofem vs Elleste Duet

Elleste Duet tablets are also a combined, sequential HRT and are produced as either 1mg or 2mg of the hormone estradiol. 

Elleste Duet is currently unavailable to purchase from The Independent Pharmacy due to a nationwide shortage caused by a manufacturing delay. 

Novofem is the recognised alternative to Elleste Duet 1mg tablets. If you are currently prescribed Elleste Duet 2mg tablets then Kliofem 2mg/1mg tablets are an equivalent alternative treatment. 

If you have concerns about the current Elleste Duet shortage you should discuss treatment options with your doctor.



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Novofem dosage

You should try to take Novofem at the same time each day with a glass of water. 

Days 1 - 16: Take 1 red tablet once a day

Days 17 - 28: Take 1 white tablet once a day

Before taking Novofem please ensure that you have read the Patient Information Leaflet thoroughly. 

Novofem tablets are for oral use only and should only be taken by women with a uterus. 

You should take Novofem continuously without a break. Once you have finished your pack, start a new pack the next day.

Novofem side effects

Novofem, like other medication, may cause some people to experience side effects.

If you experience severe side effects or an allergic reaction when taking Novofem, you must seek medical advice or attend your nearest emergency department as soon as possible. 

If you are concerned about side effects or they are bothering you, please speak to a pharmacist or doctor for advice.

Please ensure that you have read the full list of reported side effects in the Patient Information Leaflet before starting treatment using Novofem.

You should also take time to familiarise yourself with all the warnings and precautions as Novofem, like other HRT, may increase your chances of getting certain health conditions. You should discuss any questions you have with your doctor before taking this medicine.

The most commonly reported side effects associated with Novofem are:

  • Headache and migraines
  • Breast tenderness
  • Vaginal thrush & vaginal bleeding
  • Dizziness & sleeplessness
  • Indigestion, abdominal pain, wind
  • Nausea & vomiting
  • Rashes & itching
  • Swelling of the hands, ankles and feet & muscle cramps
  • Weight gain
  • Changes in libido 
  • Hair loss
  • Muscle cramps
  • Depression

Novofem ingredients

The active ingredients in Novofem: 

  • Each red tablet contains 1mg of estradiol 1 mg
  • Each white tablet contains 1mg of estradiol 1 mg and 1mg of norethisterone acetate

The inactive ingredients include: lactose monohydrate, maize starch, magnesium stearate.
titanium dioxide (E171), propylene glycol and red iron oxide (E172).

For a full list of ingredients included in Novofem tablets, please read the Patient Information Leaflet.

Novofem warnings

Please read the full information regarding warnings and precautions detailed in the Patient Information Leaflet before taking Novofem. 

Using any HRT treatment, including Novofem, carries risks. You should take time to consider whether you would like to take HRT or if you want to continue taking it. If you have any questions or concerns you should discuss these with your GP or specialist. 

Being eligible to get Novofem on repeat prescription from The Independent Pharmacy is reliant on you continuing to see your doctor for a check-up at least once a year, this must include a breast screen, blood pressure and blood tests and a cervical smear test. 

If you experience any of the following, before or while using Novofem, stop taking and consult your doctor immediately:

  • You suspect or develop breast or endometrial cancer
  • You have any unexplained vaginal bleeding or endometrial hyperplasia
  • You have or have ever had a venous blood clot or have a clotting disorder
  • You have had a heart attack, stroke or angina

If you have ever experienced any of the following, consult your doctor before starting Novofem and again if your condition worsens during treatment:

  • You have recently stopped taking or are currently taking any other prescribed or non-prescribed (including herbal) medication.
  • Uterine fibroids
  • Endometriosis or endometrial hyperplasia
  • High blood pressure or very high levels of fat in your blood
  • Liver, kidney or heart disorders
  • Diabetes, SLE, epilepsy or asthma
  • Gallstones
  • Migraine or severe headaches
  • Hypothyroidism 
  • Hereditary angioedema


Novofem and cancer

Research has highlighted that taking a combined estrogen-progestogen HRT such as Novofem can increase your risk of developing breast cancer and slightly increase your risk of developing ovarian cancer. 

This risk of developing breast cancer appears to increase the longer you take HRT but does return to normal up to 5 years after stopping treatment. For this reason it is recommended that you only take HRT for the shortest amount of time to manage your symptoms. 


Novofem and your circulation

Taking any form of HRT makes you 3 times more likely to experience blood clots and 1.5 times more likely to experience a stroke. If you think you are developing symptoms of a blood clot at any time call NHS 111 or are having a stroke call 999.


Novofem in pregnancy & breastfeeding

Novofem is only suitable in postmenopausal women and is not a contraceptive. If you have had a menstrual period in the last 12 months or are under 50 years old you should discuss contraception with your doctor before taking Novofem. 

If you become pregnant while taking Novofem stop taking it straight away and contact your doctor. You should also not take Novofem while breastfeeding.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Menopause (HRT)?

Visit our advice area or contact our support team

Novofem Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Authored By:

A photo of  Andy Boysan

Andy Boysan


Published on: 27-10-2020

Last modified on: 27-10-2020

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

Reviewed By:

A photo of  Steve Stoddart

Steve Stoddart

BPharm IP

Reviewed on: 27-10-2020

Next review date: 27-10-2022

Steve is an expert clinical pharmacist that has recently added prescribing to his repertoire.

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