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Naprosyn 500mg EC tablets

Naprosyn 250mg & 500mg EC Tablets

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Order before 3pm for delivery from Tue. 02 Mar and Wed. 03 Mar.

Product Information

  • Age: 18

    Maximum per order: 2

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Naprosyn is a branded version of the anti inflammatory pain killer Naproxen. Its available to buy online through The Independent Pharmacy after a short online consultation.
Naprosyn relieves pain and inflammation in adults with the following conditions:
Rheumatoid arthritis
Arthritis affecting the joints of the spine (ankylosing spondylitis)
Muscle and skeleton disorders such as tendinitis, sprains, strains, neck pain, back pain
Acute gout
Period pain.
Naprosyn is a non-steroidal anti-inflammatory drug (NSAID). It blocks an enzyme in the body called cyclo-oxygenase (COX). COX helps produce substances in the body called prostaglandins in response to injury and certain diseases. Prostaglandins cause swelling, pain and inflammation. By reducing prostaglandin production, Naprosyn lessens inflammation and pain.
Naprosyn relieves pain and inflammation after a single dose, however its anti-inflammatory effect builds up over a few weeks of regular doses. 
Naprosyn is especially effective at easing menstrual pain. This is because the prostaglandins that it reduces are involved in contracting the womb contract during a period. 
You should take Naprosyn with or after food to avoid irritating the stomach and causing indigestion.
Certain types of Naprosyn tablets, however’ are ‘gastro-resistant’, designed with a coating to protect the stomach. You can take these Naprosyn tablets with or without food, but you should swallow them whole, with a drink. Do not break, crush or chew these tablets as this will damage the coating. Also, don’t take antacids in the two hours before or after taking these tablets; they will prevent the protective coat from working. 

If your pain is long-term or ongoing, (for example, if you are recovering from an injury or have arthritis), your doctor may suggest that you take Naprosyn every day for improved anti-inflammatory effect and more consistent pain relief. If you are taking Naprosyn long-term, your doctor may also prescribe a medication to protect your stomach.

Naprosyn can be taken alongside paracetamol as well as opioid painkillers such as codeine, tramadol, co-codamol, or morphine alongside Naprosyn. However, Naprosyn cannot be taken with aspirin or other anti-inflammatory painkillers (NSAIDs) like ibuprofen or diclofena, as this increases the possibility of side effects on the stomach and intestines. If you take selective COX-2 inhibitors such as celecoxib or etoricoxib, do not take Naprosyn for the same reason.

Be sure to check the ingredients of other medicine before taking them with Naprosyn. Cold and flu remedies and over-the-counter painkillers may contain ibuprofen or aspirin and therefore should not be combined with Naprosyn. Ask your doctor or pharmacist for advice.
It’s also best to check with your pharmacist before using an anti-inflammatory gel (such as diclofenac, ibuprofen, ketoprofen or piroxicam) alongside Naprosyn taken by mouth, because the combination might be dangerous for you.

Inform your doctor or pharmacist about any other medicines that you take, including herbal medicines and those bought without a prescription before taking Naprosyn. This is especially important if you’re taking any of the medicines mentioned below.
You have a higher risk of ulceration or bleeding in your gut if you take Naprosyn with steroids such as prednisolone. You may also have a higher risk of bleeding in the gut if you take Naprosyn with other medicines that increase the risk of bleeding, such as those below. If you take any of these medications, you should only take Naprosyn with your doctor’s approval:
Anticoagulant medications such as warfarin, apixaban, dabigatran, edoxaban, heparin, rivaroxaban and low molecular weight heparins like enoxaparin
Antiplatelet medications e.g. dipyridamole, prasugrel, clopidogrel, low-dose aspirin
Ginko biloba
SSRI antidepressants, e.g. fluoxetine, citalopram, paroxetine. venlafaxine 
You may increase your risk of kidney side effects if you take Naprosyn with any of the following medicines:
ACE inhibitors, e.g. captopril, enalapril
Diuretics, e.g. furosemide
Naprosyn may decrease the removal of the following medicines from the body and therefore may increase the risk of their side effects:
Lithium Naprosyn may counteract the effects of blood pressure lowering medications, such as:
ACE inhibitors such as captopril
Calcium-channel blocker such as amlodipine
Beta-blockers such as atenolol
Naprosyn taken in combination with quinolone antibiotics (ciprofloxacin or norfloxacin) may carry an increased risk of seizures, particularly for people with epilepsy.
Probenecid may interfere with Naprosyn’s removal from the body. If you take this combination, inform your doctor if you believe you experience Naprosyn side effects; he/she may need to lower your dose.

Many medicines available over the counter contain aspirin or other medicines similar to naproxen (such as ibuprofen or ketoprofen). Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains naproxen, aspirin, ibuprofen, or ketoprofen.

Avoid exposure to sunlight or tanning beds. Naprosyn can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Non-Prescription Alternatives for the treatment of Pain are;

  • Ibuprofen
  • Paracetamol
  • Aspirin
  • Topical Treatments (Ibuprofen gel)
  • Rest the area

If your pain does not ease or becomes severe, contact your GP or Pharmacist for further advice.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Take one tablet twice a day when required.

Use Naprosyn exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not crush, chew, or break an extended-release or enteric-coated tablet. Swallow the pill whole. The extended-release pill is specially made to release medicine slowly in the body. The enteric-coated pill has a special coating to protect your stomach.If you use this medication long-term, you may need frequent medical tests at your doctor's office.

Store Naprosyn at room temperature away from moisture and heat.

Since Naprosyn is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Common Naprosyn side effects may include:
upset stomach, mild heartburn or stomach pain, diarrhea, constipation;
bloating, gas;
dizziness, headache, nervousness;
skin itching or rash;
blurred vision; or
ringing in your ears.

Get emergency medical help if you have any of these signs of an allergic reaction to Naprosyn: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Naprosyn and call your doctor at once if you have:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
swelling or rapid weight gain, little or no urinating;
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
bruising, severe tingling, numbness, pain, muscle weakness;
fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions) or
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

The active ingredient contained in Naprosyn tablets is:

500mg of Naproxen

Naprosyn also contains the following inactive ingredients:

methacrylic acid-ethylacrylate copolymer (1:1), magnesium stearate, maize starch, lactose ,crospovidone, propylene glycol, sodium hydroxide, shellac glaze, triethyl citrate, iron oxide black (E172), titanium dioxide (EI71), potassium sorbate (E202), sodium citrate (E331), hydroxypropyl cellulose (E463), xanthan gum (E415), purified talc (E553), beeswax.

Read the following warnings carefully to ensure you are selecting an appropriate product.


Do not take Naprosyn ec tablets if you:

  • Are allergic to Naprosyn or to any of Naprosyn GR tablets’ other ingredients.
  • Are allergic to aspirin or other non-steroidal anti-inflammatory medicines (NSAIDs), or you have experienced asthma, runny nose, skin swelling or rash while taking these medications.
  • Have or have had stomach ulcers, gastrointestinal bleeding.
  • Are in the last trimester of pregnancy or if you are breastfeeding.
  • Have severe kidney, liver or heart failure.

Check with your doctor if you are not sure about any of the above conditions.

Check with your doctor before taking Naprosyn GR tablets if you:

  • Are on a low potassium diet, as this product contains potassium sorbate.
  • Use other non-steroidal anti-inflammatory medicines (NSAIDs) or any medication which could cause bleeding or stomach ulcers.
  • Have a history of gastrointestinal disease.
  • Are a smoker.
  • Drink alcohol.
  • Are elderly.
  • Have or have had high blood pressure or liver, kidney or heart problems.
  • Have or have had bronchial asthma, breathing problems or nasal polyps.
  • Have systemic lupus erythematosus or other connective tissue disorder.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Pain?

Visit our advice area or contact our support team

Naprosyn 250mg & 500mg EC Tablets Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Authored By:

A photo of Dr Donald Grant

Dr Donald Grant

MB ChB DRCOG MRCGP Dip.orth.med

Published on: 02-02-2017

Last modified on: 22-10-2019

Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy

Reviewed By:

A photo of  William Obeng

William Obeng

MPharm IP

Reviewed on: 22-10-2019

Next review date: 22-10-2021

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