When & How To Move To A Mounjaro Maintenance Dose

Like any pathway of personal improvement, it's not just about achieving your goals. It's about maintaining the progress that you've made, so that you can reap the benefits, long-term. Mounjaro is with you for every step of your weight loss journey, including weight maintenance.

Mounjaro is often used to help people get to a healthy weight, and reduce their risk of developing long-term health issues. However, once you've achieved a healthy BMI, moving onto a maintenance dose is an essential next step in your journey, alongside continuing your dietary and lifestyle changes.

Maintenance generally involves carefully managing your dosage to prevent you from losing an unhealthy amount of weight, or gaining back weight you've lost.

Maintenance dosing is backed up by two pivotal clinical trials. These are called SURMOUNT-4 and SURPASS-4.

• Both trials support the role of tirzepatide (the active ingredient in Mounjaro) as an effective option in obesity and diabetes care, and suggest that the benefits are sustained as long as people keep taking it.
• SURMOUNT-4 shows that while tirzepatide enables long-term weight maintenance, people experience significant weight regain when they stop taking medication.
• SURPASS-4 demonstrates that tirzepatide is more effective than insulin in improving blood sugar control and reducing weight in people with type 2 diabetes and high cardiovascular risk.

In this guide, we'll tell you everything you need to know about when to transition to the maintenance phase, what to expect once you're there, and what to do if you notice unexpected changes in your appetite or weight.

Remember, our UK-based clinical team is always on hand to support you through every stage of your weight loss journey, including the maintenance phase.

How Do I Know When It’s Time To Move To A Maintenance Dose Of Mounjaro?

Mounjaro doses are usually increased gradually. This helps your body to get used to the medication and reduces the risk and severity of side effects.

There is no set time within which you have to move to a maintenance dose. It all depends on your progress and goals. However, most people tend to switch to a maintenance dose once their weight has dropped to within a healthy BMI range, and they feel happy and more confident in their appearance.

Keep in mind that it's important not to lose too much weight. This can create a different set of health problems. Likewise, switching to a maintenance dose does not mean that you've reached the limit of what you can achieve on your weight loss journey.

Your focus should be on staying within a healthy BMI and maintaining your weight within that zone. This is the key to long-term, healthy weight loss, and one that our team is ready to help with.

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Mounjaro Maintenance Dosing Options

Throughout your weight loss journey, it's important to remember that you're in control. When you reach the maintenance stage, you have three options.

These are:

Option 1 - Stay On The Dose That You Are On

SURPASS 4 found maintaining the same dose to be an effective option in helping participants maintain their weight loss. This evidence was based on people using 5,10 or 15mg doses. However, if you are currently on a different dose you can also maintain the same dosage.

Option 2 - Reduce your dose

Reducing your dose may be an option, particularly if you would rather make your weight maintenance more reliant on your new eating habits and lifestyle changes.

Alternatively, if you are finding the cost of maintaining your current dosage difficult, reducing it can also reduce your costs.

However, there is no published data to support this option yet. U.S. pharmaceutical company Eli Lilly is looking into this but it will take at least two years for the results to be published.

If you choose this option, we can support you.

Stop the treatment completely

Stopping Mounjaro treatment outright is an option. However, the studies lead us to advise against this. The SURMOUNT-4 trial demonstrates that you are likely to regain the weight that you have lost if you cease treatment completely. However, if you are confident in your lifestyle changes, we respect your decision.

You may choose to stop immediately or slowly reduce each monthly dose titration back to zero.

If you choose to re-commence treatment at a later date we will be happy to assist. However, if your break has been longer than six weeks, we will need to return to your original starting dose.

What To Expect On A Mounjaro Maintenance Dose

Maintenance doses are different for each person. However, whatever your dosage, you can expect a balance between reduced side effects and the maintenance of your new healthy weight. Your progress will be slower but easier to sustain. 

You may notice that your appetite becomes less suppressed and more stable. This is a normal part of the process. Likewise, any side effects you have experienced including constipation or nausea may reduce or disappear completely.

Remember, check-ins with our clinical team are still important to monitor your progress and make any adjustments necessary to ensure that you're getting great results while also looking after your health.

What To Do If Your Weight Starts To Fluctuate

If your weight starts to fluctuate while you are on your maintenance dose of Mounjaro, this can be a source of anxiety and concern.

Try not to worry. Little fluctuations are completely normal.

If, however, you notice a significant weight regain, this could be a result of dietary and lifestyle changes, stress, physical activity, or the way in which your body is absorbing the medication.

Do not suddenly stop taking Mounjaro. Instead, speak to a member of our clinical team. They will be able to advise you on what to do next.

This may mean:

• Reassessing your maintenance dose
• Restarting with a lower titration
• Combining treatment with other lifestyle changes

Just remember that little plateaus or slight gains are not a step backwards. They're just part of the next step forward in your long-term journey.

Healthy Lifestyle Changes For Weight Maintenance After Mounjaro

While Mounjaro is an effective tool in your long-term strategy, there is no substitute for maintaining healthy lifestyle changes to support long-term success in your weight loss.

The most important of these is a healthy, balanced, calorie-controlled diet that still allows you to enjoy food. Food habits that make you miserable are not habits that you'll be able to stick to. Likewise, eating more slowly and mindfully can prevent overeating, while regular exercise and reducing stress can help balance your stress hormone levels, preventing excessive weight gain.

Mounjaro can help you take that all-important first step, but these changes are the key to maintaining a healthy weight and BMI while optimising your health and wellbeing.

Always Remember...

It is essential that you speak to a licensed medical professional before starting or changing any weight loss medication. They can provide personalised, expert guidance, assess potential risks and ensure that your chosen treatment is safe and suitable for your health needs.

Maintenance is an extremely important part of your weight loss journey. With the right clinical support and dosage, Mounjaro can help you consolidate and capitalise on the progress you've made. Alongside the right dietary and lifestyle changes, a maintenance dose of Mounjaro can help you maintain a healthy weight and BMI, laying the foundations of good health for the rest of your life.

If you’d like to know more about maintaining your weight on Mounjaro, or if you’re starting your weight loss journey and want to learn more about how Mounjaro can help, our expert clinical team is ready to help. Schedule a consultation today.

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