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Pregnancy: Not suitable
Breastfeeding: Not suitable
Differin 0.1% Gel contains the active ingredient adapalene, a form of vitamin A that reduces the growth of pore-blocking keratin cells. Adapalene also increases skin cell renewal and aids natural exfoliation, leaving the skin clear and oil-free.
Differin 0.1% Gel is available for purchase from The Independent Pharmacy Online Doctor service, following a free consultation. To learn more about acne and available treatments, visit our Online Doctor Acne page.
Differin 0.1% Gel treats acne. Applying it to affected areas may decrease the number and severity of acne pimples and promote quick healing of breakouts. The active ingredient, adapalene, belongs to a class of medications called retinoids. It affects cell growth and decreases swelling and inflammation.
Sebum is a natural, oily substance that keeps the skin smooth and supple and is produced by glands just under the skin’s surface, called sebaceous glands. However, acne sufferers often produce too much sebum, which can mix with dead keratin skin cells and cause blocked pores. Blocked pores can then lead to spots, blackheads (comedones) and whiteheads. Differin 0.1% Gel can reduce keratin skin cells and unblock the pores and sebaceous glands, allowing the sebum to escape. This results in a reduction of acne symptoms.
Differin 0.1% Gel also aids the skin’s natural exfoliation, keeping pores unblocked and thus reducing spots and blackheads.
Differin 0.1% Gel is for external use only and treats mild to moderate acne symptoms. Currently, Differin is the only licensed medication in the UK that contains Adapalene.
Pharmacist tip:Differin 0.1% Gel should be applied once daily, in the evening, to affected areas after they have been washed and patted dry. You can use cosmetics and moisturisers whilst usingDifferin Gel, however you should allow it to absorb fully into the skin before applying other products.Wash your face no more than twice daily. Over washing can irritate the skin, remove essential oils and worsen acne symptoms.
Differin is a retinoid-like compound that is manufactured by Galderma UK Limited.
Before applying this medication, wash your hands. Clean the affected skin with a mild or soapless cleanser and pat dry. With your fingertips, apply a thin layer of medication once daily before bed. Use this medication on the skin only. Do not apply to the inner lips or inside the nose/mouth or on cut, scraped, sunburned, or eczema-affected skin. Avoid contact with eyes. If accidental contact occurs, flush eyes with water and call your doctor if irritation develops. Wash your hands after using the medication to avoid accidental contact.
During the first few weeks of using an adapalene-based product, your acne might appear to worsen. The medication is working on pimples forming inside the skin, so it may take up to 8-12 weeks to notice results.
Use Differin regularly to get the most benefit, preferably at the same time each day. Do not use a larger amount or use it more frequently than recommended as your skin will not improve faster and you risk developing redness and peeling.
Differin is available in different strengths and forms (e.g., gel, cream, solution). The best form for you will depend on your skin and its response to treatment. Inform your doctor if your condition worsens or persists.
Side effects may include:
Dry skin, irritation, burning sensation, or redness.
If you are concerned about these effects, or if the product affects you in a different way, stop using it and talk to your doctor or pharmacist.
Adapalene 0.1% w/w
Carbomer 940, propylene glycol (E1520), poloxamer 182, disodium edetate, methylparahydroxybenzoate (E218), phenoxyethanol, sodium hydroxide and purified water.
Read the following warnings to ensure you are selecting an appropriate product.
Do not use this product if you are allergic to any of its ingredients.
Do not use this medicine on cuts or broken skin, or if you have eczema.
Avoid contact with eyes, mouth or nostrils, and avoid other very sensitive areas of the body. In case of accidental contact, immediately wash the with warm water.
Avoid exposure to strong sunlight and artificial UV light.
If this medication causes you sensitivity or irritation, stop using it and consult your doctor. You may be asked to use the gel less often, or stop using if for a short time.
Tell your doctor/ pharmacist if you are taking, have recently taken or might take any other medications.
Other acne products containing benzoyl peroxide, erythromycin or clindamycin may be used with Differin. You should apply these medications in the morning and Differin at night.
Cosmetics may be used but they should be formulated to not cause blackheads or dry the skin.
The inactive ingredient Propylene glycol (E1520) which may cause skin irritations. Methyl parahydroxybenzoate (E218) may cause allergic reactions.
Please read all packaging and the Product Information Leaflet before taking any new medication and inform your doctor any medications you are taking or intend to take.
We offer FREE standard tracked delivery on orders over £40.
The following delivery options are available:
All our orders are sent out using Royal Mail. We always aim to dispatch all orders received before
All orders can be fully tracked in your account.
We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods.
Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt.
Delivery is free for all NHS prescriptions.
Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering.
If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.
Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a
Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.
You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.
We are currently unable to ship orders outside of the UK.
We are unable to ship orders to
Differin Cream is an acne treatment that contains Adapalene 0.1%, which helps to reduce the growth and increase the turnover of keratin skin cells that can build up and block pores causing acne.
In adults and children 180 years and over, Differin is applied once daily, usually in the evening. You should not apply Differin more than once in a 24-hour period. For best effects, Differin should be applied after washing your face with warm water and a mild cleanser to clear away any excess oil, skin cells and bacteria.
You can combine Differin with antibiotic acne treatments such as Tetralysal (Lymecycline), Minocin (Minocycline) or Erythromycin tablets. Differin should not be used with any other acne creams as it may cause excess drying or irritation to your skin.
Redness and irritation of the treated area, almost like sunburn, can commonly occur when you use Differin for the first time. This is not usually serious and is a sign that it is working. These effects normally subside within a week. During this time you can reduce the frequency of Differin application to once every other day to allow your skin to recover and then slowly build up to applying it daily.
Differin cream is a prescription-only acne treatment. For that reason, to ensure the safety of our patients and the legal & ethical operating of our pharmacy, we only supply a maximum of 3 months treatment at one time. Differin treatment is normally judged for effectiveness after 2-3 months. This means that if you do not find Differin as effective as you would like after this time, you are not stuck with an excess of medication. If you are happy with the results you can easily log in and re-order another supply.
Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 4pm Monday to Friday, Differin cream is available for next day delivery.
Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Differin online. The Independent Pharmacy is an NHS Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.
Just select 'Start Consultation' above, you will need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Differin to you. It all takes around 3 minutes and your treatment can be delivered to your door.
There are many advantages to buying Differin online, some include:
Differin Cream and Gel both contain the active ingredient adapalene, a form of vitamin A that treats acne.
Acne occurs when the skin’s sebaceous glands become blocked and natural oils, or sebum, accumulate. The blocked sebum provides nutrients for acne-causing bacteria which can grow and cause inflammation in the skin. Adapalene reduces the growth of the keratin skin cells that block pores and allows the sebum to escape. This decreases the occurrence of blackheads and spots.
In addition, adapalene increases the skin’s ability to exfoliate naturally. This also helps to unblock pores, and decrease blackheads and breakouts.
Differin Cream or Gel should be applied once a day, before bed.
When you first start using Differin you may feel a temporary stinging or warm sensation on your skin. The skin may redden slightly, like a mild sunburn. Differin may also cause your skin to peel or become very red and irritated.
If you notice severe redness, swelling, itching, burning sensations, blistering, crusting or peeling of your skin after using Differin, apply the medication less often or stop using it temporarily. If the irritation persists, stop using the medication completely and consult your doctor.
You can wear cosmetics or moisturisers while using this medication, but you should not apply them at the same time. Wash your skin thoroughly before applying Differin, wait for it to be absorbed into your skin, then use any cosmetics and moisturisers.
Avoid exposure to sunlight, sunlamps or sunbeds while using this medication, as it increases your skin’s sensitivity to UV light. If exposure to sunlight cannot be avoided, use sunscreens or protective clothing over treated skin.
If your skin is sunburnt, you should not use this medication until your skin has fully recovered. Severe irritation may result.
You should continue treatment with Differin for at least 8 weeks. If, after that time, there is no improvement, treatment should be stopped or new medication should be added.
Your treatment plan should be reviewed after 3 months and, if acne has cleared, Differin can be stopped. Acne may not return, but if it does treatment can be resumed.
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