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Phenergan 25mg Tablets


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Order before 3pm for delivery from Tue. 29 Sep and Thu. 01 Oct.

Phenergan 10mg & 25mg Tablets

  • Age: 5 years +

    Maximum per order: 2

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Phenergan?

At The Independent Pharmacy, you can buy Phenergan tablets online in either 10mg or 25mg strengths, by filling in a short online consultation for our pharmacy team. 

Promethazine hydrochloride is the active ingredient in Phenergan. Promethazine is a drowsy antihistamine medication which relieves the symptoms of a number of conditions, including allergies, rashes, nausea and is also known for its sedative effect. 

Phenergan is classed as a pharmacy-only medicine in the UK. It comes in packs of 56 tablets and is produced by the global manufacturer, Sanofi.


What is Phenergan used for?

Phenergan Tablets are used to treat the following conditions: 

  • For treatment of adults with difficulty sleeping (insomnia) 
  • To treat allergic reactions such as hay fever or rashes (like nettle rash or hives)
  • To treat or stop you feeling sick (nausea) or being sick (vomiting) such as travel sickness 
  • As a sedative for children aged 5 years and above
  • To ease coughing or a runny nose


How does Phenergan work?

Promethazine hydrochloride (the active ingredient in Phenergan) works by blocking the receptors of histamines and dopamine to reduce the impact of allergies and nausea but it also works directly on the brain which makes you feel relaxed. 

Promethazine hydrochloride also works by blocking acetylcholine receptors which help to reduce a runny nose or a cough.


Phenergan for anxiety

Phenergan tablets are sometimes taken by people when suffering from anxiety due to its sedative effect. Phenergan tablets can be taken in the short term to treat adults with sleeping difficulties that may be caused by anxiety. 

Although Phenergan can be used short-term to aid sleep during situational anxiety, Phenergan is not licensed to be used to treat anxiety or other mental health conditions.


How long does Phenergan take to work?

You will notice that Phenergan tablets should start to take effect around 20 minutes after they are taken and the effect can last for 12 - 24 hours. 

Phenergan is a long-acting antihistamine and, as such, only usually needs to be taken once daily, normally at night.



Patient Information Leaflet

Phenergan 10mg Patient Information Leaflet: https://www.medicines.org.uk/emc/files/pil.5587.pdf

Phenergan 25mg Patient Information Leaflet: https://www.medicines.org.uk/emc/files/pil.5588.pdf

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Phenergan Dosage

If you are taking Phenergan tablets your dose will depend on the reason you are taking it. Phenergan tablets can be purchased from The Independent Pharmacy in either 10mg or 25mg doses. 

Phenergan is only suitable for people over the age of 5 years. Phenergan tablets are for oral use only.


Phenergan 10mg

To treat allergies:

  • Children 2-5 years: Phenergan Elixir is recommended for this age group.
  • Children 5-10 years: either 1-2 tablets at night or 1 tablet twice a day.
  • Children over 10 years & adults: Start with 1 tablet twice a day, can be increased to 2 tablets 3 times a day if necessary.

To treat travel sickness:

  • Children 2-5 years: Phenergan Elixir is recommended for this age group. 
  • Children 5-10 years: Take 1 tablet the night before the journey. This may be repeated after 6-8 hours if necessary.
  • Children over 10 years & adults: Take 2 tablets the night before the journey. Can be repeated after 6-8 hours if needed. 

For short-term sedation:

  • Children 2-5 years: Phenergan Elixir is recommended for this age group.
  • Children 5-10 years: Take 2 tablets as a single night time dose.
  • Children over 10 years and Adults: Take 2-5 tablets as a single night time dose


Phenergan 25mg

For allergies (such as hay fever, rashes and hives):

  • Children 2-5 years: Phenergan Elixir should be given in this age group
  • Children 5-10 years: A single tablet (25mg) given at night (DO NOT give more than 25mg each day)
  • Children over 10 years and adults (including the elderly): Start with one tablet (25mg) taken at night. This may be increased to a maximum of one tablet (25mg) twice a day if necessary

For treatment and prevention of feeling sick or being sick (such as travel sickness):

  • Children 2-5 years: Phenergan Elixir should be given in this age group
  • Children 5-10 years: Phenergan Elixir or Phenergan 10mg Tablets should be given in this age group
  • Children over 10 years and adults (including the elderly): A single tablet (25 mg) to be taken the night before the journey. This may be repeated after 6-8 hours if necessary.

For short term sedation:

  • Children over 10 years and adults (including the elderly): One or two tablets (25mg-50mg) taken at night


What if I take too many Phenergan tablets?

If you or your child takes over the stated dose of Phenergan tablets you should speak to a doctor immediately or go to a hospital emergency department straight away. 

DO NOT drive yourself as Phenergan tablets can make you drowsy. Take your medicine pack with you so the doctor knows what you have taken. 


What if I forget to take my Phenergan tablets?

Do not take a double dose to make up for a missed dose. 

If you are taking Phenergan tablets for an allergy then take your dose as soon as you remember and then carry on as before.

If you are taking Phenergan for sleeping difficulties miss this dose and take your next dose the following evening. 


How long can I take Phenergan for?

Phenergan should not be taken for more than 7 days without the advice of a healthcare professional. If after 7 days your condition has not improved or your symptoms have become worse, talk to your doctor or a pharmacist.

Phenergan Side Effects

Like all medicines, Phenergan Tablets can cause side effects, although not everybody gets them. If you experience any adverse reactions stop taking Phenergan Tablets immediately. If the side effects continue, seek advice from a pharmacist or a doctor.

Common side effects include:

  • Feeling tired throughout the day
  • Nightmares
  • Dizziness and difficulties concentrating
  • Headaches

Some people may also develop an increased sensitivity to sunlight. 

In those over 65, it is more common to develop anticholinergic effects such as:

  • Dry mouth
  • Increased thirst
  • Difficulty passing urine
  • Blurred vision

If you experience any of the following severe side effects seek medical advice from a doctor straight away:

  • Yellowing of the skin or whites of the eyes, this may indicate liver problems
  • An allergic reaction such as; a rash, swallowing or breathing difficulties, swelling of the lips, tongue, face, throat
  • Muscle stiffness or shaking

Phenergan Ingredients

Each tablet contains either 10mg or 25mg of the active substance, promethazine hydrochloride 

The non-active ingredients include lactose, maize starch, povidone, magnesium stearate, polyethylene glycol, Opaspray (contains titanium dioxide-E171, hypromellose-E464 and indigo carmine aluminium lake blue-E132) and hypromellose

Phenergan tablets are known to interact with some other medications so it is essential that if you are currently taking any other medication, including herbal medications that you talk to a doctor before commencing treatment. 

Do Not take Phenergan tablets if in the last 2 weeks you have taken or are currently taking monoamine oxidase inhibitors (MAOIs) that are used for treating depression. If you are not sure ask your doctor or pharmacist

Check with a doctor or pharmacist before taking Phenergan tablets if any of the following apply to you:

  • You have difficulty breathing, wheezing, tightness in the chest (asthma) or an infection in your lungs (bronchitis). 
  • You have epilepsy
  • You have any serious heart problems
  • You have liver or kidney problems
  • You have a stomach blockage or difficulty passing water (urine). 
  • You have hearing problems. 
  • You have increased pressure in the eye (narrow-angle glaucoma). 
  • You have had something called Reye’s Syndrome or possible Reye’s Syndrome signs include being sick and confused following a viral illness. 
  • You are allergic to promethazine hydrochloride or any other ingredients contained in Phenergan tablets.

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Phenergan Tablets. 


Phenergan in pregnancy and breastfeeding

Most manufacturers of antihistamines advise avoiding their use during pregnancy and while breastfeeding; however, there is no evidence to suggest they cause abnormalities. 

Antihistamines are known to be passed into breast milk in varying amounts but are not known to be harmful.

Use of antihistamines in the 2 weeks before birth is not advised due to adverse effects on the newborn baby such as irritability, paradoxical excitability, and tremors.


Phenergan and alcohol

Do not drink alcohol while you are taking Phenergan Tablets. This is because it can affect the way the medicine works.


Phenergan and driving

Phenergan causes drowsiness. Drowsiness may affect the performance of skilled tasks (e.g. cycling or driving); sedating effects may be enhanced by alcohol.

If you feel drowsy when taking Phenergan tablets DO NOT drive or operate machinery. 

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 3 - 5 day delivery - £2.95
  • Express Tracked Delivery - 1 - 3 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about General Health?

Our UK based support team can help, email us at support@theindependentpharmacy.co.uk.

Phenergan Reviews

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Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • How can this medicine affect other medicines?

    This medicine should not be taken if you are taking or have taken in the last 14 days, a monoamine oxidase inhibitor (MAOI), egphenelzine, trancylcypromine, or isocarboxazid.
    If this medicine is taken in combination with any other medicine that causes drowsiness, there may be an increased effect of drowsiness.

    If taking a treatment involving histamines (such as for leukaemia), or betahistines (used for treating Ménière's disease), then this medicine should not be used as antithistamines may produce the opposite effect.

  • How does Phenergan work?

    Phenergan contains the active ingredient, promethazine, a sedating antihistamine. It prevents the actions of histamine.

    Histamine is a substance produced by the body as part of the immune system. It causes the symptoms of allergic reactions such as inflammation of the airways or skin, rashes, nasal congestion, and itching of the skin, eyes or nose. Promethazine prevents histamine from binding to its receptors in various parts of the body and this stops it from causing the symptoms of allergies.

    Histamine can also cause more severe reactions such as anaphylaxis. Promethazine treats localised allergies such as hay fever and nettle rash, as well as anaphylaxis.

    Promethazine also blocks histamine receptors in the brain in an area called the called the vomiting centre. The vomiting centre causes feelings of sickness and the vomiting reflex. It is activated when it receives nerve messages from the vestibular system in the middle ear about the body’s position.

    When something disturbs the vestibular system, such as head movements when travelling by boat or car, nerve signals are sent from the middle ear to the vomiting centre. The effect can cause motion sickness symptoms. By blocking the histamine receptors in the brain’s vomiting centre, Promethazine prevents disturbances in the middle ear from activating the vomiting reflex, thus preventing motion sickness symptoms.

  • How do I take Phenergan?

    Dosage and frequency will depend on the patient’s age and condition. Follow the instructions in the leaflet or packaging provided with this medication, or your doctor’s instructions.

    • Do not exceed the recommended dose.
    • Phenergan tablets and elixir can be taken either with or without food. The tablets should be swallowed whole with water.
    • Seek medical advice if your symptoms continue despite treatment from your doctor or pharmacist.
    • Do not use this medication for longer than seven days without advice from your doctor.
  • What are the most common side effects of Phenergan?

    Side effects while taking Phenergan can include: gastro-intestinal disturbances (diarrhoea, nausea, constipation, vomiting or abdominal pain), dry mouth, loss of appetite, tiredness, sleepiness, restlessness, dizziness and blurred vision.

    You can find more details about the side effects in our Side Effects section.

  • When should Phenergan not be used?

    Do not use Phenergan if you:

    • Are pregnant or breastfeeding
    • Have an allergy promethazine or any ingredients in Phenergan.
    • Have an allergy to sulphites, phenothiazines or benzoates.
    • Have experienced jaundice caused by other phenothiazine derivatives.
    • Take medicines that interact with Phenergan, including: monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, sedatives and hypnotics, barbiturates and opioid analgesics.

    You can find more information in our Warnings section.

  • Do other medications interact with Phenergan?

    Some medications interact with Phenergan. You should not take them while you are being treated with Phenergan unless advised by your doctor. These medications include: monoamine oxidase inhibitors (MAOIs), sedatives and hypnotics, tricyclic antidepressants, barbiturates and opioid analgesics.

    You can find more information in our Warnings section.

  • How should Phenergan be stored?

    Store Phenergan in a cool, dry place below 25°C. 

  • Does using Phenergan make skin more sensitive to sunlight?

    Phenergan can make your skin extra sensitive to sunlight. Steps should be taken to avoid sunburns. Avoid using sunbeds and going outside in strong sun. When outside, wear clothing and use sunscreen.

Authored By:

A photo of  Scott McDougall

Scott McDougall


Published on: 09-01-2017

Last modified on: 15-07-2020

Scott is one of the two founders of The Independent Pharmacy. He is a registered pharmacist and the registered manager of our service with the CQC.

Reviewed By:

A photo of  Andy Boysan

Andy Boysan


Reviewed on: 15-07-2020

Next review date: 15-07-2022

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

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