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Phenergan 25mg Tablets

Phenergan Tablets

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Order before 3pm for delivery from Tue. 07 Jul and Thu. 09 Jul.

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  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Phenergan tablets can be used by adults and children to combat a range of illnesses and symptoms. For example, if you are suffering from an allergic reaction such as hives or if you are being hit badly by hay fever season, you can use Phenergan to ease the symptoms. 

Adults that are having trouble with insomnia can use these tablets to get a restful sleep as they act as a sedative which also makes them the ideal medication if you need to be relaxed before an operation. If you are on a long journey and feel sick, try Phenergan as it can work to soothe your stomach and nausea.


Phenergan tablets

Phenergan Tablets 25mg provide complete allergy relief. It offers symptomatic treatment for allergic conditions of the skin and upper respiratory tract. This includes allergic rhinitis, urticaria, and anaphylactic reactions. It also treats insomnia, rashes, pet allergies, and travel sickness. A versatile medication, Phenergan can be used by the whole family.

Both strengths of Phenergan tablets contain the active ingredient Promethazine, a sedating antihistamine. It enters the brain in significant quantities and causes drowsiness. This effect can provide short-term help for people with sleeping difficulties.

As an antihistamine, Phenergan Tablets 25mg block the action of histamine. When the body comes into contact with allergens, it produces histamine as a defence. Histamine causes symptoms of an allergies such as sneezing, sore eyes, rashes, and nasal congestion. Promethazine blocks the histamine receptors in the brain, preventing them from receiving the messages that cause symptoms.

Phenergan can provide relief from:

  • Hay fever, allergies and nettle rash.
  • Adult insomnia.
  • Pet allergies.
  • Travel sickness, nausea and vomiting.

Pharmacist Tip

Phenergan is a versatile medication that can treat allergic reactions, travel sickness and sleeping problems. It can cause drowsiness. If this occurs, avoid driving or operating machinery.
Promethazine is an antihistamine. It blocks the histamine that your body produces in response to contact with allergens. Its other effects (anti-nausea, pain relief, sedation) may be due to its effect on other natural substances and parts of the brain.

Cough-and-cold products can be unsafe for children younger than 6. Therefore, do not use Phenergan to treat cold symptoms in children under 6 unless directed by your doctor. To prevent serious side effects, follow all dosage directions. Do not take other cough-and-cold medications while taking Phenergan.


Treating motion sickness with Phenergan

Promethazine also eases nausea and vomiting associated with motion sickness caused by air, sea train or car travel. Motion sickness is caused by conflicting information being received by the brain from the eyes and the inner ear’s vestibular system. The ear’s messages suggest motion, while the eye’s messages suggest that the body is still. The conflicting information stimulates the brain to produce the vomiting reflex. Promethazine in Phenergan 10mg & 25mg tablets binds to histamine receptors in the vestibular apparatus and to histamine receptors in the brain. This blocks the transmission of nerve impulses from the inner ear to the brain, preventing the vomiting reflex. Phenergan tablets also reduce nausea and vomiting due to other conditions including irradiation sickness, postoperative vomiting, and drug-induced nausea. 


Phenergan for sedation

Promethazine in Phenergan tablets is an H1-receptor antagonist and binds to histamine receptors in various parts of the including the brain. Blocking these brain histamine receptors is responsible for causing sedation. 

Phenergan can be used to treat travel sickness, rashes, hay fever, and it can suppress insomnia. It's active ingredients have a sedative effect and will induce a feeling of relaxation.

Whether having problems sleeping or with travel sickness, Phenergan can provide relief. It can also act as a sedative or relaxant. This is a multi-purpose medicine that will undoubtedly come in useful.

The active ingredient in Phenergan is promethazine. This is a sedating antihistamine, meaning it stops histamine in the body from performing functions. Histamine is produced in the body and causes effects such as itching skin, nasal congestion or inflammation of airways in response to the presence of allergens. By blocking histamine from acting, these symptoms of an allergic reaction are suppressed.

Histamine can cause problematic reactions such as anaphylaxis, or more localised ones such as hay fever. Promethazine can be used to treat the symptoms of both.

Promethazine also reduces histamine activity in the vomiting centre of the brain. This area of the brain is in charge of the vomiting reflex and feelings of sickness. One trigger for vomiting that the vomiting centre is activated by is a nerve signal from the vestibular apparatus in the middle ear. When head movements, such as those experienced when travelling by car or boat, are detected in the vestibular apparatus, it can send signals to the vomiting centre that result in motion sickness. The symptoms of this include dizziness, vertigo, nausea, and vomiting. Promethazine blocks the histamine receptors in the vomiting centre, meaning such signals from the vestibular apparatus will not trigger these symptoms.

Promethazine is a sedating antihistamine, meaning it also causes drowsiness. This sedating effect is used before minor surgeries. It can also be useful to provide relief for people suffering from sleeping difficulties such as insomnia.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Phenergan 10mg Tablets:

In allergic conditions:

Children 2-5 years: Phenergan Elixir is recommended for this age group.

Children 5-10 years: either ONE-TWO tablets at night or ONE tablet TWICE a day.

Children  over 10 years & adults: Start with ONE tablet TWICE a day, can be increased to TWO tablets THREE times a day if necessary.

In Travel Sickness:

Children 2-5 years: Phenergan Elixir is recommended for this age group. 

Children 5-10 years: Take ONE tablet the night before the journey. This may be repeated after 6-8 hours if necessary.

Children over 10 years & adults: Take TWO tablets the night before the journey. Can be repeated after 6-8 hours if needed. 

For short-term sedation:

Children 2-5 years: Phenergan Elixir is recommended for this age group.  

Children 5-10 years: Take TWO tablets as a single night time dose.

Children over 10 years and Adults: Take TWO-FIVE tablets as a single night time dose.

Phenergan 25mg Tablets:

Children 5 - 10 years: Swallow 1 25mg tablet at night. 

Avoid giving in excess of 25mg a day.

Adults, elderly and children over 10 years: Initially take 1 tablet of 25mg at night. 

You can then increase up to a maximum of 1 25mg tablet twice a day if required.

Phenergan Elixir

For allergies (such as hay fever, hives and rashes)

Children 2 - 5 years: One 5ml spoonful twice each day or as one single dosage of one to three 5ml spoonfuls .Avoid giving in excess of three 5ml spoonfuls a day.

Children 5 - 10 years: Two 5ml spoonfuls twice each day or as one single dosage of one to five 5ml spoonfuls. Avoid giving in excess of five 5ml spoonfuls a day.

Adults, elderly and children over 10 years: Initially give two 5ml spoonfuls each day. You can then increase up to a maximum of four 5ml spoonfuls 3 times a day. 

For travel sickness

Children 2 - 5 years: Take one 5ml spoonful at night before the journey begins to be repeated after 6-8 hours if needed.

Children 5 - 10 years: Take two 5ml spoonfuls at night before the journey to be repeated after 6-8 hours if needed.

Adults and children over 10 years: Take five 5ml spoonfuls at night before the journey to be repeated after 6-8 hours if needed.

As a sedative

Phenergan Elixir can be recommended to be used by a doctor as a short term sedative as follows:

Children 2 - 5 years: Three or four 5ml spoonfuls taken as a single dose during night time

Children 5 - 10 years: Four or five 5ml spoonfuls taken as a single dose during the night time

Adults, elderly and children over 10 years: Swallowing Phenergan tablets is more appropriate.

Not everyone will experience side effects when they take medication, however if you do they can include: 

Nightmares, drowsiness, restlessness, dizziness, headaches, disorientation, and tiredness.
Occasionally anticholinergic effects such as urinary retention, blurred vision, and dry mouth might occur.

If you are concerned about these effects, or if the product affects you in any other way, stop using it and talk to your doctor or pharmacist.

The active ingredients contained in this medicine is Promethazine hydrochloride.

Phenergan tablets contain the following inactive ingredients to make up the complete product: 

Lactose monohydrate, Maize starch, Povidone K30, Magnesium stearate, Polyethylene glycol 200, Hypromellose.

Phenergan Elixir also contains the following inactive ingredients to make up the complete product: 

Maltitol, sodium sulphinte anhydrous (E221) and sodium metabisulphite (E223).

Reading the following warnings carefully will help to ensure you are selecting an appropriate product. 

Do not take this medicine if: 

  • The person taking the medicine is under 5 years of age
  • You are allergic (hypersensitive) to promethazine hydrochloride or any of the other ingredients of Phenergan Tablets.
  • The signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
  • You are taking a medicine for depression called a monoamine oxidase inhibitor (MAOI). Also do not take Phenergan Tablets if you have stopped taking one of these MAOI medicines within the last 14 days. If you are not sure ask your doctor or pharmacist.
  • The person is unconscious (in a coma) or suffers from severe dizziness, drowsiness or headache
    Do not take this medicine if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Phenergan Tablets. 

Check with your doctor or pharmacist before taking your medicine if:

  • You have difficulty breathing, wheezing, tightness in the chest (asthma) or an infection in your lungs (bronchitis). 
  • You have epilepsy
  • You have any serious heart problems
  • You have liver or kidney problems
  • You have a stomach blockage or difficulty passing water (urine). 
  • You have hearing problems. 
  • You have increased pressure in the eye (narrow angle glaucoma). 

You have had something called Reye’s Syndrome or possible Reye’s Syndrome signs include being sick and confused following a viral illness. 
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Phenergan Tablets. 

Please read all packaging and the Product Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are only operating alternate day deliveries to many households (Mon, Wed, Fri or Tues, Thurs, Sat). This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 3pm are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 3 - 5 day delivery - £2.95
  • Express Tracked Delivery - 1 - 3 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 9pm) - £8.95
  • Saturday Guaranteed before 9pm - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 3pm the same working day. Any orders received after 3pm or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 5.30pm the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 5.30pm to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 5.30pm to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about General Health?

Our UK based support team can help, email us at support@theindependentpharmacy.co.uk.

Phenergan Tablets Reviews

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Frequently Asked Questions

  • Does using Phenergan make skin more sensitive to sunlight?

    Phenergan Elixir can make your skin extra sensitive to sunlight. Steps should be taken to avoid sunburns. Avoid using sunbeds and going outside in strong sun. When outside, wear clothing and use sunscreen.

  • Does using Phenergan Elixir cause interference with any medical tests?

    Phenergan Elixir may cause false positive or negative results in pregnancy tests.

    The antihistamines contained within Phenergan Elixir can reduce skin reactions that indicate allergies, so you should avoid taking this medicine in the 72 hours before taking a skin prick or patch test to diagnose allergies.

  • Once opened, how long does a bottle of Phenergan Elixir last?

    The Elixir should not be used past one month of opening the bottle. It is recommended that you write the date of opening on the bottle label to avoid confusion. Any remaining Elixir should be disposed of carefully, or returned to a pharmacy. 

  • How can this medicine affect other medicines?

    This medicine should not be taken if you are taking or have taken in the last 14 days, a monoamine oxidase inhibitor (MAOI), egphenelzine, trancylcypromine, or isocarboxazid.
    If this medicine is taken in combination with any other medicine that causes drowsiness, there may be an increased effect of drowsiness.

    If taking a treatment involving histamines (such as for leukaemia), or betahistines (used for treating Ménière's disease), then this medicine should not be used as antithistamines may produce the opposite effect.

  • What is Phenergan?

    Phenergan Tablets contain promethazine hydrochloride, a sedating anti-histamine. It blocks the histamine that the body produces during an allergic reaction.

  • What are Phenergan used for?

    Phenergan Tablets and Elixir can be given to you by a doctor or pharmacist. Pharmacists provide Phenergan in the following situations:

    • To treat allergic conditions such as hay fever or rashes.
    • To treat adults with insomnia.
    • To treat nausea, vomiting or travel sickness.

    Your doctor may also give you Phenergan Tablets and Elixir for the above situations or any of the following:

    • Relaxation before an operation.
    • Sleeping difficulties.
    • Sedation in both adults and children.
    • Nasal congestion associated with colds.
    • For the treatment of hives, hay fever, allergies and rashes.
  • How does Phenergan work?

    Phenergan Tablets and Elixir contain the active ingredient, promethazine, a sedating antihistamine. It prevents the actions of histamine.

    Histamine is a substance produced by the body as part of the immune system. It causes the symptoms of allergic reactions such as inflammation of the airways or skin, rashes, nasal congestion, and itching of the skin, eyes or nose. Promethazine prevents histamine from binding to its receptors in various parts of the body and this stops it from causing the symptoms of allergies.

    Histamine can also cause more severe reactions such as anaphylaxis. Promethazine treats localised allergies such as hay fever and nettle rash, as well as anaphylaxis.

    Promethazine also blocks histamine receptors in the brain in an area called the called the vomiting centre. The vomiting centre causes feelings of sickness and the vomiting reflex. It is activated when it receives nerve messages from the vestibular system in the middle ear about the body’s position.

    When something disturbs the vestibular system, such as head movements when travelling by boat or car, nerve signals are sent from the middle ear to the vomiting centre. The effect can cause motion sickness symptoms. By blocking the histamine receptors in the brain’s vomiting centre, Promethazine prevents disturbances in the middle ear from activating the vomiting reflex, thus preventing motion sickness symptoms.

  • How do I take Phenergan?

    Dosage and frequency will depend on the patient’s age and condition. Follow the instructions in the leaflet or packaging provided with this medication, or your doctor’s instructions.

    • Do not exceed the recommended dose.
    • Phenergan tablets and elixir can be taken either with or without food. The tablets should be swallowed whole with water.
    • Seek medical advice if your symptoms continue despite treatment from your doctor or pharmacist.
    • Do not use this medication for longer than seven days without advice from your doctor.
  • What are the most common side effects of Phenergan?

    Side effects while taking Phenergan can include: gastro-intestinal disturbances (diarrhoea, nausea, constipation, vomiting or abdominal pain), dry mouth, loss of appetite, tiredness, sleepiness, restlessness, dizziness and blurred vision, 

  • When should Phenergan not be used?

    Do not use Phenergan Phenergan Tablets and Elixir if you:

    • Are pregnant or breastfeeding
    • Have an allergy promethazine or any ingredients in Phenergan.
    • Have an allergy to sulphites, phenothiazines or benzoates.
    • Have experienced jaundice caused by other phenothiazine derivatives.
    • Take medicines that interact with Phenergan, including: monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, sedatives and hypnotics, barbiturates and opioid analgesics.

    Phenergan tablets 25mg should not be administered to children under 2.

  • Do other medications interact with Phenergan?

    Some medications interact with Phenergan Tablets and Elixir. You should not take them while you are being treated with Phenergan unless advised by your doctor. These medications include: monoamine oxidase inhibitors (MAOIs), sedatives and hypnotics, tricyclic antidepressants, barbiturates and opioid analgesics

  • How long should you take Phenergan?

    Continue to take Phenergan Tablets and Elixir for as long as your symptoms persist, or as recommended by your doctor but for no longer than 10 consecutive days. 

  • What should I do if I miss a dose of Phenergan?

    Take a missed dose of Phenergan as soon as you remember, unless it is almost time to take your next dose. In that case, skip the missed dose and take your next dose at its usual time. Do not take two doses at once. 

  • How should Phenergan be stored?

    Store Phenergan in a cool, dry place below 25°C. 

Authored By:

A photo of  William Obeng

William Obeng

MPharm IP

Published on: 09-01-2017

Last modified on: 09-01-2019

Reviewed By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Reviewed on: 09-01-2019

Next review date: 09-01-2021

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