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Syndol Tablets and Syndol Headache Relief Tablets are for effective and immediate relief from mild to moderate pain caused by headaches, migraines, period pains, toothache and muscle pain. Syndol Headache Relief contains 3 active ingredients: Paracetamol, Codeine and Caffeine. Syndol Original Tablets have the added benefit of the antihistamine, Doxylamine succinate, to help reduce tension.

Both tablets are available to buy online from The Independent Pharmacy when you complete a short health questionnaire for our medical team to review. Once approved your order can be delivered to you from the next day.

  • Suitable for age:12 years +
  • Maximums per order:

Syndol Information

  • What are Syndol Tablets and what are they used for?

    Syndol Headache Relief Tablets are designed to provide effective relief from the pain of headaches and migraines. It is estimated that in The UK over ten million people suffer from headaches and migraines. However, the pain they experience can vary, which makes finding the right treatment very important.

    In addition, Syndol Original Tablets have proven to not only help combat painful headaches they can also be used to relieve mild to moderate pain caused by the following factors:

    • Neuralgia (nerve pain)
    • Period pain
    • Toothache
    • Rheumatic aches and pains

    Both varieties of Syndol should only be used if your pain is not effectively managed by paracetamol, ibuprofen or aspirin alone. They are intended for short-term use only (up to 3 days) as the active ingredients may cause addiction.

    Syndol Headache Relief Tablets contain three active ingredients; paracetamol, codeine and caffeine. Whereas Syndol Original Tablets also contain an additional ingredient known as Doxylamine that works as a muscle relaxant to help reduce pain caused by tension headaches.

    Syndol tablets are manufactured by SANOFI and are suitable for adults and children over the age of 12 years, to be used if your pain is not effectively managed by paracetamol, ibuprofen or aspirin alone.

    How does Syndol work?

    Syndol Headache Relief tablets contain three active ingredients, paracetamol, codeine and caffeine to offer fast-acting, triple-action relief from pain. Syndol Original contain the same three ingredients with the added benefit of a fourth ingredient - Doxylamine.

    Paracetamol is a painkiller that works to relieve mild to moderate pain and fever. It is thought to reduce the production of prostaglandins in the brain and spinal cord. Prostaglandin is a pain-triggering chemical that acts to sensitise nerve endings at the site of trauma. By reducing their production, paracetamol can increase our tolerance to pain. So, even though the cause of the pain will remain, the painful sensation it produces will be reduced.

    Codeine is an opioid painkiller and is slightly stronger than paracetamol. Opioids work by mimicking the action of endorphins, which are the body's natural pain-relieving chemical. Codeine, like endorphins, block the transmission of pain signals being sent from the nerves to the brain. This means that even though the cause of the pain is still there, less pain is actually felt.

    Syndol also contains caffeine, which will act as a weak stimulant. This stimulant can enhance paracetamol’s pain-relieving effects. It can also act to counter the drowsiness that can be caused by codeine.

    Syndol Original Tablets also contain the active ingredient Doxylamine, which is a sedating antihistamine that primarily is used to help reduce symptoms of allergies, however, when used in conjunction with the other ingredients in Syndol it is also an effective muscle relaxant helping to reduce tension headaches and muscle pain.

    Alternatives to Syndol Tablets

    Non-Prescription alternative pain relief treatments include:

    If you are suffering specifically from migraines you may find Migraleve Yellow and Migraleve Pink tablets to be particularly effective. They use the same active ingredients to target pain with the addition of a substance proven to reduce nausea associated with migraines.

    If you find that Syndol Headache Relief or Syndol Original Tablets are not effectively managing your pain symptoms within 3 days, consult with your doctor or pharmacist.

    Syndol Tablets and paracetamol

    Do not take Syndol Headache Relief or Syndol Original with any other product that contains paracetamol. An overdose is dangerous and could potentially cause serious damage to the liver and kidneys. Many over-the-counter pain relief treatments, as well as most cough/cold remedies, contain paracetamol.

    Always check the ingredients of any medicine you buy before taking them at the same time as Syndol. If you are unsure about any medicine or its ingredients, ask your pharmacist for advice.


  • Syndol Tablets warnings

    Do not take Syndol if any other following apply to you:

    • You are allergic to paracetamol, codeine, caffeine or any of the other ingredients of this medicine.
    • You have asthma.
    • You have severe respiratory disease.
    • You suffer from alcoholism
    • You have had recent bile duct surgery e.g to remove gall stones.
    • You suffer from paralytic ileus, where your bowel has ceased to function.
    • You have recently had a head injury or raised pressure in the skull
    • You are pregnant or are breastfeeding

    Speak to a doctor or pharmacist before taking Syndol if any of the following apply to you:

    • You suffer from kidney or liver problems, including alcoholic liver disease.
    • You have an enlarged prostate gland.
    • You suffer from low blood pressure.
    • You suffer from inflammatory or obstructive bowel disorders such as
      constipation, diarrhoea or bloating.
    • You suffer from an underactive thyroid gland.
    • You are elderly or debilitated.

    Syndol and other medicines

    Syndol can interact with other medicines. You should not take this medicine if you are taking, have taken recently or plan to take any of the following:

    • Monoamine Oxidase Inhibitors (MAOIs)
    • Antidepressants
    • Phenelzine
    • Tranylcypromine
    • Isocarboxazid
    • Moclobemide
    • Selegiline
    • Paracetamol

    This is not an exhaustive list of medicines in which can be affected or affect how Syndol works. If you are currently taking or have recently stopped taking any other prescribed or non-prescribed medication, speak to a doctor or pharmacist before taking Syndol.

    Syndol and driving

    Syndol Tablets may cause drowsiness. If you find yourself affected in this manner, you should avoid driving, operating heavy machinery and drinking alcohol.

    Before taking Syndol Tablets please take the time to read the Patient Information Leaflet thoroughly.

  • Syndol tablets dosage

    Adults: Take 1-2 tablets every 4-6 hours. Do not take more than 8 tablets in 24 hours.

    Children aged 16-18 years: Take 1-2 tablets every 6 hours. Do not take more than 8 tablets in 24 hours.

    Children aged 12-15 years: Take 1 tablet every 6 hours. Do not take more than 4 tablets in 24 hours.

  • Syndol tablets ingredients

    The active ingredients in Syndol Headache Relief tablets are:
    Paracetamol 500mg, Caffeine 30mg and Codeine Phosphate 8mg.

    Syndol Original Tablets additionally contain the following active ingredient: Doxylamine succinate 5mg.

    The other ingredients in Syndol Headache Relief are: povidone, maize starch, methylcellulose, talc, purified water, calcium stearate, methyl hydroxypropyl cellulose and polyethylene glycol.

    Syndol Original also contains: povidone, croscarmellose sodium, pregelatinised
    maize starch, magnesium stearate, talc and water. The tablet film
    coating contains lactose monohydrate, hypromellose, titanium
    dioxide, polyethene glycol 4000; quinoline yellow (E104) and
    sunset yellow (E110).

Syndol reviews

Syndol FAQs

  • Syndol tablets provide pain relief from causes such as headache, migraine, toothache, muscle pain and period pain. It is an over-the-counter alternative for cases in which aspirin, paracetamol or ibuprofen have been ineffective.

  • Syndol does not require a prescription. However, take care to always read the label.

  • The active ingredient in Benadryl one A Day tablets is a non-sedating antihistamine called cetirizine. Allergy symptoms occur due to the activity of mast cells. These cells are responsible for the immune system’s reaction to foreign particles. When an allergen enters the body, mast cells release substances such as histamine. This binds to H1 receptors, which causes an inflammatory response, leading to congestion and watery eyes.

    Antihistamines work in different ways. Whereas some other medicines inhibit the release of histamine, cetirizine prevents histamine from reaching its H1 receptors. This blocks the body’s inflammatory response to allergens, easing the frustrating symptoms of hayfever and other allergies.

  • In recent years Syndol has been reformulated. Its current formulation contains paracetamol (500mg), codeine (8mg) and caffeine (30mg). It no longer contains an ingredient called doxylamine, which is an antihistamine

  • Syndol is manufactured by Sanofi. Sanofi have been working with both the manufacturing plants and regulatory authorities to determine whether the original Syndol formulation can be brought back. Whether this will happen cannot be confirmed, but we will keep you updated as to any decisions made.

  • Doxylamine is a non-habit forming antihistamine. It works by blocking the production of histamine and acetylcholine in the body. This action can cause drowsiness, which can help aid sleep. The current formulation of Syndol, which has been approved by the regulatory authorities, does not contain doxylamine. This means the product causes less drowsiness.

  • Anugesic HC Cream should be applied twice each day, and after each bowel movement.

    Before use, wash your hands and the affected area thoroughly with water. Gently dry the skin around the anus to prevent further irritation.

    For internal use, a nozzle is provided, which screws on to the top of the tube. Gently insert the tip of the nozzle into the anus, and squeeze the tube such that a small amount of cream is released. Withdraw the nozzle carefully, then use warm water to thoroughly wash both the nozzle and your hands.

    Anugesic HC suppositories should be inserted into the rectum.

  • Syndol is unsuitable for the following types of people:

    • Those with respiratory problems (e.g. shallow breathing, asthma, chronic obstructive pulmonary disease
    • Those with an allergy to any of this medicine’s ingredients
    • Those at risk of paralytic ileus (an intestinal blockage caused by nerve or muscle problems)
    • Those with increased pressure within the skull
    • Those with a liver enzyme CYP3D6 which converts codeine into morphine – this will increase the risk of side effects
    • Women who are pregnant or breastfeed
    • Anyone under the influence of alcohol
    • Children under the age of 12
    • Adolescents (under the age of 18) who have had their tonsils removed
    • Adolescents (under the age of 18) with breathing problems or heart conditions
  • Although each tablet contains only a small amount of codeine, it may still cause drowsiness. Do not drive or operate machinery until you know that Syndol will not make you feel tired or dizzy. The liver converts codeine into morphine – it is illegal to drive if this medicine is present in your saliva.

    Side effects of this medicine can vary significantly depending on how your body breaks down codeine. The range of possible side effects includes drowsiness, dizziness, shallow breathing, reduced appetite, constipation, nausea and small pupils.

    Syndol contains a small amount of caffeine. Take care if also consuming caffeine from other sources, as this may lead to unwanted side effects including anxiety, irritability, insomnia or further headaches.

    Avoid other medicines containing paracetamol while using Syndol.

    Do not exceed the recommended dose of Syndol, as it may be harmful to the kidneys and/or liver. Seek medical attention if you substantially exceed the recommended dose.

    Avoid drinking alcohol while using Syndol, as it may increase your chance of an overdose of paracetamol.

  • Syndol is only suitable for adults and children over the age of 12 years. It should not be taken by children under 12. Always read the product packaging and patient information leaflet prior to use.

  • Syndol Headache relief Tablets are only for short-term use (up to 3 days). They are suitable for treating acute moderate pain that is not sufficiently relieved by paracetamol, ibuprofen or aspirin alone. Syndol can effectively provide relief from; headaches, migraines and other pain.

  • You should take 2 tablets every 4 hours when required. Never take more than 8 tablets in a 24 hour period. Syndol should only be taken for a maximum of 3 days. If you need to it for longer than 3 days, see your doctor or pharmacist for advice. Taking painkillers for headaches for longer than three days can actually make them worse.

  • Syndol should not be taken at the same time as other products containing paracetamol. Always read the patient information leaflet for further contraindications.

  • No, Syndol Headache Relief Tablets can be purchased over-the-counter without a prescription.

Still unsure about this treatment?

Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

A small collection of medicines; A tube of orange ointment, a bottle of pills, and a tub of creamA doctor wearing glasses, with a stethoscope around his neck and an orange clipboard, welcoming a new customer with a wave

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