What is Estring?
Estring is a small, flexible vaginal ring used for hormone replacement therapy (HRT) to treat symptoms of vaginal atrophy associated with menopause, such as dryness, irritation, itching, pain during intercourse, a burning sensation and frequent urinary discomfort. It contains a low dose of estradiol, a form of oestrogen, which is gradually released over a period of 90 days.
Once inserted into the vagina, Estring works locally by delivering oestrogen directly to the vaginal tissues, helping to restore moisture and elasticity without significantly increasing oestrogen levels in the rest of the body. It's commonly prescribed to postmenopausal women seeking relief from these specific symptoms while minimising systemic hormone exposure.
Since it works locally, Estring minimises the risk of systemic side effects that might occur with oral or transdermal hormone replacement therapy.
Alternatives to Estring
There are several alternatives to Estring for treating menopausal vaginal symptoms. These alternatives include other forms of localized hormone replacement therapy (HRT)and non-hormonal treatments:
Vagifem (Estradiol Vaginal Tablets)
Vagifem is a localised oestrogen therapy in the form of small vaginal tablets. Like Estring, it delivers estradiol directly to the vaginal tissue to help restore moisture and thickness. The tablets are inserted into the vagina using an applicator, typically administered daily for the first two weeks, then twice a week for maintenance.
Estradiol Vaginal Cream (Ovestin)
Vaginal oestrogen creams provide localised oestrogen therapy to treat vaginal atrophy. They are applied directly to the vaginal tissue using an applicator, offering flexible dosing depending on symptom severity. Creams can be more customisable but may require more frequent application than Estring.
Replens (Non-Hormonal Moisturizer)
Replens is a non-hormonal vaginal moisturiser that helps alleviate dryness without the use of oestrogen. It is applied several times a week and provides temporary relief by hydrating and soothing the vaginal tissue.
Senshio (Ospemifene)
Senshio is an oral medication that treats pain during intercourse (dyspareunia) caused by vaginal atrophy. It is a selective oestrogen receptor modulator (SERM) that mimics oestrogen's effects on the vaginal tissue without being a hormone itself.
Intrarosa (Prasterone Vaginal Inserts)
Intrarosa is a vaginal insert that contains prasterone (DHEA), a hormone precursor that is converted into estrogen and testosterone in the vaginal tissues. It helps relieve moderate to severe pain during intercourse due to vaginal atrophy.