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Spedra 100mg Tablets

Spedra Tablets (50mg, 100mg & 200mg)

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Order before 3pm for delivery from Tue. 22 Jun and Wed. 23 Jun.

Description for Spedra Tablets (50mg, 100mg & 200mg)

Spedra tablets are one of the most popular treatments for Erectile Dysfunction (ED) in the UK. They can take effect as soon as 20 minutes after use and help you to achieve an erection and allow you to maintain one for a window of 4-5 hours.

Spedra can help you have a normal sex life again, however, to make sure it is the right treatment for you it is important that you discuss the causes and symptoms of your ED first, before you buy.

The Independent Pharmacy offers a fast & free, online consultation before dispensing Spedra tablets.

Order Spedra online and get immediate ED relief as quickly as the very next day.

Product Information

  • Age: 18 Years +

    Maximum per order: N/A

  • Pregnancy: N/A

    Breastfeeding: N/A

What are Spedra tablets?

Spedra tablets are an ED medication. Spedra works works by promoting blood flow towards the penis, which results in a heightened ability to maintain erections. This blood flow will only occur during sexual stimulation, so Spedra does not allow you to skip the foreplay.

Spedra is available in three doses, 50mg, 100mg and 200mg. It is recommended you start on 100mg, but all of the doses can be prescribed dependent on your needs, by our qualified, UK-based doctors and costs from £22 a tablet.


Avanafil as an ED treatment

The active ingredient of Spedra tablets is the drug avanafil (avanafil is also sold under the brand name Stendra in the US). This is a PDE-5 inhibitor, a drug which tackles ED by increasing the blood flow to your penis once you have become aroused. Other PDE-5 inhibitors are: Cialis, Levitra, and Viagra.

Read about the differences of Spedra vs Viagra in more detail here.


Is avanafil available in the UK?

Avanafil is available with a prescription in the UK from your doctor/GP or a registered online pharmacy. You will be required to complete a medical consultation in order to buy avanafil and Spedra tablets.


What is Spedra 100mg?

Spedra comes in 50mg,100mg, and 200mg dosages. It is recommended that you start by taking the 100mg tablets.

Spedra 200mg tablets are the highest dosage available and prescribed to men who have tried lower dosages or other ED treatments without success.

A Spedra 200mg tablet should be strong enough to treat almost all cases of ED. However, like all ED medication, there is a chance of little or no effect, particularly if it is one of the first times the medicine is being used. If a certain dose of Spedra isn't working, it is advised that you try it at least eight times before deciding to switch to another dose or medicine.

If side effects such as headaches or flushing appear, and persist after several uses of the medicine, you might want to consider another treatment or a reduced dosage.

Read more about the possible Spedra side effects here.


Does Spedra work?

Spedra treats ED by dealing with the physical causes that prevent a man from achieving an erection – reduced blood flow to the penis as a result of blocked or narrow arteries. ED can also be caused by psychological reasons, such as anxiety or depression. It is possible that Spedra can help in achieving an erection when ED is caused by psychological symptoms. In these cases, it is recommended that advice from a doctor or therapist is sought for a long term solution.


How long does it take for Spedra to work?

Spedra is one of the fastest solutions for ED available – it can take effect in just 20 minutes, and this can last for up to 4 or 5 hours. However, if you have recently eaten prior to taking Spedra then it can take up to 90 minutes for the medication to work.


What are the most common side effects for Spedra?

The following side effects can appear when using Spedra:

Common – may appear in up to 1 in every 10 people:

  • Flushing
  • Nasal congestion
  • Headache

If any of these concern you, or Spedra causes any other side effects, consult with a doctor or pharmacist.

Not everyone will experience side effects, read this guide for more information on Spedra side effects.


Is Spedra better than Viagra?

The active ingredient of Viagra is sildenafil citrate. While both Spedra and Viagra allow you to achieve and then maintain an erection for up to 5 hours, Viagra takes an hour to take effect, while Spedra becomes effective after just 20 minutes.

Read this guide for more information on Spedra vs Viagra.


Which erectile dysfunction treatment is best?

There are a large number of ED treatments available and the best one for you will depend on your medical circumstances and personal requirements:

  • Cialis – Best if you want a long-lasting ED treatment and well-known brand
  • Levitra – Best if you are aged over 50 and/or have diabetes
  • Sildenafil – Best if you want a cheaper alternative to Viagra
  • Spedra – Best if you want a fast-acting ED treatment
  • Tadalafil – Best if you want a long-lasting and cheaper alternative to Cialis
  • Viagra – Best if you want a well-known ED treatment that lasts 4-5 hours
  • Viagra Connect – Best if you do not have a prescription for ED medication
  • Vitaros – Best if you have found other ED medication to be ineffective 

For more information on the different medication available, check out our Compare ED Treatments table.


Spedra tablets (50mg, 100mg & 200mg) reviews

When looking for reviews of Spedra tablets it is important that you check the websites where the reviews are posted. Some of the different things for you to consider when assessing the website(s) hosting Spedra reviews are:

  • What is the posting process – how are the reviews regulated?
  • Does the website employ registered medical professionals to monitor and curate the posts?

If you are in doubt about the accuracy of the Spedra reviews you are reading, remember that it is always best to seek advice from a registered medical professional.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Spedra dosage

  • You should take one Spedra tablet around 30 minutes before sex.
  • Spedra can take up to 60 - 90 minutes to take effect in some men if it is taken on a full stomach after a large meal.
  • Spedra can produce an effect for up to 4 – 5 hours.
  • You should never take more than tablet for erectile dysfunction (Spedra, Viagra, Cialis, or Levitra) in a 24-hour period.
  • You should take Spedra on an empty stomach and try to limit your alcohol intake to ensure it remains effective.

Spedra does not always work for everyone the first time they use it. If this is the case you should not give up, guidance states that you should try Spedra at least 8 times before trying an alternative ED treatment. If you find Spedra tablets effective and do not experience any serious side effects you can request a repeat order via your online account. If you followed the above guidance and still find Spedra ineffective you may wish to increase the strength of your Spedra tablets, or alternatively try a different medicine such as Viagra, Cialis or Levitra

Spedra side effects

Not everyone will experience side effects from Spedra, although they are more likely if you have never taken Spedra before or if you take Spedra 200mg due to their high strength. If you do experience side effects from Spedra tablets they may include headache, flushing, light headedness and rarely a stuffy nose or indigestion. Spedra has a small risk of nausea, vomiting, diarrhoea, and skin rash as with all medicines. Please read the Patient Information Leaflet enclosed with your medicines for a full list of side effects.

Read this guide for more information on Spedra side effects.

Spedra ingredients

Each Spedra tablet contains avanafil as the active ingredient in either 50mg, 100mg or 200mg.

Spedra tablets also contain the following inactive ingredients: mannitol, fumaric acid, hydroxypropylcellulose, low substituted hydroxypropylcellulose, calcium carbonate, magnesium stearate and ferric oxide yellow (E172).

Spedra warnings

Do not take Spedra:

  • If you are allergic to avanafil or any of the other ingredients of this medicine (listed in section 6)
  • If you are taking “nitrate” medicines for chest pain (angina), such as amyl nitrite or glyceryl trinitrate. Spedra can increase the effects of these medicines and severely lower your blood pressure
  • If you are taking medicines for HIV or AIDS such as ritonavir, indinavir, saquinavir, nelfinavir or atazanavir
  • If you are taking medicines for fungal infections such as ketoconazole, itraconazole or voriconazole or certain antibiotics for bacterial infections, such as clarithromycin or telithromycin
  • If you have a serious cardiac problem
  • If you have had a stroke or heart attack in the last 6 months
  • If you have an irregular heartbeat (“arrhythmia”) or heart problems that run in your family, as shown on a heart tracing (ECG)
  • If you have low blood pressure or high blood pressure not controlled by medicines
  • If you have chest pain (angina) or you get chest pain during sexual intercourse
  • If you have a serious liver or kidney problem
  • If you have loss of vision in one eye due to not enough blood getting to your eye (non-arteritic ischemic optic neuropathy [NAION])
  • If certain serious eye problems run in your family (such as retinitis pigmentosa).

Do not take Spedra if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Spedra.

Warnings and precautions

Talk to your doctor or pharmacist before taking Spedra:

  • If you have heart trouble. It may be risky for you to have sexual intercourse
  • If you suffer from priapism, that is a persistent erection lasting 4 hours or more. This can happen in men with conditions like sickle cell disease, multiple myeloma or leukaemia.
  • If you have a physical condition that affects the shape of your penis (such as angulation, Peyronie’s disease or cavernosal fibrosis)
  • If you have any bleeding disorder or active peptic ulceration.

If any of the above apply to you talk to your doctor or pharmacist before taking Spedra. Check with your doctor or pharmacist if you are not sure.

Problems with your sight or hearing

Some men taking medicines like Spedra have had problems with their sight and hearing – see “Serious side effects” in section 4 for more details. It is not known if these problems are related directly to Spedra, other diseases that you may have or a combination of factors.

Spedra with food and alcohol

Grapefruit juice can increase exposure to the medicine and should be avoided within 24 hours prior to taking Spedra.

Drinking alcohol at the same time as taking Spedra may increase your heart rate and lower your blood pressure. You may feel dizzy (especially when standing), have a headache or feel your heart beating in your chest (palpitations). Drinking alcohol may also decrease your ability to get an erection.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Erectile Dysfunction (ED)?

Visit our advice area or contact our support team

Spedra Tablets (50mg, 100mg & 200mg) Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • How do I take Spedra tablets?

    In adults 18 years and over, the dose of Spedra is one tablet when required, around 30 minutes before sex. You should not take more than one Spedra tablet, or other erectile dysfunction treatment, in a 24-hour period.

  • What strengths of Spedra are available?

    There are three dosages of Spedra available. These are 50mg, 100mg, and 200mg tablets. The 100mg option is recommended for men beginning Spedra treatment. The other dosages are for men who find the response to the 100mg tablets either too weak or too strong.

  • How fast does it take Spedra to start to work?

    Spedra can take as little as 15 minutes, or as long as 90 minutes, to work. This variation depends on how full the stomach is. On an empty stomach, absorption will be very fast, whilst on a full stomach it can take a while.

  • Should I take Spedra tablets with food?

    You should take Spedra on an empty stomach where possible. If you have recently eaten, especially if it was a large meal, this may delay the absorption of the tablet and mean it can take 60 - 90 minutes to reach its full effect.

  • Does Spedra take effect faster than Viagra (sildenafil)?

    Spedra is a much faster treatment than Viagra. Viagra must be taken 1 hour before sex, whilst Spedra can work as quickly as 15-30 minutes after consumption.

    Both treatments last a similar amount of time – about 4 - 5 hours.

    Note that this does not mean that you will maintain an erection for this amount of time, but that your ability to achieve and maintain an erection will be improved during this time.

    Taking Spedra after a large meal can delay its effects.

    Read this guide for more information on Spedra vs Viagra.

  • Does Spedra last as long as Viagra?

    Both treatments last around the same amount of time, being 4-6 hours.

  • Are there less side effects from Spedra than from Viagra?

    As Spedra is a more recent product, it is difficult to know if it has less side effects than Viagra. Viagra has been used for a long time, and proven to be effective and safe. If you are concerned about side effects, using Viagra will be a simpler choice.

  • Is it safe to buy Spedra online?

    Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Spedra online. The Independent Pharmacy is an NHS Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine prescription treatments through our Online Pharmacy & Online Doctor.

    If you’re unsure, here’s more information on how to buy medicine safely.

  • How do I buy Spedra tablets online?

    Spedra should only be purchased from websites registered with the Care Quality Commission and the General Pharmaceutical Council. These sites will be regulated, ensuring they sell genuine Spedra in a safe manner.

    Buying Spedra tablets online from The Independent Pharmacy is simple: just select 'Start Consultation' above. You will then need to fill in a simple health questionnaire so our GPs & Pharmacists can ensure it is safe for us to supply your Spedra to you. It all takes around 3 minutes and your treatment can be delivered to your door.

  • What are the advantages of buying Spedra online?

    There are many advantages to buying Spedra tablets online, some include:

    • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
    • Fast delivery - We offer same-day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
    • Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
    • Tons of information - we provide all the information you could need on Spedra and other ED treatments, in easy to digest formats, at a time to suit you.
  • Is Spedra available for next day delivery?

    Yes, we understand that sometimes you want to get your treatment as soon as possible. If ordered before 4pm Monday to Friday, Spedra tablets are available for next day delivery.

  • Can I use other Erectile Dysfunction treatments with Spedra?

    You should not take any other erectile dysfunction treatments or tablets with Spedra or within 24 hours of taking it. If you find that Spedra tablets are not as effective as you would like, you should consider increasing your dose if on a lower strength.

  • Why can't I buy 64 tablets of Spedra online at one time like some other pharmacies?

    Spedra tablets are a prescription-only erectile dysfunction. For that reason, to ensure the safety of our patients and the legal operating of our pharmacy, we only supply a maximum of 32 tablets at one time. This is normally enough for 2 - 3 months of treatment, which can then be easily reordered if necessary.

  • What are the most common side effects for Spedra?

    The following side effects can appear when using Spedra:
    Common – may appear in up to 1 in every 10 people: Flushing, nasal congestion, headache
    If any of these concern you, or Spedra causes any other side effects, consult with a doctor or pharmacist.
    Not everyone will experience side effects.

  • Which medicines should you not take with Spedra?

    Inform your doctor or pharmacist of any medicines you are taking and intend to take.

    Medicines such as Spedra can alter the effects of other medicines, and other medicines can also alter the effect of Spedra. Spedra can affect these medicines, and so you should not combine them:

    • Nitrate medicines such as amyl nitrate or glyceryl trinitrate, for chest pain.
    • Medicine for AIDS or HIV, such as indinavir, ritonavir, saquinavir, atazanafir, or nelfinavir.
    • Medication for fungal infections such as itraconazole, voriconazole, or ketoconazole.
    • Certain antibiotics such as clarithromycin or telithromycin

    If you are using any of the following medications, inform your doctor or pharmacist before using Spedra:

    • Alpha-blockers for lowering of the blood pressure or prostate problems
    • Medications for treating arrhythmia, such as procainamide, quinidine, sotalol or amiodarone
    • Antibiotics such as erythromycin
    • Primidone, phenobarbital, or carbamazepine for epilepsy
    • Riociguat Moderate CYP3A4 inhibitors which may prevent Spedra from breaking down inside the body. These include aprepitant, diltiazem, amprenavir, fosamprenavir, fluconazole, and verapamil

    Do not combine Spedra with other treatments for erectile dysfunction, such as tadalafil, vardenafil, or sildenafil. Before using Spedra, make sure to read all the instructions and packaging.

  • Buying Spedra online in the UK

    Spedra should only be purchases from websites registered with the Care Quality Commission and the General Pharmaceutical Council. These sites will be regulated, ensuring they sell genuine Spedra in a safe manner.

  • Is there an unbranded Spedra alternative available?

    Spedra is under patent in the UK, and so there are no generic unbranded Spedra drugs available. Any website claiming to offer cheaper and generic unbranded Spedra is breaking the law.

  • Which is more effective, Spedra or Viagra?

    In clinical trials, Viagra provides effective treatment for erectile dysfunction in about 80% of men. Spedra only provides effective treatment to about 60% of men. Viagra is a well known and trusted treatment for erectile dysfunction. However, Spedra is a significantly faster acting treatment.

    If speed is important to you, then you should see if Spedra is an effective treatment for you. If Spedra does not produce the effect that you desire, then you should consider using Viagra instead.

    It is recommended that you discuss treatment options and side effects with a doctor before using any new medicines.

    To see a full list of treatments for erectile dysfunction, take a look at our erectile dysfunction treatment page.

  • Can Spedra be combined with other erectile dysfunction treatments?

    Other treatments for erectile dysfunction should be used in conjunction with Spedra, or taken within 24 hours of using Spedra.

    If Spedra 100mg tablets are not satisfactory, consider using Spedra 200mg tablets.

  • What are the ingredients in Spedra?

    The active ingredient in Spedra is avanafil. Spedra 100mg tablets contain 100mg of avanafil.

    Spedra is a type of medicine known as a PDE-5 inhibitor that is used in treating erectile dysfunction (ED) in men. Spedra is the most recent medicine that has been approved for ED treatments. Spedra is a medicine for men who suffer from ED, much like other well known treatments such as Cialis, Viagra, and Levitra.

    Erectile dysfunction (ED) is a condition where the man cannot achieve an erection that can be used for sexual activity. When using Spedra, sexual stimulation is still required in order to achieve an erection.

    Spedra was released to in May 2014 and under exclusive licence to be marketed only by Menarini. The wholesale price of Spedra is competitive with other branded treatments for ED, though there are some unbranded treatments (such as sildenafil, which is identical to Viagra) which are cheaper.

  • How long does avanafil last?

    Avanafil takes effect in as little as 20 minutes and lasts as long as 5 hours. 

  • How much does avanafil cost?

    Avanafil costs from £4.50 per tablet, making Spedra cheaper than Cialis, Levitra, Viagra, and Vitaros.

  • Does avanafil work?

    Trials have shown that 72% of people who used avanafil have been able to successfully engage in sexual intercourse within minutes of taking the medication. 

Authored By:

A photo of  Andy Boysan

Andy Boysan


Published on: 06-01-2017

Last modified on: 11-10-2019

Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy.

Reviewed By:

A photo of  William Obeng

William Obeng

MPharm IP

Reviewed on: 11-10-2019

Next review date: 11-10-2021

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