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Nytol Original 25mg Caplets

Nytol Original 25mg Caplets (20 caplets)

Order before 4pm for delivery from Sat. 23 Mar.

Description for Nytol Original 25mg Caplets

Nytol Original Easy Swallow Caplets: If you are having trouble sleeping at night, just two Nytol Easy Swallow Caplets may be all you need to get a deep and restful sleep. This special sleeping aid from Nytol can be purchased over the counter and it won't leave you feeling groggy the next morning. These tablets are designed to be easy to swallow and they won?t get stuck in your throat.

Product Information

  • Age: 16 years +

    Maximum per order: 2

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

Nytol One-A-Night caplets help in achieving a natural sleep and provide relief from sleepless nights.

A single dose is contained within one easy to swallow caplet, and will work quickly to provide short-term relief from sleeplessness. Nytol One-A-Night is a clinically proven sleeping aid that encourages the first natural stages of sleep, helping to regulate a consistent sleep schedule.

When having trouble sleeping, Nytol One-A-Night caplets can provide short-term relief. They provide a more natural solution than heavy duty sleeping medication, as they encourage the body to drift to sleep naturally.

Nytol One-A-Night caplets represent a choice to maintain a natural and healthy sleep pattern, rather than to rely on medication to fall asleep every night.

This is the healthier choice as it ensures that upon waking in the morning, you will feel fully awake and ready to start your day – whilst use of traditional sleeping pills often incur grogginess and difficulty waking.

Nytol One-A-Night caplets are a temporary sleeping solution. It is recommended that you take one caplet before bed. Taking it around twenty minutes before trying to go to sleep will give the active ingredients ample time to relax your body for a peaceful sleep.

Nytol One-A-Night caplets contain diphenhydramine. This is a sedating antihistamine which directly influences the brain, encouraging drowsiness and helping you fall asleep.

Nytol One-A-Night can be used to combat sleeping difficulties. The active ingredient is the sedating histamine diphenhydramine hydrochloride, which causes drowsiness.

There are many causes of sleeping difficulties, such as stress or jet lag. Taking a Nytol One-A-Night caplet is a proven method of helping you fall asleep faster when suffering from these difficulties, letting you have a deeper and more peaceful sleep.

*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Adults, 16 years and over:

Swallow 2 caplets 20 minutes before you sleep.

Do not exceed the stated dose.

Not everyone will experience side effects when they take medication, however if you do they can include:

Drowsiness is the most common side effect. If this occurs do not operate or drive machinery.

If you are concerned about these effects, or if the product affects you in any other way, stop using it and talk to your doctor or pharmacist.

The active ingredients contained in this medicine is/are:

25mg of Diphenhydramine Hydrochloride per caplet.

The medicine also contains the following inactive ingredients to make up the complete product:

Silicon Dioxide, Maize Starch Microcrystalline Cellulose, Stearic Acid and Anhydrous Lactose.

Reading the following warnings carefully will help to ensure you are selecting an appropriate product.

  • If you are using other medication, or if you are expectant or breastfeeding, consult your doctor before you swallow these tablets. 
  • Unless directed by your doctor, you should not be take this medication containing an antihistamine, if you are sensitive to Diphenhydramine or if you suffer from narrow angle glaucoma, stomach ulcers, chronic pulmonary disease, and shortness of breath, asthma, bladder neck obstruction, symptomatic prostatic hypertrophy or pyloroduodenal obstruction. 
  • Use these tablets with caution in individuals with seizure disorders. 

Please read all packaging and the Product Information Leaflet before taking any new medicine and inform your doctor of medicines you are taking or intend to take.

Delivery & Shipping Information


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2/3 day delivery - £2.95
  • Express Tracked Delivery - 1/2 day delivery - £4.45
  • DPD Next Day - 1 working day - £6.95
  • Special Delivery (Guaranteed before 1pm) - £8.95
  • Saturday Guaranteed before 1pm - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail orders received before 4pm the same working day. Any orders received after 4pm or over the weekend will be dispatched the next working day. We aim to dispatch all DPD orders placed before 3pm on the same working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email and in your account.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.



DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 5.30pm the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 5.30pm to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 5.30pm to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Insomnia?

Visit our advice area or contact our support team

Nytol Original 25mg Caplets Reviews

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Take a free online assessment with our medical team for impartial help and advice on your condition.

Frequently Asked Questions

  • What are Nytol One-A-Night and Original caplets used for?

    Nytol One-A-Night and Original caplets provide temporary sleeping aid when experiencing sleeping difficulties.

  • How do Nytol caplets work?

    The active ingredient of Nytol One-A-Night caplets is the sedating antihistamine diphenhydramine. Once this chemical reaches the brain, it allows you to fall asleep faster and encourages a deeper sleep. This means Nytol One-A-Night caplets are an effective method for dealing with temporary sleeping difficulties. For best results, take a Nytol One-A-Night caplet twenty minutes before going to bed.

  • How can this medicine affect other medicines?

    If taken alongside any of the following medicines which cause drowsiness, there may be increased effects of drowsiness:

    • Alcohol
    • Antipsychotics (such as haloperidol)
    • Barbiturates (such as phenobarbital and amobarbital)
    • Benzodiazepines (such as diazepam and temazepam)
    • Sedating histamines (such as chlorphenamine and hydroxyzine)
    • Sleeping tablets (such as zopiclone)
    • Opioid painkillers (such as codeine, dihydrocodeine and morphine)
    • Tricyclic antidepressants (such as amitriptyline)


    If this medicine is taken alongside monoamine oxidase inhibitors (MAOIs), such as trancylcypromine, isocarboxazid, or phenelzine, there may be an increase in the side effects of blurred vision, drowsiness and a dry mouth.

  • Why are there different herbal formualtions?

    Because the herbal formulations tackle factors such as stress and anxiety, herbal formulations may treat insomnia in some patients better than others.

    Everyone has different sleep needs; some people require eight hours while others need only four. However, if you wake up frequently or find it difficult to wind down, Nytol can give you a fuller night’s sleep and will help you feel refreshed and ready to go the next day.
    On the occasions when you can’t sleep, Nytol is the ideal way to get back into a healthy sleeping routine and enjoy some rest.

  • WHY do the herbal formulations exist, if the conventional formula works fine?

    The best treatment for you will depend on your body and the causes of your insomnia. Whereas the conventional formula simply induces drowsiness, the herbal formulae tackle underlying stress and anxiety. The conventional Nytol formula should only be used in the short term, whereas the Nytol Herbal formula is more suitable for use in the long term.

  • How do herbal sleeping tablets work?

    Some plants such as valerian, hops, wild lettuce and passiflora are well-known for their sedative properties.

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We are regulated by a number of organisations in the UK including the MHRA, GPhC & CQC to ensure we offer the highest level of service to every one of our customers.

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It's easy! Follow our simple process to get the treatment or advice you need in no time.

  • 1 Complete a simple health questionnaire
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  • 3 You receive the right treatment or advice
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