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Efracea 40mg MR Capsules

Efracea 40mg MR Capsules (14 capsules)

Order before 3pm for delivery from Sat. 07 Aug.

Efracea Information

  • Age: 18 Years +

    Maximum per order: 12

  • Pregnancy: Not suitable

    Breastfeeding: Not suitable

What is Efracea?

Efracea capsules are a rosacea medication which contains an active ingredient known as doxycycline in a slow-release formulation. It can be used by adults as a treatment for the pimples and red bumps around the face associated with acne rosacea. Efracea capsules are manufactured by Galderma and are only available via prescription in the UK.

Doxycycline is type of antibiotic known as a tetracycline antibiotic. It works by killing a wide range of bacteria, and is an effective treatment for bacterial infections throughout the skin and respiratory system. It can also be used to combat STDs and malaria.

Efracea is a prescription-only treatment that has been designed specifically to treat the symptoms associated with rosacea. Rosacea is a dermatological condition which can massively impact upon an individual’s life, causing patches, bumps, spots, and veins to appear on the skin and face.


How does Efracea treat rosacea?

In most cases, rosacea is a lifelong skin condition which will undergo periods of activity and inactivity. Generally, it is a condition that occurs on the face, creating a range of symptoms including thickening of the skin; visible blood vessels; abnormal redness; and flushing. Some sufferers will have small raised spots called papules and sometimes even pustules, or pus-filled bumps.

Efracea is an effective and long term treatment for these symptoms. Because of the low dosage of doxycycline present in Efracea, it can safely be used for long periods of time. Treating your rosacea with Efracea will calm the skin, decreasing redness and irritation, and in some cases, completely eliminating your rosacea symptoms all together.

For many, rosacea is a condition that will be with them throughout their lives, cycling between periods of activity and inactivity. Rosacea usually occurs mainly on the face and creates a range of symptoms including:

  • Thickening of the skin.
  • Visible blood vessels.
  • Increased redness and flushing.
  • Small spots known as papules.
  • Pus-filled spots can also occur in some individuals.

The condition is fairly common with approximately 10 percent of people suffering from some form of rosacea according to the NHS. Despite its prevalence among the general population, little is known about what exactly causes rosacea in the first place.

Some medical professionals postulate that rosacea is brought about when blood vessels become dilated due to sun exposure. Others think that the cause of rosacea stems from tiny skin-mites known as demodex folliculorum. These mites are generally harmless; however they secrete damaging bacteria, and in large enough numbers can produce the symptoms listed above.

It is also thought that peptides play a role in creating the symptoms associated with rosacea. Peptides are compounds of amino acids present in your skin. It is thought that certain stimuli, such as excessive alcohol or very spicy foods, make your peptides enter a period of high activity, making your immune system react and produce the symptoms associated with rosacea.

Despite the fact that researchers are unsure as to the exact cause of rosacea, sufferers indicate certain triggers which can cause an outbreak. These triggers can include:

  • Alcohol
  • Caffeine
  • Dairy 
  • Extreme weather conditions
  • Long-term exposure to UV rays
  • Stress

Efracea can treat the symptoms of rosacea because of doxycycline, the antibiotic agent present in the treatment. The exact process by which this works is unknown as the underlying cause of rosacea is still not fully understood. Despite this, it is thought that doxycycline works by clearing up any pustules and stopping the bacteria from spreading. This reduces inflammation and decreases the unpleasantness of sore skin and nasty bumps.


Efracea and other rosacea treatments

Efracea capsules are an oral antibiotic treatment for rosacea. They can be combined with other topical, non-antibiotic rosacea treatments, such as:



*Prescription medicines are supplied subject to a medical consultation at the discretion of a doctor.

Efracea dose

Efracea comes in capsule form and should be swallowed with a glass of water while sitting or standing. Efracea capsules should be taken with a meal in order to prevent any stomach issues. That being said, don't consume any dairy products or antacids at the same time as Efracea capsules as they can affect the rate at which doxycycline is absorbed by your gut. If in doubt, wait at least 3 hours after using Efracea capsules before consuming any high calcium products. 

Efracea should usually be taken for up to 16 weeks, however if your symptoms have not improved after six weeks, consult your doctor.

The usual dosage of Efracea capsules is one 40mg capsule each day, usually taken in the morning. This is the standard dosage unless otherwise stated by your doctor.

You should also avoid exposing your skin to the sunlight for very long or during intense periods while using Efracea capsules.

Do not exceed the dose prescribed by your doctor.

Never take a double dose to make up for a missed dose. If you do forget a dose, just skip it and continue as normal the next day.

Efreacea side effects

Side effects from taking Efracea are fairly common and will affect 1 to 10 users in every 100. If you do suffer any side effects they could include:

Common (affect between 1 in 10 and 1 in 100 people)

  • Diarrhoea
  • Abdominal pain
  • Dry mouth
  • Inflammation of the nose and throat
  • Inflammation of the sinuses
  • Sinus headache
  • Fungal infections
  • Raised blood pressure
  • Back pain
  • Anxiety
  • Change in results of liver function tests
  • Raised blood sugar levels

Unknown frequency

  • Headache
  • Mild increase in pressure within the skull (benign intracranial hypertension). 

Stop taking this medicine and consult your doctor if you experience a severe persistent headache or any changes in your vision.

If you have any concerns regarding Efracea or experience any side effects not listed above then cease usage and consult with your doctor immediately.

Efracea ingredients

Efracea capsules contain one active ingredient known as doxycycline (monohydrate).

Efracea capsules also contain several inactive ingredients including:

  • Hypromellose
  • Methacrylic acid-ethyl acrylare copolymer (1:1)
  • Triethyl citrate
  • Talc
  • Hypromellose
  • Titanium dioxide
  • Macrogol 400
  • Yellow iron oxide
  • Red iron oxide
  • Polysorbate 80
  • Sugar spheres such as maize starch and sucrose

The capsules themselves contain:

  • Gelatin
  • Black iron oxide
  • Red iron oxide
  • Yellow iron oxide
  • Titanium dioxide

The ink printed onto the capsules contains:

  • Shellac
  • Propylene glycol
  • Black iron oxide
  • Indigo carmine aluminium lake
  • Allura red AC, brilliant blue FCF, and D & C yellow no. 10 aluminium lake

Efracea warnings

Before deciding to use Efracea capsules you should consider the following warnings:

  • Do not take Efracea if you have every had an allergic reaction to any of the ingredients listed above.
  • Do not take Efracea if you are in or have passed the fourth month of pregnancy as it may affect the unborn baby. If you become pregnant whilst taking Efracea then consult with you doctor as soon as possible.
  • Do not take Efracea if you are currently using any oral retinoids.
  • Do not take Efracea if you suffer from achlorhydria (an absence of stomach acid) or have had any surgery on the duodenum (upper part of the gut).

You should always consult with you doctor before beginning a course of efracea if you:

  • Have liver disease.
  • Are predisposed to candidiasis overgrowth.
  • Are currently suffering from an oral or vaginal fungal or yeast infection. 
  • Currently suffer from muscle disease.
  • Currently suffer from colitis.
  • Experience any oesophageal ulceration or irritation. 
  • Have rosacea affecting the eyes.
  • Expose yourself to strong UV light as sunburn can occur more easily.

Always speak to your doctor if you are taking or have recently taken any other medication as this may interfere with Efracea.

You should not use Efracea if you are currently using the medication isotretinoin as this can increase the risk of pressure in the brain.

Do not use any of the following products within three hours of taking efracea:

  • Antacids
  • Vitamin supplements
  • Any product which contains calcium – this includes dairy products
  • Products containing aluminium, magnesium, iron, and bismuth
  • Cholestyramine
  • Activated charcoal
  • Sucralfate

Some medications for ulcers and heartburn may reduce the effectiveness of Efracea and should not be taken within two hours of each other.

If you suffer from diabetes, or are currently on blood thinners, consult with your doctor about altering your dosages.

Certain antibiotics can become less effective when used alongside Efracea.

The following medications may reduce the length of time that Efracea will remain active within body:

  • Carbamazepine (epilepsy)
  • Barbituates (sleeping pills or short-term pain killers) 
  • Primidone (anti-convulsant) or cyclosporine (organ transplant)
  • Rifampicin (tuberculosis)
  • Diphenylhydantoin and phenytoin (seizures of the brain)

Efracea should also not be used in conjunction with the anaesthetic methoxylfluorane as this can cause severe damage to your kidneys.

Efracea capsules should always be taken with plenty of water in order to properly wash down them down your throat, reducing irritation in the gullet. Any dairy products, such as milk, should not be taken at the same time as Efracea as calcium can decrease its effectiveness.

Always read the label and accompanying product information before making any decision regarding new medication.

Delivery & Shipping Information

Please note that due to the current situation with COVID-19, Royal Mail are experiencing some delays. This may mean that your order takes longer to arrive than you would normally expect. We are working hard to ensure that, where possible, all orders placed before 15:00 are still dispatched the same working day.


UK Orders

We offer FREE standard tracked delivery on orders over £40.

The following delivery options are available:

  • Standard Tracked Delivery - 2 - 3 day delivery - £2.95
  • Express Tracked Delivery - 1 - 2 day delivery - £4.45
  • DPD Next Day - 1 - 2 working days - £6.95
  • Special Delivery (Guaranteed before 21:00) - £8.95
  • Saturday Guaranteed before 21:00 - £10.45

Important Delivery Information

All our orders are sent out using Royal Mail (unless stated). We always aim to dispatch all Royal Mail & DPD orders received before 15:00 the same working day. Any orders received after 15:00 or over the weekend will be dispatched the next working day. Orders will not be dispatched on weekends or bank holidays.

All orders are subject to approval by our team of doctors and pharmacists. Your delivery date in the checkout is subject to your consultation being approved by our healthcare team.

All orders can be fully tracked from your dispatch email, in your online account and from any notifications from your courier.

We ensure all parcels are in plain packaging for discreet delivery of your medicines and pharmacy goods. Where possible, we will attempt to size all parcels to fit through your letterbox in tamper-proof packaging. By placing an order on our website, you confirm that it is safe and appropriate for a package containing medicines to be posted through your letterbox, if the carrier is able to do so. You should notify our customer support team if it is not safe for the package to be posted through the letterbox, for example due to animals or small children.

Deliveries containing pharmacy-only or prescription medicines may require a signature on receipt. 

Delivery is free for all NHS prescriptions.


Royal Mail


  • Fully tracked delivery
  • SMS & email notifications
  • Four-hour delivery window
  • Change delivery date directly with Royal Mail
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local Post Office or Royal Mail Customer Service Point.

Royal Mail are the most widely recognised mail delivery company in the UK. Being on the UK’s 29 million doorsteps six days a week means they offer unparalleled price and convenience. The Independent Pharmacy uses Royal Mail’s Tracked 48, Tracked 24, and Special Delivery Guaranteed parcel services to offer reliable, fully-tracked delivery at very competitive prices. Your Royal Mail parcel will arrive with your normal daily delivery of post.

Please note: Royal Mail do not deliver on Sundays or Bank Holidays - this should be taken into account when ordering. 

If you are not home to accept your delivery, a card should be left by the Royal Mail representative. This card will provide details of where you can collect the order or how to arrange re-delivery.

Should you be unable to collect your missed delivery or arrange for your medication to be redelivered by Royal Mail, the pharmacy can resend your medication to the same, or a different address provided it has been returned to us and this happens within a 30 day window.

Once a package has been shipped with Royal Mail we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.




  • Fully tracked delivery
  • SMS & email notifications
  • One-hour delivery window
  • Change delivery date directly with DPD
  • Update delivery location - add a Safeplace, preferred neighbour, or update your delivery location to a local collection point.

DPD Local is the most innovative parcel carrier around. Thanks to their industry-leading Predict service, they provide parcel recipients with a one hour delivery window, notified by email, so you don't have to wait in all day. What's more, it enables receivers to watch the progress of their delivery on a real-time map, all the way down to a final 15 minute time-slot. 

As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That's why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

  • Select an alternative delivery date
  • Opt for delivery to a nominated neighbour
  • Have the parcel left in a specified safe place
  • Collect the parcel from your local DPD Pickup Shop
  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays - this should be taken into account when ordering. 

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.


Forwarding houses

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.


BFPO Postcodes

Unfortunately we are unable to deliver medicines to BFPO postcodes.


Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver by 17:30 the next working day in the following postcode areas:
AB30 - 39, 41 - 45, 51 - 56
GY9 Alderney (Channel Islands)
HS1, 3 - 9
IV21 - 28, 40 - 49, 51 - 56
KA27, 28
KW1 - 3, 5 - 15
KW16 Stromness Town only
PA20 (0&9)
PA28 - 38, 41 - 49, 76, 77
PH15, 17 - 26, 31 - 40, 49, 50


We deliver within two working days by 17:30 to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
PA60 - 75, 78
ZE2, 3


We deliver within three working days by 17:30 to the following postcode areas:
KW16 - non-Town
PH30, 41 - 44


Please note: This applies to our 'Special Delivery' and 'Saturday Guaranteed' services.


International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Need to know more about Rosacea?

Visit our advice area or contact our support team

Efracea 40mg MR Capsules Reviews

Unsure about a treatment?
Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

Frequently Asked Questions

  • What is Efracea?

    Efracea is a treatment for the skin condition known as rosacea. It contains an antibiotic called doxycycline which is known to treat the symptoms associated with rosacea in adults.

  • How does Efracea treat rosacea?

    Each capsule contains 40mg of doxycycline in a slow release form. This will have anti-inflammatory effect, decreasing the symptoms of rosacea locally, without any unnecessary absorption elsewhere in the body.

  • What is the best way to take Efracea?

    You should take one capsule of efracea in the morning, every day. Each dose should be accompanied by plenty of water. Efracea can become less effective when interacting with certain types of food. For this reason each capsule should be taken two to three hours before eating.

    Efracea can take a long time to work, and you may not see any results for the first several weeks. If after six weeks there is still no sign of improvement then speak to your doctor and review the treatment.

  • How do I know if Efracea is suitable for me?

    Efracea capsules are recommended for people that are suffering from rosacea and have tried topical treatments, such as Rozex, Mirvaso, or Finacea, with little success.

    Efracea cannot be used by everybody and should not be used by people who:

    • Suffer from liver problems.
    • Suffer from achlorhydria (lack of stomach acid).
    • Have had a duodenum bypass.
    • Are pregnant or breastfeeding.

    If you are currently taking any other medications then you should consult with your doctor before you start taking Efracea. Extra caution should be given if you are currently taking any of the following:

    • Cyclosporin.
    • Other antibiotics.
    • Anticoagulants.
    • Quinapril.

    It should also be noted that the effectiveness of the oral contraceptive pill can be reduced if taken at the same time as a course of Efracea.

  • Are there any side effects when taking Efracea?

    Some antibiotics can cause your body to have a negative reaction such as an inflammation of the bowel (colitis). This has not been reported in efracea as the levels of the antibiotic doxycycline are so low. If, however, you experience severe diarrhoea or bloody stools, cease use of this medication immediately.

  • Is it okay to drink alcohol while using Efracea?

    Studies have shown that the active ingredient in efracea, doxycycline, will be less effective at treating rosacea if large amounts of alcohol have been consumed. It is unlikely that drinking small amounts while on a course of efracea will cause any problems, however if you experience any negative effects, cease usage and consult your doctor.

  • Is it okay to take Efracea at the same time as other medications?

    There may be an increased risk of benign intracranial hypertension (increased skull pressure) when using efracea in conjunction with retinoids, such as acitretin, isotretinoin, and tretinoin.

    Certain other medications can decrease your body’s absorption of doxycycline, making it less effective. Three hours should be given before or after each efracea capsule is taken if you are using any of the following:

    • Medication for heartburn or indigestion that contains aluminium, magnesium, calcium, or magnesium.
    • Any kind of calcium supplement.
    • Iron preparations such as ferrous sulphate.
    • Kaolin.
    • Magnesium salts.
    • Ranitidine bismuth citrate
    • Zinc salts.

    Doxycycline can also increase the effects of anticoagulants (blood-clotting agents) such as warfarin. If you are taking any anticoagulants then you should speak to your doctor before starting this treatment.

    There is a chance that doxycycline may increase your blood levels of immunosuppressants such as cyclosporine. If you are taking these two medications together then you should consult with your doctor as they may want to monitor your situation.

  • Are Efracea capsules available over the counter?

    Efracea capsules can only be purchased via a prescription. At The Independent Pharmacy, our doctors will review your online consultation and take care of the prescription for you, meaning our pharmacy can send you the medication you need as soon as the next working day.

  • How should I store Efracea capsules?

    Keep Efracea capsules at a temperature below 30°C and out of the reach of children.

  • Can I use Efracea capsules while I am pregnant?

    Efracea capsules are not suitable for women who are pregnant or breastfeeding.

  • Can I drive while using Efracea capsules?

    In short, yes. There are unlikely to be any effects that impair your ability to drive. That being said, if you do experience any side effects that may make driving more difficult or unsafe, do not drive and let your doctor know.

Authored By:

A photo of  Scott McDougall

Scott McDougall


Published on: 16-09-2016

Last modified on: 16-09-2018

Scott is one of the two founders of The Independent Pharmacy. He is a registered pharmacist and the registered manager of our service with the CQC.

Reviewed By:

A photo of  Chris Newbury

Chris Newbury

BPharm IP

Reviewed on: 16-09-2020

Next review date: 16-09-2022

Chris is a vastly experienced clinical pharmacist and has been registered as an Independent Prescriber since 2014.

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