The Independent Pharmacy

How Long Does Tadalafil Take To Work

Daniel Hurley
Daniel HurleyMPharm IPPharmacist Independent Prescriber

Reviewed on 8 Apr 2024

If your doctor has given you Tadalafil (you might also know its branded version Cialis) to treat erectile dysfunction, you’re probably wondering: how long does Tadalafil take to work?

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Tadalafil Tablets (10mg & 20mg)
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Tadalafil is a popular choice for treating this condition, and it usually starts to do its thing, helping you get an erection that’s strong enough for sex about 30 to 60 minutes after you take it.

However, how fast Tadalafil works can be a bit different for everyone. Your body’s own health can make the timing vary.

Cialis Tablets (10mg & 20mg)
Cialis Tablets (10mg & 20mg)
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Now, let’s dive into how long Tadalafil takes to kick in, what can change how well it works, and tips on how to get the best results from it.

Key Takeaways:

  • Tadalafil typically starts working within 30 to 60 minutes of ingestion. However, individual factors can affect this timing.
  • Factors like diet, overall health, and lifestyle habits such as smoking and alcohol consumption can influence Tadalafil’s efficacy.
  • For best results, adhere to prescribed dosages and monitor lifestyle factors that may affect its effectiveness.
  • Tadalafil offers a longer duration of action compared to Viagra, lasting up to 36 hours, making it a preferred option for some due to its extended effectiveness period.
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Viagra Tablets (25mg, 50mg & 100mg)
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How Long Does Tadalafil Take to Work?

Usually, Tadalafil starts to work in about 30 to 60 minutes after taking it with a full glass of water. The typical dose prescribed, such as 10mg or 20mg, can also impact how fast you experience results. Plus, everyone’s body processes medications a bit differently. So, or some, it might take a bit longer to feel the full effects of Tadalafil, and that's okay. Everyone's journey towards improvement is different, and patience can be key.

The key is being patient when first starting treatment of erectile dysfunction with Tadalafil and carefully observing your body’s unique timing and reactions. Track when you take Tadalafil (generic version of Cialis) and any changes you notice after 30 minutes, 1 hour, etc. This helps discover your perfect window for planning and results.

Factors That Affect How Quickly Tadalafil Works

A few key elements contribute to differences people notice in how rapidly Tadalafil begins working effectively:

  • Your health - Underlying health conditions like diabetes or high blood pressure may influence results. Genetics and natural metabolism differences also play roles in regulating speed.
  • Other habits - Smoking intensely reduces blood flow, which is crucial for erectile function. Excess alcohol has similar damping impacts that may hamper efficacy.

Accounting for these factors will help set realistic expectations around onset periods. Tracking lifestyle details surrounding faster or slower occasions also enables optimising your personal effectiveness.

Boosting Your Success With Tadalafil

Best Tips for Ideal Results

To maximise Tadalafil’s efficacy, consider this advice:

  • Follow your doctor’s lead - Carefully stick to the prescribed tablet amounts without doubling up typical Tadalafil (Cialis) doses randomly. Consult them on fine-tuning quantities as needed.
  • Establish reminders - Set medication timers, ensuring regularly scheduled daily Tadalafil or alarms 30-60 minutes before sex, reminding preemptive taking.
  • Track lifestyle factors - Note diet, stress, sleep or other elements surrounding better or worse outcomes, adjusting and experimenting over time.

Over a few consistent tries, you’ll discover your perfect plan, ensuring peak experiences with Tadalafil on board!

Lifestyle Considerations With Tadalafil

It’s important to remember that efficacy performance fluctuates normally from person to person, regardless of lifestyle choices. Be patient and give Tadalafil multiple earnest tries spanning different days before assuming it’ll never work well or that diet and stress alone sabotage success.

Still, tracking details like food consumption, energy levels, sleep patterns and emotional states during the stronger or weaker Tadalafil experiences can illuminate useful connections over time. You might discover that timing doses 30-60 minutes after low-fibre meals and moderate exercise enables the best erection firmness and duration, for example. Piece by piece, determine any helpful adjustments providing ingredients for peak interactions with Tadalafil.

Discuss your lifestyle factor observations openly with your healthcare provider, too, regarding influences noticed. They can best advise you on maximising regimens, stress coping, ideal timing of doses and more for pumping effectiveness odds.

What To Avoid With Tadalafil

To make sure Tadalafil does its job well in helping the blood flow to the penis and giving you the strength for sexual activity, here are things you should steer clear of:

  • Grapefruit Juice and Some Other Foods - Ever heard that grapefruit juice can mess with your medication? It’s true! Drinking grapefruit juice while on Tadalafil can lead to more of the medication staying in your body for a longer time. This might sound good, but it actually increases your chances of having Tadalafil (Cialis) side effects, such as muscle pain or headaches. Stick to water or other drinks and avoid grapefruit juice.
  • Mixing It with Certain Drugs - Tadalafil, being one of the PDE5 inhibitors, is like a team player working with your body to tackle erectile dysfunction. But when you mix it with other drugs, especially ones for chest pain, prostate issues, or blood pressure medications, it can cause a dangerous drop in your blood pressure. Always check with your healthcare provider for any drug interactions before adding any new medication to your treatment plan.
  • Too Much Alcohol - Having a little alcohol might not hurt, but drinking a lot can interfere with how Tadalafil works. Excessive alcohol consumption can lead to a drop in blood pressure, making it harder to achieve an erection, and can increase other potential side effects like dizziness or headaches. It’s best to limit how much alcohol you drink to ensure Tadalafil can do its thing.
  • Skipping or Doubling Doses - Whether you’re taking Tadalafil on a daily dose basis or just when you need it, sticking to your prescribed amount is key. Taking too much, hoping for maximum effects, or forgetting your medication can lead to problems like a painful erection or not getting the help you need when the time comes. Use a medication timer or set reminders to keep on track.

Remember, achieving the best results with Tadalafil isn’t just about taking the medication; it’s also about paying attention to these avoidables.

Always get medical advice from your healthcare provider, especially if you have health conditions like heart problems, kidney issues, or a history of stroke. They’ll give you the scoop on how to use this effective treatment for erectile dysfunction without running into trouble.

Taking care of these details will help you maintain your health and get the most out of your treatment, making sure you’re ready for intimate moments without any hiccups.

What If Tadalafil Seems Slow Acting?

If you don't see the results you were hoping for with Tadalafil right away, don't lose heart. There could be several reasons it's not working as expected, many of which can be addressed. You're not alone in this, and together with your healthcare provider, you can explore the reasons and find solutions:

  • Medication interactions – Other drugs you’re taking could be interfering with intended effects and absorption pacing.
  • Insufficient wait times – Leaping into intimacy too soon after taking before full efficacy may mistakenly seem like slow action.
  • Dosage issues – Don’t independently increase your amounts without medical advice and consultation. But do chat with a licensed healthcare professional about potential timing benefits from dose adjustments.

The remedy for optimising Tadalafil onset speed is not giving up or guessing solo about fixes. Instead, openly communicate with your healthcare provider about your experiences and timeline expectations to make cooperative adjustments dialling things in.

Take the Next Step With The Independent Pharmacy

Want personalised advice on optimising erectile dysfunction treatments like Tadalafil? The Independent Pharmacy has a friendly team who are ready to listen and help guide appropriate solutions and effective treatment options.

Reach out online and complete your ED consultation, sharing your situation confidentially via a quick questionnaire. Our knowledgeable team reviews submissions promptly, providing compassionate feedback on productive next steps worth considering.

Getting embarrassed and postponing proactive outreach for awkward issues helps no one. So risk a simple chat – relief and answers await!


Does Tadalafil keep you hard after coming?

No, Tadalafil only enhances erections when aroused by sexual stimulation. Once ejaculatory excitement subsides, enhanced swelling and hardness fade away naturally also, even with Tadalafil on board. The effect of the medication doesn’t override natural responses and the refractory time after ejaculation.

Is Tadalafil stronger than Viagra?

Both Tadalafil and Sildenafil (Viagra) improve erection abilities similarly by increasing penile blood flow. But while Viagra wears off in about 5 hours, a single Tadalafil dose enables easier erections for up to 36 hours when continually aroused. This longer-lasting action gives Tadalafil an edge in effectiveness.

Is 20mg of Tadalafil too much?

20mg is the maximum recommended starting amount, with 10mg actually being the most widely prescribed dose, given its efficacy and value. Exceeding 20mg risks heightened potential side effects without added boosts, so carefully follow medical guidance around the ideal personal dosage.

Is it safe to take 2 Tadalafil tablets?

It is not recommended to exceed your prescribed single dose without first consulting your doctor. Taking twice the amount risks heightened side effects without necessarily increasing positive erection effects. Carefully follow medical advice around the ideal Tadalafil quantity tailored to your situation for safe results.


NHS (2022). About tadalafil -

Xiuwei Shen, Fan Chen, Fengwei Wang, Peng Huang, and Wenchao Luo (2020). The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats -

NHS (2022). How and when to take tadalafil -

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