Codis tablets give short-term (up to three days) relief from mild to moderate pain, including non-serious arthritic or rheumatic pain, headaches, migraine, sprains and strains, backache, nerve pain (neuralgia), tendonitis, period pain and toothache. Codis 500 should be used only when paracetamol, aspirin or ibuprofen have not relieved the pain.
You can also use Codis 500 tablets for colds, flu, fever and also inflamed joints, so it is a very useful medication to keep at home. Codis 500 tablets are to be used for three days only.If you ned to take them for longer periods you should see your doctor.
The two active ingredients of codis 500 are aspirin and codeine phosphate and this combination is sometimes referred to as co-codaprin.
Aspirin is a non-steroidal anti-inflammatory drug (NSAIDs), which works by interfering with the action of cyclo-oxygenase, a substance found in the body which is involved in producing certain chemicals in the body, one of which is prostaglandins. In response to certain diseases or injury, prostaglandins cause pain, inflammation and swelling. It is by stopping the action of cyclo-oxygenase that aspirin reduces the production of the prostaglandins and so can therefore be used to relieve pain and inflammation.
Codeine is slightly stronger than aspirin and is classed as an opioid, working by imitating the action of endorphins, naturally occurring pain-reducing chemicals found in the brain and spinal cord. This medicine reduces pain by combining with opioid receptors.
Like would natural endorphins, codeine combines with the opioid receptors which are present in the brain and spinal cord, thus blocking transmission of the pain signals sent from the nerves to the brain so, even though the cause of pain is still present, a reduced pain is actually felt.
Codis 500 soluble tablets are made up of 8mg of codeine. When combined with the aspirin, it is effective in relieving mild to moderate pain.
In March 2015, a new ‘drug driving’ law came into force, which addresses the specified limits of certain medicines or drugs in your body. These medicines include morphine and, when codeine is taken, the liver converts this into morphine, so codeine is also included on the list of medicines not allowed to be taken by drivers. Police will test for presence of certain drugs via a saliva test and medicines will have a higher limit than will prohibited drugs. Unless driving dangerously, people on these medications will not therefore be breaking the law. If you are taking medication, carry the medication information leaflet in the car, in case you should be asked to take a saliva test. Do not drive if this medication affects your alertness or ability to drive safely e.g. if you feel unable to concentrate, sleepy, dizzy, or if your eyesight seems to be affected.
The body metabolises codeine in different ways for different people and, for some, this means there may be a higher chance of experiencing side-effects. Such side-effects include slow and shallow breathing, reduced levels of consciousness, sleepiness, ‘pin-point’ pupils, nausea, vomiting, a lack of appetite and also constipation. Should you experience side-effects, do not take any more medicine until you have spoken with your doctor. It is possible that some people may find that this medication doesn’t have enough effect and, even in this case, speak with your doctor or a pharmacist.
Codis should not be taken for more than three days without having spoken with your doctor as, if taken for longer, your body can develop a tolerance to it and cease to relieve pain effectively. Prolonged use can also lead to a dependency and trying to stop taking the medication at a later date could cause withdrawal symptoms e.g. irritability and restlessness. Also, taking painkillers for headaches over a prolonged period can actually increase the pain.
Aspirin should never be taken with other non-steroidal anti-inflammatory drugs (NSAIDs) e.g. diclofenac, ibuprofen and naproxen, as it can increase the risk of side-effects.
If taking anticoagulants to prevent the risk of blood clotting e.g. warfarin or dabigatran, do not take aspirin, as to do so could irritate the stomach lining and also heighten the effects of warfarin, both increasing the likelihood of bleeding.
Increased bleeding could also occur if aspirin is taken when also taking:
‘blood-thinning’ (antiplatelet) medicines e.g. clopidogrel or dipyridamole
iloprostheparin SSRI antidepressants such as citalopram, fluoxetine and paroxetine.
An increased risk of ulceration or bleeding in the stomach or intestines is possible if aspirin is taken alongside corticosteroids e.g. prednisolone or dexamethasone.
Aspirin also has a lessening effect on the rate at which methotrexate can be removed from the body, so they should not usually be used together. Aspirin also opposes the effect of probenecid and sulfinpyrazone.
If aspirin is taken with acetazolamide, there can be an increase in the side-effects.
Codeine should not be taken by those currently taking a monoamine oxidase inhibitor (MAOI) or have done so in the last 14 days. MAOIs include such medications as the antidepressants phenelzine, moclobemide, tranylcypromine, isocarboxazid, as well as selegiline, which is an anti-Parkinson’s medicine.
The dose of codeine in this codis medicine is not likely to cause drowsiness, but this could occur if it is taken with:
sleeping tablets e.g. zopiclone
sedating antihistamines e.g. chlorphenamine, triprolidine, hydroxyzine and promethazine, (these can sometimes be found in non-prescription cold, cough and hayfever remedies)
benzodiazepines e.g. temazepam, diazepam
antipsychotics e.g. haloperidol and chlorpromazine
other strong opioid painkillers e.g. morphine, tramadol and dihydrocodeine
tricyclic antidepressants e.g. amitriptyline.
Codeine phosphate can have the effect of reducing muscular activity in the gut and so may oppose the action of some medicines on the gut. These medicines include:
There could be an increased risk of a dry mouth, constipation and blurred vision, if codeine and antimuscarinic medicines are taken together. These include:
antimuscarinic medicines which are taken for Parkinson’s symptoms e.g. procyclidine, trihexiphenidyl and orphenadrine
antimuscarinic medicines which are taken for urinary incontinence e.g. oxybutynin, flavoxate, propiverine, tolterodine and trospium
antispasmodics e.g. atropine and hyoscine.
If codeine is taken with antimotility medicines for diarrhea e.g. loperamide, severe constipation could result.
Quinidine can have the effect of reducing the painkilling effect of codeine, as could rifampicin and ritonavir.
Particles or sediment of the medicine are sometimes left in the glass but don’t be concerned about this, as the medicine has already been dissolved in the water. When quick pain relief is needed e.g. migraine, dispersible tablets can give relief within a couple of hours and are particularly useful when it may prove difficult to swallow tablets.
When dropped into water, dispersible or effervescent tablets dissolve quickly, allowing quick absorption and therefore faster action than conventional tablets.
Non-Prescription Alternatives for the treatment of Pain are;
- Topical Treatments (Ibuprofen gel)
- Rest the area
If your pain does not ease or becomes severe, contact your GP or Pharmacist for further advice.